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| 1 | 两种新型骨水泥的组织学和生物力学研究显示文摘我们研制了两种可被骨长入的骨水泥:一种是部分可吸收的骨水泥(PRC),以双酚α-甲基丙烯酸甘油酯(Bis-GMA)为基质,混合硅铝陶瓷和可吸收性聚合体颗粒调制成;另一种是磷酸钙骨水泥(CPC),由磷酸三钙、一水磷酸二氢钙、二水磷酸二钙和黄原胶组成。将这两种骨水泥分别植入家兔股骨和胫骨髁的骨缺损中,植入后2、4、12和24周取材,进行组织学观察和生物力学测试。结果发现,CPC组有递增的骨整合,伴有生物降解及巨噬细胞出现,力学测试显示抗压强度在4周之前一直降低,4周后才轻微升高,弹性模量随时间普遍降低。到第4周时,组织学观察还发现新生骨与CPC边缘直接接触。整个观察过程中未发现炎症反应。PRC组,骨整合及生物降解都很轻微,但在各个观察阶段,其抗压强度比松质骨和CPC组高(p<0.05),在4周之前,它的弹性模量高于松质骨和CPC组,4周后低于松质骨。(Bone 25:41S--45S;1999)。 | 卢建熙 I ABOUT G STEPHAN P VAN LANDUYT J DEJOU M FIOCCHI J LEMAITRE J-P PROUST | 2000 | 医用生物力学2000，15，3： | 10 |
| 2 | Tumor cells educate mesenchymal stromal cells to release chemoprotective and immunomodulatory factors显示文摘Factors released by surrounding cells such as cancer-associated mesenchymal stromal cells(CA-MSCs)are involved in tumor progression and chemoresistance.In this study,we characterize the mechanisms by which naYve mesenchymal stromal cells(MSCs)can acquire a CA-MSCs phenotype.Ovarian tumor cells trigger the transformation of MSCs to CA-MSCs by expressing pro-tumoral genes implicated in the chemoresistance of cancer cells,resulting in the secretion of high levels of CXC chemokine receptors 1 and 2(CXCR1/2)ligands such as chemokine(C-X-C motif)ligand 1(CXCL1),CXCL2,and interleukin 8(IL-8).CXCR1/2 ligands can also inhibit the immune response against ovarian tumor cells.Indeed,through their released factors,CA-MSCs promote the differentiation of monocytes towards M2 macrophages,which favors tumor progression.When CXCR1/2 receptors are inhibited,these CA-MSC-activated macrophages lose their M2 properties and acquire an anti-tumoral phenotype.Both ex vivo and in vivo,we used a CXCR1/2 inhibitor to sensitize ovarian tumor cells to carboplatin and circumvent the pro-tumoral effects of CA-MSCs.Since high concentrations of CXCR1/2 ligands in patients*blood are associated with chemoresistance,CXCR1/2 inhibition could be a potential therapeutic strategy to revert carboplatin resistance. | Augustin Le Naour Melissa Prat Benolt Thibault Renaud Mével Léa Lemaitre Helene Leray Marie-Veronique Joubert Kimberley Coulson Muriel Golzio Lise Lefevre Eliane Mery Alejandra Martinez Gwénael Ferron Jean-Pierre Delord Agnès Coste Bettina Couderc | 2020 | Journal of Molecular Cell Biology2020，12，3： | 3 |
| 3 | Selecting and seheduling observations of agile satellites显示文摘 | LEMAITRE M | 2002 | Aerospace Sciences and Technology2002，6，5： | 1 |
| 4 | Fractal porous media IV: three-dimensional stokes flow through random media and regular fractals显示文摘 | Lemaitre R Adler P M | 1990 | Tra -nsport in porous media1990，5，： | 1 |
| 5 | FOXP3 expressing CD4^+CD25^+ high regulatory T ceils are overrepresented in human metastatic melanoma lymph nodes and inhibit the function of infiltrating T cells显示文摘 | Viguier M Lemaitre F Verola O | 2004 | J Immunol2004，173，2： | 1 |
| 6 | Foxp3 expressing CD4+ CD25 (high) regulatory T cells are over represented in human metastatic melanoma lymph nodes and inhibit the function of infiltrating T cells显示文摘 | Viguier M Lemaitre F Verola O | 2004 | J Immunol2004，173，： | 1 |
| 7 | Design of yeast-secreted albumin derivatives for human therapy:biological and antiviral properties of a serum albumin-CD4 genetic conjugate 显示文摘 | YEH P LANMRIS D LEMAITRE M | 1992 | Proe Natl Acad Sci1992，89，5： | 1 |
| 8 | Imaging of chronic and intermittent adult upper urinary tract obstruction 显示文摘 | Lemaitre L Claudon M Fauquet I | 2004 | J Radiol2004，85，2： | 1 |
| 9 | Can bioactivity be tested in vitro with SBF solution显示文摘 | Bohner M Lemaitre J | | 0，，12： | 1 |
| 10 | Earth observation satellite management 显示文摘 | Bensana E Lemaitre M and Verfaillie G | 1999 | Constraints : An Internat1999，4，3： | 1 |
| 11 | Use of PCR-restriction fragment length polymorphism of inlA for rapid screening of Listeria monocytogenes strains deficient in the ability to invade Caco-2 cells显示文摘 | Rousseaux S Olier M Lemaitre JP | 2004 | Appl Environ Microbiol2004，70，21： | 1 |
| 12 | Fibrinolytic activation markers predict myocardial infarction in the elderly 显示文摘 | Lemaitre RN Kuller LH | 1999 | Arterioscler Thromb Vasc Biol1999，19，3： | 1 |
| 13 | The Drosophila amidase PGRP-LB modulates the immune response to bacterial infection显示文摘 | Zaidman-Rémy A Hervé M Poidevin M Pili-Floury S Kim MS Blanot D Oh BH Ueda R Mengin-Lecreulx D Lemaitre B | | 0，，04： | 1 |
| 14 | Staff concerns in heroin-assisted treatment centres显示文摘 | Demaret I Lemaitre A Ansseau M | | 0，，06： | 1 |
| 15 | Selecting and scheduling observations of agile satellites显示文摘 | Lemaitre M Verfaillie G Jouhaud F | 2002 | Aerospace Science and Technology2002，6，5： | 1 |
| 16 | transPalmitoleic acid,other dairy fat biomarkers,and incident diabetes:the multi-ethnic study of atherosclerosis(MESA)显示文摘 | D Mozaffarian M C d O Otto R N Lemaitre | 2013 | American Journal of Clinical Nutrition2013，97，4： | 1 |
| 17 | Foxpg expressing CD4^+ CD25 (high) regulatory T cells are over represented in human metastatic melanoma lymph nodes and inhibit the function of infiltrating T cells 显示文摘 | Viguier M Lemaitre F Verola O | 2004 | J Immunol2004，173，： | 1 |
| 18 | Foxp3 expressing CIM+ CD'25 (high) regulatory T cells are overrepresented in human metastatic melanollalymph nodes and inhibit the function of infiltrating T ceils 显示文摘 | Viguier M Lemaitre F Verola O | 2004 | J lmmunol2004，173，2： | 1 |
| 19 | Renal angiomyolipoma: Growth followed up with CT and/or Us显示文摘 | Laurent Lemaitre MD Yann Robert MD Michel Claudon M D | 1995 | Radiol1995，197，4： | 1 |
| 20 | Se- lecting and scheduling observations of agile satellites显示文摘 | LEMAITRE M VERFAILLIE G JOUHAUD F | 2002 | Aerospace Science and Technology2002，6，5： | 1 |
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