|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Diagnosis and management of choledocholithiasis in the golden age of imaging, endoscopy and laparoscopy显示文摘Biliary lithiasis is an endemic condition in both Western and Eastern countries, in some studies affecting 20% of the general population. In up to 20% of cases, gallbladder stones are associated with common bile duct stones(CBDS), which are asymptomatic in up to one half of cases. Despite the wide variety of examinations and techniques available nowadays, two main open issues remain without a clear answer: how to cost-effectively diagnose CBDS and, when they are finally found, how to deal with them. CBDS diagnosis and management has radically changed over the last 30 years, following the dramatic diffusion of imaging, including endoscopic ultrasound(EUS) and magnetic resonance cholangiography(MRC), endoscopy and laparoscopy. Since accuracy, invasiveness, potential therapeutic use and costeffectiveness of imaging techniques used to identifyCBDS increase together in a parallel way, the concept of 'risk of carrying CBDS' has become pivotal to identifying the most appropriate management of a specific patient in order to avoid the risk of 'under-studying' by poor diagnostic work up or 'over-studying' by excessively invasive examinations. The risk of carrying CBDS is deduced by symptoms, liver/pancreas serology and ultrasound. 'Low risk' patients do not require further examination before laparoscopic cholecystectomy. Two main 'philosophical approaches' face each other for patients with an 'intermediate to high risk' of carrying CBDS: on one hand, the 'laparoscopy-first' approach, which mainly relies on intraoperative cholangiography for diagnosis and laparoscopic common bile duct exploration for treatment, and, on the other hand, the 'endoscopy-first' attitude, variously referring to MRC, EUS and/or endoscopic retrograde cholangiography for diagnosis and endoscopic sphincterotomy for management. Concerning CBDS diagnosis, intraoperative cholangiography, EUS and MRC are reported to have similar results. Regarding management, the recent literature seems to show better short and long term outcome of surgery in terms of retained stones and need for further procedures. Nevertheless, open surgery is invasive, whereas the laparoscopic common bile duct clearance is time consuming, technically demanding and involves dedicated instruments. Thus, although no consensus has been achieved and CBDS management seems more conditioned by the availability of instrumentation, personnel and skills than cost-effectiveness, endoscopic treatment is largely preferred worldwide. | Renato Costi Alessandro Gnocchi Francesco Di Mario Leopoldo Sarli | 2014 | World Journal of Gastroenterology2014，20，37： | 48 |
| 2 | Review of natural products with hepatoprotective effects显示文摘The liver is one of the most important organs in the body,performing a fundamental role in the regulationof diverse processes,among which the metabolism,secretion,storage,and detoxification of endogenous and exogenous substances are prominent.Due to these functions,hepatic diseases continue to be among the main threats to public health,and they remain problems throughout the world.Despite enormous advances in modern medicine,there are no completely effective drugs that stimulate hepatic function,that offer complete protection of the organ,or that help to regenerate hepatic cells.Thus,it is necessary to identify pharmaceutical alternatives for the treatment of liver diseases,with the aim of these alternatives being more effective and less toxic.The use of some plants and the consumption of different fruits have played basic roles in human health care,and diverse scientific investigations have indicated that,in those plants and fruits so identified,their beneficial effects can be attributed to the presence of chemical compounds that are called phytochemicals.The present review had as its objective the collecting of data based on research conducted into some fruits(grapefruit,cranberries,and grapes)and plants[cactus pear(nopal)and cactus pear fruit,chamomile,silymarin,and spirulina],which are consumed frequently by humans and which have demonstrated hepatoprotective capacity,as well as an analysis of a resin(propolis)and some phytochemicals extracted from fruits,plants,yeasts,and algae,which have been evaluated in different models of hepatotoxicity. | Eduardo Madrigal-Santillán Eduardo Madrigal-Bujaidar Isela álvarez-González María Teresa Sumaya-Martínez José Gutiérrez-Salinas Mirandeli Bautista ángel Morales-González Manuel García-Luna y González-Rubio J Leopoldo Aguilar-Faisal José A Morales-González | 2014 | World Journal of Gastroenterology2014，20，40： | 10 |
| 3 | Effect of corneal light scatter on vision: a review of the literature显示文摘The cornea is the transparent connective tissue window at the front of the eye.The physiological role of the cornea is to conduct external light into the eye,focus it,together with the lens,onto the retina,and to provide rigidity to the entire eyeball.Therefore,good vision requires maintenance of the transparency and proper refractive shape of the cornea.The surface structures irregularities can be associated with wavefront aberrations and scattering errors.Light scattering in the human cornea causes a reduction of visual quality.In fact,the cornea must be transparent and maintain a smooth and stable curvature since it contributes to the major part of the focusing power of the eye.In most cases,a simple examination of visual acuity cannot demonstrate the reduction of visual quality secondary light scattering.In fact,clinical techniques for examining the human cornea in vivo have greatly expanded over the last few decades.The measurement of corneal back scattering qualifies the degree of corneal transparency.The measurement of corneal forward-scattering quantifies the amount of visual impairment that is produced by the alteration of transparency.The aim of this study was to review scattering in the human cornea and methods of measuring it. | Leopoldo Spadea Giorgia Maraone Francesca Verboschi Enzo Maria Vingolo Daniele Tognetto | 2016 | International Journal of Ophthalmology(English edition)2016，9，3： | 7 |
| 4 | Photorefractive keratectomy after cataract surgery in uncommon cases: long-term results显示文摘AIM: To evaluate the efficacy and safety of the excimer laser correction of the residual refractive errors after cataract extraction with intraocular lens(IOL) implantation in uncommon cases.METHODS: Totally 24 patients with high residual refractive error after cataract surgery with IOL implantation were examined. Twenty-two patients had a history of phacoemulsification and IOL implantation, and two had extra-capsular cataract extraction with IOL implantation. Detailed examination of preoperative medical records was done to explain the origin of the post-cataract refractive errors. All patients underwent photorefractire keratectomy(PRK) enhancement. The mean outcome measures were refraction, uncorretted visual acuity(UCVA), best corrected visual acuity(BCVA) and corneal transparency and follow up ranged from 1 to 8 y.RESULTS: The principal causes of residual ametropia was inexact IOL calculation in abnormal eyes with high myopia and congenital lens abnormalities, followed by corneal astigmatism both suture induced and preexisting. After cataract surgery and before the laser enhancement the mean spherical equivalent(SE) was-0.56±3 D ranging from-4.62 to +2.25 D in high myopic patients, instead it was-1±1.73 D ranging from-3.25 to +3.75 D in the astigmatic eyes, with a mean cylinder of-3.75±0 ranging from-3 to +5.50 D. After laser refractive surgery the mean SE was 0.1±0.73, ranging from-0.50 to +1.50 in the myopic group, and it was-0.50±0.57 ranging from-1.25 to +0.50 in astigmatic patients, with a mean cylinder of-0.25±0.75. In myopic patients the mean UCVA and BCVA were 0.038±0.072 logMAR and 0.018±0.04 respectively, both ranging from 0.10 to 0.0. In astigmatic patients, the mean UCVA and BCVA were 0.213±0.132 and 0.00±0.0 respectively, UCVA ranging from 0.50 to 0.22 and BCVA was 0.00. All patients presented normal corneal transparency. No ocular hypertension was detected and no corneal haze was observed. All registered values remained stable also at the end line evaluation.CONCLUSION: The excimer laser treatment of residual refractive errors after cataract surgery with IOL implantation in abnormal eyes resulted in satisfactory and stable visual outcome with good safety and efficacy. | Anna Maria Roszkowska Mario Urso Giuseppe Alberto Signorino Leopoldo Spadea Pasquale Aragona | 2018 | International Journal of Ophthalmology(English edition)2018，11，4： | 4 |
| 5 | Role of the HLA-DQ locus in the development of chronic gastritis and gastric carcinoma in Mexican patients显示文摘AIM: To determine the HLA-DQ locus in Mexican patients with Chronic gastritis and gastric adenocarcinoma. METHODS: Oligotyping for HLA-DQ locus was performed in 45 Mexican patients with chronic gastritis and 13 Mexican patients with diffuse-type gastric adenocarcinoma, and was then compared with 99 clinically healthy unrelated individuals. H pylori infection and CagA status were assessed in patients by enzyme-linked immunosor-bent assay (ELISA) method. RESULTS: We found a significant increased frequency of HLA-DQB1*0401 allele in H pylori-positive patients with chronic gastritis when compared with healthy subjects [19 vs 0%, P= 1 × 10-7, odds ratio (OR) = 4.96; 95% confidence interval (95% CI), 3.87-6.35]. We also found a significant increased frequency of HLA-DQB1*0501 in patients with diffuse-type gastric carcinoma in comparison with healthy individuals (P = 1 × 10-6, OR = 13.07; 95% CI, 2.82-85.14). CONCLUSION: HLA-DQ locus may play a different role in the development of H pylori-related chronic gastritis and diffuse-type gastric adenocarcinoma in the Mexican Mestizo population. | Roberto Herrera-Goepfert Jesús K Yamamoto-Furusho Luis F Oate-Ocaa Margarita Camorlinga-Ponce Leopoldo Muoz Jorge A Ruiz-Morales Gilberto Vargas-Alarcón Julio Granados Cellular Biology Section | 2006 | World Journal of Gastroenterology2006，12，48： | 4 |
| 6 | Portable adaptive optics for exoplanet imaging显示文摘The portable adaptive optics(PAO)device is a low-cost and compact system,designed for 4-meter class telescopes that have no adaptive optics(AO)system,because of the physical space limitation at the Nasmyth or Cassegrain focus and the historically high cost of conventional AO.The initial scientific observations of the PAO are focused on the direct imaging of exoplanets and sub-stellar companions.This paper discusses the concept of PAO and the associated high-contrast imaging performance in our recent observational runs.PAO deliver a Strehl ratio better than 60%in H band under median seeing conditions of 1'.Combined with our dedicated image rotation and subtraction(IRS)technique and the optimized IRS(O-IRS)algorithm,the averaged contrast ratio for a 5≤V_(mag)≤9 primary star is 1.3×10^(-5)and3.3×10^(-6)at angular distance of 0.36'with exposure time of 7 minutes and 2 hours,respectively.PAO has successfully revealed the known exoplanet ofκAnd b in our recent observation with the 3.5-meter ARC telescope at Apache Point Observatory.We have performed the associated astrometry and photometry analysis of the recoveredκAnd b planet,which gives a projected separation of 0.98'±0.05',a position angle of 51.1°±0.5°and a mass of 10.15_(-1.255)^(+2.19) MJup.These results demonstrate that PAO can be used for direct imaging of exoplanets with medium-sized telescopes. | Yong-Tian Zhu Jiang-Pei Dou Xi Zhang Gang Zhao Jing Guo Leopoldo Infante | 2021 | Research in Astronomy and Astrophysics2021，21，4： | 4 |
| 7 | Long term results of no- alcohol laser epithelial keratomileusis and photorefractive keratectomy for myopia显示文摘AIM: To evaluate the long term clinical results of mechanical no-alcohol-assisted laser epithelial keratomileusis(LASEK) versus standard photorefractive keratectomy(PRK) for low-moderate myopia.METHODS: Twenty-five eyes treated with LASEK and twenty-five eyes treated with PRK were evaluated with a mean follow-up duration of 60 mo. Mechanical separation of the epithelium was performed with blunt spatula and without application of alcohol. Laser ablation was performed with the MEL-70 excimer laser. All patients were examined daily until epithelial closure; at 1, 3, 6,and 12 mo, and every year subsequently. Main outcome measures were uncorrected distance visual acuity(UDVA), corrected distance visual acuity(CDVA),manifest refraction, haze, efficacy and safety indexes.RESULTS: Twenty-one eyes and 22 eyes completed follow-up of 60 mo in LASEK and PRK group respectively. Manifest refraction at 60 mo follow-up was-0.01 and 0.26 in LASEK and PRK group respectively. In the LASEK group mean UDVA and mean CDVA after60 mo were 20/22 and 20/20 respectively(P >0.01). In the PRK group mean UDVA and mean CDVA at 60 mo follow-up were 20/20 and 20/20 after 60mo(P >0.01). The efficacy indexes were 0.87 and 0.95, and the safety indexes were1.25 and 1.4 respectively for LASEK group and PRK group.CONCLUSION: Both standard PRK and no-alcohol LASEK offer safe and effective correction of low-moderate myopia in the long term without any statistically significant difference between the two groups. | Leopoldo Spadea Francesca Verboschi Vittoria De Rosa Mariella Salomone Enzo Maria Vingolo | 2015 | International Journal of Ophthalmology(English edition)2015，8，3： | 3 |
| 8 | Effect of a triage course on quality of rating triage codes in a group of university nursing students:a before-after observational study显示文摘BACKGROUND:Most current triage tools have been tested among hospital nurses groups but there are not similar studies in university setting.In this study we analyzed if a course on a new fourlevel triage model,triage emergency method(TEM),could improve the quality of rating in a group of nursing students.METHODS:This observational study was conducted with paper scenarios at the University of Parma,Italy.Fifty students were assigned a triage level to 105 paper scenarios before and after a course on triage and TEM.We used weighted kappa statistics to measure the inter-rater reliability of TEM and assessed its validity by comparing the students' predictions with the triage code rating of a reference standard(a panel of five experts in the new triage method).RESULTS:Inter-rater reliability was K=0.42(95%Cl:0.37-0.46) before the course on TEM,and K=0.61(95%CI:0.56-0.67) after.The accuracy of students' triage rating for the reference standard triage code was good:81%(95%Cl:71-90).After the TEM course,the proportion of cases assigned to each acuity triage level was similar for the student group and the panel of experts.CONCLUSION:Among the group of nursing students,a brief course on triage and on a new inhospital triage method seems to improve the quality of rating codes.The new triage method shows good inter-rater reliability for rating triage acuity and good accuracy in predicting the triage code rating of the reference standard. | Nicola Parenti Maria Letizia Bacchi Reggiani Diego Sangiorgi Vito Serventi Leopoldo Sarli | 2013 | World Journal of Emergency Medicine2013，4，1： | 3 |
| 9 | Re-bleeding events in patients with obscure gastrointestinal bleeding after negative capsule endoscopy显示文摘AIM: To investigate long-term re-bleeding events after a negative capsule endoscopy in patients with obscure gastrointestinal bleeding(OGIB) and the risk factors associated with the procedure.METHODS: Patients referred to Hospital Egas Moniz(Lisboa, Portugal) between January 2006 and October 2012 with OGIB and a negative capsule endoscopy were retrospectively analyzed. The following study variables were included: demographic data, comorbidities, bleeding-related drug use, hemoglobin level, indication for capsule endoscopy, post procedure details, work-up and follow-up. Re-bleeding rates and associated factors were assessed using a Cox proportional hazard analysis. The Kaplan-Meier method was used to estimate the cumulative incidence of re-bleeding at 1, 3 and 5 years, and the differences between factors were evaluated.RESULTS: The study population consisted of 640 patients referred for OGIB investigation. Wireless capsule endoscopy was deemed negative in 113 patients(17.7%). A total of 64.6% of the population was female, and the median age was 69 years. The median follow-up was forty-eight months(interquartile range 24-60). Re-bleeding occurred in 27.4% of the cases. The median time to re-bleeding was fifteen months(interquartile range 2-33). In 22.6%(n = 7) of the population, small-bowel angiodysplasia was identified as the culprit lesion. A univariate analysis showed that age > 65 years old, chronic kidney disease, aortic stenosis, anticoagulant use and overt OGIB were risk factors for re-bleeding; however, on a multivariate analysis, there were no risk factors for re-bleeding. The cumulative risk of re-bleeding at 1, 3 and 5 years of follow-up was 12.9%, 25.6% and 31.5%, respectively.Patients who presented with overt OGIB tended to rebleed sooner(median time for re-bleeding: 8.5 mo vs 22 mo).CONCLUSION: Patients with OGIB despite a negative capsule endoscopy have a significant re-bleeding risk; therefore, these patients require an extended follow-up strategy. | Pedro Magalhes-Costa Miguel Bispo Sofia Santos Gilberto Couto Leopoldo Matos Cristina Chagas | 2015 | World Journal of Gastrointestinal Endoscopy2015，7，4： | 3 |
| 10 | Screening of unknown atrial fibrillation through handheld device in the elderly显示文摘Objective To estimate the prevalence of unknown atrial fibrillation(AF)in the elderly population of the Veneto Region,Italy.Methods 1820 patients aged≥65 years with no history of AF and not anticoagulated were enrolled in primary-care settings.They underwent an opportunistic electrocardiogram screening with a handheld device(My Diagnostick)designed to specifically detect AF.The electrocardiogram recordings were reviewed by the researchers,who confirmed the presence of AF.Results The device detected an arrhythmia in 143 patients,which was confirmed as AF in 101/143(70.6%),with an overall prevalence of AF of 5.5%(101/1820).Prevalence of unknown AF resulted in 3.6%in patients aged 65–74 years,and 7.5%in patients age 75 or older,and increased according to CHA2 DS2-VASc score:3.5%in patients with a score of 1 or 2,5.6%in patients with a score of 3,7.0%in patients with a score of 4,and 7.2%in patients with a score≥5.The detection rate was significantly higher in patients with mild symptoms compared to asymptomatic counterparts(24.1%vs.4.0%,P<0.0001).At multivariate analysis,congestive heart failure and age≥75 years-old were independent predictors for screen-detected AF.Conclusions An opportunistic screening with handheld device revealed an unexpectedly high prevalence of unknown AF in elderly patients with mild symptoms.Prevalence increased with age and CHA2DS2-VASc score. | Francesco Rivezzi Riccardo Vio Claudio Bilato Leopoldo Pagliani Giampaolo Pasquetto Salvatore Saccà Roberto Verlato Federico Migliore Sabino Iliceto Vito Bossone Emanuele Bertaglia | 2020 | Journal of Geriatric Cardiology2020，17，8： | 3 |
| 11 | Clinical outcomes after implantation of a new intrastromal corneal ring with 140-degree of arc in patients with corneal ectasia显示文摘AIM:To evaluate the clinical and tomographic outcomes after implantation of a new intrastromal corneal ring segment(ICRS) with 140-degrees of arc in eyes with corneal ectasia.METHODS:We evaluated patients with corneal ectasia implanted with Ferrara 140° ICRS from April 2010 to February 2015.Outcome measures included preoperative and postoperative corrected distance visual acuity(CDVA),keratometry simulated(K) reading,tomographic astigmatism and asphericity.All patients were evaluated using the Pentacam Scheimpflug system.RESULTS:The study evaluated 58 eyes.The mean followup was 16.81±10.8 mo.The CDVA(logM AR) improved from 0.5±0.20(20/60) to 0.3±0.21(20/40)(P<0.01).The average K reduced from 49.87±7.01 to 47.34±4.90 D(P<0.01).The asphericity changed from-0.60±0.86 to-0.23±0.67 D(P<0.01).The mean preoperative tomographic astigmatism decreased from-8.0±3.45 to-4.53±2.52 D(P<0.01).CONCLUSION:The new ICRS model with 140-degrees of arc effectively improve the visual acuity and reduce the high astigmatism usually found in patients with corneal ectasia. | Jordana Sandes Larissa R.S.Stival Marcos Pereira de Avila Paulo Ferrara Guilherme Ferrara Leopoldo Magacho Luana P.N.Araujo Leonardo Torquetti | 2018 | International Journal of Ophthalmology(English edition)2018，11，5： | 2 |
| 12 | Altered microperfusion at the rectal stump is predictive for rectal anastomotic leak显示文摘 | Andrea Vignali Luca Gianotti Marco Braga Giovanni Radaelli Leopoldo Malvezzi Valerio Di Carlo | 2000 | Diseases of the Colon & Rectum2000，，1： | 2 |
| 13 | Altered microperfusion at the rectal stump is predictive for rectal anastomotic leak显示文摘 | Andrea Vignali M.D. Luca Gianotti M.D. Ph.D. Dr. Marco Braga M.D. Giovanni Radaelli M.B. Leopoldo Malvezzi M.D. Valerio Di Carlo M.D | 2000 | Diseases of the Colon & Rectum2000，，1： | 2 |
| 14 | Toll‐Like Receptors and Cytokines are Upregulated during H elicobacter pylori Infection in Children显示文摘 | Hugo Lagunes‐Servin Javier Torres Carmen Maldonado‐Bernal Martha Pérez‐Rodríguez Sara Huerta‐Yépez Armando Madrazo de la Garza Leopoldo Mu?oz‐Pérez Lourdes Flores‐Luna Guillermo Ramón‐García Margarita Camorlinga‐Ponce | 2013 | Helicobacter2013，，6： | 2 |
| 15 | Cholecystocolonic fistula: facts and myths. A review of the 231 published cases显示文摘 | Renato Costi Bruto Randone Vincenzo Violi Olivier Scatton Leopoldo Sarli Olivier Soubrane Bertrand Dousset Thierry Montariol | 2009 | Journal of Hepato - Biliary - Pancreatic Surgery2009，，1： | 2 |
| 16 | Interlayer structure in YBCO-coated conductors prepared by chemical solution deposition显示文摘 | Leopoldo Molina-Luna Ricardo Egoavil Stuart Turner Thomas Thersleff Jo Verbeeck Bernhard Holzapfel Oliver Eibl Gustaaf Van Tendeloo | 2013 | Superconductor Science and Technology2013，，7： | 2 |
| 17 | Number of lymph nodes examined and prognosis of TNM stage II colorectal cancer显示文摘 | Leopoldo Sarli Giovanni Bader Domenico Iusco Carlo Salvemini Davide Di Mauro Antonio Mazzeo Gabriele Regina Luigi Roncoroni | 2004 | European Journal of Cancer2004，，2： | 2 |
| 18 | Matching dependencies: semantics and query answering显示文摘匹配的相关性(MD ) 被用来说明地指定鉴定(或匹配) 在一些数据库元组的某些属性值,某类似什么时候在另外的值上调节,满足。他们的实施能被看作实体分辨率的自然归纳。在我们把称为 MD 实施的纯盒子的,从内在的数据域的任意的值能被用于值在普通那被用于匹配。然而,属性价值的变化的全面数字被期望被坚守最小。我们以语义和通过 MD 的实施清洗的数据的性质调查这个案例。我们描绘打算的干净例子,并且另外询问的干净答案,作为那些,那在清洗过程下面是不变的。计算干净例子和干净质问回答的复杂性被调查。取决于 MD 的易控制、难处理的案例被识别并且描绘。 | Jaffer GARDEZI Leopoldo BERTOSSI Iluju KIRINGA | 2012 | Frontiers of Computer Science2012，6，3： | 2 |
| 19 | Burn resuscitation 显示文摘 | Ricardo A Kevin K Leopoldo C | 2009 | Burns2009，35，： | 1 |
| 20 | The serotonin 5- HT 7 receptor agonist LP 4:4 microinjected into the dorsal ra phe nucleus suppresses REM sleep in the rat显示文摘 | MORITI J M LEOPOLDO M JANTOS H | 2008 | Behav Brain Res2008，191，2： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员