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| 1 | Next-Generation Stool DNA Test Accurately Detects Colorectal Cancer and Large Adenomas显示文摘 | David A. Ahlquist Hongzhi Zou Michael Domanico Douglas W. Mahoney Tracy C. Yab William R. Taylor Malinda L. Butz Stephen N. Thibodeau Linda Rabeneck Lawrence F. Paszat Kenneth W. Kinzler Bert Vogelstein Niels Chr. Bjerregaard S?ren Laurberg Henrik Toft S? | 2012 | Gastroenterology2012，，2： | 7 |
| 2 | Mammary gland growth and vascularity at parturition and during lactation in primiparous ewes fed differing levels of selenium and nutritional plane during gestation显示文摘Background: Objectives were to examine the effects of selenium(Se) supply and maternal nutritional plane during gestation on mammary gland growth, cellular proliferation, and vascularity at parturition and d 20 of lactation. Rambouillet primiparous ewes(n = 84) were allocated to treatments in a 2 x 3 factorial. Factors were dietary Se(adequate Se [ASe, 11.5 μg/kg BW] or high Se [HSe, 77.0 μg/kg BW]) and nutritional plane(60% [RES], 100% [CON], or 140% [EXC]). At parturition, lambs were removed and 42 ewes(7/treatment) were necropsied. Remaining ewes were fed a common diet meeting requirements for lactation and mechanically milked twice daily until necropsy on d 20. At both necropsy periods, mammary glands were dissected and tissues harvested. Samples were analyzed for RNA, DNA, and protein content, cell proliferation, and vascularity. Where interactions were present(P ≤ 0.05), least squares means from the highest-order interaction are presented. Results: Final body weight of ewes was least(P ≤ 0.002) in RES, intermediate for CON, and greatest for EXC, regardless of stage of the ewe at necropsy(parturition or d 20 of lactation). In ewes necropsied at parturition, mammary glands were heavier(P = 0.02) in EXC compared to RES, with CON intermediate. Concentration of RNA(mg/g) was decreased(P = 0.01) in EXC compared to CON at parturition. There was a tendency(P = 0.07) for a Se by nutrition interaction in percentage of cells proliferating where ASe-EXC ewes had greater(P ≤ 0.02) number of proliferating cells then all other treatments. Mammary vascular area tended(P = 0.08) to be affected by a Se by nutrition interaction where ASe-CON had less(P = 0.007) vascular area than HSe-CON ewes. In ewes necropsied at d 20 of lactation, the number of alveoli per area was decreased(P ≤ 0.05) in RES compared to CON and EXC-fed ewes. Conclusions: Results of this study indicate that proper maternal nutritional plane during gestation is important for mammary gland development, even out to d 20 of lactation. | Tammi L Neville Allison M Meyer Arshi Reyaz Pawel B Borowicz Dale A Redmer Lawrence P Reynolds Joel S Caton Kimberly A Vonnahme | 2013 | Journal of Animal Science and Biotechnology2013，4，4： | 3 |
| 3 | 2009年南极冰穹A的双色天光背景统计和分析显示文摘天光背景是天文台址的一个重要指标。利用2009年位于南极冰穹A的CSTAR望远镜两个波段的观测数据,对南极冰穹A的天光背景进行了统计和分析。结果表明约74%的g波段天光背景的ADU值小于每像素100/s;90.5%的r波段的天光背景的ADU值小于每像素100/s。在不考虑大气消光的情况下,定标后的结果为2009年冰穹A的观测数据中天光背景亮度的中值:g波段为19.9 mag/arcsec2,r波段为20.1 mag/arcsec2。 | 宗伟凯 付建宁 牛家树 Ashley Michael C B 宫雪非 Lawrence J S 刘强 Luong-Van Daniel Pennypacker C R Storey John W V 王灵芝 王力帆 杨惠根 袁祥岩 York Donald G 朱镇熹 | 2014 | 天文研究与技术2014，11，1： | 2 |
| 4 | Yttrium-90 microsphere selective internal radiation therapy for liver metastases following systemic chemotherapy and surgical resection for metastatic adrenocortical carcinoma显示文摘Adrenocortical carcinoma(ACC)is a rare malignancy with generally poor outcomes and limited treatment options.While surgical resection can be curative for early local disease,most patients present with advanced ACC owing to nonspecific symptoms.For those patients,treatment options include systemic chemotherapy and locoregional therapies including radiofrequency ablation and transarterial chemoembolization.We present the first reported case of utilizing yttrium-90 microsphere selective internal radiation therapy(SIRT)in combination with first line EDP-M(Etoposide,Doxorubicin,Cisplatin,Mitotane)chemotherapy and debulking surgical primary tumor resection for treatment of metastatic ACC.Stable complete radiologic response has been maintained after twelve months with resolution of clinical symptoms.These findings prompt the need for further consideration and studies to elucidate the role of SIRT in combination with systemic and surgical treatment for metastatic ACC. | Mina S Makary Lawrence S Krishner Evan J Wuthrick Mark P Bloomston Joshua D Dowell | 2018 | World Journal of Clinical Oncology2018，9，1： | 2 |
| 5 | Treatment and prognostic factors for long-term outcome in patients with anti-NMDA receptor encephalitis: an observational cohort study显示文摘 | Maarten J Titulaer Lindsey McCracken I?igo Gabilondo Thaís Armangué Carol Glaser Takahiro Iizuka Lawrence S Honig Susanne M Benseler Izumi Kawachi Eugenia Martinez-Hernandez Esther Aguilar Núria Gresa-Arribas Nicole Ryan-Florance Abiguei Torrents Albert S | 2013 | Lancet Neurology2013，，2： | 2 |
| 6 | The black box of organizational demography 显示文摘 | Lawrence B S | 1997 | Organization Science1997，8，1： | 1 |
| 7 | Estimating Flowtimes and Setting Due--dates in Complex Production Systems显示文摘 | Lawrence S R | 1995 | IIE Transactions1995，27，5： | 1 |
| 8 | Identification of inertial and friction parameters for excavator arms 显示文摘 | Tafazoli S Lawrence P D Salcudean S E | 1999 | IEEE Transactions on Robotics and Automation1999，15，5： | 1 |
| 9 | State anxiety modulation of the amygdala response to unattended threat-related stimuli显示文摘 | Bishop S Duncan J Lawrence AD | 2004 | J Neurosci2004，24，10： | 1 |
| 10 | Organizational demography : the difference effects of age and tenure distributions on technical communication 显示文摘 | Zenger Todd R Barbara S Lawrence | 1989 | Academy of Management Journal1989，32，： | 1 |
| 11 | Yeast re- sponses to stresses associated with industrial brewery han- dling 显示文摘 | Gibson B R Lawrence S J Leclaire J P R | 2007 | FEMS Microbiology Reviews2007，31，5： | 1 |
| 12 | The Sunnybrook Stroke Study: A Prospective Study of Depressive Symptoms and Functional Outcome显示文摘 | Herrmann N Black S E Lawrence J | 1998 | Stroke1998，29，3： | 1 |
| 13 | Radiological assessment of os- teoarthrosis显示文摘 | KELLGREN J H LAWRENCE J S | 1957 | Ann Rheum Dis1957，16，4： | 1 |
| 14 | Activated protein C stimulates the fibrinolytic activity of cultured endothelial cell and decreases antiactivator activity显示文摘 | Sakata Y Curriden S Lawrence D | 1985 | Proc Natl Acad Sci USA1985，82，： | 1 |
| 15 | Aluminm alloy 2519 in military vehicles显示文摘 | James J F Lawrence S K Joseph R P | 2002 | Advanced Materials and Processes2002，160，9： | 1 |
| 16 | The use of 3-Ddose volume analysis to predict radiation hepatitis显示文摘 | Lawrence T S Ten Haken R K Kessler M L | 1992 | Int J Radiat Oncol Biol Phys1992，23，9： | 1 |
| 17 | Context and Page Analysis for Improved Web Search显示文摘 | Lawrence S Giles C L | 1998 | IEEE Internet Computing1998，2，4： | 1 |
| 18 | Aluminum alloy 2519 in military vehicles显示文摘 | James J F Lawrence S K Joseph R P | 2002 | Advanced Materials and Processes2002，160，9： | 1 |
| 19 | Nonlinear dimensionalityreduction by locally linear embedding 显示文摘 | Sam T R Lawrence K S | 2000 | Science2000，290，22： | 1 |
| 20 | Treatment of select open calcaneal fractures with reduction and inter-nal fixation:an intermediate term review 显示文摘 | l_outzenhiser L Lawrence S J Donegan RP | 2008 | Foot An-kle Int2008，29，8： | 1 |
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