|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Intrahepatic distribution of hepatitis B virus antigens in patients with and without hepatocellular carcinoma显示文摘AIM: To study the intrahepatic expression of hepatitis B surface antigen(HBs Ag) and hepatitis B core antigen(HBc Ag) in chronic hepatitis B patients with and without hepatocellular carcinoma. METHODS: A total of 33 chronic hepatitis B patients(mean age of 40.3 ± 2.5 years), comprising of 14 HBe Ag positive and 19 HBe Ag negative patients; and 13 patients with hepatitis B virus related hepatocellular carcinoma(mean age of 49.6 ± 4.7 years), were included in our study. Immunohistochemical staining for HBc Ag and HBs Ag was done using standard streptavidin-biotin-immunoperoxidase technique on paraffin-embedded liver biopsies. The HBc Agand HBs Ag staining distributions and patterns were described according to a modified classification system. RESULTS: Compared to the HBe Ag negative patients, the HBe Ag positive patients were younger, had higher mean HBV DNA and alanine transaminases levels. All the HBe Ag positive patients had intrahepatic HBc Ag staining; predominantly with 'diffuse' distribution(79%) and 'mixed cytoplasmic/nuclear ' pattern(79%). In comparison, only 5% of the HBe Ag-negative patients had intrahepatic HBc Ag staining. However, the intrahepatic HBs Ag staining has wider distribution among the HBe Ag negative patients, namely; majority of the HBe Ag negative cases had 'patchy' HBs Ag distribution compared to 'rare' distribution among the HBe Ag positive cases. All but one patient with HCC were HBe Ag negative with either undetectable HBV DNA or very low level of viremia. Intrahepatic HBc Ag and HBs Ag were seen in 13(100%) and 10(77%) of the HCC patients respectively. Interestingly, among the 9 HCC patients on anti-viral therapy with suppressed HBV DNA, HBc Ag and HBs Ag were detected in tumor tissues but not the adjacent liver in 4(44%) and 1(11%) patient respectively. CONCLUSION: Isolated intrahepatic HBc Ag and HBs Ag can be present in tumors of patients with suppressed HBV DNA on antiviral therapy; that may predispose them to cancer development. | Parham Safaie Mugilan Poongkunran Ping-Ping Kuang Asad Javaid Carl Jacobs Rebecca Pohlmann Imad Nasser Daryl TY Lau | 2016 | World Journal of Gastroenterology2016，22，12： | 5 |
| 2 | Expression and functions of vasoactive substances regulated by hypoxia-inducible factor-1 in chronic hypoxemia 显示文摘 | Tipoe GL Lau TY Nanji AA | 2006 | Cardiovasc Hematol Agents Med Chem2006，4，3： | 1 |
| 3 | Endoscopic retreatment compared with surgery inpatients with recurrent bleeding affer initial endoscopic control of bleeding ulcers显示文摘 | Lau TY Sung JJ Lam Y | 1999 | N Engl J Med1999，340，3： | 1 |
| 4 | Combined photodynamic therapy and intravitreal triamcinolone for choroi- dal neovascularization secondary to punctuate inner choroi-dop- athy or of idiopathic origin:one-year results of a prospective se- ries显示文摘 | Chan WM Lai TY Lau TT Lee VY Liu DT Lam DS | 2008 | Retina2008，28，1： | 1 |
| 5 | Female ageing and reproductive outcome in assisted reproduction cycles显示文摘 | Tan TY Lau SK Loh SF | 2014 | Singapore Med2014，55，6： | 1 |
| 6 | Prenatal diagnosis of morbidly adherentplacenta显示文摘 | Lau TK Leung TY | 2011 | Int J Obstet Anesth2011，20，2： | 1 |
| 7 | rAAV-mediated stable expression of heme oxygenase-1 in stellate cells: a new approach to attenuate liver fibrosis in rats 显示文摘 | Tsui TY Lau CK Ma J | 2005 | Hepatology2005，42，2： | 1 |
| 8 | Expression and func- tions of vasoactive substances regulated by hypoxia-inducible factor-1 in chronic hypoxemia显示文摘 | TIPOE CL LAU TY NANJI AA | 2006 | Cardiovasc Hematol Agents Med Chem2006，4，3： | 1 |
| 9 | Expression andfunctions of vasoactive substances regulated byhypoxia-inducible factor-1 in chronic hypoxemia显示文摘 | Tipoe GL Lau TY Nanji AA | 2006 | Cardiovasc Hematol Agents Med Chem2006，4，3： | 1 |
| 10 | Lgr5 homologues associate with Wnt receptors and mediate R-spondin signalling显示文摘 | de Lau W Barker N Low TY | 2011 | Nature2011，476，： | 1 |
| 11 | Prenatal diagnosis of morbidly adherent placenta 显示文摘 | Lau TK Leung TY | 2011 | Int J Anesth2011，20，2： | 1 |
| 12 | Expression and functions of vasoactive substances regulated by hypoxa- inducble factor-1 in chronic hypoxemia 显示文摘 | Tipoe GL Lau TY Nanji AA | 2006 | Cardiovasc Hematol Agents Med Chem2006，4，3： | 1 |
| 13 | A study of fetal sex determination in coelomic fluid显示文摘 | Lau TK Fung TY Wong YF | 1998 | Gynecol Obstet Invest1998，45，： | 1 |
| 14 | Epigallocatechin-3-gallate (EGCG) reduces liver inflammation,oxidative stress and fibrosis in carbon tetrachloride (CCl4)-induced liver injury in mice显示文摘 | Tipoe GL Leung TM Liong EC Lau TY Fung ML Nanji AA | | 0，，1： | 1 |
| 15 | A study of fetal sex determination in coclomic fluid显示文摘 | Lau TK Fung TY Wong YF | 1998 | Gynecol Obstel Invest1998，45，1： | 1 |
| 16 | Long-term therapy of chronic hepatitis B with lamivudine显示文摘 | M Farooq khokhar Edward Doo | 2000 | Hepatology2000，32，： | 1 |
| 17 | Microfluidics digital PCR reveals a higher than expected fraction of fe- tal DNA in maternal plasma显示文摘 | Lun FMF Chiu RWK Chan KCA Leung TY Lau TK Lo YMD | 2008 | Clin Chem2008，54，10： | 1 |
| 18 | rAAV-mediated stable expression of heine oxygenase-1 in stellate ceils : a new approach to attenuate liver fibrosis in rats 显示文摘 | Tsui TY Lau CK Ma J | 2005 | Hepatology2005，42，： | 1 |
| 19 | Outcome of transvaginal pelvic reconstructive surgery with Prolift after a median of 2 years' follow- up显示文摘 | Huang WC Lin TY Lau HH | 2011 | Int Urogynecol J2011，22，2： | 1 |
| 20 | Prevention of chronic deteriora- tion of heart allograft by recombinant adeno-assoeiated virus-me- diated heine oxygenase-1 gene transfer 显示文摘 | Tsui TY Wu X Lau CK | 2003 | Circulation2003，107，20： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员