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| 1 | Mitochondrial neuronal uncoupling proteins:a target for potential disease-modification in Parkinson’s disease Philip显示文摘This review gives a brief insight into the role of mitochondrial dysfunction and oxidative stress in the converging pathogenic processes involved in Parkinson’s disease(PD).Mitochondria provide cellular energy in the form of ATP via oxidative phosphorylation,but as an integral part of this process,superoxides and other reactive oxygen species are also produced.Excessive free radical production contributes to oxidative stress.Cells have evolved to handle such stress via various endogenous anti-oxidant proteins.One such family of proteins is the mitochondrial uncoupling proteins(UCPs),which are anion carriers located in the mitochondrial inner membrane.There are five known homologues(UCP1 to 5),of which UCP4 and 5 are predominantly expressed in neural cells.In a series of previous publications,we have shown how these neuronal UCPs respond to 1-methyl-4-phenylpyridinium(MPP+;toxic metabolite of MPTP)and dopamine-induced toxicity to alleviate neuronal cell death by preserving ATP levels and mitochondrial membrane potential,and reducing oxidative stress.We also showed how their expression can be influenced by nuclear factor kappa-B(NF-B)signaling pathway specifically in UCP4.Furthermore,we previously reported an interesting link between PD and metabolic processes through the protective effects of leptin(hormone produced by adipocytes)acting via UCP2 against MPP+-induced toxicity.There is increasing evidence that these endogenous neuronal UCPs can play a vital role to protect neurons against various pathogenic stresses including those associated with PD.Their expression,which can be induced,may well be a potential therapeutic target for various drugs to alleviate the harmful effects of pathogenic processes in PD and hence modify the progression of this disease. | WL Ho Jessica WM Ho Hui-Fang Liu Danny HF So Zero HM Tse Koon-Ho Chan David B Ramsden Shu-Leong Ho | 2012 | Translational Neurodegeneration2012，1，1： | 3 |
| 2 | Identification of KIF21A mutations as a rare cause of congenital fibrosis of the extraocular muscles type 3 ( CFEOM3 ) 显示文摘 | Yamada K Chan WM Andrews C Bosley TM Sener EC Zwaan JT | 2004 | Invest Ophthalmol Vis Sci2004，45，7： | 1 |
| 3 | Validated questionnaire on diagnosis and symptom severity functional constipation in the Chinese population 显示文摘 | Chan AO Lam KF Hui WM | 2005 | Aliment Pharmacol2005，5，22： | 1 |
| 4 | Lamivudine for the prevention of hepatitis B virus reactivation in hepatitis B s-antigen seropositive cancer patients undegoing cytotoxic chemotherapy显示文摘 | Yeo W Chan PK Ho WM | 2004 | JCO2004，22，5： | 1 |
| 5 | Transverse testicular ectopia detected by MR imaging and MR Venography 显示文摘 | Lam WM Le SD Chan KL | 2002 | Pediatr Radiol2002，32，2： | 1 |
| 6 | Combined photodynamic therapy and intravitreal triamcinolone for choroi- dal neovascularization secondary to punctuate inner choroi-dop- athy or of idiopathic origin:one-year results of a prospective se- ries显示文摘 | Chan WM Lai TY Lau TT Lee VY Liu DT Lam DS | 2008 | Retina2008，28，1： | 1 |
| 7 | Assessing the risk of nasopharyngeal carcinoma on the basis of EBV antibody spectrum显示文摘 | Cheng WM Chan KH Chen HL etag | 2002 | Int J Cancer2002，97，4： | 1 |
| 8 | Dietary administration of the licorice flavonoid isoliquiritigenin deters the growth of MCF-7 cells overexpressing aromatase显示文摘 | Ye L Gho WM Chan FL | | 0，，05： | 1 |
| 9 | The meaning of hope from the perspective of Chinese advanced cancer patients in Hong Kong显示文摘 | Mok E Lam WM Chan LN | 2010 | Int J Palliat Nurs2010，16，6： | 1 |
| 10 | The clinical applications of multifocal electroretinography: a systematic re- view 显示文摘 | Lai TY Chan WM Lai RY Ngai JW Li H Lmn DS | 2007 | Surv Ophthalmol2007，52，1： | 1 |
| 11 | Photo- dynamic therapy with verteportin for sub- foveal choroidal neovascularisation of pa- thologic myopia in Chinese eyes: a pros- pective series of 1 and 2 year follow up显示文摘 | Lain DS Chan WM Liu DT | 2004 | Br J Ophthalmol2004，88，10： | 1 |
| 12 | Multifocal electroretinographic changes in patients receiving hydroxych-loroquine therapy显示文摘 | Lai TY Chan WM Li H | | 0，，： | 1 |
| 13 | Assessing the risk of nasopharyngeal carcinoma on the basis of EBV antibody spectrum显示文摘 | Cheng WM Chan KH Chen HL | 2002 | Int J Cancer2002，97，4： | 1 |
| 14 | Assessing the risk of nasopharyngeal carcinoma on the basis of B antibody spectrum 显示文摘 | Cheng WM Chan KH Chen HL | 2002 | Int J Cancer2002，97，4： | 1 |
| 15 | Aqueous humor levels of vascular endothelial growth factor and pigment epithelium- derived factor in polypoidal choroidal vasculopathy and choroidal neovascularization显示文摘 | Tong J P Chan WM Liu DT | 2006 | Am J Ophthalmol2006，141，3： | 1 |
| 16 | Conservation of PDX-1 structure,function and expression in zebrafish 显示文摘 | Milewski WM Dugauy SJ Chan SJ | 1998 | Endocrinology1998，139，3： | 1 |
| 17 | Intravi- treal ranibizumab for the primary treat- ment ofchoroidal neovascularization sec- ondary to pathologic myopia 显示文摘 | Lai TY Chan WM Liu DT | 2009 | Retina2009，29，6： | 1 |
| 18 | Effect of strept- avidin-biotin on endothelial vasoregulation and leukocyte adhesion 显示文摘 | Chan BP Reichert WM Truskey GA | 2004 | Biornaterials2004，25，18： | 1 |
| 19 | Assessing the risk ofnasopharyngeal carcinoma on the basis of EBV antibody spec-trum显示文摘 | Cheng WM Chan KH Chen HL | 2002 | Int J Cancer2002，97，： | 1 |
| 20 | Chlorpromazine-in duced refractile corneal deposits and cataract 显示文摘 | Leung AT Cheng AC Chan WM | 1999 | Arch Ophthalmol1999，117，12： | 1 |
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