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| 1 | Gastrointestinal endoscopy biopsy derived proteomic patterns predict indeterminate colitis into ulcerative colitis and Crohn's colitis显示文摘Patients with indeterminate colitis(IC) are significantly younger at diagnosis with onset of symptoms before the age of 18 years with significant morbidity in the interim. The successful care of IC is based on microscopic visual predict precision of eventual ulcerative colitis(UC) or Crohn's colitis(CC) which is not offered in 15%-30% of inflammatory bowel disease(IBD) patients even after a combined state-of-the-art classification system of clinical, visual endoscopic, radiologic and histologic examination. These figures have not changed over the past 3 decades despite the introduction of newer diagnostic modalities. The patient outcomes after restorative proctocolectomy and ileal pouch-anal anastomosis may be painstaking if IC turns into CC. Our approach is aiming at developing a single sensitive and absolute accurate diagnostic test tool during the first clinic visit through endoscopic biopsy derived proteomic patterns. Matrix-assisted-laser desorption/ionization mass spectrometry(MS) and/or imaging MS technologies permit a histology-directed cellular test of endoscopy biopsy which identifies phenotype specific proteins, as biomarker that would assist clinicians more accurately delineate IC as beingeither a UC or CC or a non-IBD condition. These novel studies are underway on larger cohorts and are highly innovative with significances in differentiating a UC from CC in patients with IC and could lend mechanistic insights into IBD pathogenesis. | Billy Ray Ballard Amosy Ephreim M'Koma | 2015 | World Journal of Gastrointestinal Endoscopy2015，7，7： | 7 |
| 2 | Scirrhous hepatocellular carcinoma displaying atypical findings on imaging studies显示文摘We describe a 15-mm scirrhous hepatocellular carcinoma(HCC) in a 60-year-old man with B-type cirrhosis.Ultrasound disclosed a 15-mm hypoechoic nodule in segment 7.Contrast-enhanced US revealed heterogeneous,not diffuse,hypervascularity in the early phase and a defect in the Kupffer phase.Contrast-enhanced computed tomography(CT) revealed a heterogeneous hypervascular nodule in the early phase and a low-density area in the late phase.Magnetic resonance imaging(MRI) revealed iso-to hypointensity at T1 and high intensity at T2-weighted sequences.Contrast-enhanced MRI also revealed a heterogeneous hypervascular nodule in the early phase and washout in the late phase.Super-paramagnetic iron oxide-MRI revealed a hyperintense nodule.CT during hepatic arteriography and CT during arterial portography revealed heterogeneous hyperattenuation and a perfusion defect,respectively.Based on these imaging findings the nodule was diagnosed as a mixed well-differentiated and moderately-differentiated HCC.Histologically,the nodule was moderately-differentiated HCC characterized by typical cytological and structural atypia with dense fibrosis.Immunohistochemically,the nodule was positive for heterochromatin protein 1 and alpha-smooth muscle actin,and negative for cytokeratin 19.From the above findings,the nodule was diagnosed as scirrhous HCC.Clinicians engaged in hepatology should exercise caution with suspected scirrhous HCC when imaging studies reveal atypical findings,as shown in our case on the basis of chronic liver disease. | Soo Ryang Kim Susumu Imoto Taisuke Nakajima Kenji Ando Keiji Mita Katsumi Fukuda Ryo Nishikawa Yu-ichiro Koma Toshiyuki Matsuoka Masatoshi Kudo Yoshitake Hayashi | 2009 | World Journal of Gastroenterology2009，15，18： | 4 |
| 3 | Programmed cell death during terminal bud senescence in a sympodial branching tree, Eucommia ulmoides显示文摘Eucommia ulmoides Oliv. is a typical sympodial branching tree. The apical bud of the branch ages and dies every year, replaced by the nearby axillary bud in the second year. Structural assays and a series of biochemical analyses were performed to analyze the senescence mechanism in the apical bud. It was revealed that most cells of the apical bud underwent the programmed cell death (PCD) during the senescence: the chromosomes were congregated and the nuclear contents were condensed, as shown by 4′,6-diamidino-2-phenylindole (DAPI) fluorescence. DNA fragmentation was detected during senescence using the terminal deoxynucleotidyl transferase (TdT)-mediated dUTP nick end in situ labeling (TUNEL) method, coincident with the appearance of a DNA ladder. Moreover, a 20 kD DNase related to fragmentation was found. PCD was initiated first in the young leaves, leaf primordia and peripheral zone cells, then in the central mother cells and initial layer cells in the apical meristem. The terminal buds remain in vegetative growth during senescence, in contrast to buds of many annual plants. | Kalima-N'Koma MWANGE | 2004 | Progress in Natural Science:Materials International2004，14，8： | 3 |
| 4 | Development of a serotyping enzyme-linked immunosorbent assay system based on recombinant truncated hantavirus nucleocapsid proteins for New World hantavirus infection显示文摘 | Takaaki Koma Kumiko Yoshimatsu Midori Taruishi Daisuke Miyashita Rika Endo Kenta Shimizu Shumpei P. Yasuda Takako Amada Takahiro Seto Ryo Murata Haruka Yoshida Hiroaki Kariwa Ikuo Takashima Jiro Arikawa | 2012 | Journal of Virological Methods2012，，1： | 2 |
| 5 | 杜仲形成层休眠机理(英文)显示文摘对杜仲 (EucommiaulmoidesOliv .)一年生枝条休眠中的芽和维管形成层的结构和蛋白质含量进行了研究 ,探讨了杜仲不同休眠期转化的生理生化机理。结果证实了杜仲树的休眠期包括 2个被动休眠期和一个生理休眠期。在生理休眠期 ,无论用外源IAA处理 ,还是给予适当的温度和光照 ,形成层都不能恢复活动。而且 ,雌株进入各个休眠阶段的时间都比雄株早。树皮中的蛋白质含量在第一被动休眠期间 (Q1)显著地逐步增高 (P <0 .0 1) ,进入生理休眠期 (R)后 ,急剧降低 ,但第二被动休眠期 (Q2 )开始后又显著升高 (P <0 .0 1)。杜仲雌雄株树皮中的蛋白质含量变化趋势基本一致 ,但雄株发生变化的时间比雌株早。SDS_PAGE电泳结果表明 ,在Q1 R Q2的转变期出现一11.8kD的特异蛋白条带。此特异蛋白条带可能与形成层休眠期中各阶段的转变调节有关。 | Kalima N’Koma MWANGE 王学文 崔克明 | 2003 | Acta Botanica Sinica2003，45，6： | 1 |
| 6 | Weyl symmetric representation of hadronic flux tubes in the dual GinzburgLandau theory 显示文摘 | KOMA Y IIGENFRITZ E M SUZUKI T | 2001 | Phys Rev2001，64，： | 1 |
| 7 | Discovery of 1-[4-( N -benzylamino)phenyl]-3-phenylurea derivatives as non-peptidic selective SUMO-sentrin specific protease (SENP)1 inhibitors显示文摘 | Masaharu Uno Yosuke Koma Hyun Seung Ban Hiroyuki Nakamura | 2012 | Bioorganic & Medicinal Chemistry Letters2012，，16： | 1 |
| 8 | H5N1 avian influenza virus induces apoptotic cell death in mammalian airway epithelial cells 显示文摘 | Daidoji T Koma T Du A | 2008 | J Virol2008，82，11： | 1 |
| 9 | Rapid, whole blood diagnostic test for detecting anti-hantavirus antibody in rats显示文摘 | Takako Amada Kumiko Yoshimatsu Shumpei P. Yasuda Kenta Shimizu Takaaki Koma Nobuhito Hayashimoto Chandika D. Gamage Sanae Nishio Akira Takakura Jiro Arikawa | 2013 | Journal of Virological Methods2013，，： | 1 |
| 10 | Endothelium-dependent and independent relaxation of the rat aorta by cyclic nucleotide phosphodiesterase inhibitors 显示文摘 | Komas N Lugnier C Stoclet JC | 1991 | Br J Pharmacol1991，104，： | 1 |
| 11 | Increased red blood cell distribution width associates with cancer stage and prognosis in patients with lung cancer显示文摘 | Koma Y Onishi A Matsuoka H | 2013 | PLoS One2013，，80： | 1 |
| 12 | IGSF4 : a new intercellular ad- hesion molecule that is called by three names, TSLC1, SgIGSF and SynCAM, by virtue of its diverse function显示文摘 | Watabe K ho A Koma YI | 2003 | Histol Histopathol2003，18，4： | 1 |
| 13 | Comparison of surgical results after pneumonectomy and sleeve lobectomy for non-small cell lung cancer: trends over time and 20-year institutional experience 显示文摘 | Takeda S Maeda H Koma M | 2006 | Eur J Cardiothorac Surg2006，29，3： | 1 |
| 14 | Single administration toxicity studies of T-3761 in mice,rats and dogs显示文摘 | Nakagawa S Iwai N Komae N | 1995 | Jpn J Antibiot1995，48，6： | 1 |
| 15 | ]genA] a]phA-Actinin-4:purification And puromycin aminonucleoside binding property显示文摘 | Goto H Wakui H Koma%uda A | 2005 | Nephron Exp Nephroi2005，95，1： | 1 |
| 16 | Reproductive and developmental toxicity study of T-3762 in rats administered intravenously during the period of organogenesis显示文摘 | Komae N Sanzen T Kozaki T | 1998 | Jpn J Antibiot1998，51，11： | 1 |
| 17 | Con- ceptual design study on advanced aqueous repro- cessing system for fast reactor fuel eycle显示文摘 | TAKATA T KOMA Y SATO K | 2004 | Journal of Nuclear Science and Technology2004，41，3： | 1 |
| 18 | Localization of 14-3-3σ/ζon the neuronal cell surface显示文摘 | Yamamoto Y Koma H Yagami T | 2015 | Exp Cell Res2015，338，2： | 1 |
| 19 | Ultracy to chemical localization of ATPase during the secondary xylem differentiation and differentiation in Eucommia ulmoides Trunk显示文摘 | Wang Y Q Kalina-N Koma M W | 2000 | Acta Botan Sinica2000，42，5： | 1 |
| 20 | Chemokine markers predict biochemical recurrence of prostate cancer following prostatectomy显示文摘 | Blum D L Koyama T M'Koma A E | 2008 | Clin Cancer Res2008，14，23： | 1 |
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