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| 1 | The role of photovaporization of the prostate in small volume benign prostatic hyperplasia and review of the literature显示文摘Objective:Our objective was to characterize the safety and efficacy of the 180 W XPS-GreenLight laser in men with lower urinary tract symptoms secondary to a small volume benign prostatic hyperplasia(BPH).Methods:A retrospective analysis was performed for all patients who underwent 180 W XPSlaser photoselective vaporization of the prostate(PVP)vaporization of the prostate between 2012 and 2016 at two-tertiary medical centers.Data collection included baseline comorbidities,disease-specific quality of life scores,maximum urinary flow rate(Qmax),postvoid residual(PVR),complications,prostate volume and prostate-specific antigen(PSA).The secondary endpoints were the incidence of intraoperative and postoperative adverse events.Complications were stratified using the Clavien-Dindo grading system up to 90 days after surgery.Results:Mean age of men was 67.8 years old,with a mean body mass index of 29.7 kg/m2.Mean prostate volume as measured by transrectal ultrasound was 29 mL.Anticoagulation use was 47%and urinary retention with catheter at time of surgery was 17%.Mean hospital stay and catheter time were 0.5 days.Median follow-up time was 6 months with the longest duration of follow-up being 22.5 months(interquartile range,3-22.5 months).The International Prostate Symptom Score improved from 22.8±7.0 at baseline to 10.7±7.4(p<0.01)and 6.3±4.4(p<0.01)at 1 and 6 months,respectively.The Qmax improved from 7.70±4.46 mL/s at baseline to 17.25±9.30 mL/s(p<0.01)and 19.14±7.19 mL/s(p<0.001)at 1 and 6 months,respectively,while the PVR improved from 216.0±271.0 mL preoperatively to 32.8±45.3 mL(p<0.01)and 26.2±46.0 mL(p<0.01)at 1 and 6 months,respectively.The PSA dropped from 1.97±1.76 ng/mL preoperatively to 0.71±0.61 ng/mL(p<0.01)and 0.74±0.63 ng/mL at 1 and 6 months,respectively.No patient had a bladder neck contracture postoperatively and no capsular perforations were noted intraoperatively.Conclusion:The 180 W GreenLight XPS system is safe and effective for men with small volume BPH.PVP produced improvements in symptomatic and clinical parameters without any safety concern.It represents a safe surgical option in this under studied population. | Dominique Thomas Kevin C.Zorn Malek Meskawi Ramy Goueli Pierre-Alain Hueber Lesa Deonarine Vincent Misrai Alexis Te Bilal Chughtai | 2019 | Asian Journal of Urology2019，6，4： | 6 |
| 2 | 从风险评估的角度评价美国疾病预防控制中心全国暴露报告生物监测数据:化学物的全面展望显示文摘[背景]《全国人体环境化学物暴露报告》[NER,美国疾病预防控制中心(2012)]中的生物监测数据提供了人体血液和尿液中存在的400种以上化学物及其浓度的信息。如今,用生物监测当量(biomonitoring equivalents,BEs)和其他基于风险的估值能够从风险评估的角度解读这些生物监测数据。[目的]对NER中测定的生物标志物浓度与BE值和类似的风险估值进行比较,为NER中近130种分析物的测定水平提供一个全面的化学物风险评估展望。[方法]确定现有基于风险评估的生物标志物筛选值,包括BE值和德国人类生物监测委员会的人类生物监测-I值(humanbiomonitoring-I,HBM-I)。将NER人群生物标志物浓度的几何均数和95百分位数与可用的筛选值比较,得出特定化学物的危害系数(hazard quotients,HQs)或癌症风险估值。[结论]NER中大多数分析物的HQ值<1;但有一些分析物(包括丙烯酰胺、二恶英类化学物、苯、二甲苯、多种金属、邻苯二甲酸二辛酯、一些传统的有机氯农药)的几何均数或95百分位数接近或超过HQ值1或癌症风险>1×10-4,这表明暴露水平可能超过所公布的人类健康基准。本文首次从化学物的风险评估角度提出多种环境化学物的人群生物监测数据验证方法。比较所得结果可用来明确更详细的特定化学物数据测定和提出化学物风险管理和研究的重点。 | Lesa L.Aylward Christopher R.Kirman Rita Schoeny Christopher J.Portier Sean M.Hays 汪源(译) 张晶(译) 郑轻舟(译) 王晓宇(译) 金泰廙(校) | 2013 | 环境与职业医学2013，30，6： | 3 |
| 3 | The university as innovator 显示文摘 | ROBERT E L LESA M REEDY E J | 2007 | Issues in Science and Technology2007，23，4： | 1 |
| 4 | Determination of 20 coecid iostats in egg and avian muscle tissue using ultra high perform ance liquid chromatography-tandem mass spectrometry 显示文摘 | Mary M Lesa C John O M | 2012 | Journal of Chromatography A2012，1253，： | 1 |
| 5 | A comparison of nutrition knowledge and atti- tudes, dietary practices and bone densities of postmenopausal women, female college athletes, and nonathletic college women 显示文摘 | Lesa F Sarah TH | 1992 | J Am Diet Assoc1992，92，3： | 1 |
| 6 | Bench-scale testson ultrasound-assisted acid washing and thermal desorption of mercury from dredging sludge and other solid matrices显示文摘 | Lesa B Aneggi E Rossi G | 2009 | Journal of Hazardous Materials2009，171，： | 1 |
| 7 | A mechanism-based cancer risk assessment for 1,4-dichlorobenzene 显示文摘 | Byron E B Lesa L A Sean M H | 2007 | Regulatory Toxicology and Pharmacology2007，49，： | 1 |
| 8 | A mechanism-based cancer risk assessment for 1,4-dichlorobenzene显示文摘 | BYRON E B LESA L A SEAN M H | 2007 | Regulatory Toxicology and Pharmacology2007，49，： | 1 |
| 9 | Developing Mechanisms of Temperamental Effortful Control显示文摘 | Rothbart M K Lesa K Ellis M | 2003 | Journal of Personality2003，71，6： | 1 |
| 10 | Students' feelings of and desire for sense of community in face-to-face and online course显示文摘 | Michelle Drouin Lesa Rae Vartanian | 2010 | The Quarterly Review of Distance Education2010，11，3： | 1 |
| 11 | Electrolytic treatment of beer brewery wastewater显示文摘 | VIJAYARAGHAVAN K AHNAD D LESA R | 2006 | J Ind Eng Chem Res2006，45，： | 1 |
| 12 | Physical assessment:implications for nurse e- ducators and nursing practice 显示文摘 | Lesa R Dixun A | 2007 | Int Nurs Rev2007，54，2： | 1 |
| 13 | FOXP3 gene polymorphisms in preeclampsia显示文摘 | Tom D Metz Lesa M | 2012 | Am J Obstet Gynecol2012，206，2： | 1 |
| 14 | Positive and negative tissue-spe- cific signaling by a nematode epidermal growth factor re- ceptor显示文摘 | Lesa GM Steinberg PW | 1997 | Mol Biol Cell1997，8，5： | 1 |
| 15 | Haiti Disaster Relief: One Third-World Humanitarian Medical Mission Group’s Experience显示文摘 | Lesa Beth Titus | 2011 | Journal of Emergency Nursing2011，，2： | 1 |
| 16 | Eiectrolytic treatment of beer brewery wastewater 显示文摘 | Vijayaraghavan K Ahmad D Lesa R | 2006 | Ind Eng Chem Res2006，45，20： | 1 |
| 17 | Vascular endothelial growth factor-A gene polymorphisms in women with recurrent pregnancy loss显示文摘 | Alexandra G. Eller D. Ware Branch Lesa Nelson T. Flint Porter Robert M. Silver | 2010 | Journal of Reproductive Immunology2010，，： | 1 |
| 18 | Online Learning for Seniors: Barriers and Opportunities显示文摘 | Notess Mark Lorenzen -- Huber Lesa | 2007 | Elearn Magazine2007，，5： | 1 |
| 19 | Complexes of the enzyme phos-phomannomutase/phosphoglucomutase with a slow substrate and an inhibitor显示文摘 | Catherine R Grant S S Lesa J B | | 0，，： | 1 |
| 20 | The moderating ef- fects of external monitors on the ~elationship between R&D spend- ing and firm performance 显示文摘 | LESA WALTERS KROLLM | 2006 | Journal d Business Research2006，59，2： | 1 |
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