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| 1 | 两种新型骨水泥的组织学和生物力学研究显示文摘我们研制了两种可被骨长入的骨水泥:一种是部分可吸收的骨水泥(PRC),以双酚α-甲基丙烯酸甘油酯(Bis-GMA)为基质,混合硅铝陶瓷和可吸收性聚合体颗粒调制成;另一种是磷酸钙骨水泥(CPC),由磷酸三钙、一水磷酸二氢钙、二水磷酸二钙和黄原胶组成。将这两种骨水泥分别植入家兔股骨和胫骨髁的骨缺损中,植入后2、4、12和24周取材,进行组织学观察和生物力学测试。结果发现,CPC组有递增的骨整合,伴有生物降解及巨噬细胞出现,力学测试显示抗压强度在4周之前一直降低,4周后才轻微升高,弹性模量随时间普遍降低。到第4周时,组织学观察还发现新生骨与CPC边缘直接接触。整个观察过程中未发现炎症反应。PRC组,骨整合及生物降解都很轻微,但在各个观察阶段,其抗压强度比松质骨和CPC组高(p<0.05),在4周之前,它的弹性模量高于松质骨和CPC组,4周后低于松质骨。(Bone 25:41S--45S;1999)。 | 卢建熙 I ABOUT G STEPHAN P VAN LANDUYT J DEJOU M FIOCCHI J LEMAITRE J-P PROUST | 2000 | 医用生物力学2000，15，3： | 10 |
| 2 | Tumor cells educate mesenchymal stromal cells to release chemoprotective and immunomodulatory factors显示文摘Factors released by surrounding cells such as cancer-associated mesenchymal stromal cells(CA-MSCs)are involved in tumor progression and chemoresistance.In this study,we characterize the mechanisms by which naYve mesenchymal stromal cells(MSCs)can acquire a CA-MSCs phenotype.Ovarian tumor cells trigger the transformation of MSCs to CA-MSCs by expressing pro-tumoral genes implicated in the chemoresistance of cancer cells,resulting in the secretion of high levels of CXC chemokine receptors 1 and 2(CXCR1/2)ligands such as chemokine(C-X-C motif)ligand 1(CXCL1),CXCL2,and interleukin 8(IL-8).CXCR1/2 ligands can also inhibit the immune response against ovarian tumor cells.Indeed,through their released factors,CA-MSCs promote the differentiation of monocytes towards M2 macrophages,which favors tumor progression.When CXCR1/2 receptors are inhibited,these CA-MSC-activated macrophages lose their M2 properties and acquire an anti-tumoral phenotype.Both ex vivo and in vivo,we used a CXCR1/2 inhibitor to sensitize ovarian tumor cells to carboplatin and circumvent the pro-tumoral effects of CA-MSCs.Since high concentrations of CXCR1/2 ligands in patients*blood are associated with chemoresistance,CXCR1/2 inhibition could be a potential therapeutic strategy to revert carboplatin resistance. | Augustin Le Naour Melissa Prat Benolt Thibault Renaud Mével Léa Lemaitre Helene Leray Marie-Veronique Joubert Kimberley Coulson Muriel Golzio Lise Lefevre Eliane Mery Alejandra Martinez Gwénael Ferron Jean-Pierre Delord Agnès Coste Bettina Couderc | 2020 | Journal of Molecular Cell Biology2020，12，3： | 3 |
| 3 | Aerosol Removal by Emergency Spray in PWR Containment显示文摘 | E. Porcheron P. Lemaitre D. Marchand | 2011 | Journal of Energy and Power Engineering2011，5，7： | 2 |
| 4 | Treatment of anilio-caval thrombosis by mechanical thrombolysis 显示文摘 | Moughabghab A Socolovsky C Lemaitre RM | 1995 | Int-Care Med1995，21，： | 2 |
| 5 | Stiffened panel stability behaviour and performance gains with plate prismatic sub-stiffening显示文摘 | D. Quinn A. Murphy W. McEwan F. Lemaitre | 2009 | Thin-Walled Structures2009，，12： | 2 |
| 6 | Thin water film around a cable subject to wind显示文摘 | C. Lemaitre P. Hémon E. de Langre | 2007 | Journal of Wind Engineering & Industrial Aerodynamics2007，，9： | 2 |
| 7 | Stabilization and processing of aqueous BaTiO3 suspension with polyacrylic acid显示文摘 | CHEN Z C RING T A LEMAITRE L | 1992 | J Am Ceram Soc1992，75，12： | 2 |
| 8 | Direct observation of photonic Landau levels and helical edge states in strained honeycomb lattices显示文摘We report the realization of a synthetic magnetic field for photons and polaritons in a honeycomb lattice of coupled semiconductor micropillars.A strong synthetic field is induced in both the s and p orbital bands by engineering a uniaxial hopping gradient in the lattice,giving rise to the formation of Landau levels at the Dirac points.We provide direct evidence of the sublattice symmetry breaking of the lowest-order Landau level wavefunction,a distinctive feature of synthetic magnetic fields.Our realization implements helical edge states in the gap between n=0 and n=±1 Landau levels,experimentally demonstrating a novel way of engineering propagating edge states in photonic lattices.In light of recent advances in the enhancement of polariton–polariton nonlinearities,the Landau levels reported here are promising for the study of the interplay between pseudomagnetism and interactions in a photonic system. | Omar Jamadi Elena Rozas Grazia Salerno Marijana Milicevic Tomoki Ozawa Isabelle Sagnes Aristide Lemaitre Luc Le Gratiet Abdelmounaim Harouri Iacopo Carusotto Jacqueline Bloch Alberto Amo | 2020 | Light(Science & Applications)2020，9，1： | 2 |
| 9 | The dorsoventral regulatory gene cassette spatzle/Toll/ccctus controls the potent antifungal response in Drosophila adults显示文摘 | Lemaitre B Nicolas E Michaut L | 1996 | Cell1996，86，6： | 1 |
| 10 | Thin water film around a cable subject to wind显示文摘 | LEMAITRE C | 2007 | Journal of Wind Engineering and Industrial Aerodynamics2007，95，： | 1 |
| 11 | The host defense of Drosophila melanogaster显示文摘 | Lemaitre B Hoffnann J | 2007 | Annu Rev Immunol2007，25，： | 1 |
| 12 | The road to toll显示文摘 | LEMAITRE B | 2004 | Nat Rev Immunol2004，4，： | 1 |
| 13 | The dorsoventral regulatory gene cassette spatzle/Toll/cactus controls the potene antifungal response in Drosophila adults 显示文摘 | Lemaitre B Nicolas E Michaut L | 1996 | Cell1996，86，： | 1 |
| 14 | Selecting and seheduling observations of agile satellites显示文摘 | LEMAITRE M | 2002 | Aerospace Sciences and Technology2002，6，5： | 1 |
| 15 | Drosophilia host defense differential induction of antimicrobial peptide genes after infection by various classes of microorganism显示文摘 | Lemaitre B Reichhart JM | 1997 | Proc Natl Acad Sci USA1997，94，14： | 1 |
| 16 | The host defense of Drosophila melanogaster显示文摘 | Lemaitre B Hoffmann J | 2007 | Annu Rev Immunol2007，25，： | 1 |
| 17 | Fractal porous media IV: three-dimensional stokes flow through random media and regular fractals显示文摘 | Lemaitre R Adler P M | 1990 | Tra -nsport in porous media1990，5，： | 1 |
| 18 | FOXP3 expressing CD4^+CD25^+ high regulatory T ceils are overrepresented in human metastatic melanoma lymph nodes and inhibit the function of infiltrating T cells显示文摘 | Viguier M Lemaitre F Verola O | 2004 | J Immunol2004，173，2： | 1 |
| 19 | Two distinct pathways can control expression of the gene encoding the droso-phila antimicrobial peptide metchnikowin 显示文摘 | Ohresser S Lemaitre B | 1998 | J Mol Biol1998，278，3： | 1 |
| 20 | How to use damage mechanics 显示文摘 | Lemaitre J | 1984 | Nuclear Engineering andDesign1984，80，： | 1 |
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