|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Role of nitric oxide in hepatic ischemia-reperfusion injury显示文摘Hepatic ischemia-reperfusion injury (IRI) occurs upon restoration of hepatic blood flow after a period of ischemia. Decreased endogenous nitric oxide (NO) production resulting in capillary luminal narrowing is central in the pathogenesis of IRI. Exogenous NO has emerged as a potential therapy for IRI based on its role in decreasing oxidative stress,cytokine release,leukocyte endothelial-adhesion and hepatic apoptosis. This review will highlight the influence of endogenous NO on hepatic IRI,role of inhaled NO in ameliorating IRI,modes of delivery,donor drugs and potential side effects of exogenous NO. | Arunotai Siriussawakul Ahmed Zaky John D Lang | 2010 | World Journal of Gastroenterology2010，16，48： | 14 |
| 2 | Redox therapeutics in hepatic ischemia reperfusion injury显示文摘Ischemia-reperfusion plays a major role in the injury experienced by the liver during transplantation. Much work has been done recently investigating the role of redox species in hepatic ischemia-reperfusion. As animal models are better characterized and developed, and more insights are gained into the pathophysiology of hepatic ischemia reperfusion injury in humans the questions into exactly how oxidants participate in this injury are becoming more refined. These questions include effects of cellular location, timing of injury, and ability of therapeutics to access this site are increasing our appreciation of the complexity of ischemia reperfusion and improving attempts to ameliorate its effects. In this review, we aim to discuss the various methods to alter redox chemistry during ischemia reperfusion injury and future prospects for preventing organ injury during hepatic ischemia reperfusion. | Rakesh P Patel John D Lang Alvin B Smith Jack H Crawford | 2014 | World Journal of Hepatology2014，6，1： | 9 |
| 3 | Role of nitric oxide in liver transplantation:Should it be routinely used?显示文摘Ischemia-reperfusion injury(IRI) continues to be a major contributor to graft dysfunction, thus supporting the need for therapeutic strategies focused on minimizing organ damage especially with growing numbers of extended criteria grafts being utilized which are more vulnerable to cold and warm ischemia. Nitric oxide(NO·) is highly reactive gaseous molecule found in air and regarded as a pollutant. Not surprising, it is extremely bioactive, and has been demonstrated to play major roles in vascular homeostasis, neurotransmission, and host defense inflammatory reactions. Under conditions of ischemia, NO· has consistently been demonstrated to enhance microcirculatory vasorelaxation and mitigate pro-inflammatory responses, making it an excellent strategy for patients undergoing organ transplantation. Clinical studies designed to test this hypothesis have yielded very promising results that includes reduced hepatocellular injury and enhanced graft recovery without any identifiable complications. By what means NO· facilitates extra-pulmonary actions is up for debate and speculation. The general premise is that they are NO· containing intermediates in the circulation, that ultimately mediate either direct or indirect effects. A plethora of data exists explaining how NO·-containing intermediate molecules form in the plasma as S-nitrosothiols(e.g., S-nitrosoalbumin), whereas other compelling data suggest nitrite to be a protective mediator. In this article, we discuss the use of inhaled NO· as a way to protect the donor liver graft against IRI in patients undergoing liver transplantation. | Kyota Fukazawa John D Lang | 2016 | World Journal of Hepatology2016，8，34： | 4 |
| 4 | Molecular phenotypes of human parvovirus B19 in patients with myocarditis显示文摘AIM:To investigate molecular phenotypes of myocardial B19V-infection to determine the role of B19V in myocarditis and dilated cardiomyopathy(DCM).METHODS:Endomyocardial biopsies(EMBs) from 498 B19V-positive patients with myocarditis and DCMwere analyzed using molecular methods and functional experiments.EMBs were obtained from the University Hospitals of Greifswald and Tuebingen and additionally from 36 German cardiology centers.Control tissues were obtained at autopsy from 34 victims of accidents,crime or suicide.Identification of mononuclear cell infiltrates in EMBs was performed using immunohistological staining.Anti-B19V-IgM and anti-B19V-IgG were analyzed by enzyme-linked immunosorbent assay(ELISA).B19V viral loads were determined using in-house quantitative real-time polymerase chain reaction(PCR).For B19V-genotyping a new B19V-genotype-specific restriction fragment length polymorphism(RFLP)-PCR was established.B19V-genotyping was verified by direct DNAsequencing and sequences were aligned using BLAST and BioEdit software.B19V P6-promoter and HHV6-U94-transactivator constructs were generated for cell culture experiments.Transfection experiments were conducted using human endothelial cells 1.Luciferase reporter assays were performed to determine B19Vreplication activity.Statistical analysis and graphical representation were calculated using SPSS and Prism5 software.RESULTS:The prevalence of B19V was significantly more likely to be associated with inflammatory cardiomyopathy(iCMP) compared to uninflamed DCM(59.6% vs 35.3%)(P < 0.0001).The detection of B19V-mRNA replication intermediates proved that replication of B19V was present.RFLP-PCR assays showed that B19V-genotype 1(57.4%) and B19V-genotype 2(36.7%) were the most prevalent viral genotypes.B19V-genotype 2 was observed more frequently in EMBs with iCMP(65.0%) compared to DCM(35%)(P = 0.049).Although there was no significant difference in gender-specific B19V-loads,women were more frequently infected with B19V-genotype 2(44.6%) than men(36.0%)(P = 0.0448).Coinfection with B19V and other cardiotropic viruses was found in 19.2% of tissuesamples and was associated with higher B19V viral load compared to B19V-monoinfected tissue(P = 0.0012).The most frequent coinfecting virus was human herpes virus 6(HHV6,16.5%).B19V-coinfection with HHV6 showed higher B19V-loads compared to B19V-monoinfected EMBs(P = 0.0033),suggesting that HHV6 had transactivated B19V.In vitro experiments confirmed a 2.4-fold increased B19V P6-promoter activity by the HHV6 U94-transactivator.CONCLUSION:The finding of significantly increased B19V loads in patients with histologically proven cardiac inflammation suggests a crucial role of B19V-genotypes and reactivation of B19V-infection by HHV6-coinfection in B19V-associated iCMP.Our findings suggest that B19V-infection of the human heart can be a causative event for the development of an endothelial cell-mediated inflammatory disease and that this is related to both viral load and genotype. | C-Thomas Bock Anja Düchting Friederike Utta Eva Brunner Bui Tien Sy Karin Klingel Florian Lang Meinrad Gawaz Stephan B Felix Reinhard Kandolf | 2014 | World Journal of Cardiology2014，6，4： | 3 |
| 5 | Favorable lifestyle before diagnosis associated with lower risk of screen-detected advanced colorectal neoplasia显示文摘AIM: To investigate the association between adherence to health recommendations and detection of advanced colorectal neoplasia(ACN) in colorectal cancer(CRC) screening.METHODS: A total of 14832 women and men were invited to CRC screening, 6959 in the fecal immunochemical test arm and 7873 in the flexible sigmoidoscopy arm. These were also sent a self-reported lifestyle questionnaire to be completed prior to their first CRC screening. A lifestyle score was created to reflect current adherence to healthy behaviors in regard to smoking, body mass index, physical activity, alcohol consumption and food consumption, and ranged from zero(poorest) to six(best). Odds ratios(ORs) and 95%CIs were calculated using multivariable logistic regression to evaluate the association between the single lifestyle variables and the lifestyle score and the probability of detecting ACN.RESULTS: In all 6315 women and men completed the lifestyle questionnaire, 3323(53%) in the FIT arm and 2992(47%) in the FS arm. This was 89% of those who participated in screening. ACN was diagnosed in 311(5%) participants of which 25(8%) were diagnosed with CRC. For individuals with a lifestyle score of two, three, four, and five-six, the ORs(95%CI) for the probability of ACN detection were 0.82(0.45-1.16), 0.43(0.28-0.73), 0.41(0.23-0.64), and 0.41(0.22-0.73), respectively compared to individuals with a lifestyle score of zero-one. Of the single lifestyle factors, adherence to non-smoking and moderate alcohol intake were associated with a decreased probability of ACN detection compared to being a smoker or having a high alcohol intake 0.53(0.42-0.68) and 0.63(0.43-0.93) respectively.CONCLUSION: Adopted healthy behaviors were inversely associated with the probability of ACN detection. Lifestyle assessment might be useful for risk stratification in CRC screening. | Markus D Knudsen Thomas de Lange Edoardo Botteri Dung-Hong Nguyen Helge Evensen Chloé B Steen Geir Hoff Tomm Bernklev Anette Hjartaker Paula Berstad | 2016 | World Journal of Gastroenterology2016，22，27： | 3 |
| 6 | Early Mucosal Healing With Infliximab Is Associated With Improved Long-term Clinical Outcomes in Ulcerative Colitis显示文摘 | Jean Frédéric Colombel Paul Rutgeerts Walter Reinisch Dirk Esser Yanxin Wang Yinghua Lang Colleen W. Marano Richard Strauss Bj?rn J. Oddens Brian G. Feagan Stephen B. Hanauer Gary R. Lichtenstein Daniel Present Bruce E. Sands William J. Sandborn | 2011 | Gastroenterology2011，，4： | 3 |
| 7 | Best Practices in Managing Investor Relations Websites: Directions for Future Research显示文摘 | Bollen Laury H Hassink Harold F de Lange Rindert K Buijl Saskia D | 2008 | Journal of Information Systems2008，，2： | 2 |
| 8 | Investigation of an outbreak of mult-drug resistant Pseudomonas aeruginosa in an intensive care burns unit显示文摘 | ROBERT S A FINDLAY R LANG S D | 2001 | J Hosp Infect2001，48，3： | 1 |
| 9 | CD133,a novel marker for human prostatic epithelial stem cells显示文摘 | Richardson G D Robson C N Lang S H Neal D E Maitland N J Collins A T | 2004 | J Cell Sci2004，117，16： | 1 |
| 10 | KRAS status and efficacy in the first-line treatment of patients with metastatic colorectal cancer (mCRC) treated with FOLFIRI with or without cetuximab:The CRYSTAL experience显示文摘 | Van Cutsen E Lang I D'Haens G | 2008 | J Clin Oncol2008，26，5： | 1 |
| 11 | Sweet cherry fruit distribution and leaf populations: modeling canopy dynamics and management strategies显示文摘 | Lang G A Olmstead J W Whiting M D | 2004 | Aeta Hortic2004，636，： | 1 |
| 12 | Sin 1,amutation affecting female fertility in Arabidopsis,interacts with modl,its recessive modifier显示文摘 | LANG J D RAY S RAY A | 1994 | Genetics1994，137，4： | 1 |
| 13 | Effective-medium theory of chemical binding: Application to chemisorption显示文摘 | Norskov J K Lang N D | 1980 | Phys Rev B1980，21，： | 1 |
| 14 | The goodrich 3rd generation DB-110 system: operational on tactical and unmanned aircraft显示文摘 | Iyengar M Lange D | 2006 | SPIE2006，6209，： | 1 |
| 15 | The Biocompatibility and Biofilm of Implant Coatings Based on Hydrophilic Polymer Brushes Conjugated with Antimicrobial Peptides显示文摘 | Gao G Z Lange D Hilpert K | 2011 | Biomaterials2011，32，16： | 1 |
| 16 | C-Methyl-flavonoids from the leaf waxes of some Myrtaceae显示文摘 | Eckhard Wollenweber Rüdiger Wehde Marion D?rr Günter Lang Jan F Stevens | 2000 | Phytochemistry2000，，8： | 1 |
| 17 | The Reaction of a Phosphorus Ylide with Aroyl Cyanides显示文摘 | Soulen R L Carlson S D Lang F | 1973 | J Org Chem1973，38，3： | 1 |
| 18 | Gender differences in sympathetic nervous system regulation显示文摘 | Hinojosa-Laborde C Chapa I Lange D | 1999 | Clin Exp Pharmacol Physiol1999，26，2： | 1 |
| 19 | Beyond Megalopolis:Exploring America's New 'Megapllitan 'Geography显示文摘 | R E Lang D Dhavale | | 0，，01： | 1 |
| 20 | Temporary cov- ers maintain fall bermudagrass quality, enhance spring green- up, and increase stem carbohydrate levels 显示文摘 | Goatley J M Maddox V L Lang D L etal | 2005 | HortScienee2005，40，1： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员