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| 1 | Radiofrequency combined with immunomodulation for hepatocellular carcinoma: State of the art and innovations显示文摘Hepatocellular carcinoma(HCC)is the most common primary liver tumor and has been considered a very immunogenic tumor.The treatment with radiofrequency ablation(RFA)has been established as the standard ablative therapy for early HCC,and is currently recognized as the main ablative tool for HCC tumors<5 cm in size;however,progression and local recurrence remain the main disadvantages of this approach.To solve this clinical problem,recent efforts were concentrated on multimodal treatment,combining different strategies,including the combination of RFA and immunotherapy.This article reviewed the combination treatment of RFA with immunotherapy and found that this treatment strategy leads to an increased response of anti-tumor T cells,significantly reduces the risk of recurrence and improves survival rates compared to RFA alone.This review highlighted scientific evidence that supports the current recommendations for pre-clinical studies,and discuss the need for further research on this topic. | Adriano Carneiro da Costa Mikael Sodergren Kumar Jayant Fernando Santa Cruz Duncan Spalding Madhava Pai Nagy Habib | 2020 | World Journal of Gastroenterology2020，26，17： | 5 |
| 2 | Molecular docking studies of anti-cancerous candidates in Hippophae rhamnoides and Hippophae salicifolia显示文摘Actinorhizal plants contain numerous antioxidants that may play a crucial role in preventing the formation of tumors.H-Ras p21,a member of the Ras-GTPase family,is a promising target to treat various kinds of cancers.An in silico docking study was carried out to identify the inhibitory potential of compounds of these plants against H-Ras by using Discovery Studio 3.5 and by using Autodock 4.2.Docking studies revealed that four compounds,isorhamnetin-7-rhamnoside,quercetin-3-glucoside-7-rhamnoside(present in H.rhamnoides),zeaxanthin,and translutein(present in H.salicifolia) significantly bind with binding energies-17.1534,-14.7936,-10.2105 and-17.2217 Kcal/mol,respectively,even though they slightly deviate from Lipinski's rule.Absorption,distribution,metabolism,excretion and toxicity(ADME/tox) analyses of these compounds and their stereoisomers showed that they were less toxic and non-mutagenic.Amongst them,isorhamntein-7-rhamnoside showed hepatotoxicity.Hence,these compounds can be further investigated in vivo to optimize their formulation and concentration and to develop potential chemical entities for the prevention and treatment of cancers. | Talambedu Usha Sushil Kumar Middha Arvind Kumar Goyal Mahesh Karthik DA Manoj Syed Faizan Peyush Goyal HP Prashanth Veena Pande | 2014 | The Journal of Biomedical Research2014，28，5： | 3 |
| 3 | Influence of Bone-Lead stores on the observed effectiveness of lead harzad intervention显示文摘 | Rust SW Kumar P Burgoon DA | 1999 | Environ Res1999，81，： | 1 |
| 4 | Influence of bone-lead stores on the observed effectiveness of lead hazard intervention显示文摘 | Rust SW Kumar P Burgoon DA | 1999 | Environ Res1999，81，： | 1 |
| 5 | Cataract surgery in the setting of trauma显示文摘 | Agarwal A Kumar DA Nair V | 2010 | Curr Opin Ophthalmol2010，21，1： | 1 |
| 6 | CYP2C9 inhibition: impact of probe selection and pharmacogenetics on in vitro inhibition profiles显示文摘 | Kumar V Wahlstrom JL Rock DA Warren CJ Gorman LA Tracy TS | 2006 | Drug Metab Dispos2006，34，12： | 1 |
| 7 | Antioxidant potential of a novel tetrapeptide derivative in isoproterenol-induced myocardial necrosis in rats显示文摘 | Manikandan P Sumitra M Kumar DA | 2002 | Pharmacology2002，65，2： | 1 |
| 8 | Evaluation of Intraocular Lens Tilt With Anterior Segment Optical Coherence Tomography显示文摘 | Kumar DA Agarwal A Prakash G | 2011 | Am J Ophthalmol2011，151，： | 1 |
| 9 | GBP5 promotes NLRP3 inflammasome assembly and immunity in mammals显示文摘 | Shenoy AR Wellington DA Kumar P | 2012 | Science2012，336，6080： | 1 |
| 10 | Neurologic impairment from ectopic bone in the lumbar canal : a potential complication of off - label PLIF/TLIF use of bone morphogenetic protein - 2 ( BMP - 2) 显示文摘 | Wong DA Kumar A Jatana S | 2008 | Spine2008，6，： | 1 |
| 11 | Antioxidant potential of a novel tetrapoptide derivative in isoproterenol-induced myocardial necrosis in rats 显示文摘 | Manikandan P Sumitra M Kumar DA | 2002 | Pharmacology2002，65，2： | 1 |
| 12 | Conscious sedation with high-dose midazolam for pediatric gastrointestinal endoscopy显示文摘 | Kumar S Sacks AI | 1997 | South Med J1997，90，8： | 1 |
| 13 | GBP5 promotesNLRP3 inflammasome assembly and immunity in mammals 显示文摘 | Shenoy AR Wellington DA Kumar P | 2012 | Science2012，336，6080： | 1 |
| 14 | Kras Mutation Analysis of Fine Needle Aspirate Under EUS Guidance Facilitates Risk Stratification of Patients With Pancreatic Mass显示文摘 | Fauze Maluf-Filho Atul Kumar René Gerhardt Márcia Kubrusly Paulo Sakai Fabio Hondo Sergio Eiji Matuguma Everson Artifon José Eduardo Monteiro da Cunha Marcel Cerqueira César Machado Shinichi Ishioka Elias Forero | 2007 | Journal of Clinical Gastroenterology2007，，10： | 1 |
| 15 | Viscocannula-assisted re- inversion of implantable collamer lens : comparison of postoperative outcomes with the fellow eyes 显示文摘 | Kumar DA Agarwal A Prakash G | 2012 | Am J Ophthalmol2012，153，1： | 1 |
| 16 | Raltegravir with optimized background therapy for resistant HIV-1 infection显示文摘 | Steigbigel RT Cooper DA Kumar PN | 2008 | N Engl J Med2008，359，4： | 1 |
| 17 | Rahegravir with opti- mized background therapy for resistant HIV-1 infection显示文摘 | Steigbigel RT Cooper DA Kumar PN et o1 | 2008 | N En- gl J Med2008，359，4： | 1 |
| 18 | Elevated cy'tokine and chemokine levels in the placenta are associated with in-utero HIV- t mother-to-child transmission 显示文摘 | Kumar SB Rice CE Milner DA Jr | 2012 | AIDS2012，26，6： | 1 |
| 19 | Femtosecond sub-bowman keratomileusis : a prospective,long-term,intereye comparison of safety and outcomes of 90-vereus 100-jijn flaps显示文摘 | Prakash G Agarwal A Kumar DA Chari M Agarwal A Jacob S | 2011 | Am J Ophthalmol2011，152，4： | 1 |
| 20 | Epicardial Adipose Tissue as a Source of Nuclear Factor-κB and c-Jun N-Terminal Kinase Mediated Inflammation in Patients with Coronary Artery Disease显示文摘 | A R. Baker A L. Harte N Howell D C. Pritlove A M. Ranasinghe N F. da Silva E M. Youssef K Khunti M J. Davies R S. Bonser S Kumar D Pagano P G. McTernan | 2009 | The Journal of Clinical Endocrinology & Metabolism2009，，： | 1 |
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