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| 1 | 太阳能电池研究的新进展显示文摘简要回顾了第一代晶体硅和第二代薄膜太阳能电池的发展状况熏并介绍了基于薄膜技术的第三代高性能太阳能电池的基本原理和发展趋势。 | 倪萌 M K Leung K Sumathy | 2004 | 可再生能源2004，22，2： | 38 |
| 2 | The modulation of co-stimulatory molecules by circulating exosomes in primary biliary cirrhosis显示文摘Exosomes 是 endocytic 起源的 nanoparticles,由由他们调制 cell-to-cell 通讯的能力的优点正在吸引增加的注意的无数房间人口藏匿了。他们也在许多免疫学的问题正在吸引注意,包括 autoimmunity 和,特别地调整 cytokine 和 chemokine 激活的他们的能力。主要胆汁的肝硬化(PBC ) 被认为一个模型自体免疫疾病,它对胆汁的上皮的房间有高度集中的细胞毒素的回答。我们与 PBC 和 30 健康控制(HC ) 从 29 个病人从血浆孤立 exosomes,并且用一个前 vivo 系统在 mononuclear 房间人口在 co-stimulatory 分子表示和 cytokine 生产上学习了这些 exosomes 的效果。我们也与 HC exosomes 相比在 PBC 识别了 microRNA (miRNA ) 人口。我们此处报导尽管 exosomes 不改变 cytokine 生产,他们显著地确实在介绍抗原的人口上改变 co-stimulatory 分子表示。进一步,我们在 CD14 + 单核白血球上表明了那 CD86 起来调整的表情,而在 CD11c + 上起来调整的 CD40 由从有 PBC 的病人的 exosomes 的树枝状的房间。另外,有在有 PBC 的病人的传播 exosomes 的 miRNA 表示的差别。这些数据基于 co-stimulatory 分子玩的观察有重要重要性在 T 房间激活的规定的一个微分角色。我们的观察显示从 PBC 的异常 exosomes 有选择地在介绍抗原的房间的不同子集导致 co-stimulatory 分子的表示。这些改变可以在自体免疫的肝疾病的致病包含。 | Takashi Tomiyama Guo-Xiang Yang Ming Zhao Weici Zhang Hajime Tanaka Jing Wang Patrick SC Leung Kazuiclli Okazaki Xiao-Song He Qianjin Lu Ross L Coppel Christopher L Bowlus M Eric Gershwin | 2017 | Cellular & Molecular Immunology2017，14，3： | 18 |
| 3 | 太阳能制氢技术显示文摘氢能是一种高效、无污染的新能源,利用可再生能源制氢是开发氢能源的有效途径.文章总结了国内外目前利用太阳能制氢技术的发展现状,介绍了利用光伏系统转化的电能电解水制氢和利用太阳能的热化学反应循环制氢2种清洁无污染的制氢工艺. | 倪萌 M K H Leung K Sumathy | 2004 | 可再生能源2004，22，3： | 13 |
| 4 | 生物质热化学过程制氢技术显示文摘生物质是世界上最丰富的可再生资源之一氢能源是未来理想的能源载体。生物质生长周期短产量巨大作为能源利用时,其CO2排放量几乎为零因此被视为非常有潜力的清洁能源之一。生物质制氢技术主要包括热化学过程和生物过程,其中热化学过程主要是将生物质气化或生成生物油再进行重整和水气置换反应从而获得较高产量的氢气。文章介绍了利用生物质热裂解和气化(包括超临界水条件下气化)制氢技术并对其未来的发展做了展望. | 倪萌 M K H Leung K Sumathy | 2004 | 可再生能源2004，22，5： | 8 |
| 5 | Dietary advanced glycation end-products aggravate non-alcoholic fatty liver disease显示文摘AIM To determine if manipulation of dietary advanced glycation end product(AGE), intake affects nonalcoholic fatty liver disease(NAFLD) progression and whether these effects are mediated via RAGE. METHODS Male C57Bl6 mice were fed a high fat, high fructose, high cholesterol(HFHC) diet for 33 wk and compared with animals on normal chow. A third group were given a HFHC diet that was high in AGEs. Another group was given a HFHC diet that was marinated in vinegar to prevent the formation of AGEs. In a second experiment, RAGE KO animals were fed a HFHC diet or a high AGE HFHC diet and compared with wildtype controls. Hepatic biochemistry, histology, picrosirius red morphometry and hepatic mR NA were determined. RESULTS Long-term consumption of the HFHC diet generated significant steatohepatitis and fibrosis after 33 wk. In this model, hepatic 4-hydroxynonenal content(a marker of chronic oxidative stress), hepatocyte ballooning, picrosirius red staining, α-smooth muscle actin and collagen type 1A gene expression were all significantly increased. Increasing the AGE content of the HFHC diet by baking further increased these markers of liver damage, but this was abrogated by pre-marination in acetic acid. In response to the HFHC diet, RAGE-/-animals developed NASH of similar severity to RAGE+/+ animals but were protected from the additional harmful effects of the high AGE containing diet. Studies in isolated Kupffer cells showed that AGEs increase cell proliferation and oxidative stress, providing a likely mechanism through which these compounds contribute to liver injury. CONCLUSION In the HFHC model of NAFLD, manipulation of dietary AGEs modulates liver injury, inflammation, and liver fibrosis via a RAGE dependent pathway. This suggests that pharmacological and dietary strategies targeting the AGE/RAGE pathway could slow the progression of NAFLD. | Christopher Leung Chandana B Herath Zhiyuan Jia Sof Andrikopoulos Bronwyn E Brown Michael J Davies Leni R Rivera John B Furness Josephine M Forbes Peter W Angus | 2016 | World Journal of Gastroenterology2016，22，35： | 7 |
| 6 | Hematopoietic cell transplantation for Crohn’s disease;is it time?显示文摘AIM: To review all studies in the literature that have assessed Hematopoietic cell transplantation (HCT) and Crohn’s disease (CD) with the ultimate aims of determining if this is a viable treatment option for those with CD. A secondary aim was to review the above literature and determine if the studies shed further light on the mechanisms involved in the pathogenesis of CD. METHODS: An extensive Medline search was performed on all articles from 1970 to 2005 using the ; bone marrow transplant, stem cell, hematopoietic cell, Crohn’s disease and inflammatory bowel disease. RESULTS: We identified one case in which a patient developed CD following an allogeneic HCT from a sibling suffering with CD. Evidence for transfer of the genetic predisposition to develop CD was also identified with report of a patient that developed severe CD following an allogeneic HCT. Following HCT it was found that the donor (that had no signs or symptoms of CD) and the recipient had several haplotype mismatches in HLA class Ⅲ genes in the IBD3 locus including a polymorphism of NOD2/CARD15 that has been associated with CD. Thirty three published cases of patients with CD who underwent either autologous or allogeneic HCT were identified. At the time of publication 29 of these 33 patients were considered to be in remission. The median follow-up time was seven years, and twenty months for allogeneic and autologous HCT respectively.For patients who underwent HCT primarily for treatment of their CD there have been no mortalities related to transplant complications. CONCLUSION: Overall these preliminary data suggest that both allogeneic and autologous HCT may be effective in inducing remission in refractory CD. Thissupports the hypothesis that the hematolymphatic cells play a key role in CD and that resetting of the immune system may be a critical approach in the management or cure of CD. | Y Leung M Geddes J Storek R Panaccione PL Beck | 2006 | World Journal of Gastroenterology2006，12，41： | 5 |
| 7 | 氢——未来的绿色燃料显示文摘石油燃料在几十年内逐渐耗尽 ,而燃料电池以其高效、清洁的特点将会成为未来交通的推动力。本文对可再生绿色能源载体———氢的研制方法进行了研究 ,详细阐述了两种制氢的工艺过程———热化学工艺和电解水工艺过程。给出了氢气的四种储存方法 ,其中金属氢化物和碳质吸附储氢两种方法 ,由于安全可靠 ,储存效率较高 ,是目前广泛研究的储氢方式。本文综述了氢能系统的各项技术 。 | 倪萌 M K H Leung K Sumathy | 2004 | 现代车用动力2004，，2： | 3 |
| 8 | Sedated vs unsedated colonoscopy:A prospective study显示文摘AIM:To compare sedated to unsedated colonoscopy in terms of duration,pain and the patient’s willingness to repeat the procedure.METHODS:Consecutive patients who underwent colonoscopies over a 2-year period were invited to participate.All patients who were to undergo our endoscopy unit were offered sedation with standard intravenous sedatives and analgesics,or an unsedated colonoscopy was attempted.Demographic details were recorded.The patient anxiety level prior to the procedure,time to reach the cecum,total discharge time,patient and endoscopist pain assessments,satisfaction after the examination and the patient’s willingness to return for the same procedure in the future were recorded.RESULTS:Among the 403 observed patients,more males were observed in the unsedated group(66.2%vs 55.2%,P=0.04).Additionally,the unsedated group patients were less anxious prior to the procedure(5.1vs 6.0,P<0.01).The colonoscopy completion rates were comparable between the 2 groups(85.9%vs84.2%,P=0.66).The time to reach the cecum was also comparable(12.2 min vs 11.8 min);however,the total discharge times were shorter in the unsedated group(20.7 min vs 83.0 min,P<0.01).Moreover,the average patient pain score(3.4 vs 5.7,P<0.01)was lower in the sedated group,while the satisfaction score(8.8 vs 7.8,P<0.01)was significantly higher.There was no significant difference,however,between the groups in terms of willingness to repeat the procedure if another was required in the future(83.3%vs 77.3%,P=0.17).CONCLUSION:Unsedated colonoscopy is feasible in willing patients.The option saves the endoscopy units up to one hour per patient and does not affect the patient willingness to return to the same physician again for additional colonoscopies if a repeated procedure is needed. | Abdulrahman M Aljebreen Majid A Almadi Felix W Leung | 2014 | World Journal of Gastroenterology2014，20，17： | 3 |
| 9 | Adaptive immunity in the liver显示文摘 | Zongwen Shuai Miranda WY Leung Xiaosong He Weici Zhang Guoxiang Yang Patrick SC Leung M Eric Gershwin | 2016 | Cellular & Molecular Immunology2016，13，3： | 3 |
| 10 | Sedation-risk-free colonoscopy for minimizing the burden of colorectal cancer screening显示文摘Unsedated colonoscopy is available worldwide,but is not a routine option in the United States(US).We conducted a literature review supplemented by our experience and expert commentaries to provide data to support the use of unsedated colonoscopy for colorectal cancer screening.Medline data from 1966 to 2009 were searched to identify relevant articles on the subject.Data were summarized and co-authors provided critiques as well as accounts of unsedated colonoscopy for screening and surveillance.Diagnostic colonoscopy was initially dev eloped as an unsedated procedure.Procedure-re lated discomfort led to wide adoption of sedation in the US,although unsedated colonoscopy remains the usual practice elsewhere.The increased use of colonoscopy for colorectal cancer screening in healthy,asymptomatic individuals suggests a reass-essment of the burden of sedation in colonoscopy for screening is appropriate in the US for lowering costs and minimizing complications for patients.A water method developed to minimize discomfort has shown promise to enhance outcomes of unsedated colonoscopy.The use of scheduled,unsedated colono scopy in the US appears to be feasible for colorectal cancer screening.Studies to assess its applicability in diverse practice settings deserve to be conducted and supported. | Felix W Leung Abdulrahman M Aljebreen Emilio Brocchi Eugene B Chang Wei-Chih Liao Takeshi Mizukami Melvin Schapiro Konstantinos Triantafyllou | 2010 | World Journal of Gastrointestinal Endoscopy2010，2，3： | 3 |
| 11 | The conversion factor of K_(eff) to K_(3.7) in thermoluminescence dating显示文摘In the fine-grain TL dating the full o dose must be converted into the equivalent P dose. The conversion is finished by Keff-value, which is an effective or effectiveness. But the Keff can not be measured directly for each sample and only the external radiative efficiency K3.7 can be measured. In order to obtain the Keff a special study for the conversion factor of Keff to K3.t has been made using the ultrathin TLD. The results show that the conversion factor of tile TLD for archaeological samples is 0.847, which is in agreement with calculated value 0.85. | Wang Wei-Da Zhou Zhi-Xin Xia Jun-Ding (Research Laborotory for Conservation and Archaeology, Shanghai Museum, Shanghai 200951)Leung P L Stokes M J(Department of Physics and Materials Science, City University of Hong Kong) | 1998 | Nuclear Science and Techniques1998，9，4： | 3 |
| 12 | Proteomic analysis reveals distinctive protein profiles involved in CD8^(+) T cell-mediated murine autoimmune cholangitis显示文摘Autoimmune cholangitis arises from abnormal innate and adaptive immune responses in the liver,and T cells are critical drivers in this process.However,little is known about the regulation of their functional behavior during disease development.We previously reported that mice with T cell-restricted expression of a dominant negative form of transforming growth factor beta receptor type Ⅱ(dnTGFβ RII)spontaneously develop an autoimmune cholangitis that resembles human primary biliary cholangitis(PBC).Adoptive transfer of CD8^(+) but not CD4^(+) T cells into Rag1^(−/−)mice reproduced the disease,demonstrating a critical role for CD8^(+) T cells in PBC pathogenesis.Herein,we used SOMAscan technology to perform proteomic analysis of serum samples from dnTGFβRII and B6 control mice at different ages.In addition,we analyzed CD8 protein profiles after adoptive transfer of splenic CD8^(+) cells into Rag1^(−/−)recipients.The use of the unique SOMAscan aptamer technology revealed critical and distinct profiles of CD8 cells,which are key to biliary mediation.In total,254 proteins were significantly increased while 216 proteins were significantly decreased in recipient hepatic CD8^(+) cells compared to donor splenic CD8^(+) cells.In contrast to donor splenic CD8^(+) cells,recipient hepatic CD8^(+) cells expressed distinct profiles for proteins involved in chemokine signaling,focal adhesion,T cell receptor and natural killer cell-mediated cytotoxicity pathways. | Weici Zhang Ren Zhang Jun Zhang Ying Sun Patrick SC Leung Guo-Xiang Yang Zongwen Shuai William M Ridgway M Eric Gershwin | 2018 | Cellular & Molecular Immunology2018，15，8： | 3 |
| 13 | The effects of Spirulina on anemia and immune function in senior citizens显示文摘Anemia and immunological dysfunction(i.e.immunosenescence)are commonly found in older subjects and nutritional approaches are sought to counteract these phenomena.Spirulina is a filamentous and multicellular bule-green alga capable of reducing inflammation and also manifesting antioxidant effects.We hypothesized that Spirulina may ameliorate anemia and immunosenescence in senior citizens with a history of anemia.We enrolled 40 volunteers of both sexes with an age of 50 years or older who had no history of major chronic diseases.Participants took a Spirulina supplementation for 12 weeks and were administered comprehensive dietary questionnaires to determine their nutritional regimen during the study.Complete cell count(CCC)and indoleamine 2,3-dioxygenase(IDO)enzyme activity,as a sign of immune function,were determined at baseline and weeks 6 and 12 of supplementation.Thirty study participants completed the entire study and the data obtained were analyzed.Over the 12-week study period,there was a steady increase in average values of mean corpuscular hemoglobin in subjects of both sexes.In addition,mean corpuscular volume and mean corpuscular hemoglobin concentration also increased in male participants.Older women appeared to benefit more rapidly from Spirulina supplements.Similarly,the majority of subjects manifested increased IDO activity and white blood cell count at 6 and 12 weeks of Spirulina supplementation.Spirulina may ameliorate anemia and immunosenescence in older subjects.We encourage large human studies to determine whether this safe supplement could prove beneficial in randomized clinical trials. | Carlo Selmi Patrick SC Leung Laura Fischer Bruce German Chen-Yen Yang Thomas P Kenny Gerry R Cysewski M Eric Gershwin | 2011 | Cellular & Molecular Immunology2011，8，3： | 2 |
| 14 | Effect of closure of live poultry markets on poultry-to-person transmission of avian influenza A H7N9 virus: an ecological study显示文摘 | Hongjie Yu Joseph T Wu Benjamin J Cowling Qiaohong Liao Vicky J Fang Sheng Zhou Peng Wu Hang Zhou Eric H Y Lau Danhuai Guo Michael Y Ni Zhibin Peng Luzhao Feng Hui Jiang Huiming Luo Qun Li Zijian Feng Yu Wang Weizhong Yang Gabriel M Leung | 2013 | The Lancet2013，，： | 2 |
| 15 | Dynamic strip algorithm in curve fitting显示文摘 | Leung M K | 1991 | Computer Vision Graphics & Image Processing1991，51，： | 1 |
| 16 | Green tea polyphenols as an anti-oxidant and anti-inflammatory agent for cardiovascular protection 显示文摘 | TIPOE G L LEUNG T M HUNG M W | 2007 | Cardiovasc Hematol Disord Drug Targets2007，7，2： | 1 |
| 17 | Indigenous Chinese personality constructs: Is the five factor model complete? 显示文摘 | CHEUNG F M LEUNG K ZI-IANG J X | 2001 | J Cross Cultural Psychol2001，32，40： | 1 |
| 18 | Differential in situ cytokine gene expression in acute versus chronic atopic dermatitis显示文摘 | Boguniewicz M Leung DY | 1994 | J Clin Invest1994，94，： | 1 |
| 19 | Human infection with influenza H9N2 显示文摘 | Peiris M Yuen KY Leung CW | 1999 | Lancet1999，354，： | 1 |
| 20 | A trustworthiness-based QoS routing protocol for wireless ad hoe networks 显示文摘 | Yu M Leung K K | 2009 | IEEE Trans on Wireless Communications2009，8，4： | 1 |
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