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| 1 | Tumor cells educate mesenchymal stromal cells to release chemoprotective and immunomodulatory factors显示文摘Factors released by surrounding cells such as cancer-associated mesenchymal stromal cells(CA-MSCs)are involved in tumor progression and chemoresistance.In this study,we characterize the mechanisms by which naYve mesenchymal stromal cells(MSCs)can acquire a CA-MSCs phenotype.Ovarian tumor cells trigger the transformation of MSCs to CA-MSCs by expressing pro-tumoral genes implicated in the chemoresistance of cancer cells,resulting in the secretion of high levels of CXC chemokine receptors 1 and 2(CXCR1/2)ligands such as chemokine(C-X-C motif)ligand 1(CXCL1),CXCL2,and interleukin 8(IL-8).CXCR1/2 ligands can also inhibit the immune response against ovarian tumor cells.Indeed,through their released factors,CA-MSCs promote the differentiation of monocytes towards M2 macrophages,which favors tumor progression.When CXCR1/2 receptors are inhibited,these CA-MSC-activated macrophages lose their M2 properties and acquire an anti-tumoral phenotype.Both ex vivo and in vivo,we used a CXCR1/2 inhibitor to sensitize ovarian tumor cells to carboplatin and circumvent the pro-tumoral effects of CA-MSCs.Since high concentrations of CXCR1/2 ligands in patients*blood are associated with chemoresistance,CXCR1/2 inhibition could be a potential therapeutic strategy to revert carboplatin resistance. | Augustin Le Naour Melissa Prat Benolt Thibault Renaud Mével Léa Lemaitre Helene Leray Marie-Veronique Joubert Kimberley Coulson Muriel Golzio Lise Lefevre Eliane Mery Alejandra Martinez Gwénael Ferron Jean-Pierre Delord Agnès Coste Bettina Couderc | 2020 | Journal of Molecular Cell Biology2020，12，3： | 3 |
| 2 | Stabilization and processing of aqueous BaTiO3 suspension with polyacrylic acid显示文摘 | CHEN Z C RING T A LEMAITRE L | 1992 | J Am Ceram Soc1992，75，12： | 2 |
| 3 | The dorsoventral regulatory gene cassette spatzle/Toll/ccctus controls the potent antifungal response in Drosophila adults显示文摘 | Lemaitre B Nicolas E Michaut L | 1996 | Cell1996，86，6： | 1 |
| 4 | The dorsoventral regulatory gene cassette spatzle/Toll/cactus controls the potene antifungal response in Drosophila adults 显示文摘 | Lemaitre B Nicolas E Michaut L | 1996 | Cell1996，86，： | 1 |
| 5 | The dorsoventral regulatory gene cassette spatzle/Toll/cactus controls the potent antifungal response in drosophila adults显示文摘 | Lemaitre B Nicolas E Michaut L Reichhart J Hoffmann J | 1996 | Cell1996，86，6： | 1 |
| 6 | The dorsoventral regulatory gene cassette spatzle/Toll/cactus controls the potent antifungal response in Drosophila adults 显示文摘 | LEMAITRE B NICOLAS E MICHAUT L | 1996 | Celi1996，86，6： | 1 |
| 7 | Imaging of chronic and intermittent adult upper urinary tract obstruction 显示文摘 | Lemaitre L Claudon M Fauquet I | 2004 | J Radiol2004，85，2： | 1 |
| 8 | The dorsoventral regulatory gene cassette sp tzle/TolV cactus controls the potent antifungal response in Drosophila adults 显示文摘 | LEMAITRE B NICOLAS E MICHAUT L | 1996 | Cell1996，86，6： | 1 |
| 9 | The dorsoventral regulatory gene cassette spatzle/Toll/cactus controls the potent antifungal response in Drosophila adults 显示文摘 | Lemaitre B Nicolas E Michaut L Reichhart JM Hoffmann JA | 1996 | Cell1996，86，5： | 1 |
| 10 | Communication and auto-induction in the species Listeria monocytogenes : A central role for the agr system显示文摘 | Garmyn D Gal L Lemaitre J P | 2009 | Commun Integr Biol2009，2，4： | 1 |
| 11 | The dorsoventral regu- latory gene cassette spatzle/Toll/cactus conlxols the potent anti- fungal response in Drosophilaadults 显示文摘 | Lemaitre B Nicolas E Michaut L | 1996 | Cell1996，86，： | 1 |
| 12 | The dorsoventral regulatory gene cassette sp(a)tzle/Toll/cactus controls the potent antifungal response in Drosophila adults显示文摘 | Lemaitre B Nicolas E Michaut L | | 0，，06： | 1 |
| 13 | Production and purification of active FGF2 via recombinant fusion protein显示文摘 | Lemaitre G Laaroubi K Soulet L | 1995 | Biochimie1995，77，3： | 1 |
| 14 | A recessive mutation , immune deficiency, defines two distinct control pathways in the drosophila host defense 显示文摘 | Kromer M E Miichaut L | 1995 | Proc Natl Acad Sci USA1995，92，21： | 1 |
| 15 | Aspect phenomenologique de la rupture par endommagement显示文摘 | Lemaitre J Chaboche J L | 1978 | Journal de Mecanique Applique1978，2，3： | 1 |
| 16 | Renal angiomyolipoma:growth followed up with CT and/or US显示文摘 | LEMAITRE L ROBERT R CIAUDON M et a1 | 1995 | Radiology1995，197，3： | 1 |
| 17 | The dorsoventral regulatory gene cassette spatzle/Toll/cactus controls the potent antifugal response in Drosophila adults显示文摘 | Lemaitre B Nicolas E Michaut L | 1996 | Cell1996，86，： | 1 |
| 18 | Coinfection with Plasmodium falciparum and Suhistosomu haematobium:Additional evidence of the protective effect of schistosomiasis on malaria in Senegalese children显示文摘 | Lemaitre M Watier L Briand V | 2014 | Am J Trop Med Hyg2014，90，2： | 1 |
| 19 | Renal angiomyo- lipoma: growth followed up with CT and/or US 显示文摘 | Lemaitre L Tobert Y Dubrulle F | 1995 | Radio- logy1995，197，3： | 1 |
| 20 | Fish intake and risk of incident heart failure 显示文摘 | Mozaffarian D Bryson C L Lemaitre R N | 2005 | J Am Coil Cardiol2005，45，12： | 1 |
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