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| 1 | ROS-induced DNA damage and PARP-1 are required for optimal induction of starvation-induced autophagy显示文摘响应滋养的应力,房间开始能导致改编或死亡的一个 autophagy 节目。位于从饥饿发信号到 autophagy 的开始下面的机制充分没被理解。在当前的学习,我们证明 PARP-1 的缺席或 inactivation 强烈推迟导致饥饿的 autophagy。我们发现了那 DNA 损坏是由 γ 测量了的导致饥饿的 autophagy 的一个早事件; -H2AX 累积和彗星试金,与在两个参数显示减小的 PARP-1 猛烈房间。在饥饿期间,导致 ROS 的 DNA 损坏激活 PARP-1,导致 ATP 弄空(在滋养的剥夺以后的一个早事件) 。PARP-1 的缺席弄钝 AMPK 激活并且阻止了 mTOR 活动的完全的损失,导致在 autophagy 的延期。PARP-1 弄空在饥饿的房间赞成 apoptosis,建议在滋养的剥夺以后的 autophagy 和 PARP-1 激活的一个支持幸存的角色。在 PARP-1 变异的老鼠的出生不满一月的婴儿使遭到了到尖锐饥饿的 vivo 结果表演,也显示缺乏的肝 autophagy,暗示为在导致饥饿的 autophagy 的 PARP-1 的一个生理的角色。因此,表明小径的 PARP 是 autophagy 承诺追随者饥饿的起始的步骤的一个关键管理者。 | Jose Manuel Rodriguez-Vargas Maria Jose Ruiz-Magana Carmen Ruiz-Ruiz Jara Majuelos-Melguizo Andreina Peralta-Lea Maria Isabel Rodriguez Jose Antonio Munoz-Gaimez Mariano Ruiz de Almodovar Eva Siles Abelardo Lopez Rivas Marja Jaattela F Javier Oliver | 2012 | Cell Research2012，22，7： | 8 |
| 2 | Genome-wide variants of Eurasian facial shape differentiation and a prospective model of DNA based face prediction显示文摘It is a long-standing question as to which genes define the characteristic facial features among different ethnic groups. In this study, we use Uyghurs, an ancient admixed population to query the genetic bases why Europeans and Han Chinese look different. Facial traits were analyzed based on high-dense 3D facial images; numerous biometric spaces were examined for divergent facial features between European and Han Chinese, ranging from inter-landmark distances to dense shape geometrics. Genome-wide association studies(GWAS) were conducted on a discovery panel of Uyghurs. Six significant loci were identified, four of which, rs1868752, rs118078182, rs60159418 at or near UBASH3B, COL23A1, PCDH7 and rs17868256 were replicated in independent cohorts of Uyghurs or Southern Han Chinese. A prospective model was also developed to predict 3D faces based on top GWAS signals and tested in hypothetic forensic scenarios. | Lu Qiao Yajun Yang Pengcheng Fu Sile Hu Hang Zhou Shouneng Peng Jingze Tan Yan Lu Haiyi Lou Dongsheng Lu Sijie Wu Jing Guo Li Jin Yaqun Guan Sijia Wang Shuhua Xu Kun Tang | 2018 | Journal of Genetics and Genomics2018，45，8： | 7 |
| 3 | Improved dissolution and oral absorption by co-grinding active drug probucol and ternary stabilizers mixtures with planetary beads-milling method显示文摘The objective of this work is to construct a nanosuspension drug delivery system of probucol,a BCS II drug,in order to improve its dissolution and oral bioavailability.The wet milling procedure using planetary beads-milling equipment was utilized to grind the raw probucol to ultrafine nanoparticle/nanocrystal aqueous suspension that was further solidified by freeze-drying process.Cellulose derivatives of different substitution groups and molecular weights,including HPMC,HPC,and MC,were evaluated as the primary stabilizer of probucol nanosuspension.Ternary stabilizers system composed of a primary stabilizer(cellulose derivative,i.e.HPC),a nonionic surfactant(Pluronic R F68),and an anionic surfactant(SDS)was employed to obtain probucol nanosuspension of finer particle size and enhanced dissolution in aqueous media.The probucol nanosuspension with good physical stability showed no obvious change of particle size even after storing over 7 d at 4°C or 25°C.The solidified probucol nanosuspension with trehalose as the cryoprotectant showed the highest dissolution rate(>60%at 2 h)compared to other cryoprotectant.The in vivo pharmacokinetic evaluation indicated about 15-folds higher AUC value of the probucol nanosuspension compared to that of coarse probucol suspension after oral administration to rats.The probucol nanosuspension prepared by wet-milling and ternary stabilizers system may find wide applications for improving the dissolution and oral absorption of water-insoluble drugs. | Fang Li Linsen Li Shaoning Wang Yan Yang Jia Li Dongchun Liu Sijie Zhang Siling Wang Hui Xu | 2019 | Asian Journal of Pharmaceutical Sciences2019，14，6： | 5 |
| 4 | Homogeneous PLGA-lipid nanoparticle as a promising oral vaccine delivery system for ovalbumin显示文摘In this study,a polymeric lipid nanoparticle(NP)(simplified as Lipid NP)was reported as a promising oral vaccine delivery system.The Lipid NPs composed of a hydrophobic polymeric poly(D,L-lactide-co-glycolide)(PLGA)core and a surface coating of lipid monolayer.Membrane emulsification technique was used to obtain uniform-sized Lipid NPs.Ovalbumin(OVA)was used as a model vaccine.Compared with the pure PLGA NPs,the Lipid NPs achieved higher loading capacity(LC)and entrapment efficiency(EE)for the encapsulated OVA.An in vitro oral release profile showed that the OVA-Lipid NPs were with lower initial burst and could protect the loaded OVA from the harsh gastrointestinal(GI)environment for a long time.In addition,a human microfold cell(M-cell)transcytotic assay demonstrated that due to a lipid layer structure on the particle surface,the Lipid NPs showed higher affinity to the M-cells.Since the M-cell in the intestinal epithelium played an important role in particle transportation as well as intimately associated with the underlying immune cells,the OVA-Lipid NPs effectively induced mucosal and humoral immune responses. | Tongtong Ma Lianyan Wang Tingyuan Yang Guanghui Ma Siling Wang | 2014 | Asian Journal of Pharmaceutical Sciences2014，9，3： | 4 |
| 5 | Disulfiram thermosensitive in-situ gel based on solid dispersion for cataract显示文摘To improve the corneal permeability and water-solubility of disulfiram(DSF), which is an ocular drug for cataract, P188 was selected as a matrix to prepare solid dispersion of DSF(DSF SD) by hot melt method. The DSF SD was characterized by DSC, XRD, and IR, and the results suggested that DSF was amorphous in DSF SD. The DSF SD was added to borate buffer solution(BBS) contained 20% poloxamer P407 and 1.2% poloxamer P188 to form in-situ gel. In vitro and in vivo experiments revealed that DSF SD combined with in-situ gel(DSF SD/in-situ gel) increased the residence time and the amount of DSF penetrated through the corneal. The pharmacodynamics studies exhibited DSF SD/in-situ gel delayed the development of selenium-induced cataract at some content. These results investigated that DSF SD/in-situ gel as a drug delivery system can improve DSF ocular permeability. | Chunjuan Zhang Tonghua Xu Donglei Zhang Wei He Siling Wang Tongying Jiang | 2018 | Asian Journal of Pharmaceutical Sciences2018，13，6： | 3 |
| 6 | Review of surface transient charge measurement on solid insulating materials via the Pockels technique显示文摘Surface charges accumulated on solid insulating materials in electrical apparatuses and electronic devices could distort the initial electric field and severely damage the insulation performance.Accurate transient surface charge measurement is critical to determine the mechanisms of charge transport and flashover occurrence,and estimate surface insulation strength under high voltage.The measurement technique based on the Pockels electro-optic effect is considered as the only approach for 2-D dynamic charge distribution behaviour so far,and it has good capability to avoid original electric field distortion caused by conven-tional methods featured by metal probes.This paper reviews recent progress of the non-invasive dynamic surface charge measurement systems on the Pockels technique.We focus especially on typical systems with transmitting and reflecting configurations and the frequently used fast inversion algorithms.It can be inferred that higher spatial-temporal resolution,higher signal-to-noise ratio,and better compatibility for both transparent and opaque materials are the future development trends,which greatly depend on multiple technological breakthroughs at impact-resistant electro-optic crystals,advanced high-speed photography and high-performance inversion algorithms.In addition,the recent studies on transient behaviour of surface discharge,together with the present limitation and future prospects are discussed.It is expected that more ideas will be inspired in transient surface charge measurement by the Pockels technique and other relevant electro-optic methods. | Bo Zhang Jianyi Xue Xingyu Chen Sile Chen Haibao Mu Yang Xu Guanjun Zhang | 2021 | High Voltage2021，6，4： | 2 |
| 7 | Alginate encapsulated mesoporous silica nanospheres as a sustained drug delivery system for the poorly water-soluble drug indomethacin显示文摘We applied a combination of inorganic mesoporous silica material,frequently used as drug carriers,and a natural organic polymer alginate(ALG),to establish a sustained drug delivery system for the poorly water-soluble drug Indomethacin(IND).Mesoporous silica nanospheres(MSNs)were synthesized using an organic template method and then functionalized with aminopropyl groups through postsynthesis.After drug loading into the pores of aninopropyl functionalized MSNs(AP-MSNs),IND loaded AP-MSNs(IND-AP-MSNs)were encapsulated by ALG through the ionic interaction.The effects of surface chemical groups and ALG layer on IND release were systematically studied using scanning electron microscopy(SEM),transmission electron microscopy(TEM),nitrogen adsorption,zetapotential analysis and TGA analysis.The surface structure and surface charge changes of the ALG encapsulated AP-MSNs(ALG-AP-MSNs)were also investigated.The results showed that sustained release of IND from the designed drug delivery system was mainly due to the blockage effect from the coated ALG.We believe that this combination will help designing oral sustained drug delivery systems for poorly water-soluble drugs. | Liang Hu Changshan Sun Aihua Song Di Chang Xin Zheng Yikun Gao Tongying Jiang Siling Wang | 2014 | Asian Journal of Pharmaceutical Sciences2014，9，4： | 2 |
| 8 | Mechanism on improved surface flashover performances in vacuum of epoxy resin using fluorocarbon plasma treatment显示文摘To improve the insulation,strength of materials is a permanent topic in the fields of high voltage and insulation,and surface insulation is one of the difficulties.Research shows that the surface fluorination by a non-equilibrium plasma is a promising method to enhance the surface flashover characteristics of insulating materials.However,the de-terminants of flashover characteristics are so many that the mechanism is not well known.This paper aims to find out the reasons for the surface insulation improvement and optimise the plasma process parameters.The epoxy resin surfaces are modified by a fluorocarbon plasma,and the flashover voltages in vacuum and secondary electron emission yield are tested experimentally.Combined with the state of the art and the authors'previous work,the mechanism of improved surface flashover performances is investigated in depth from three aspects:the plasma process parameters,the surface physical and chemical properties and the surface electrical performances.A compre-hensive understanding of the mechanism is concluded,of which the whole processes from the plasma surface modification of materials to the surface insulation performances are taken into account.It is hopeful to promote the practical applications of plasma fluorination in electrical engineering through the findings of this paper. | Sile Chen Tao Cheng Zhaoquan Chen Guanjun Zhang | 2022 | High Voltage2022，7，3： | 2 |
| 9 | Sequential trapping of single nanoparticles using a gold plasmonic nanohole array显示文摘We have used a gold nanohole array to trap single polystyrene nanoparticles, with a mean diameter of 30 nm, into separated hot spots located at connecting nanoslot regions. A high trap stiffness of approximately 0.85 fN∕(nm·m W)at a low-incident laser intensity of ~0.51 m W∕μm^2 at 980 nm was obtained. The experimental results were compared to the simulated trapping force, and a reasonable match was achieved. This plasmonic array is useful for lab-on-a-chip applications and has particular appeal for trapping multiple nanoparticles with predefined separations or arranged in patterns in order to study interactions between them. | XUE HAN VIET GIANG TRUONG PRINCE SUNIL THOMAS SILE NIC CHORMAIC | 2018 | Photonics Research2018，6，10： | 2 |
| 10 | Age-related changes of the nitric oxide system in the rat brain显示文摘 | Siles E Martinez-Lara E Canuedo A | 2002 | Brain Res2002，956，2： | 1 |
| 11 | Liquid chromatography: Theory and methodology显示文摘 | Dorsey J G Cooper W T Siles B A | 1996 | Anal Chem1996，68，12： | 1 |
| 12 | Impact of ammonia and sulphate concentration on thermophilic anaerobic digestion显示文摘 | J.A. Siles J. Brekelmans M.A. Martín A.F. Chica A. Martín | 2010 | Bioresource Technology2010，，23： | 1 |
| 13 | Early decrease of serum Clara cell protein in silica-exposed workers 显示文摘 | Bernard AM Gonzalez-Lorenzo JM Siles E | 1994 | Eur Respir J1994，7，11： | 1 |
| 14 | On-Line Solid-Phase Chelation for the Determination of Six Metals in Sea Water by Inductively Coupled Plasma Mass Spectrometry 显示文摘 | SANCH EZ T RUJILLO I VEREDA ALONSO E SILES CORDERO M T | 2010 | Journal of Analyti- cal Atomic Spectrometry2010，25，： | 1 |
| 15 | Plasma jet treatment of five polymers at atmospheric pressure:surface modifications and the relevance for adhesion显示文摘 | MICHAEL Noeske JOST Degenhardt SILE Strudthoff | 2004 | International Journal of Adhesion & Adhesives2004，24，： | 1 |
| 16 | Design, synthesis, and biological evaluation of combretastatin nitrogen-containing derivatives as inhibitors of tubulin assembly and vascular disrupting agents 显示文摘 | Monk KA Siles R Hadimani MB | 2006 | Bioorg Med Chem2006，14，： | 1 |
| 17 | Expanding roles of ZEB factors in tumorigenesis and tumor progression显示文摘 | Sanchez-Tille E Siles L de Barrios O | 2011 | Am J Cancer Res2011，1，7： | 1 |
| 18 | Integrated ozonation and biomethanization treatments of vinasse derived from ethanol manufacturing显示文摘 | Siles J A Garc A-Garc A I Mart N A | 2011 | J Hazard Mater2011，188，13： | 1 |
| 19 | Selecting measures for bal- ance and mobility to improve assessment and treatment of indi- viduals after stroke显示文摘 | Kegelmeyer DA Kloos AD Siles AB | 2014 | Top Stroke Rehabil2014，21，4： | 1 |
| 20 | Delivery of different length poly(l-lysine)-conjugated ODN to HepG2 cells using N-stearyllactobionamide-modified liposomes and their enhanced cellular biological effects显示文摘 | Siling W Lihua C Jinghai Z | 2006 | Int J Pharm2006，311，12： | 1 |
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