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| 1 | Multidisciplinary approach for multifocal, bilobar hepatocellular carcinoma: A case report and literature review显示文摘BACKGROUND Hepatocellular carcinoma(HCC) is the second most lethal malignancy worldwide. There has been virtually no change in the survivability of HCC in spite of improvement in therapies. Surgery is considered the ideal first, curative intervention, however most patients present in advanced stages with unresectable disease. Therefore, systemic and liver-directed non-operative therapies are initially offered to downstage the disease. To ensure optimal management, a multidisciplinary team approach is often warranted. Our case highlights the benefits of a multidisciplinary approach in a young woman with multifocal, bilobar HCC.CASE SUMMARY A 36-year-old Chinese woman with untreated hepatitis B was found to have large bilobar HCC during work up for abdominal pain. Her initial serum alphafetoprotein was significantly elevated to 311136 ng/mL. Computed tomography scan demonstrated bulky bilobar liver masses, consistent with intermediate stage HCC, Barcelona Clinic Liver Cancer Stage B. Her case was discussed and a personalized care plan was developed at the Multidisciplinary Center for Advanced Minimally Invasive Liver Oncologic Therapies at the University of Washington. She initially underwent bilobar transarterial chemoembolization with partial response of the left lobar tumor. Salvage hypofractionated proton beam radiation therapy was delivered to the right lobe followed by two additional transarterial chemoembolizations to the left lobe with good response.Finally, to remove left lobar residual disease, she was taken to the operating roomfor a left hepatectomy eleven months after her initial presentation. She continues to be without evidence of disease.CONCLUSION Coordinating the multiple HCC treatment modalities is complex and our case highlights the benefits of a multidisciplinary approach. | Kevin P Labadie Stephanie K Schaub Derek Khorsand Guy Johnson Smith Apisarnthanarax James O Park | 2019 | World Journal of Hepatology2019，11，1： | 2 |
| 2 | Host-range determinants on the PB2 protein of influenza A viruses control the interaction between the viral polymerase and nucleoprotein in human cells显示文摘 | Labadie K Dos Santos Afonso E Rameix-Welti MA | 2007 | Virology2007，362，2： | 1 |
| 3 | Host-range determinants on the PB2 protein of influenza A viruses control the interaction between the viral polymerase and nucleoprotein in human cells 显示文摘 | Labadie K Dos Santos Afonso E Rameix-Welti M A | 2007 | Virol2007，362，2： | 1 |
| 4 | Poliovirus mutants excreted by a chronically infected hypogammaglobulinemic patient establish persistent infections in human intestinal cells 显示文摘 | LABADIE K PELLETIER I SAULNIER A | 2004 | Virology2004，318，1： | 1 |
| 5 | Development of analyti-cal procedures for trace-level determination of polybrominat-ed diphenyl ethers and tetrabromobisphenol A in river waterand sediment显示文摘 | Labadie P Tlili K Alliot F | 2010 | Anal Bioanal Chem2010，396，： | 1 |
| 6 | Spatial Decision Support System for Integrated River Basin Flood Control显示文摘 | Shim K C Fontane D G Labadie J W | 2002 | Journal of Water Resources Planning and Management2002，128，3： | 1 |
| 7 | The banana (Musa acuminata) genome and the evolution of monocotyledonous plants显示文摘 | D'HontA Denoeud F Aury J M Baurens F C Carreel F Garsmeur O Noel B Bocs S Droc G Rouard M Da Silva C Jabbari K Cardi C Poulain J Souquet M Labadie K Jourda C Lengelle J Rodier-Goud M Alberti A Bernard M Correa M Ayyampalayam S McKain M R Leebens-Mack J Bu | | 0，，： | 1 |
| 8 | Evaluation and Comparison of Urolithiaisis Scoring Systems in Percutaneous Kidney Stone Surgery显示文摘 | Labadie K Okhunov Z Akhavein A | 2015 | J Urol2015，193，1： | 1 |
| 9 | Host range determinants on the PB2 protein of influenza A viru- ses control the interaction between the viral polymerase and nu cleoproteinin human cells显示文摘 | Labadie K Dos Santos Afonso E Ramei:Welti MA | 2007 | Virology2007，362，27： | 1 |
| 10 | Poliovirus mutants excreted by a chronically infected hypogammaglobulinemic patient establish persistent infections in human intestinal cells 显示文摘 | Labadie K Pelletier I Saulnier A | 2004 | Virology2004，318，1： | 1 |
| 11 | Chikungunya disease in nonhuman primates involves long-term viral persistence in macrophages显示文摘 | Labadie K Larcher T Joubert C | 2010 | J Clin Invest2010，120，3： | 1 |
| 12 | Host-range determinants on the PB2 protein of influenza A viruses control the interaction between the viral polymerase and nucleoprotein in human cells 显示文摘 | Labadie K Dos Santos Afonso E Rameix-Wehi M A | 2007 | Virology2007，362，2： | 1 |
| 13 | Host-range determinants on the PB2 protein of influenza A viru- ses control the interaction between the viral polyrnerase and nu- cleoprotein in human cells 显示文摘 | Labadie K Dos Santos Afonso E Rameix-Welti MA | 2007 | Virology2007，362，2： | 1 |
| 14 | Evidence for the migration of steroidal estrogens through river bed sediments显示文摘 | Labadie P Cundy A B Stone K | 2007 | Environmental Science & Technology2007，41，12： | 1 |
| 15 | Host-range determinants on the PB2 protein of influenza A viruses control the interaction between the viral polymerase and nucleoprotein in human cells显示文摘 | LABADIE K DOS SANTOS AFONSO E RAMEIX-WELTI M A | 2007 | Virology2007，362，2： | 1 |
| 16 | River Geo-DSS for agro-environmental enhancement of Colorado's Lower Arkansas River Basin, part I : model development and calibration 显示文摘 | TRIANA E LABADIE J W GATES T K | 2010 | Journal of Water Resources Planning and Management-asce2010，136，2： | 1 |
| 17 | Nanoporous polyimides 显示文摘 | Hedrick J L Carter K R Labadie J W | 1999 | Advances in Polymer Science1999，141，： | 1 |
| 18 | Development of analytical procedures for trace-level determination of polybrominated diphenyl ethers and tetrabromobisphenol A in river water and sediment显示文摘 | LABADIE P TLILI K ALLIOT F | 2010 | Anal Bioanal Chem2010，396，2： | 1 |
| 19 | Nanoporous polyimides: Progress in polyimide chemistry II显示文摘 | J Hedrick K Carter J Labadie | 1999 | Advances in Polymer Science1999，141，： | 1 |
| 20 | Poliovirus mutants excreted by a chronically infected hypogammaglobulinemic patient establish persistent infections in human intestinal cells显示文摘 | Labadie K Pelletier I Saulnier A | 2004 | Virology2004，318，1： | 1 |
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