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| 1 | A critical role of IL-17 in modulating the B-cell response during H5N1 influenza virus infection显示文摘Interleukin-17(IL-17),a member of the IL-17 cytokine family,plays a crucial role in mediating the immune response against extracellular bacteria and fungi in the lung.Although there is increasing evidence that IL-17 is involved in protective immunity against H1 and H3 influenza virus infections,little is known about the role of IL-17 in the highly pathogenic H5N1 influenza virus infection.In this study,we show that H5N1-infected IL-17 knockout(KO)mice exhibit markedly increased weight loss,more pronounced lung immunopathology and significantly reduced survival rates as compared with infected wild-type controls.Moreover,the frequency of B cells in the lung were substantially decreased in IL-17 KO mice after virus infection,which correlated with reduced CXCR5 expression in B cells and decreased CXCL13 production in the lung tissue of IL-17 KO mice.Consistent with this observation,B cells from IL-17 KO mice exhibited a significant reduction in chemokine-mediated migration in culture.Taken together,these findings demonstrate a critical role for IL-17 in mediating the recruitment of B cells to the site of pulmonary influenza virus infection in mice. | Xiaohui Wang Chris CS Chan Min Yang Jun Deng Vincent KM Poon Virtual HC Leung King-Hung Ko Jie Zhou Kwok Yung Yuen Bo-Jian Zheng Liwei Lu | 2011 | Cellular & Molecular Immunology2011，8，6： | 2 |
| 2 | Liver abscess forma- tion after transarterial chemoembolization for malignanthepat- ic tumor 显示文摘 | Huang SF Ko CW Chang CS | 2003 | Hepatogastroenterology2003，50，52： | 1 |
| 3 | Liver abscess formation after transarterial chemoembolization for malignant hepatic tumor显示文摘 | Huang SF Ko CW Chang CS | 2003 | Hepatogastroenterology2003，50，52： | 1 |
| 4 | Prevalence of extended-spectrum betalactamases in Escherichia coli and Klebsiella pneumoniae from Daejeon Korean显示文摘 | Ko CS Sung JY | 2007 | Lab Med2007，27，5： | 1 |
| 5 | Liver abscess formation after transarterial chemoembolization for malignant hepatic tumor 显示文摘 | Huang SF Ko CW Chang CS | 2003 | Hepatogastroenterology2003，50，52： | 1 |
| 6 | A genetic algorithm approach to developing the multi-echelon reverse logistics network for product returns显示文摘 | Min H Ko HJ Ko CS | 2006 | Omega2006，34，1： | 1 |
| 7 | The accuracy of video imaging prediction in soft tissue outcome after bimaxillary orthognathic surgery 显示文摘 | Lu CH Ko EW Huang CS | 2003 | J Oral Maxillofac Surg2003，61，3： | 1 |
| 8 | Psychiatric Comorbidity of Internet Addiction in College Students:An Interview Study显示文摘 | Ko CH Yen JY Chen CS | 2008 | CNS Spectr2008，13，2： | 1 |
| 9 | Psychiatric comorbidity of Internet addiction in college students:an interview study显示文摘 | Ko CH Yen JY Chen CS | | 0，，02： | 1 |
| 10 | Mandibular lengthening by distraction osteogenesis in children -a one-year follow -up study 显示文摘 | Huang CS Ko WC Lin WY | 1999 | Cleft Palate Craniofac J1999，36，3： | 1 |
| 11 | The ginsenoside metabolite compound K, a novel agonist of glucocorticoid receptor, induces tolerance to endotoxin-induced lethal shock 显示文摘 | Yang CS Ko SR Cho BG | 2008 | J Cell Mol Med2008，12，5： | 1 |
| 12 | Importance of genetic factors in the etiology of atopic dermatitis : a twin study显示文摘 | Thomsen SF Ulrik CS Kyvik KO | 2007 | Allergy Asthma Proc2007，28，5： | 1 |
| 13 | Prevalence of extendedspectrum lactamases in Escherichia coli and Klebsiella pneumoniae from Daejeon显示文摘 | Ko CS Sung JY Koo SH | 2007 | Korean J Lab Med2007，27，5： | 1 |
| 14 | Type II collagen-chondroitin sulfate-hyaluronan scaffold cross-linked by genipin for cartilage tissue engineering显示文摘 | Ko CS Huang JP Huang CW | 2009 | Journal of Bioscience and Bioengineering2009，107，： | 1 |
| 15 | Serum and pleural fluid procalcitonin in predicting bacterial infection in patients with parapneumonic effusion显示文摘 | Ko YC Wu WP Hsu CS | 2009 | J Korean Med Sci2009，24，3： | 1 |
| 16 | Symmetry of the nose afterpresurgical nasoalveolar molding in infants with unilateralcleft lip and palate:a preliminary study显示文摘 | Pai BC Ko EW Huang CS | 2005 | Cleft Palate Cra-niofac J2005，42，6： | 1 |
| 17 | The association between dyslipidaemia and obesity in Chinese men after adjustment for insulin resistance显示文摘 | Ko GT Chan JC Cockram CS | 1998 | Atherosclerosis1998，138，1： | 1 |
| 18 | Comparison of transverse dimension-al changes in surgical skeletal Class III patients with and without presurgical orthodontics显示文摘 | Wang YC Ko EW Huang CS | | 0，，08： | 1 |
| 19 | Varying postprandial abdominovagal and cardiovagal activity in normal subjects 显示文摘 | Chang CS Ko CW Lien HC | 2010 | Neurogastroenterol Motil2010，22，： | 1 |
| 20 | Mitochondrial-dependent, reactive oxygen species-independent apoptosis by myrieetin:roles of protein kinase C, cytochrome e, and caspase cascade 显示文摘 | Ko CH Shen SC Hsu CS | 2005 | Biochem Pharmaco12005，69，6： | 1 |
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