|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Pathological bacterial translocation in liver cirrhosis显示文摘 | Reiner Wiest Melissa Lawson Markus Geuking | 2014 | Journal of Hepatology2014，，1： | 8 |
| 2 | Effects of overburden characteristics on dynamic failure in underground coal mining显示文摘Dynamic failures, or ‘‘bumps', remain an imperative safety concern in underground coal mining, despite significant advancements in engineering controls. The presence of spatially discrete, stiff roof units are one feature that has been linked to these events. However, an empirical stratigraphic review indicates that no significant difference exists in the relative commonality of discrete units between bumping and non-bumping deposits. Instead an apparent relationship exists between reportable bumping and the overall stiffness of the host rock. However, this initial study is too simplistic to be conclusive; to weight the relative impact of changes in a single variable, such as the thickness or location of sandstone members, it must be examined in isolation—i.e., in a setting where all other variables are held constant.Numerical modelling provides this setting, and the effects of variability in a stiff discrete member in a hypothetical longwall mining scenario are investigated within the context of three stratigraphic ‘‘types',Compliant, Intermediate and Stiff. A modelling experiment examines changes in rupture potential in stiff roof units for each stratigraphic type as discrete unit thickness and location are manipulated through a range of values. Results suggest that the stiff-to-compliant ratio of the host rock has an impact on the relative stress-inducing effects of discrete stiff members. In other words, it is necessary to consider both the thickness and the distance to the seam, within the context of the host rock, to accurately anticipate areas of elevated rupture-induced hazard; acknowledging the presence of a discrete unit within the overburden in general terms is an insufficient indicator of risk. This finding helps to refine our understanding of the role of individual stiff, strong roof members in bumping phenomena, and suggests that a holistic view of overburden lithology and site-specific numerical modelling may be necessary to improve miner safety. | Lawson Heather E. Tesarik Douglas Larson Mark K Abraham Habte | 2017 | International Journal of Mining Science and Technology2017，27，1： | 7 |
| 3 | Analysis of the current rib support practices and techniques in U.S. coal mines显示文摘Design of rib support systems in U.S. coal mines is based primarily on local practices and experience. A better understanding of current rib support practices in U.S. coal mines is crucial for developing a sound engineering rib support design tool. The objective of this paper is to analyze the current practices of rib control in U.S. coal mines. Twenty underground coal mines were studied representing various coal basins,coal seams,geology,loading conditions,and rib control strategies. The key findings are:(1) any rib design guideline or tool should take into account external rib support as well as internal bolting;(2) rib bolts on their own cannot contain rib spall,especially in soft ribs subjected to significant load—external rib control devices such as mesh are required in such cases to contain rib sloughing;(3) the majority of the studied mines follow the overburden depth and entry height thresholds recommended by the Program Information Bulletin 11-29 issued by the Mine Safety and Health Administration;(4) potential rib instability occurred when certain geological features prevailed—these include draw slate and/or bone coal near the rib/roof line,claystone partings,and soft coal bench overlain by rock strata;(5) 47% of the studied rib spall was classified as blocky—this could indicate a high potential of rib hazards; and(6) rib injury rates of the studied mines for the last three years emphasize the need for more rib control management for mines operating at overburden depths between 152.4 m and 304.8 m. | Mohamed Khaled M. Murphy Michael M. Lawson Heather E. Klemetti Ted | 2016 | International Journal of Mining Science and Technology2016，26，1： | 6 |
| 4 | Dynamic failure in coal seams Implications of coal composition for bump susceptibility显示文摘As a contributing factor in the dynamic failure(bumping) of coal pillars,a bump-prone coal seam has been described as one that is ‘‘uncleated or poorly cleated,strong...that sustains high stresses.'Despite extensive research regarding engineering controls to help reduce the risk for coal bumps,there is a paucity of research related to the properties of coal itself and how those properties might contribute to the mechanics of failures. Geographic distribution of reportable dynamic failure events reveals a highly localized clustering of incidents despite widespread mining activities. This suggests that unique,contributing geologic characteristics exist within these regions that are less prevalent elsewhere. To investigate a new approach for identifying coal characteristics that might lead to bumping,a principal component analysis(PCA) was performed on 306 coal records from the Pennsylvania State Coal Sample database to determine which characteristics were most closely linked with a positive history of reportable bumping. Selected material properties from the data records for coal samples were chosen as variables for the PCA and included petrographic,elemental,and molecular properties. Results of the PCA suggest a clear correlation between low organic sulfur content and the occurrence of dynamic failure,and a secondary correlation between volatile matter and dynamic failure phenomena. The ratio of volatile matter to sulfur in the samples shows strong correlation with bump-prone regions,with a minimum threshold value of approximately 20,while correlations determined for other petrographic and elemental variables were more ambiguous. Results suggest that the composition of the coal itself is directly linked to how likely a coal is to have experienced a reportable dynamic failure event. These compositional controls are distinct from other previously established engineering and geologic criteria and represent a missing piece to the bump prediction puzzle. | Lawson Heather Weakley Andrew Miller Arthur | 2016 | International Journal of Mining Science and Technology2016，26，1： | 6 |
| 5 | 不同叶龄拟南芥荧光参数分析及对强光的响应显示文摘采用叶绿素荧光图像分析系统,研究了野生型拟南芥(Wild Arabidopsis thaliana)Col-0不同叶龄叶片的荧光参数变化及对强光的响应。结果表明,随叶片趋于成熟或衰老,20 min暗适应的最大PSⅡ光化学量子效率(Fv/Fm),稳定作用光下的PSⅡ有效和实际光化学效率(Fv′/Fm′和ΦPSⅡ)以及光化学猝灭系数(q P)均呈降低趋势,而非光化学猝灭系数(NPQ)增加;但短期5 d的处理期间其变化都不明显。与低光强相比,强光处理时Fv/Fm,ΦPSⅡ,Fv′/Fm′和q P呈降低趋势而NPQ明显升高。说明不同发育阶段的叶片具有明显差异的光化学反应特性,强光下光抑制现象明显;NPQ增加说明拟南芥能通过非辐射的热能耗散途径消耗过多的激发能,从而能避免光合机构的继续伤害。 | 师生波 Neil Baker Tracy Lawson 张德罡 | 2011 | 草原与草坪2011，31，4： | 4 |
| 6 | Aggressive juvenile polyposis in children with chromosome 10q23 deletion显示文摘Juvenile polyps are relatively common findings in children,while juvenile polyposis syndrome(JPS) is a rare hereditary syndrome entailing an increased risk of colorectal cancer.Mutations in BMPR1A or SMAD4 are found in roughly half of patients diagnosed with JPS.Mutations in PTEN gene are also found in patients with juvenile polyps and in Bannayan-Riley-Ruvalcaba syndrome and Cowden syndrome.Several previous reports have described microdeletions in chromosome 10q23 encompassing both PTEN and BMPR1A causing aggressive polyposis and malignancy in childhood.These reports have also described extra-intestinal findings in most cases including cardiac anomalies,developmental delay and macrocephaly.In this report we describe a boy with a 5.75 Mb deletion of chromosome 10q23 and a 1.03 Mb deletion within chromosome band 1p31.3who displayed aggressive juvenile polyposis and multiple extra-intestinal anomalies including macrocephaly,developmental delay,short stature,hypothyroidism,atrial septal defect,ventricular septal defect and hypospadias.He required colectomy at six years of age,and early colectomy was a common outcome in other children with similar deletions.Due to the aggressive polyposis and reports of dysplasia and even malignancy at a young age,we propose aggressive gastrointestinal surveillance in children with 10q23 microdeletions encompassing the BMPR1A and PTEN genes to include both the upper and lower gastrointestinal tracts,and also include a flowchart for an effective genetic testing strategy in children with juvenile polyposis. | Seth Septer Lei Zhang Caitlin E Lawson Jose Cocjin Thomas Attard Holly H Ardinger | 2013 | World Journal of Gastroenterology2013，19，14： | 4 |
| 7 | 碳排放成本的扩展价值分析显示文摘企业根据公认会计原则(GAAP)按期编制反映其财务业绩的报表。这样的报表固然提供了有用的信息,但人们也越来越感觉到,它们未能提供在今天的经济与社会环境下企业所需要的宽阔视野。为弥补这一缺陷,企业越来越多地采用反映“三重底线(triple-bottom line三重经营效果)”的报表,即采用三套指标,从三个方面(经济、社会和环境)衡量其业绩。 | Saurav Dutta Raef Lawson 杨继良(翻译) 周学园(翻译) | 2008 | 财会通讯(上)2008，，3： | 4 |
| 8 | 9 二磷酸盐导致颌骨坏死:7例报告及文献复习显示文摘二磷酸盐、焦磷酸盐衍生物是破骨细胞抑制剂,临床主要用于预防骨质疏松症及肿瘤的骨转移。但应用二磷酸盐(bisphosphonates)、帕米磷酸盐(Pamindronate)、唑来膦酸(Zolendronic acid)治疗疾病所导致颌骨坏死的报道逐渐增多,这些患者一般首诊口腔外科医师并由其治疗.上颌骨骨坏死若不处理可导致鼻窦炎,耳鼻咽喉科医师也参与其中。该文对2003~2004年间2所医院的7例患者进行回顾,对患者病史进行分析。结果:患者均有顽固性骨髓炎病史及二磷酸盐服用史.4例发病期间正应用二磷酸盐,3例先前应用过二磷酸盐。3例行手术切除死骨,1例行鼻窦镜手术。结论:二磷酸盐导致颌骨坏死的报道逐渐增多,且治疗困难。因此,对易感人群及此药的安全剂量需要进一步研究。 | Mortensen M Lawson W Montazem A | 2007 | 中国口腔颌面外科杂志2007，5，2： | 4 |
| 9 | 文化价值观对消费行为的影响显示文摘文化价值观从本质上影响消费者的消费行为 ,决定市场营销人员营销策略的制定。本文从文化特征和文化价值观的界定入手 。 | Robert Lawson 郭晓春 | 2002 | 鄂州大学学报2002，9，1： | 4 |
| 10 | PrP^C-related signal transduction is influenced by copper, membrane integrity and the alpha cleavage site显示文摘铜绑定,抛锚膜的、细胞的 prion 蛋白质(PrPC ) 有二个组成的劈开地点生产不同 N 终端和 C 终端碎片(N1/C1 和 N2/C2 ) 。用表示也人的 PrPC,鼠标 PrPC 或鼠标 PrPC 的 RK13 房间带 3F4 epitope,这研究在 endoproteolytic 劈开和一个通常认为的 PrPC 函数上探索了 PrPC 主要顺序的影响,地图 kinase 信号 transduction,响应外长的铜与或没有使不安的膜环境。PrPC 主要顺序,特别在 N1/C1 劈开地点附近,看起来在这个地点和细胞外的调整信号的 kinase 1/2 (ERK1/2 ) phosphorylation 影响解朊作用的基础层次,与处理激活增加与基础 ERK1/2 表明一种反的关系。人的 PrPC 独自响应铜显示出增加的 N1/C1 劈开,由特定的 p38 和 JNK/SAPK phosphorylation 伴随了。到加扣押胆固醇的抗菌素 filipin 的铜的联合暴露导致了一只老鼠信号蛋白质 phosphorylation 的 PrPC 特定的实质的增加,由 N1/C1 劈开的增加伴随了。怀有人的 N1/C1 劈开地点的老鼠 PrPC 基础地并且响应铜假定更似人类的侧面并且改变了膜环境。我们的结果证明在 N1/C1 劈开地点附近的 PrPC 主要顺序影响在这个地点处理的 endoproteolytic,它显得连接了基础地并且响应铜印射 kinase 信号 transduction。进一步,主要顺序看起来响应外长的刺激在 PrPC 相关的信号 transduction 的忠实上授与 N1/C1 劈开和膜完整的相互的依赖。 | Cathryn L Haigh | 2009 | Cell Research2009，19，9： | 4 |
| 11 | Exploration of petrographic,elemental,and material properties of dynamic failure-prone coals显示文摘The purpose of this study is to explore how the geochemical and petrographic components of coal may impact its physical properties and how these correlate with a history of reportable dynamic failure in coal mines.Dynamic failure events,also termed bumps,bounces,or bursts,are the explosive failures of rock in a mining environment.These events occur suddenly and often with no warning,resulting in worker injury up to and including fatality in greater than 60%of reportable cases through the Mine Safety and Health Administration(MSHA).A database of variables was compiled using publicly available datasets,which includes compositional geographic,strength,and Hardgrove grindability index(HGI)data.Results indicated that bumping coals were less mature,lower in carbon,higher in oxygen,softer,and less well cleated than coals that did not bump.High liptinite content was found to correlate with higher average uniaxial compressive strength(UCS)values.However,no clear and direct correlation between UCS and dynamic failure status was observed.The findings of this study established that differences existed between coals that had versus had not experienced reportable dynamic failure accidents.These differences were inherent to the coal itself and were independent of mining-induced risk factors.Results further illuminated how compositional attribute of coal influenced physical properties and began to clarify potential links between geochemistry and dynamic failure status.Only through the better understanding of risk can more effective mitigating strategies be enacted. | Heather Lawson | 2020 | International Journal of Mining Science and Technology2020，30，1： | 3 |
| 12 | Theories and Practice in Prevention and Treatment Principles in Relation to Chinese Herbal Medicine and Bone Loss显示文摘Osteoporosis is a world wide problem that is increasing in significance as the global population both increases and ages. While osteoporosis has been extensively studied in recent years, the utilization of Traditional Chinese Herbal Medicine for the prevention and treatment of this condition have seldom been examined in the Western world. This paper reviews the theories and the literature that relate to prevention and treatment of bone loss at the time of menopause according to the principles of Traditional Chinese Herbal Medicine. Practical developments in these areas are also illustrated in this paper based on the authors' research findings in recent studies. | 徐红 David LAWSON | 2004 | Journal of Traditional Chinese Medicine2004，24，2： | 3 |
| 13 | EECP in the treatment of endothelial dysfunction: preventing progression of cardiovascular disease显示文摘 | John CK Hui William E Lawson Gregory W Barsness | 2010 | Journal of Geriatric Cardiology2010，7，2： | 3 |
| 14 | HPLC法测定大蒜匀浆中的大蒜辣素及其他硫代亚磺酸酯含量显示文摘用反相高效液相色谱法《C_(18)-HPLC)分离和定量大蒜匀浆中所有可检测的烷基和烯基硫代亚磺酸酯及其构型异构体的含量。首次发现5种新的硫代亚磺酸酯,其中4种含有反式-1-丙烯基。大蒜于4C贮藏时其大蒜辣素含量增加一半以至若干倍,且伴随γ-谷氨酰肽含量降低。研究了硫代亚磺酸酯含量与不同产地、商店、球茎、蒜瓣及储存时间的关系。作者提出一个大蒜辣素的标准定量方法,并与其他的分析方法进行对比。 | Lawson L D 陈汉平 | 1992 | 国外医药(植物药分册)1992，7，5： | 3 |
| 15 | Application of Piezoelectric Actuator and Compliant Structures to Achieve Flapping Wing Motion for a MAV显示文摘Micro Aerial Vehicles(MAVs) are the smallest artificial aircraft.Most of the flapping wings MAVs are powered by electric motors of various capacities.We report in this paper the application of piezoelectric actuators as power system for a flapping wing MAV using a compliant displacement amplification mechanism.The actuator used for this application is a pre-stressed cut piece of TH-7R type Thunder actuator.A two-bar compliant mechanism with two flexures has been developed to convert the linear displacement into angular movement and amplification.The specimens were made from carbon fiber links and nylon flexures.We also proposed to use the product of frequency(F) and tip displacement(D), F * D as a criteria for the characterization of an amplifying mechanism.The best specimen according to this criterion is obtained for a 5mm length flexure specimen made of three layers of nylon.The F*D value obtained for this specimen was(0.58) Hz.m.ANSYS finite element analysis results for different flexural thickness and lengths were obtained and have been compared to the experimental results.The effect of both the thickness and length of the flexure on a particular arrangement has been discussed. | Kranti. K. Lal Kummari S. J. Croucher N. J. Lawson E. E. Liani G. Allegri S. Guo Hsien-Chun Chung Z. Huang | 2008 | 材料科学与工程学报2008，26，4： | 3 |
| 16 | Metals, oxidative stress and neurodegenerative disorders显示文摘 | Klaudia Jomova Dagmar Vondrakova Michael Lawson Marian Valko | 2010 | Molecular and Cellular Biochemistry2010，，1： | 2 |
| 17 | 变革管理心理学显示文摘'心理学上的一些突破性成就解释了人们思想和行为方式的成因,通过应用这些成就,公司可以转变员工的态度和行为。' | Emily Lawson Colin Price | 2007 | 商学院2007，，5： | 2 |
| 18 | NF-kappaB activition is a critical regulator of human granulocyte apoptosis in vitro显示文摘 | Ward C Chilvers ER Lawson MF | 1999 | J Biol Chem1999，274，7： | 2 |
| 19 | Local immunotherapy with interleuk in-2 delivered from biodegradable p olymer microspheres combined with interstitial chemotherapy:a novel treatme nt for experimental malignant glioma显示文摘OBJECTIVE:Local delivery of carmustine(BCNU)from biodegradable polymers prolon gs survival against experimental brain tumors.Moreover,paracrine administration of inte rleukin-2(IL-2)has been shown to elicit a potent antitumor immune response and to improve survival in animal brain tumor models.We r eport the use of a novel polymeric mic rosphere delivery vehicle to release IL-2.We demonstr ate both in vitro release of cytokine from the microspheres and histological evidence of the inflammatory response elicited by I L-2released from the microspheres i n the rat brain.These microspheres a re used to deliver IL-2,and biodegradable polymer wafers are used to deliver BCNU,directly at the site of an intracranially implanted glioma in the rat.The two agents administered locally show a s ynergistic effect.METHODS:Fischer 344rats challenged intracranially with 9L gliosarcoma received an intracranial implant of either empty microspheres or microspheres containing IL-2(IL-2MS ).Five days later,animals in each group were randomized to receiv e polymer implants loaded with 0,3.8,or 10%BCNU at the tumor site.RESULTS:Animals that received the combination of IL-2MS a nd 3.8%BCNU polymer(median survival,28.5d )or IL-2MS and 10%BCNU polymer(median survival,45.5d )showed significantly improved surv ival compared with animals that rece ived monotherapy with IL-2microsph eres(median survival,24d ),3.8%BCNU polymer(median survival,24d ),or 10%BCNU polymer(median survival,32.5d ).Control animals had a median survival of 18days.The combination of either 3.8or 10%BCNU polymer with IL-2MS resulted in 7and 25%long-term survivors,respectively.CONCLUSION:By showing synergy of IL-2and BCNU in an animal glioma model and using a reproducible synthetic delivery sy stem for each agent (i.e.,one that did not rely on genetic ally engineered cells or viruses),we hope that the combination of local immunotherapy and chemotherapy can take an important step closer to clinical applic ation in patients with malignant brain | Rhines LD DiMeco F Lawson HC Tyler BM Hanes J Olivi A Brem H | 2003 | 癌症2003，22，7： | 2 |
| 20 | Gastric Cancer显示文摘 | Joshua D. Lawson Jason K. Sicklick Paul T. Fanta | 2011 | Current Problems in Cancer2011，，3： | 2 |
您所在的机构暂未开通此部分的功能，请联系管理员