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| 1 | Is autoimmune hepatitis a frequent finding among HCV patients with intense interface hepatitis?显示文摘AIM:To evaluate the overlap of autoimmune hepatitis in hepatitis C virus(HCV)-infected patients with intense interface hepatitis.METHODS:Among 1759 patients with hepatitis C submitted to liver biopsy,92(5.2%) presented intense interface hepatitis.These patients were evaluated regarding the presence of antinuclear antibody(ANA),anti-smooth muscle antibody(SMA) and anti-liver/kidney microsomal antibody(LKM-1),levels of γ-globulin and histological findings related to autoimmune hepatitis(plasma cell infiltrate and presence of rosettes).RESULTS:Among patients with hepatitis C and intense interface hepatitis there was a low prevalence of autoantibodies(ANA=12%,SMA=5%,LKM-1=0%) and the median γ-globulin level was within the normal range.Typical histological findings of autoimmune disease were observed in only two cases(2%).After applying the score for diagnosis of autoimmune hepatitis,only one patient was classified with a definitive diagnosis of autoimmune hepatitis.Since overlap with autoimmune hepatitis was not the explanation for the intense necroinflammatory activity in patients with chronic hepatitis C we sought to identify the variables associated with this finding.The presence of intense interface hepatitis was associated with more advanced age,both at the time of infection and at the time of the biopsy,and higher prevalence of blood transfusion and alcohol abuse.CONCLUSION:Although possible,overlap with autoimmune hepatitis is a very rare association in HCV-infected patients with intense interface hepatitis,an unusual presentation which seems to be related to other host variables. | Rosilene G Badiani Vitória Becker Renata M Perez Carla AL Matos Lara B Lemos Valéria P Lanzoni Luis Eduardo C Andrade Alessandra Dellavance Antonio Eduardo B Silva Maria Lucia G Ferraz | 2010 | World Journal of Gastroenterology2010，16，29： | 7 |
| 2 | Protection from UV- induced skin carcinogenesis by genetic inhibition of the ataxia telangi-ectasia and Rad3-related(ATR )kinase显示文摘 | Kawasumi M Lemos B Bradner JE | 2011 | Proc Natl Acad Sci USA2011，108，13： | 1 |
| 3 | Responses of Stylosanthes humilis (Fabaceae) populations to saline stress显示文摘 | Lovato M B De Lemos Filho J P Martins P S | 1999 | Environmental and Experimental Botany1999，41，： | 1 |
| 4 | Relation of family history of myocardial infarction and the presence of coronary arterial calcium in various age and risk factor groups显示文摘 | Philips B Lemos JA Patel MJ | | 0，，09： | 1 |
| 5 | Impact of diabetes mellitus on epicardial and microvascular flow after fibrinolytic therapy显示文摘 | Angeja B G De Lemos J Murphy S A | 2002 | Am Heart J2002，144，4： | 1 |
| 6 | Characterization of specific antibodies against cytomegalovirus(CMV)-encoded interleukin 10 produced by 28%of CMV seropositive blood donors显示文摘 | de Lemos Rieper C Galle P Pedersen B K | 2011 | Journal of Gene Virology2011，92，7： | 1 |
| 7 | Hypertension induced by immunosuppressive drugs:a comparative analysis between sirolimus and cyclosporine显示文摘 | REIS F PARADA B TEIXEIRA DE LEMOS E | 2009 | In:Transplantation proceedings:2009:Elsevier2009，，： | 1 |
| 8 | Relation of family history of myocardial infarction and the presence of coronary arterial calcium in various age and risk factor groups显示文摘 | Philips B Lemos JA Patel MJ | 2007 | Am J Cardiol2007，99，6： | 1 |
| 9 | Development Environment for Control Strategies of Hybrid Active Power Filters Using Matlab and dSpace DSP显示文摘 | Brag R A M Lemos F A B Libano F B | 2001 | Power Technology Proceedings IEEE Porto2001，2，： | 1 |
| 10 | Dioclein, a new nitric oxide-and endothelium-dependent vasodilator fla- vonoid显示文摘 | Lemos VS Freitas MR Muller B | 1999 | Europen Journal of Pharmacology1999，386，1： | 1 |
| 11 | Relevant Factors for TacitKnowledge Transfer Within Organisations显示文摘 | JOIA L A LEMOS B | 2010 | Journal ofKnowledge Management2010，14，3： | 1 |
| 12 | Duodenal somatostatinoma of the ampulla of vater diagnosed by endoscopic fine needle aspiration biopsy:a case report显示文摘 | Guo M Lemos L B Bigler S | 2001 | Acta Cytol2001，45，4： | 1 |
| 13 | Clinical characteristics of Merkel cell carcinoma at diagnosis in 195 patients: the 'AEIOU' features 显示文摘 | Heath M Jaimes N Lemos B | 2008 | J Am Acad Dermatol2008，58，3： | 1 |
| 14 | Demulsification ofwater-in-crude oil emulsions using ionic liquids and micro-wave irradiation显示文摘 | Lemos R C B Da S Elisangela B | 2010 | Energy and Fuels2010，248，： | 1 |
| 15 | Association between Natriuretic Peptides and Mortality among Patients Admitted with Myocardial Infarction:A Report from the ACTION Registry-GWTG(TM)显示文摘 | Scirica Benjamin M Kadakia Mitul B de Lemos James A Roe Matthew T Morrow David A Li Shuang Wiviott Stephen D Kontos Michael C | 2013 | Clinical Chemistry2013，59，8： | 1 |
| 16 | Optical integration of a real-valued function by measurement of a stokes parameter 显示文摘 | Lemos G B Ribeiro P H Walborn S P | 2014 | Journal of the Optical Society of America A2014，31，4： | 1 |
| 17 | ST segment resolution as a tool for assessing the efficacy of reperfusion therapy显示文摘 | James A Lemos D Eugene B | 2001 | J Am Coll Cardial2001，38，6： | 1 |
| 18 | Sex, race, and the development of acute lung injury 显示文摘 | LEMOS FILHO L B MIKKELSEN M E MARTIN G S | 2013 | Chest2013，143，4： | 1 |
| 19 | Clinical characteristics of Merkel cell carcinoma at diagnosis in 195 patients:the 'AEIOU ' features 显示文摘 | Heath M Jaimes N Lemos B | 2008 | J Am Acad Dermatol2008，58，3： | 1 |
| 20 | Radiation monotherapy as regional treatment for lymph node-positive Merkel cell carcinoma 显示文摘 | Fang LC Lemos B Douglas J | 2010 | Cancer2010，116，7： | 1 |
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