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| 1 | Tumor cells educate mesenchymal stromal cells to release chemoprotective and immunomodulatory factors显示文摘Factors released by surrounding cells such as cancer-associated mesenchymal stromal cells(CA-MSCs)are involved in tumor progression and chemoresistance.In this study,we characterize the mechanisms by which naYve mesenchymal stromal cells(MSCs)can acquire a CA-MSCs phenotype.Ovarian tumor cells trigger the transformation of MSCs to CA-MSCs by expressing pro-tumoral genes implicated in the chemoresistance of cancer cells,resulting in the secretion of high levels of CXC chemokine receptors 1 and 2(CXCR1/2)ligands such as chemokine(C-X-C motif)ligand 1(CXCL1),CXCL2,and interleukin 8(IL-8).CXCR1/2 ligands can also inhibit the immune response against ovarian tumor cells.Indeed,through their released factors,CA-MSCs promote the differentiation of monocytes towards M2 macrophages,which favors tumor progression.When CXCR1/2 receptors are inhibited,these CA-MSC-activated macrophages lose their M2 properties and acquire an anti-tumoral phenotype.Both ex vivo and in vivo,we used a CXCR1/2 inhibitor to sensitize ovarian tumor cells to carboplatin and circumvent the pro-tumoral effects of CA-MSCs.Since high concentrations of CXCR1/2 ligands in patients*blood are associated with chemoresistance,CXCR1/2 inhibition could be a potential therapeutic strategy to revert carboplatin resistance. | Augustin Le Naour Melissa Prat Benolt Thibault Renaud Mével Léa Lemaitre Helene Leray Marie-Veronique Joubert Kimberley Coulson Muriel Golzio Lise Lefevre Eliane Mery Alejandra Martinez Gwénael Ferron Jean-Pierre Delord Agnès Coste Bettina Couderc | 2020 | Journal of Molecular Cell Biology2020，12，3： | 3 |
| 2 | A highly sensitive and selectivefluorescent molecular sensor for Pb(II)based on a calixarenebearing four dansyl groups显示文摘 | Métivier R Leray I Valeur B | 2003 | Chem Commun2003，37，： | 1 |
| 3 | A study of radiation vulnerability of ferroelectric material and devices显示文摘 | COLC Y M MUSSEAU O LERAY J L | 1994 | IEEE Trans Nucl Sci1994，41，3： | 1 |
| 4 | Stereo-regular bioresorbable polyesters for orthopaedie surgery显示文摘 | Vert M Chabot F Leray J | 1981 | Makromol Chem1981，，5： | 1 |
| 5 | The effects of obesityassociated insulin resistance on mRNA expression of peroxisome proliferator-activated receptor-gamma target genes, in dogs显示文摘 | Gayet C Leray V Saito M | 2007 | Nguyen P Br J Nutr2007，98，3： | 1 |
| 6 | Blood and liver enzymes in rainbow trout (Salmo gairdneri Rich) with emphasis on their diagnostic use: study of CC14 toxicity and a case of Aeromonas infection显示文摘 | Racicot J G Gaudet M Leray C | 1975 | J Fish Biol1975，7，： | 1 |
| 7 | Plasma-assisted diesel oxidation catalyst on bench scale, focus on light-off temperature and NOx behavior显示文摘 | Leray A Guy A Makarov M | 2013 | Topics in Catalysis2013，56，1： | 1 |
| 8 | A new versatile primer set targeting a short fragment of the mitochondrial COI region for metabarcoding metazoan diversity:application for characterizing coral reef fish gut contents显示文摘 | LERAY M YANG J Y MEYER C P | 2013 | Front Zool2013，10，： | 1 |
| 9 | Effects of deferasirox and deferiprone on cellular iron load in the human hepatoma cell line HepaRG显示文摘 | Gaboriau F Leray AM Ropert M | 2010 | Biometals2010，23，： | 1 |
| 10 | Slow continuous and daily ultrafitration for refractory congestive heart failure显示文摘 | Canaul B Leblane M Leray H | 1998 | Nephrol Dial Transplant1998，13，4： | 1 |
| 11 | Slow continuous and dialy ultrafitration for refractorg congestive heart failurt 显示文摘 | Leblane M Leray H | 1998 | Nephrol Dial Transplant1998，13，4： | 1 |
| 12 | Simultaneous determination of homologues of vitamin E and coenzyme Q and products of ct-tocopherol oxidation 显示文摘 | Leray C Andriamampandry M D Freund M | 1998 | Lipids1998，39，： | 1 |
| 13 | 查看详情显示文摘 | Ferlet-Cavrois V Colladant 'r Paillet P Leray J Musseau O Schwank J R Shaneyfelt M R Pelloie J Poncharraorst J P | | 0，，： | 1 |
| 14 | Selective blockade of the mGluRl receptor reduces traumatic neuronal injury in vitro and improves outcome after trauma显示文摘 | FADEN A L O'LERAY D M FAN L | 2001 | Exp Neurol2001，167，2： | 1 |
| 15 | Liver lipid metabolism显示文摘 | Nguyen P Leray V Diez M | 2008 | JAnim Physiol An N2008，92，3： | 1 |
| 16 | Simultaneous determination of homologous of vitamin E and coenzyme Q and products of α-tocopherol oxidation显示文摘 | Leray C Anadriamampandry M Freund M | 2001 | Journal of Lipid Research2001，39，： | 1 |
| 17 | Effeets of deferasirox and deferiprone on cellular iron load in the human hepatoma cell line HepaRG显示文摘 | Gaboriau F Leray A M Ropert M | 2010 | Biometals2010，23，2： | 1 |
| 18 | The effects of obesity-associated insulin resistance on mRNA expression of peroxisome proliferator- activated receptor-gamma target genes, in dogs 显示文摘 | Gayet'C Leray V Saito M | 2007 | Br J Nutr2007，98，： | 1 |
| 19 | Stereo-regularbioresorbable polyesters for orthopaedic surgery 显示文摘 | Vert M Chabot F Leray J | 1981 | Makromol Chem Suppl1981，5，： | 1 |
| 20 | A study of radiation vulnerability of ferroelectric material and devices 显示文摘 | Colc Y M Musseau O Leray J L | 1994 | IEEE Trans Nucl Sci1994，41，3： | 1 |
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