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| 1 | Total neoadjuvant therapy vs standard therapy of locally advanced rectal cancer with high-risk factors for failure显示文摘BACKGROUND For locally advanced rectal cancer(LARC),standard therapy[consisting of neoadjuvant chemoradiotherapy(CRT),surgery,and adjuvant chemotherapy(ChT)]achieves excellent local control.Unfortunately,survival is still poor due to distant metastases,which remains the leading cause of death among these patients.In recent years,the concept of total neoadjuvant treatment(TNT)has been developed,whereby all systemic ChT-mainly affecting micrometastases-is applied prior to surgery.AIM To compare standard therapy and total neoadjuvant therapy for LARC patients with high-risk factors for failure.METHODS In a retrospective study,we compared LARC patients with high-risk factors for failure who were treated with standard therapy or with TNT.High-risk for failure was defined according to the presence of at least one of the following factors:T4 stage;N2 stage;positive mesorectal fascia;extramural vascular invasion;positive lateral lymph node.TNT consisted of 12 wk of induction ChT with capecitabine and oxaliplatin or folinic acid,fluorouracil and oxaliplatin,CRT with capecitabine,and 6-8 wk of consolidation ChT with capecitabine and oxaliplatin or folinic acid,fluorouracil and oxaliplatin prior to surgery.The primary endpoint was pathological complete response(pCR).In total,72 patients treated with standard therapy and 89 patients treated with TNT were included in the analysis.RESULTS Compared to standard therapy,TNT showed a higher proportion of pCR(23%vs 7%;P=0.01),a lower neoadjuvant rectal score(median:8.43 vs 14.98;P<0.05),higher T-and N-downstaging(70%and 94%vs 51%and 86%),equivalent R0 resection(95%vs 93%),shorter time to stoma closure(mean:20 vs 33 wk;P<0.05),higher compliance during systemic ChT(completed all cycles 87%vs 76%;P<0.05),lower proportion of acute toxicity grade≥3 during ChT(3%vs 14%,P<0.05),and equivalent acute toxicity and compliance during CRT and in the postoperative period.The pCR rate in patients treated with TNT was significantly higher in patients irradiated with intensity-modulated radiotherapy/volumetricmodulated arc radiotherapy than with 3D conformal radiotherapy(32%vs 9%;P<0.05).CONCLUSION Compared to standard therapy,TNT provides better outcome for LARC patients with high-risk factors for failure,in terms of pCR and neoadjuvant rectal score. | Mojca Tuta Nina Boc Erik Brecelj Monika Peternel Vaneja Velenik | 2021 | World Journal of Gastrointestinal Oncology2021，13，2： | 3 |
| 2 | 国际托管银行收费和定价模式研究显示文摘介绍和比较目前全球托管银行的主要托管收费和定价方式。包括三部分:收费方式:统一收费,按服务种类分别收费,按市场分层次定价,关系定价等。收费标准:虽然美国的投资管理协会组织要求建立统一的托管收费标准,但目前世界上各托管银行的定价和收费存在很大差异,特别是关于核心和非核心业务区分差异较大。托管银行定价策略主要考虑市场战略、客户要求、成本结构等因素,没有固定模式。 | BOC NewYork Branch | 2004 | 国际金融研究2004，，6： | 2 |
| 3 | Correlation of Aluminum Content, Inclusion Structureand Core Loss of Nonoriented Electrical Steel 显示文摘 | Boc I | 1986 | J ApplPhys1986，64，10： | 1 |
| 4 | The banana(Musa acuminata)genome andthe evolution of monocotyledonous plants显示文摘 | HONT A D DENOEUD F AURY J M BAURENSF C CARREELF GARSMEUR O NOEL B BOCS S DROC G ROUARD M SILVA C D JABBARI K CARDI C POULAIN J SOUQUET M LABADIEK JOURDA C LENGELLE J MARGUERITE R G ALBERTI A BERNARD M CORREA M AYYAMPALAYAM S MCKAIN M R JIM L M | 2012 | Nature2012，488，： | 1 |
| 5 | Manufacturing in Decli- ne? A Matter of Definition 显示文摘 | Kakaomerlioglu Dllek Cetindamar BoC'arlsson | 1999 | Economics of Innovation and New Technology1999，，8： | 1 |
| 6 | Contribution of maternal-fetal adrenomedullin polymor-phism to gestational hypertension and preedlampsia-gene - gene interaction pilot study 显示文摘 | Boc Zalewska A Seremak Mrozikiewicz A Barlik M | 2012 | Ginekol Pol2012，83，7： | 1 |
| 7 | The banana (Musa acuminata) genome and the evolution of monocotyledonous plants显示文摘 | D'HontA Denoeud F Aury J M Baurens F C Carreel F Garsmeur O Noel B Bocs S Droc G Rouard M Da Silva C Jabbari K Cardi C Poulain J Souquet M Labadie K Jourda C Lengelle J Rodier-Goud M Alberti A Bernard M Correa M Ayyampalayam S McKain M R Leebens-Mack J Bu | | 0，，： | 1 |
| 8 | Func tional improvement of dystrophic muscle by myostatin blockade显示文摘 | BOC DANOVICH S KRAG T O BARTON E R | 2002 | Nature2002，420，： | 1 |
| 9 | The cyclosporin A-sensitive nuclear factor of activated T cells(NFAT) proteins are expressed in vascular smooth muscle cells显示文摘 | Bocs V Abbott KL Wang XF | 1998 | J Bio Chem1998，273，19： | 1 |
| 10 | Effectsofporouspoly-styreneresinparametersoncandidaantarcticalipasebadsorp-tion,distribution,andpolyestersynthesisactivity显示文摘 | BOC MILLER M E RICHARDAG | | 0，，： | 1 |
| 11 | The cyclosporin A-sensitive nuclear factor of activated T cells (NFAT) proteins are expressed in vascular smooth muscle cells显示文摘 | Bocs V Abbott KL Wang XF | 1998 | J Biol Chem1998，273，19： | 1 |
| 12 | Analysis of Inclusions in Cold Rolled Si-Fe Strips显示文摘 | Boc I | | 0，，： | 1 |
| 13 | 大跨度峒室构筑的新方法显示文摘 | BoC维尔霍图洛夫 汪东云 | 1991 | 地下空间1991，，02： | 1 |
| 14 | Ankle arthrodesis显示文摘 | Boc S F Norem N D | 2012 | Clin Podiatr Med Surg2012，29，1： | 1 |
| 15 | Integrated hydrodynamic and economic modelling of flood damage in the Netherlands显示文摘 | Jonkman S N Bocˇkarjova M Kok M | 2008 | Ecological Economics2008，66，1： | 1 |
| 16 | A chromosome-level,haplotype-phased Vanilla planifolia genome highlights the challenge of partial endoreplication for accurate wholegenome assembly显示文摘Vanilla planifolia, the species cultivated to produce one of the world’s most popular flavors, is highly proneto partial genome endoreplication, which leads to highly unbalanced DNA content in cells. We report herethe first molecular evidence of partial endoreplication at the chromosome scale by the assembly and annotation of an accurate haplotype-phased genome of V. planifolia. Cytogenetic data demonstrated that thediploid genome size is 4.09 Gb, with 16 chromosome pairs, although aneuploid cells are frequentlyobserved. Using PacBio HiFi and optical mapping, we assembled and phased a diploid genome of 3.4 Gbwith a scaffold N50 of 1.2 Mb and 59 128 predicted protein-coding genes. The atypical k-mer frequenciesand the uneven sequencing depth observed agreed with our expectation of unbalanced genome representation. Sixty-seven percent of the genes were scattered over only 30% of the genome, putatively linkinggene-rich regions and the endoreplication phenomenon. By contrast, low-coverage regions (non-endoreplicated) were rich in repeated elements but also contained 33% of the annotated genes. Furthermore, this assembly showed distinct haplotype-specific sequencing depth variation patterns, suggesting complexmolecular regulation of endoreplication along the chromosomes. This high-quality, anchored assemblyrepresents 83% of the estimated V. planifolia genome. It provides a significant step toward the elucidationof this complex genome. To support post-genomics efforts, we developed the Vanilla Genome Hub, a userfriendly integrated web portal that enables centralized access to high-throughput genomic and other omicsdata and interoperable use of bioinformatics tools. | Quentin Piet Gaetan Droc William Marande Gautier Sarah Stephanie Bocs Christophe Klopp Mickael Bourge Sonja Siljak-Yakovlev Olivier Bouchez Ce line Lopez-Roques Sandra Lepers-Andrzejewski Laurent Bourgois Joseph Zucca Michel Dron Pascale Besse Michel Grisoni Cyril Jourda Carine Charron | 2022 | Plant Communications2022，3，5： | 1 |
| 17 | Postcholecystectomy syndromes显示文摘 | Pribram BOC | 1950 | JAMA1950，142，： | 1 |
| 18 | Analysis of Inclusion in Cold Rolled Si - Fe Strips显示文摘 | Boc I | 1990 | Journal of Magnetism and Magnetic Materials1990，83，： | 1 |
| 19 | Analysis of inclusions in cold - rolled no Si-Fe strips 显示文摘 | Boc I Cziraki Grof T | 1990 | Journal of Magnetism and Magnetic Materials1990，83，1： | 1 |
| 20 | Effective management of major lower extremity wounds using an acellular regenerative tissue matrix: a pilot study显示文摘 | Bigido SA Boc SF Lopez RC | 2004 | Orthopedics2004，1，： | 1 |
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