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| 1 | 美国临床生化科学院检验医学实践指南:睾丸、前列腺、结直肠、乳腺及卵巢癌肿瘤标志物的应用显示文摘经美国临床生化科学院(NCAB)授权,由鄢盛恺教授组织学者、专家翻译审定2009年NCAB检验医学实践指南:睾丸、前列腺、结直肠、乳腺及卵巢癌中肿瘤标志物的应用单行本(Catharine M.Sturgeon教授和Eleftherios P.Diaman-dis教授编辑)。该指南包含第1至6章共6部分内容,参加指南制订的专家阵容强大,分别从临床及检验角度对睾丸、前列腺、结直肠、乳腺及卵巢癌中肿瘤标志物的检测与临床应用方面的问题进行了详细阐述与说明,是目前国内外在肿瘤实验诊断方面的纲领性应用文件。不仅适合广大检验人员、临床医护人员学习使用,也非常适合相关仪器试剂生产厂商研发应用。本指南由刘洋、薛丽、林文涛、李江、梁红艳、顾兵、潘世扬、郑磊等翻译,姜晓峰、沈文梅、田亚平、鄢盛恺审校,最后由鄢盛恺统稿审定。本指南的翻译出版,不仅有助于我国检验人员和医护人员合理的检测和应用睾丸、前列腺、结直肠、乳腺及卵巢癌肿瘤标志物,对我国检验医学指南的编写与应用也有一定的借鉴作用。本刊特在本期刊发,以飨广大读者。 | 鄢盛恺 Ulf-Hkan Stenman Rolf Lamerz Leendert H.Looijenga Nils Brünner Michael J.Duffy Caj Haglund Mads Holten-Andersen Hans JФrgen Nielsen Francisco J.Esteva Nadia Harbeck Daniel F.Hayes Rafael Molina Daniel W.Chan Robert C.Bast Jr Ie-Ming Shih Lori J.Sokoll Gyrgy Slétormos 刘洋 梁红艳 姜晓峰 田亚平 薛丽 林文涛 顾兵 潘世扬 沈文梅 郑磊 李江 | 2012 | 临床检验杂志2012，30，2： | 32 |
| 2 | 子宫颈癌筛查异常妇女处理的共识指南(2006版)显示文摘2001年,美国阴道镜与宫颈病理学会(American Society for Colposcopyand Cervical Pathology,ASCCP)联合其他专业学会以及联邦与国际组织.制订了2001版的宫颈癌细胞学筛查结果异常妇女处理的共识指南。这是全面的、以循证医学为依据的指南,其目的是帮助所有亚专业的临床医生,处理每年约480万诊断为细胞学异常的美国妇女。 | 李志刚(翻译) Thomas C. Wright Jr L Stewart Massad Charles J. Dunton MarkSpitzer Edward J. Wilkinson DianeSolomon | 2008 | 循证医学2008，8，4： | 16 |
| 3 | Effect of metabolic structures and energy requirements on curdlan production by Alcaligenes faecalis显示文摘 | Zheng, ZY Lee, AW Zhan, XB Shi, Z Wang, L Zhu, L Wu, JR Lin, CC | 2007 | 中国生物学文摘2007，21，10： | 13 |
| 4 | 在材料研制中的连续介质细观力学有限元建模现状评论显示文摘评述了机械载荷下材料力学行为有限元模拟的先进技术.分析了考虑材料微观及细观结构情况下,对材料变形、损伤、断裂进行模拟时各种方法的优缺点及发展前景.阐述了对材料行为模拟方法的发展,包括基本的及先进的方法,如体胞方法、真实结构模拟、粘结区模型等. | Leon L Mishnaevsky Jr Siegfried Schmauder 陈少华 魏悦广 | 2002 | 力学进展2002，32，3： | 9 |
| 5 | 瘦素通过醛固酮依赖机制,诱发肥胖雌性小鼠高血压和血管内皮功能障碍显示文摘肥胖是男性与女性心血管病的主要危险因素。然而,肥胖是否通过类似机制触发两性心血管病尚不清楚。在男性中,脂肪细胞因子瘦素通过增强交感神经活性,增加肥胖相关的心血管病。女性可分泌出高于男性3~4倍的瘦素,但未表现出与肥胖相关的较高的交感神经张力。 | 刘莉 叶鹏 Huby AC Otvos L Jr Belin de Chantemèle EJ | 2016 | 中华高血压杂志2016，24，3： | 5 |
| 6 | Counter-regulatory phosphatases TNAP and NPP1 temporally regulate tooth root cementogenesis显示文摘Cementum is critical for anchoring the insertion of periodontal ligament fibers to the tooth root. Several aspects of cementogenesis remain unclear, including differences between acellular cementum and cellular cementum, and between cementum and bone.Biomineralization is regulated by the ratio of inorganic phosphate(Pi) to mineral inhibitor pyrophosphate(PPi), where local Piand PPi concentrations are controlled by phosphatases including tissue-nonspecific alkaline phosphatase(TNAP) and ectonucleotide pyrophosphatase/phosphodiesterase 1(NPP1). The focus of this study was to define the roles of these phosphatases in cementogenesis. TNAP was associated with earliest cementoblasts near forming acellular and cellular cementum. With loss of TNAP in the Alpl null mouse, acellular cementum was inhibited, while cellular cementum production increased, albeit as hypomineralized cementoid. In contrast, NPP1 was detected in cementoblasts after acellular cementum formation, and at low levels around cellular cementum. Loss of NPP1 in the Enpp1 null mouse increased acellular cementum, with little effect on cellular cementum.Developmental patterns were recapitulated in a mouse model for acellular cementum regeneration, with early TNAP expression and later NPP1 expression. In vitro, cementoblasts expressed Alpl gene/protein early, whereas Enpp1 gene/protein expression was significantly induced only under mineralization conditions. These patterns were confirmed in human teeth, including widespread TNAP, and NPP1 restricted to cementoblasts lining acellular cementum. These studies suggest that early TNAP expression creates a low PPienvironment promoting acellular cementum initiation, while later NPP1 expression increases PPi, restricting acellular cementum apposition. Alterations in PPihave little effect on cellular cementum formation, though matrix mineralization is affected. | Laura E Zweifler Mudita K Patel Francisco H Nociti Jr Helen F Wimer Jose L Milln Martha J Somerman Brian L Foster | 2015 | International Journal of Oral Science2015，7，1： | 5 |
| 7 | MGMT and MLH1 methylation in Helicobacter pylori-infected children and adults显示文摘AIM:To evaluate the association between Helicobacter pylori(H.pylori) infection and MLH1 and MGMT methylation and its relationship with microsatellite instability(MSI).METHODS:The methylation status of the MLH1 and MGMT promoter region was analysed by methylation specific methylation-polymerase chain reaction(MSPPCR) in gastric biopsy samples from uninfected or H.pylori-infected children(n = 50),from adults with chronic gastritis(n = 97) and from adults with gastric cancer(n = 92).MLH1 and MGMT mRNA expression were measured by real-time PCR and normalised to a constitutive gene(β actin).MSI analysis was performed by screening MSI markers at 4 loci(Bat-25,Bat-26,D17S250 and D2S123) with PCR;PCR products were analysed by single strand conformation polymorphism followed by silver staining.Statistical analyses were performed with either the χ 2 test with Yates continuity correction or Fisher's exact test,and statistical significance for expression analysis was assessed using an unpaired Student's t-test.RESULTS:Methylation was not detected in the promoter regions of MLH1 and MGMT in gastric biopsy samples from children,regardless of H.pylori infection status.The MGMT promoter was methylated in 51% of chronic gastritis adult patients and was associated with H.pylori infection(P < 0.05);this region was methylated in 66% of gastric cancer patients,and the difference in the percentage of methylated samples between these patients and those from H.pylori-infected chronic gastritis patients was statistically significant(P < 0.05).MLH1 methylation frequencies among H.pylori-infected and non-infected chronic gastritis adult patients were 13% and 7%,respectively.We observed methylation of the MLH1 promoter(39%) and increased MSI levels(68%) in samples from gastric cancer patients in comparison to samples from H.pylori-infected adult chronic gastritis patients(P < 0.001 and P < 0.01,respectively).The frequency of promoter methylation for both genes was higher in gastric cancer samples than in H.pylori-positive chronic gastritis samples(P < 0.05).The levels of MLH1 and MGMT mRNA were significantly reduced in chronic gastritis samples that were also hypermethylated(P < 0.01).CONCLUSION:In summary,MGMT and MLH1 methylation did not occur in earlier-stage H.pylori infections and thus might depend on the duration of infection. | Marisa C Alvarez Juliana C Santos Nathália Maniezzo Marcelo S Ladeira Artur LC da Silva Isabel CA Scaletsky José Pedrazzoli Jr Marcelo L Ribeiro | 2013 | World Journal of Gastroenterology2013，19，20： | 5 |
| 8 | 奶牛业中霉菌和霉菌毒素的问题(一)显示文摘霉菌毒素是由真菌(霉菌)产生的毒性次级代谢产物,当动物采食了被污染的饲料,或者接触或吸人霉菌时,可引起不良影响(霉菌中毒),其生物学影响包括肝和肾的中毒、中枢神经系统与雌激素的影响等。只有部分霉菌产生霉菌毒素,称为产毒霉菌。霉菌毒素的化学变化多,这也代表化学家族的多样性——分子量范围约200~500。 | 王银东 L W Whitlow W M Hagler Jr | 2010 | 中国畜牧杂志2010，46，2： | 5 |
| 9 | Comparison of gene expression between normalcolon mucosa and colon carcinoma by means of messenger RNA differential display显示文摘 | Wang L Lu W Chen YG Zhou XM Gu JR | 1999 | World Journal of Gastroenterology1999，5，6： | 4 |
| 10 | Magnetic resonance angiography for the primary diagnosis of pulmonary embolism: A review from the international workshop for pulmonary functional imaging显示文摘Pulmonary contrast enhanced magnetic resonance angiography(CE-MRA) is useful for the primary diagnosis of pulmonary embolism(PE). Many sites have chosen not to use CE-MRA as a first line of diagnostic tool for PE because of the speed and higher efficacy of computerized tomographic angiography(CTA). In this review, we discuss the strengths and weaknesses of CEMRA and the appropriate imaging scenarios for the primary diagnosis of PE derived from our unique multiinstitutional experience in this area. The optimal patient for this test has a low to intermediate suspicion for PE based on clinical decision rules. Patients in extremis are not candidates for this test. Younger women(< 35 years of age) and patients with iodinated contrast allergies are best served by using this modality We discuss the history of the use of this test, recent technical innovations, artifacts, direct and indirect findings for PE, ancillary findings, and the effectiveness(patient outcomes) of CE-MRA for the exclusion of PE. Current outcomes data shows that CE-MRA and NM V/Q scans are effective alternative tests to CTA for the primary diagnosis of PE. | Nanae Tsuchiya Edwin JR van Beek Yoshiharu Ohno Hiroto Hatabu Hans-Ulrich Kauczor Andrew Swift Jens Vogel-Claussen Jürgen Biederer James Wild Mark O Wielpütz Mark L Schiebler | 2018 | World Journal of Radiology2018，10，6： | 4 |
| 11 | SEM in situ laboratory investigations on damage growth in GFRP composite under three-point bending tests显示文摘Glass fiber-reinforced polymer (GFRP) composites are widely used in low-weight constructions.SEM (scanning electron microscopy) in situ experiments of damage growth in GFRP composite under three-point bending loads are carried out.By summarizing the experimental results of three groups of samples with different orientation angles of fibers,the dependence of mechanical parameters on the orientation angles of fibers are analyzed.The regression analysis show that the peak strengths,the elastic strengths and the elastic modulus of the composites decease with the orientation angles of fibers almost linearly.Moreover,the damage growth and meso-scale structure changes in GFRP composites during three-point bending loading are analyzed. | ZHOU HongWei MISHNAEVSKY Jr L BRONDSTED p TAN JinBiao GUI LeLe | 2010 | Chinese Science Bulletin2010，55，12： | 3 |
| 12 | The endoscopic assessment of esophagitis: A progress report on observer agreement显示文摘 | D Armstrong JR Bennett AL Blum J Dent FT De Dombal JP Galmiche L Lundell M Margulies JE Richter SJ Spechler GN Tytgat L Wallin | 1996 | Gastroenterology1996，，1： | 2 |
| 13 | Structure of glycerol dehydratase reactivase:a new type of molecular chaperone显示文摘 | Liao D L Reiss L Turner Lvan Jr | 2003 | Structure2003，11，： | 2 |
| 14 | Diet, microbial virulence, and Helicobacter pylori-induced gastric cancer显示文摘 | Timothy L Cover Richard M Peek Jr | 2013 | Gut Microbes2013，，： | 2 |
| 15 | 苄基异喹啉化合物Mollinedine的抗实验性心律失常作用显示文摘Mollinedine(Moll)5mg/kg,iv可显著提高恒速iv哇巴因诱发豚鼠心律失常的用量;显著降低大鼠iv CaCl2的死亡率;预防氯仿引起小鼠心室纤颤的发生;对抗大鼠心肌缺血复灌引起的心律失常;但对iv乌头碱诱发大鼠心律失常的作用无效。小鼠恒速iv Moll随剂量增加,心电图PR间期、QRS明显延长。Moll 5mg/kg iv能降低麻醉大鼠的收缩压、舒张压,左心室压、左室压的变化速率。降压与抑制心肌收缩力作用时间较短,很快可恢复到给药前水平。由此说明,Moll具有抗实验性心律失常作用。 | 胡国胜 钱家庆 Jose A. Lpez Youssef Aly Lan K.Wong Paul L.Schiff Jr | 1990 | 同济医科大学学报1990，19，1： | 2 |
| 16 | Surgical stress and cytoskeletal changes in lens epithelial cells following manual and femtosecond laser-assisted capsulotomy显示文摘AIM:To study the effect of mechanical stress on the cytoskeleton in lens epithelial cells following conventional phacoemulsification surgery(CPS)and femtosecond laserassisted cataract surgery(FLACS).METHODS:The cytoskeleton of the epithelial cells of the anterior lens capsules(ALC)removed by CPS and FLACS was examined by immunohistochemistry.Expression of the intermediate filament,glial fibrillary acidic protein(GFAP),and glutamine synthetase(GS)immunoreactivity were detected.In order to map the actin network of cells,fluorescently labeled phalloidin was used.The samples were examined using confocal laser scanning microscopy.RESULTS:GFAP expression was visible in a larger number of the epithelial cells after CPS compared to FLACS.In CPS sample’s epithelial cells,GFAP immunoreactivity indicated robust morphological change.Regarding the actin filaments,the presence of tubular elements connecting epithelial cells,regular actin pattern and marked cortical network after CPS were found.Following FLACS,the actin cytoskeleton of the epithelial cells remained densely structured,and the tubular elements were undetectable,however,the above-mentioned regular actin pattern and the marked cortical network were visible.CONCLUSION:The conventional removal of the ALC induces more robust changes of the cytoskeleton of the lens epithelial cells. | ANDrea Krisztina Sükosd Krisztina Szabadfi Edina Szabó-Meleg Beáta Gáspár Pavel Stodulka Gyorgy SétálóJr Róbert Gábriel Miklós Nyitrai Zsolt Biró Hajnalka Abrahám | 2020 | International Journal of Ophthalmology(English edition)2020，13，6： | 2 |
| 17 | TSC1-mTOR-PLK轴以阶段特异性方式调节从施旺细胞增殖到髓鞘形成的内稳态开关显示文摘恰如其分的外周髓鞘形成取决于雪旺细胞增殖与分化进程间的平衡。丝氨酸/苏氨酸激酶(mTOR)整合多种环境因素,是细胞生长、代谢、发挥作用的中枢调节者。本文报道了一种mTOR的负性调节剂——结节性硬化复合体(TSC1),通过控制细胞增殖和髓鞘稳态,建立了雪旺细胞谱系进展和髓鞘形成的阶段依赖性程序。小鼠雪旺细胞祖细胞中TSC1的解离导致mTOR信号通路激活,继而导致雪旺细胞过量增殖,分化受阻,髓鞘形成减少。转录组分析显示,TSC1突变体中的mTOR活化使得polo样激酶(PLK)依赖性通路和细胞周期调节剂上调。弱化mTOR或者对PLK进行药理抑制部分挽救了因TSC1缺失导致的外周神经发育过程中的髓鞘形成减少。相较之下,成年小鼠成熟雪旺细胞中TSC1缺失可导致髓鞘的过度增殖和过度生长。本文的发现提示了TSC1-mTOR-PLK信号轴在控制雪旺细胞的发育过程中,从增殖到分化和髓鞘内稳态中起到的阶段特异性功能。 | Jiang M Rao R Wang J Wang J1 Xu L Wu LM Chan JR Wang H Lu QR 聂昊(编译) | 2018 | 神经损伤与功能重建2018，13，5： | 2 |
| 18 | Effects on reproduction performance of administration of GnRH to early postpartum dairy cows显示文摘 | Nash Jr J G Ball L Olson J D | 1980 | J Anim Sci1980，50，： | 2 |
| 19 | Effect of propranolol on the splanchnic and peripheral renin angiotensin system in cirrhotic patients显示文摘AIM:To evaluate the effect of β-blockade on angiotensins in the splanchnic and peripheral circulation of cirrhotic patients and also to compare hemodynamic parameters during liver transplantation according to propranolol pre-treatment or not. METHODS:Patients were allocated into two groups:outpatients with advanced liver disease(LD) and during liver transplantation(LT). Both groups were subdivided according to treatment with propranolol or not. Plasma was collected through peripheral venipuncture to determine plasma renin activity(PRA),Angiotensin(Ang) Ⅰ,Ang Ⅱ,and Ang-(1-7) levels by radioimmunoassay in LD group. During liver transplantation,hemodynamic parameters were determined and blood samples were obtained from the portal vein to measure renin angiotensin system(RAS) components.RESULTS:PRA,Ang Ⅰ,Ang Ⅱ and Ang-(1-7) were signifi cantly lower in the portal vein and periphery in all subgroups treated with propranolol as compared to non-treated. The relationships between Ang-(1-7) and Ang Ⅰ levels and between Ang Ⅱ and Ang Ⅰ were significantly increased in LD group receiving propranolol. The ratio between Ang-(1-7) and Ang Ⅱ remained unchanged in splanchnic and peripheral circulation in patients under β-blockade,whereas the relationship between Ang Ⅱ and Ang Ⅰ was significantly increased in splanchnic circulation of LT patients treated with propranolol. During liver transplantation,cardiac output and index as well systemic vascular resistance and index were reduced in propranolol-treated subgroup. CONCLUSION:In LD group,propranolol treatment reduced RAS mediators,but did not change the ratio between Ang-(1-7) and Ang Ⅱ in splanchnic and peripheral circulation. Furthermore,the modification of hemodynamic parameters in propranolol treated patients was not associated with changes in the angiotensin ratio. | Walkíria Wingester Vilas-Boas Antnio Ribeiro-Oliveira Jr Renata da Cunha Ribeiro Renata Lúcia Pereira Vieira Jerusa Almeida Ana Paula Nadu Ana Cristina Sim■es e Silva Robson Augusto Souza Santos | 2008 | World Journal of Gastroenterology2008，14，44： | 2 |
| 20 | D-MELD risk capping improves post-transplant and overall mortality under markov microsimulation显示文摘AIM: To hypothesize that the product of calculated Model for End-Stage Liver Disease score excluding exception points and donor age(D-MELD) risk capping ± Rule 14 could improve post liver transplant and overall survival after listing.METHODS: Probabilities derived from the United Network for Organ Sharing database between 2002 and 2004 were used to simulate potential outcomes for all patients listed for transplantation. The Markov simula-tion was then modified by screening matches using a 1200 or 1600 D-MELD risk cap ± allowing transplants for Model for End-Stage Liver Disease(MELD) ≤ 14(Rule 14). The differential impact of the rule changes was assessed.RESULTS: The Markov simulation accurately reproduced overall and post transplant survival. A 1200 D-MELD risk cap improved post-transplant survival. Both the 1200 and 1600 risk caps improved overall survival for waitlisted patients. The addition of Rule 14 further improved post transplant and overall survival by redistribution of donor livers to recipients in higher MELD subgroups. The mechanism for improved overall and post-transplant survival after listing was due to shifting a larger percentage of transplants to the moderate MELD score subgroup(MELD 15-29) while also ensuring that high MELD recipients have livers of high quality to achieve excellent post transplant survival.CONCLUSION: A 1200 D-MELD risk cap + Rule 14 provided the greatest overall benefit primarily by focusing liver transplantation towards the moderate MELD recipient. | Jeffrey B Halldorson Robert L Carithers Jr Renuka Bhattacharya Ramasamy Bakthavatsalam Iris W Liou Andre A Dick Jorge D Reyes James D Perkins | 2014 | World Journal of Transplantation2014，4，3： | 2 |
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