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| 1 | Role of microRNAs in alcohol-induced liver disorders and non-alcoholic fatty liver disease显示文摘MicroRNAs(miRNAs) are small non-coding RNAs that regulate multiple physiological and pathological functions through the modulation of gene expression at the post-transcriptional level. Accumulating evidence has established a role for miRNAs in the development and pathogenesis of liver disease. Specifically, a large number of studies have assessed the role of miRNAsin alcoholic liver disease(ALD) and non-alcoholic fatty liver disease(NAFLD), two diseases that share common underlying mechanisms and pathological characteristics. The purpose of the current review is to summarize and update the body of literature investigating the role of miRNAs in liver disease. In addition, the potential use of miRNAs as biomarkers and/or therapeutic targets is discussed. Among all miRNAs analyzed, miR-34 a, miR-122 and miR-155 are most involved in the pathogenesis of NAFLD. Of note, these three miRNAs have also been implicated in ALD, reinforcing a common disease mechanism between these two entities and the pleiotropic effects of specific miRNAs. Currently, no single miRNA or panel of miRNAs has been identified for the detection of, or staging of ALD or NAFLD. While promising results have been shown in murine models, no therapeutic based-miRNA agents have been developed for use in humans with liver disease. | Jorge-Luis Torres Ignacio Novo-Veleiro Laura Manzanedo Lucía Alvela-Suárez Ronald Macías Francisco-Javier Laso Miguel Marcos | 2018 | World Journal of Gastroenterology2018，24，36： | 19 |
| 2 | Alcoholic liver disease and hepatitis C virus infection显示文摘Alcohol consumption and hepatitis C virus(HCV) infection have a synergic hepatotoxic effect, and the coexistence of these factors increases the risk of advanced liver disease. The main mechanisms of this effect are increased viral replication and altered immune response, although genetic predisposition may also play an important role. Traditionally, HCV prevalence has been considered to be higher(up to 50%) in alcoholic patients than in the general po pulation. However, the presence of advanc e d alcoholic liver disease(ALD) or intravenous drug use(IDU) may have confounded the results of previous studies, and the real prevalence of HCV infection in alcoholic patients without ALD or prior IDU has been shown to be lower. Due to the toxic combined effect of HCV and alcohol, patients with HCV infection should be screened for excessive ethanol intake. Patients starting treatment for HCV infection should be specifically advised to stop or reduce alcohol consumption because of its potential impact on treatment efficacy and adherence and may benefi t from addi tionalsupport during antiviral therapy. This recommendation might be extended to all currently recommended drugs for HCV treatment. Patients with alcohol dependence and HCV infection, can be treated with acamprosate, nalmefene, topiramate, and disulfiram, although baclofen is the only drug specifically tested for this purpose in patients with ALD and/or HCV infection. | Ignacio Novo-Veleiro Lucía Alvela-Suárez Antonio-Javier Chamorro Rogelio González-Sarmiento Francisco-Javier Laso Miguel Marcos | 2016 | World Journal of Gastroenterology2016，22，4： | 2 |
| 3 | Stepped-impedance lowpass filters with spurious pass-band suppression显示文摘 | J Garcia-Garcia J Bonache F Falcone J D Baena F Martin I Gil T Lopetegi M A G Laso A Marcotegui R Marques M Sorolla | 2004 | Electronic Letters2004，40，14： | 1 |
| 4 | Multiple-frequency-tuned photonic bandgap microstrip structures显示文摘 | M A G Laso T Lopetegi M J Erro | 2000 | IEEE Microwave and Guided Wave Letters2000，10，6： | 1 |
| 5 | High frequency oscillatory ventilation in the newborn infant显示文摘 | Gutlerrez Laso A Garcia Canto E Izquierdo Macian I | 1997 | An Esp Pediatr1997，46，2： | 1 |
| 6 | High performance double-sided microstrip PBG filter 显示文摘 | TAKIN LASO M A G DELOSE | 2002 | Microwave and Optical Technology Letters2002，，10： | 1 |
| 7 | Recent advances in the catalytic asymmetric nitroaldol (Henry) reaction 显示文摘 | C Palomo M Oiarbide A Laso | 2007 | Eur J Org Chem2007，，： | 1 |
| 8 | Recent Advances in the Catalytic Asymmetric Nitroaldol(Henry) Reaction显示文摘 | Palomo C Oiarbide M Laso A | | 0，，： | 1 |
| 9 | Effects of antiepileptic drugs on immune system显示文摘 | Basta-Kaim A Budziszewska B LasońW | | 0，，11： | 1 |
| 10 | Production of inflammstory cytokines by peripheral blood monocytes in chronic alcoholism: Relationship with ethanol intake and liver disease 显示文摘 | Laso FJ Vaquero JM Almeida J Marcos M Orfao A | 2007 | Cytometry B Clin Cytom2007，72，5： | 1 |
| 11 | Babinet Principle Applied to the Design of Metasurfaees and Metamaterials 显示文摘 | Falcone F Lopetegi T Laso M A G | 2004 | Phys Rev Lett2004，93，19： | 1 |
| 12 | Recent advances in the catalytic asymmetric nitroaldol (Henry) reaction显示文摘 | Palomo C Oiarbide M Laso A | | 0，，16： | 1 |
| 13 | Catalytic enantioselective Aza-Henry reaction with broad substrate scope显示文摘 | Palomo C Oiarbide M Laso A | 2005 | J Am Chem Soc2005，127，17： | 1 |
| 14 | Prognostic value of mierometasrases in esophageal and eolorectal carcinoma(a clinical experience)显示文摘 | Laso C A Gonzalez J J Fresno F | 2004 | Hepatogastroentem-logy2004，51，58： | 1 |
| 15 | Chirped delay lines in microstrip technology显示文摘 | LASO M A G LOPETEGI T ERRO M J | 2001 | IEEE Microwave and Wireless Components Letters2001，11，12： | 1 |
| 16 | Optimization of compact photonic bandgap microstrip structures显示文摘 | LOPETEGI T LASO M A G IRISARRI M | 2000 | Microw Opt Technol Lett2000，26，4： | 1 |
| 17 | Impact of 17beta-estradiolon cytokine-mediated apoptotic effects in primary hippocampal andneocortical cell cultures显示文摘 | Kajta M Trotter A LasońW | 2006 | Brain Res2006，1116，1： | 1 |
| 18 | Novel photonic bandgap microstrip structures using network topology 显示文摘 | M A G Laso M J Erro D Benito M J Garde F Falcone M Sorolla | 2000 | Microwave Opt Technol Lett2000，25，4： | 1 |
| 19 | Novel wideband photonic bandgap microstrip structures 显示文摘 | T Lopetegi M J Erro D Benito M J Garde M Sorolla | 2000 | Microwave Opt Technol Lett2000，24，3： | 1 |
| 20 | Simpson– G olabi– B ehmel Syndrome Type 1 and Hepatoblastoma in a Patient With a Novel Exon 2–4 Duplication of the GPC 3 Gene显示文摘 | María Elena Mateos Katrin Beyer Eduardo López‐Laso Juan López Siles Juan Luis Pérez‐Navero María José Pe?a Juana Guzmán Juliana Matas | 2013 | Am J Med Genet2013，，5： | 1 |
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