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| 1 | Viral respiratory infections among Hajj pilgrims in 2013显示文摘Middle East respiratory syndrome coronavirus(MERS-Co V) has emerged in the Arabian Gulf region, with its epicentre in Saudi Arabia, the host of the ‘Hajj' which is the world's the largest mass gathering. Transmission of MERS-Co V at such an event could lead to its rapid worldwide dissemination. Therefore, we studied the frequency of viruses causing influenza-like illnesses(ILI) among participants in a randomised controlled trial at the Hajj 2013. We recruited 1038 pilgrims from Saudi Arabia, Australia and Qatar during the first day of Hajj and followed them closely for four days. A nasal swab was collected from each pilgrim who developed ILI. Respiratory viruses were detected using multiplex RT-PCR. ILI occurred in 112/1038(11%) pilgrims. Their mean age was 35 years, 49(44%) were male and 35(31%) had received the influenza vaccine pre-Hajj. Forty two(38%) pilgrims had laboratory-confirmed viral infections; 28(25%) rhinovirus, 5(4%) influenza A, 2(2%) adenovirus, 2(2%) human coronavirus OC43/229 E, 2(2%) parainfluenza virus 3, 1(1%) parainfluenza virus 1, and 2(2%) dual infections. No MERS-Co V was detected in any sample. Rhinovirus was the commonest cause of ILI among Hajj pilgrims in 2013. Infection control and appropriate vaccination are necessary to prevent transmission of respiratory viruses at Hajj and other mass gatherings. | Osamah Barasheed Harunor Rashid Mohammad Alfelali Mohamed Tashani Mohammad Azeem Hamid Bokhary Nadeen Kalantan Jamil Samkari Leon Heron Jen Kok Janette Taylor Haitham El Bashir Ziad A.Memish Elizabeth Haworth Edward C.Holmes Dominic E Dwyer Atif Asghar Robert Booy | 2014 | Virologica Sinica2014，29，6： | 3 |
| 2 | Enhanced Efficiency of Human Pluripotent Stem Cell Genome Editing through Replacing TALENs with CRISPRs显示文摘 | Qiurong Ding Stephanie N. Regan Yulei Xia Leoníe A. Oostrom Chad A. Cowan Kiran Musunuru | 2013 | Cell Stem Cell2013，，4： | 2 |
| 3 | Association of polymyositis with rheumatoid arthritis 显示文摘 | Martinez-Cordero E Leon DE Ortega LA | 2001 | Rheumatol Int2001，0，3： | 2 |
| 4 | 非酒精性脂肪性肝病和非酒精性脂肪性肝炎的无创性诊断显示文摘非酒精性脂肪性肝病(NAFLD)在美国和世界上许多其他地区都是最常见的慢性肝病,其患病率持续上升,目前美国约1/4的成人和10%的儿童患NAFLD。NAFLD包括多种疾病状态,从通常呈良性、非进展性临床过程的单纯性脂肪肝直至更为严重的、可进展为肝硬化和终末期肝病的非酒精性脂肪性肝炎(NASH)。目前,NASH的诊断依赖于创伤性肝活检,而肝活检存在取样和读片误差的缺陷。NASH的临床危险因素包括糖尿病和代谢综合征,但这些因素本身不足以预测NASH。常规肝酶水平预测可靠性低,新型血浆肝细胞死亡标记物单独或与临床危险因素联合今后可能成为无创性诊断工具。本文对无创性诊断工具在鉴别单纯性脂肪肝与NASH以及确定肝纤维化的存在及其范围中的作用作一概述。 | Leon A ADAMS Ariel E FELDSTEIN 张海燕 钱本余 马雄 | 2011 | 胃肠病学2011，16，3： | 2 |
| 5 | Study of the adsorption of alkyl benzene-derived amphiphiles on asphaltene particles显示文摘 | LEON O ROGEL E URBINA A | 1999 | Langmuir1999，15，22： | 1 |
| 6 | Coregulator exchange and sphingosinesensitive eooperativity of steroidogenic factor-1, general control nonderepressed5 ,p54 ,and p160 coaetivators regulate cyclic adenosine 3, 5-monophosphatedependent cytochromeP450e17 transcription rate 显示文摘 | Dammer E B Leon A Sewer M B | 2007 | Mol Endocrinol2007，，： | 1 |
| 7 | Water content, organic carbon and dry bulk density in flooded sediments显示文摘 | Avnimelech Y Gad R Leon E M | 2001 | Aquacultural engineering2001，25，： | 1 |
| 8 | Interactions of different carrageenan isoforms and flour components in breadmaking 显示文摘 | Leon A E Ribotta P Ausar F | 2000 | Journal Agricultural Food Chemistry2000，48，： | 1 |
| 9 | The influence of the adsorption of amphiphiles and resins in controlling asphaltene flocculation显示文摘 | LEON O CONTRERAS E ROGEL E | 2001 | Energy & Fuels2001，15，5： | 1 |
| 10 | Laparoscopic management of small bowel obstruction: indications and outcome显示文摘 | Leon E L Metzger A Tsiotos G G | 1998 | J Gastrointest Surg1998，2，2： | 1 |
| 11 | Effect of freezing and frozen storage of doughs on bread quality显示文摘 | Ribotta P D leon A E Anon M C | 2001 | Journal of Agricultural and Food Chemistry2001，，2： | 1 |
| 12 | Power-electronic systems for the grid integration of renewable energy sources: A survey 显示文摘 | CARRASCO J M FRANQUELO L G BIALASIEWICZ J T GALVAN E GUISADO R C P PRATS M A M LEON J I MORENO N | 2006 | IEEE Transactions on Industrial Electronics2006，53，4： | 1 |
| 13 | Involvement of chemokine receptor 4/stromal cell-derived factor 1 system during osteosarcoma tumor progression显示文摘 | Perissinotto E Cavalloni G Leone F | | 0，，2： | 1 |
| 14 | Expression patterns of CEACAM5 and CEACAM6 in primary and metastatic caneers显示文摘 | BLUMENTHAL R D LEON E HANSEN H J | 2007 | BMC Cancer2007，7，1： | 1 |
| 15 | Adsorption of native resins on asphaltene particles:A correlation between adsorption and activity显示文摘 | LEON O CONTRERAS E ROGEL E | 2002 | Langmuir2002，18，13： | 1 |
| 16 | The microcirculation of cigarette smoking on the microcirculation of a replanted digit 显示文摘 | Leon N A van Adrichen S E R Hovius R | 1992 | J Hand Surg1992，，17： | 1 |
| 17 | The AmpliChip CYP450 genotyping test: integrating a new clinical tool 显示文摘 | Leon DJ Susce MT Murray - Carmichael E | 2006 | Mol Diagn Ther2006，10，： | 1 |
| 18 | Amphiphile adsorption on asphaltene particles:Adsorption isotherms and asphaltene stabilization显示文摘 | LEON O CONTRERAS E ROGEL E | 2001 | Colloids and Surfaces A:Physicochemical and Engineering Aspects2001，189，13： | 1 |
| 19 | Concentration and enantiomeric ratios of organochlorine pesticides in soils from the U S cornbelt显示文摘 | Leone A D Falconer R L | 1998 | Environ Sci Tech Nol1998，，32： | 1 |
| 20 | Results of the Predictors of Response to CRT (PROSPECT) trial显示文摘 | CHUNG E S LEON A R TAVAZZI L | 2008 | Circulation2008，117，： | 1 |
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