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| 1 | Hepatocellular carcinoma redirects to ketolysis for progression under nutrition deprivation stress显示文摘癌症房间以他们的能力著名给新陈代谢的小径换新电线在各种各样的压力条件下面支持幸存和增长。尽管在肝生产了,酉同类身体没在正常的成年的肝房间被消费。我们这里发现酉同类分解代谢或 ketolysis 在 hepatocellular 被重新激活在营养剥夺条件下面的癌(HCC ) 房间。机械学地, 3-oxoacid CoA-transferase 1 (OXCT1 ) ,其表情在正常的成年的肝纸巾被压制的限制率的 ketolytic 酶,被浆液重新导致被触发饥饿的 mTORC2-AKT-SP1 在 HCC 房间发信号。而且,我们观察到在 HCC 的那提高的 ketolysis 为 AMPK 激活的压抑是批评的并且保护 HCC 房间免受过多的 autophagy 的伤害,从而提高肿瘤生长。重要地,临床的 HCC 样品的分析表明那增加的 OXCT1 表情预言更高耐心的死亡。一起拿,我们这里揭开剥夺营养的 HCC 房间为精力由采用酉同类身体的新奇新陈代谢的改编供应和癌症前进。 | De Huang Tingting Li Lin Wang Long Zhang Ronghui Yan Kui Li Songge Xing Gongwei Wu Lan Hu Weidong Jia Sheng-Cai Lin Chi V Dang Libing Song Ping Gao Huafeng Zhang | 2016 | Cell Research2016，26，10： | 27 |
| 2 | Live cell screening platform identifies PPAR6 as a regulator of cardiomyocyte proliferation and cardiac repair显示文摘Zebrafish 能高效地通过 cardiomyocyte 增长改革他们的心。相反,哺乳动物的 cardiomyocytes 站立即在出生以后增殖,限制出生后的哺乳动物的心的再生能力。因此,如果出生后的 cardiomyocyte 增长的内长的潜力能被提高,它能为心失败病人提供有希望的未来治疗。这里,我们开始系统地识别触发出生后的 cardiomyocyte 增长的小分子。由屏蔽为估计房间周期阶段利用一个基于 Fucci 的系统的化学复合图书馆,我们作为出生后的 cardiomyocyte 增长的 inducer 识别了 carbacyclin。在 vitro, carbacyclin 经由 peroxisome 导致了新生、成年的 mononuclear 老鼠 cardiomyocytes 的增长激活 proliferator 的受体(PPAR )/PDK1/p308Akt/GSK3/-catenin 小径。PPAR 的抑制在 zebrafish 心新生期间减少了 cardiomyocyte 增长。尤其是,象有在在老鼠的心肌的梗塞以后的 PPAR 收缩筋的治疗一样的组成地活跃的 PPAR 的可诱导的 cardiomyocyte 特定的 overexpression 在 cardiomyocytes 导致了房间周期前进,减少了结疤,并且改进了心脏的功能。一起,我们建立了屏蔽系统和礼品的 cardiomyocyte 增长有为心脏的病理的治疗的诺言的一个新 drugable 目标由 cardiomyocyte 损失引起了。 | Ajit Magadum Yishu Ding Lan He Teayoun Kim Mohankrishna Dalvoy Vasudevarao Qinqiang Long Kevin Yang Nadeera Wickramasinghe Harsha V Renikunta Nicole Dubois Gilbert Weidinger Qinglin Yang Felix B Engel | 2017 | Cell Research2017，27，8： | 6 |
| 3 | Angiotensin Ⅱ up-regulates angiotensin I -conver-ting enzyme (ACE), but down-regulates ACE2 via the AT1-ERK/p38 MAP kinase pathway 显示文摘 | Koka V Huang XR Chung AC Wang W Truong LD Lan HY | 2008 | Am J Pathol2008，172，5： | 1 |
| 4 | Second-order Markov chain based multiple-model algorithm for maneuvering target tracking显示文摘 | Lan J Li X R and Jilkov V P | 2013 | IEEE Transactions on Aerospace and Electronic Systems2013，49，1： | 1 |
| 5 | Transforming growth factor-beta and Smad signalling in kidney diseases 显示文摘 | Wang W Koka V Lan HY | 2005 | Nephrology (Carlton)2005，10，1： | 1 |
| 6 | Sphingosine l-phosphate receptor agonism impairs skin dendritic cell migration and homing to secondary lymphoid tissue: Association with prolonged allograft survival显示文摘 | Lan YY Tokita D Wang Z Wang HC Zhan J Brinkmann V | 2008 | Trans Immunol2008，20，12： | 1 |
| 7 | Transforming growth factor - beta and Smad signalling in kidney diseases 显示文摘 | Wang W Koka V Lan HY | 2005 | Nephrology(Carlton)2005，10，1： | 1 |
| 8 | mGluRl-media- ted potentiation of NMDA receptors involves a rise in in- traceUular calcium and activation of protein kinase C 显示文摘 | Skeberdis V A Lan J Opitz T | 2001 | Neuropharmacology2001，40，： | 1 |
| 9 | Transforming growth factor - beta and smad signaling in diseases 显示文摘 | Wang W Koka V Lan HY | 2005 | Nephrology ( Carlton )2005，10，1： | 1 |
| 10 | Q-VD-OPh,a pancaspase inhibitor,reduces trauma-induced apoptosis and improves the recovery of hind-limb function in rats after spinal cord injury显示文摘 | Colak A Antar V Karao?lan A | | 0，，： | 1 |
| 11 | Activation of metabotropic glutamate receptor 1 accelerates NMDA re- ceptor trafficking显示文摘 | Lan J Y Skeberdis V A Jover T | 2001 | J Neurosci2001，21，： | 1 |
| 12 | Determinants of attenuation and temperature sensitivity in the type 1 poliovirus Sabin vaccine显示文摘 | Bouchard M J Lan D H Racaniello V R | 1995 | J Virol1995，69，8： | 1 |
| 13 | Nitrogen digestion and metabolism in sheep consuming diets containing contrasting forms and levels of nitrogen显示文摘 | Siddons R E No lan J V Boever D E | 1985 | British Journal of Nutrition1985，54，： | 1 |
| 14 | Induced Foxp3 (+) regulatory T cells:a potential new weapon to treat autoimmune and inflammatory diseases显示文摘 | Lan Q Fan H Quesnianx V | | 0，，01： | 1 |
| 15 | Induced Foxp3~regulatory T cells: a potential new weapon to treat autoimmune and inflammatory diseases显示文摘 | Lan Q Fan H Quesniaux V | 2012 | J Mol Cell Biol2012，4，： | 1 |
| 16 | A novol assay for cobalt- albumin binding and its potential as a marker tor myocardial ischemia-a preliminary report显示文摘 | BAR-OR D LAN E WINKLER J V | 2000 | J Emtry Med2000，19，： | 1 |
| 17 | Screening druginduced arrhythmiausing human induced pluripotent stem cell-derived cardiomyocytes and low-impedance microelectrode arrays显示文摘 | Navarrete EG Liang P Lan F Sanchez-Freire V Simmons C Gong T | 2013 | Circulation2013，128，111： | 1 |
| 18 | Influence of TNF-α gene polymorphisms on TNF-αproduction and disease 显示文摘 | Ali H Hajeer lan V | 2001 | Human Immunology2001，62，： | 1 |
| 19 | Transmit diversity and combining scheme for spatial multiplexing over correlated channels显示文摘 | Lan Z Dubey V K | 2004 | VTC-O4-Spring2004，1，3： | 1 |
| 20 | Distributed Compressive CSIT Estimation and Feedback for FDD Multi-user Massive MIMO Systems显示文摘 | RAO X LAN V K N | 2014 | IEEE Trans Signal Process2014，62，12： | 1 |
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