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| 1 | Multidisciplinary approach for multifocal, bilobar hepatocellular carcinoma: A case report and literature review显示文摘BACKGROUND Hepatocellular carcinoma(HCC) is the second most lethal malignancy worldwide. There has been virtually no change in the survivability of HCC in spite of improvement in therapies. Surgery is considered the ideal first, curative intervention, however most patients present in advanced stages with unresectable disease. Therefore, systemic and liver-directed non-operative therapies are initially offered to downstage the disease. To ensure optimal management, a multidisciplinary team approach is often warranted. Our case highlights the benefits of a multidisciplinary approach in a young woman with multifocal, bilobar HCC.CASE SUMMARY A 36-year-old Chinese woman with untreated hepatitis B was found to have large bilobar HCC during work up for abdominal pain. Her initial serum alphafetoprotein was significantly elevated to 311136 ng/mL. Computed tomography scan demonstrated bulky bilobar liver masses, consistent with intermediate stage HCC, Barcelona Clinic Liver Cancer Stage B. Her case was discussed and a personalized care plan was developed at the Multidisciplinary Center for Advanced Minimally Invasive Liver Oncologic Therapies at the University of Washington. She initially underwent bilobar transarterial chemoembolization with partial response of the left lobar tumor. Salvage hypofractionated proton beam radiation therapy was delivered to the right lobe followed by two additional transarterial chemoembolizations to the left lobe with good response.Finally, to remove left lobar residual disease, she was taken to the operating roomfor a left hepatectomy eleven months after her initial presentation. She continues to be without evidence of disease.CONCLUSION Coordinating the multiple HCC treatment modalities is complex and our case highlights the benefits of a multidisciplinary approach. | Kevin P Labadie Stephanie K Schaub Derek Khorsand Guy Johnson Smith Apisarnthanarax James O Park | 2019 | World Journal of Hepatology2019,11,1: | 2 |
| 2 | Analysis of hormonal steroids in fish plasma and bile by coupling solid-phase extraction to GC/MS 显示文摘 | Budzinski H Devier M H Labadie P | 2006 | Anal Bioanal Chem2006,386,5: | 1 |
| 3 | DNA Sequencing on a Chip 显示文摘 | Wallraff G Labadie J Brock P | 1997 | Chemtech1997,,: | 1 |
| 4 | Identification of Listeria monocytogenes genes involved in salt and alkaline-pH tolerance显示文摘 | Gardan R Cossart P Labadie J | 2003 | Appl Enviromental Microbiol2003,69,: | 1 |
| 5 | Light-directed synthesis of high-density oligonucleotide arrays using semiconductor photoresists 显示文摘 | McGall G Labadie J Brock P | 1996 | Proc Natl Acad Sci USA1996,93,13: | 1 |
| 6 | Pharmacokinetic interaction between voriconazole and methadone at steady state in patients on methadone therapy显示文摘 | Liu P Foster G Labadie R | 2007 | Antimicrob Agents Chemother2007,51,1: | 1 |
| 7 | Development of analyti-cal procedures for trace-level determination of polybrominat-ed diphenyl ethers and tetrabromobisphenol A in river waterand sediment显示文摘 | Labadie P Tlili K Alliot F | 2010 | Anal Bioanal Chem2010,396,: | 1 |
| 8 | Pharmacokinetic interaction between voriconazole and methadone at steady state in patients on methadone therapy 显示文摘 | Liu P Foster G Labadie R | 2007 | Antimierob Agents Chemother2007,51,1: | 1 |
| 9 | Assessment of hemodynamic and gastric mucosal acidosis with modified fluid versus 6% hydroxyethyl starch: a prospective, randomized study 显示文摘 | Kerkeni N Labadie F | 2000 | Intensive Care Med2000,26,9: | 1 |
| 10 | Alteration of steroid hormone profile in ju-venile turbot(Psetta maxima)as a consequence of short-term expo-sure to 17α-ethynylestradiol显示文摘 | Labadie P Budzinski H | | 0,,08: | 1 |
| 11 | Pharmacokinetic interaction between voriconazole and efavirenz at steady state in healthy male subjects显示文摘 | Liu P Foster G LaBadie RR Gutierrez M J Sharma A | | Journal of Clinical Pharmacology0,,: | 1 |
| 12 | Pharmacokinetic interaction between voriconazole and efavirenz at steady state in healthy male subjects显示文摘 | Liu P Foster G Labadie R R | 2008 | J Clin Pharmacol2008,48,1: | 1 |
| 13 | Determination of steroid- al hormone profiles along the Jalle d'Eysines River (near Bordeaux, France)显示文摘 | LABADIE P BUDZINSKI H | 2005 | Journal of Environmental Science & Technology2005,39,14: | 1 |
| 14 | Pharmacokinetic interaction between voriconazole and efavirenz at steady state in healthy male subjects 显示文摘 | Liu P Foster G Labadie R R | 2008 | J Clin Pharmacol2008,48,1: | 1 |
| 15 | Partitioning behaviour of perfluorinated alkyl contaminants between water, sediment and fish in the Orge River (nearby Paris, France)显示文摘 | LABADIE P CHEVREUIL M | 2011 | Envi- ronmental Pollution2011,159,2: | 1 |
| 16 | Light-directed synthesis of high-density oligonucleotide arrays using semiconductor photoresists 显示文摘 | Mcgall G Labadie J Brock P | 1996 | Proc Natl Acad Sci USA1996,,: | 1 |
| 17 | Partitioning behaviour of perfluorinated alkyl contaminants between water, sediment and fish in the Urge River ( nearby Paris, France) 显示文摘 | LABADIE P CHEVREUIL M | 2011 | Environmental Pollution2011,159,2: | 1 |
| 18 | Identification of Listeria monocytogenes genes involved in salt and alkaline-pH tolerance显示文摘 | Gardan R Cossart P Labadie J | 2003 | Appl Enviromental Microbiol2003,69,: | 1 |
| 19 | Light-directed synthesis of high-density oligonucleotide arrays using semiconductor photoresists显示文摘 | Labadie J Brock P | 1996 | Proc Natl Acad Sci USA1996,93,13: | 1 |
| 20 | Evidence for the migration of steroidal estrogens through river bed sediments显示文摘 | Labadie P Cundy A B Stone K | 2007 | Environmental Science & Technology2007,41,12: | 1 |