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| 1 | Nrf2是调控解毒、抗氧化、抗炎等细胞保护机制的重要转录因子--它的活性可被保健食物及其他因素增强(英文)显示文摘转录因子Nrf2(nuclear factor erythroid-2-related factor 2)可激活人类基因组中500多种基因的转录,这些基因大多数具有细胞保护功能。Nrf2通过解毒机制产生细胞保护作用,这些机制增强了有害异物和有毒金属的解毒和排泄。Nrf2经20多种基因的作用来增加高度协调的抗氧化活性;Nrf2也具有重要的抗炎作用;Nrf2促进线粒体的生物合成抑或提高线粒体功能;Nrf2增强细胞自噬以清除毒性蛋白的聚集体和功能异常的细胞器。有益健康的营养素和其他因素,包括酚类抗氧化剂、γ-和δ-生育酚和三烯生育酚、长链Ω-3脂肪酸DHA和EPA、类胡萝卜素(其中番茄红素可能活性最强)、十字花科蔬菜中的异硫氰酸酯、葱蒜类蔬菜中的硫化物、及萜类化合物,至少部分是通过增加Nrf2活性起作用的。其他一些有益健康并增加Nrf2活性的因素包括低水平的氧化应激[毒物兴奋效应(hormesis)]、锻炼和热量限制。现已发现,增加Nrf2活性可预防和/或治疗模型动物和/或人类许多慢性炎症性疾病,包括各种心血管疾病、肾脏疾病、肺脏疾病、中毒性肝损伤疾病、癌症(预防)、糖尿病/代谢综合征/肥胖、败血症、自身免疫性疾病、炎性肠病、HIV/AIDS及癫痫。较少证据提示增加Nrf2活性可降低其他16种疾病的风险,这些疾病中的大多数可能是NO/ONOO-环有关的疾病,而Nrf2可削弱NO/ONOO-环元素的多种作用。已知最健康的饮食(地中海和冲绳地区的传统饮食)富含促进Nrf2活性的营养素,这就像我们的祖先在旧石器时代的饮食一样。Nrf2是否同时具有延长寿命和促进健康的作用是有争议的。Nrf2活性过度的可能负面作用也被讨论。Nrf2不是一个灵丹妙药,但可能对于促进健康非常重要,特别是对于那些日常暴露于有毒化学药品的人。 | Martin L Pall Stephen Levine | 2015 | 生理学报2015，67，1： | 35 |
| 2 | 脑缺氧是影响严重颅脑创伤患者短期预后的独立危险因素(英文)显示文摘Background:Brain hypoxia(BH)can aggravate outcome after severe traumatic brain injury(TBI).Whether BH or reduced brain oxygen(Pbto2)is an independent outcome predictor or a marker of disease severity is not fully elucidated.Objective To analyze the relationship between Pbto2,intracranial pressure(ICP),and cerebral perfusion pressure(CPP)and to examine whether BH correlates with worse outcome independently of ICP and CPP.Methods We studied103patients | Oddo M Levine JM Mackenzie L Frangos S Feihl F Kasner SE Katsnelson M Pukenas B Macmurtrie E Maloney-Wilensky E Kofke WA Leroux PD | 2011 | 中华神经外科疾病研究杂志2011，10，5： | 21 |
| 3 | Reduced EGFR signaling enhances cartilage destruction in a mouse osteoarthritis model显示文摘Osteoarthritis(OA) is a degenerative joint disease and a major cause of pain and disability in older adults. We have previously identified epidermal growth factor receptor(EGFR) signaling as an important regulator of cartilage matrix degradation during epiphyseal cartilage development. To study its function in OA progression, we performed surgical destabilization of the medial meniscus(DMM) to induce OA in two mouse models with reduced EGFR activity, one with genetic modification(EgfrWa5/1mice) and the other one with pharmacological inhibition(gefitinib treatment). Histological analyses and scoring at 3 months post-surgery revealed increased cartilage destruction and accelerated OA progression in both mouse models. TUNEL staining demonstrated that EGFR signaling protects chondrocytes from OA-induced apoptosis, which was further confirmed in primary chondrocyte culture. Immunohistochemistry showed increased aggrecan degradation in these mouse models, which coincides with elevated amounts of ADAMTS5 and matrix metalloproteinase 13(MMP13), the principle proteinases responsible for aggrecan degradation, in the articular cartilage after DMM surgery. Furthermore, hypoxia-inducible factor 2a(HIF2a), a critical catabolic transcription factor stimulating MMP13 expression during OA, was also upregulated in mice with reduced EGFR signaling. Taken together, our findings demonstrate a primarily protective role of EGFR during OA progression by regulating chondrocyte survival and cartilage degradation. | Xianrong Zhang Ji Zhu Fei Liu Yumei Li Abhishek Chandra L Scott Levin Frank Beier Motomi Enomoto-Iwamoto Ling Qin | 2014 | Bone Research2014，2，3： | 9 |
| 4 | The Stroke Outcomes and Neuroimaging of Intracranial Atherosclerosis (SONIA) Trial显示文摘 | E Feldmann J L. Wilterdink A Kosinski M Lynn M I. Chimowitz J Sarafin H H. Smith F Nichols J Rogg H J. Cloft L Wechsler J Saver S R. Levine C Tegeler R Adams M Sloan | 2007 | Neurology2007，，24： | 2 |
| 5 | Elevated circulating levels of tumor necrosis factor in severe chronic heart failure显示文摘 | Levine B Kalman J Mayer L | 1990 | N Engl J Med1990，323，4： | 2 |
| 6 | Folate and vitamin B12 in idiopathic male infertility显示文摘尽管 methylenetetrahydrofolate reductase,叶酸的酶基因,与自发的男不孕被联系了,很少研究检验了另外的叶酸相关的代谢物和基因。我们调查了自发的男不孕是否与变体被联系在叶酸,维生素 B 12(B12 ) 和全部的 homocysteine (tHcy ) 联系了基因并且在血测量了这些代谢物。我们进行了与自发的不孕和在生育力中心和胎儿的照顾中心招募的 184 肥沃的男控制包括了 153 个人的盒子控制研究,大学医院, Malmö并且 Lund,瑞典。浆液叶酸的、红房间叶酸(RCF ) ,浆液 B12,血浆 tHcy 和精液质量被测量。题目是为在与 folate/B12/homocysteine 新陈代谢有关的 12 基因的 20 普通变体的 genotyped。代谢物集中和遗传型分布为 covariates 与调整用线性、逻辑的回归在案例和控制之间被作比较。phosphatidylethanolamine N-methyltransferase (PEMT ) M175V 和 TCblR rs173665 多型性显著地与不孕被联系(P=0.01 和 P=0.009,分别地) ,然而并非与精液质量。在补充的非用户之中,有的不肥沃的人降低浆液叶酸的集中比肥沃的人(12.89 对 14.73 nmol l −1 ;P=0.02 ) ,但是在 RCF, B12 或 tHcy 没有重要差别。叶酸, B12 和 tHcy 集中没与任何精液参数被相关。这研究几乎不提供小支持为低叶酸或在自发的男不孕的致病的 B12 地位。尽管另外的数据被需要证实这些起始的调查结果,我们的结果建议那 PEMT 和 TCblR,基因在胆碱和 B12 新陈代谢包含了,在自发的男不孕应得进一步的调查。 | Laurel E Murphy James L Mills Anne M Molloy Cong Qian Tonia C Carter Helena Strevens Dag Wide-Swensson Aleksander Giwercman Richard J Levine | 2011 | Asian Journal of Andrology2011，13，6： | 2 |
| 7 | Predictors of progression in Barrett’s esophagus III: baseline flow cytometric variables显示文摘 | Peter S Rabinovitch Gary Longton Patricia L Blount Douglas S Levine Brian J Reid | 2001 | The American Journal of Gastroenterology2001，，11： | 2 |
| 8 | Predictors of progression in Barrett’s esophagus II: baseline 17p (p53) loss of heterozygosity identifies a patient subset at increased risk for neoplastic progression显示文摘 | Brian J Reid Laura J Prevo Patricia C Galipeau Carissa A Sanchez Gary Longton Douglas S Levine Patricia L Blount Peter S Rabinovitch | 2001 | The American Journal of Gastroenterology2001，，10： | 2 |
| 9 | Relationships between soil properties and vegetation at the Northern Experimental Forest, Howland, Maine显示文摘 | LEVINE L R KNOX R G AND LAWRENCE W T | 1994 | Remote Sensing of Environment1994，47，： | 1 |
| 10 | Structural testing of concurrent programs显示文摘 | Taylor R N Levine D L Kelly C D | 1992 | IEEE Trans Softw Eng1992，18，3： | 1 |
| 11 | The Stability of the Coumot Oligopoly Model: A Reassessment 显示文摘 | AL-NOWAIHI A LEVINE P L | 1985 | Journal of Economic Theory1985，35，： | 1 |
| 12 | Effect of topical alendronate on root resorption of dried replanted dog teeth显示文摘 | Levin L Bryson EC Caplan D | 2001 | Dent Traumatol2001，17，3： | 1 |
| 13 | The design and performance of real-time object request brokers显示文摘 | Schmidt D C Levine D L Mungee S | 1998 | Computer Communications1998，21，2： | 1 |
| 14 | Free radical-mediated oxidation of free amino acids and amino acid residues in proteins显示文摘 | Stadtman E R Levine R L | 2003 | Amino Adds2003，25，34： | 1 |
| 15 | Acrodermatitis enteropathica-like syndrome secondary to branched-chain amino acid deficiency during treatment of maple syrup urine disease显示文摘 | Delgiesser D Levin L Elpeleg O | 2006 | Implant Dent2006，15，2： | 1 |
| 16 | Highly effective inhibition of Akabane virus replication by siRNA genes显示文摘 | Levin A Kutznetova L Kahana R | 2006 | Virus Res2006，120，12： | 1 |
| 17 | Gingival recession in young adults: occurrence, severity, and relationship to past orthodontic treatment and oral piercing显示文摘 | Slutzkey S Levin L | 2008 | Am J Orthod Dentofacial Orthop2008，134，5： | 1 |
| 18 | Prevalence of abnormal serum vitamin D,PTH,calcium,and phosphorus in patients with chronic kidney disease:results of the study to evaluate early kidney disease显示文摘 | Levin A Bakris G L Molitch M | | 0，，01： | 1 |
| 19 | Ventralhippocampal alpha7 and alpha4beta2 nicotinic receptor blockade and clozapine effectsonmemory in female rats显示文摘 | Pocivavsek A Icenogle L Levin ED | | 0，，： | 1 |
| 20 | New advances in the pathogenesis and therapy of essential thrombocythemia显示文摘 | Levine R L Heaney M | | 0，，： | 1 |
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