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| 1 | How the Bcl-2 family of proteins interact to regulate apoptosis显示文摘到 apoptosis 的房间的承诺主要被在 Bcl-2 蛋白质家庭的成员之间的蛋白质蛋白质相互作用管理。它的三个亚科有不同角色:BH3 仅仅,蛋白质经由他们的 BH3 领域由绑定触发 apoptosis 到支持幸存的亲戚,当 pro-apoptotic Bax 和 Bak 有一个必要下游的角色包含 organellar 膜和 caspase 激活的正式就职的混乱时。BH3 仅仅,蛋白质充当损坏传感器,由压力信号保持惰性直到他们的激活。一旦激活,他们被认为杂乱地绑在支持幸存的蛋白质目标,但是意外选择最近从他们的相互作用的分析出现了。BH3 仅仅,蛋白质也绑在 Bax 和 Bak 的一些。Bax 和 Bak 是否被这些 BH3 仅仅直接激活蛋白质,或间接地作为后果 BH3 仅仅蛋白质抵销他们的支持幸存的目标是强烈争论的题目。不管这,在家庭成员之间的相互作用的详细理解,经常选择,为设计反癌症药指向 Bcl-2 家庭有著名含意。 | Mark F van Delft David CS Huang | 2006 | Cell Research2006，16，2： | 38 |
| 2 | The relation between HLA-DQA1 genes and genetic susceptibility to duodenal ulcer in Wuhan Hans显示文摘AIM To study the genetic susceptibility of HLA-DQA1 alleles to duodenal ulcer in Wuhan Hans.METHODS Seventy patients with duodenalulcer and fifty healthy controls were examinedfor HLA-DQA1 genotypes.HLA-DQA1 typing wascarried out by digesting the locus specificpolymerase chain reaction amplified productswith alleles specific restriction enzymes(PCR-RFLP),i.e.,Apal Ⅰ,Bsaj Ⅰ,Hph Ⅰ,Fok Ⅰ,Mbo Ⅱ and Mnl Ⅰ.RESULTS The allele frequencies of DQA1 * 0301and DQA1 * 0102 in patients with duodenal ulcerwere significantly higher and lower respectivelythan those in healthy controls(0.40 vs 0.20,P = 0.003,mcorret = 0.024)and(0.05 vs 0.14,P = 0.012,but Pcorret>0.05),respectively.CONCLUSION DQA1 * 0301 is a susceptiblegene for duodenal ulcer in Wuhan Hans,andthere are immunogenetic differences in HLA-DQA1 locus between duodenal ulcer patients andhealthy controls. | Du YP Deng CS Lu DY Huang MF Guo SF Hou W | 2000 | World Journal of Gastroenterology2000，6，1： | 37 |
| 3 | TT viral infection through blood transfusion:retrospective investigation on patients in a prospective study of post-transfusion hepatitis显示文摘AIM To investigate the role of bloodtransfusion in TT viral infection(TTV).METHODS We retrospectively studied serumsamples from 192 transfusion recipients whounderwent cardiovascular surgery and bloodtransfusion between July 1991 and June 1992.Allpatients had a follow-up every other week for atleast 6 months after transfusion.Eightyrecipients received blood before screeningdonors for hepatitis C antibody(anti-HCV),and112 recipients received screened blood.Recipients with alanine aminotransferase level>2.5 times the upper normal limit were testedfor serological markers for viral hepatitis A,B,C,G,Epstein-Barr virus and cytomegalovirus.TTV infection was defined by the positivity forserum TTV DNA using the polymerase chainreaction method.RESULTS Eleven and three patients,whoreceived anti-HCV unscreened and screened'blood,respectively,had serum ALT levels>90 IU/L.Five patients(HCV and TTV:1;HCV,HGV,and TTV:1;TTV:2;and CMV and TTV:1)were positive for TTV DNA,and four of them hadsero-conversion of TTV DNA.CONCLUSION TTV can be transmitted viablood transfusion.Two recipients infected byTTV alone may be associated with the hepatitis.However,whether TTV was the causal agentremains unsettled,and further studies arenecessary to define the role of TTV infection inchronic hepatitis. | Yang SS Wu CH Chen TH Huang YY Huang CS | 2000 | World Journal of Gastroenterology2000，6，1： | 8 |
| 4 | Thymoma is associated with relapse of symptoms after transsternal thymectomy for myasthenia gravis 显示文摘 | Hsu HS Huang CS Huang BS | 2006 | Interact Cardiovasc Thorac Surg2006，5，1： | 1 |
| 5 | A new approach for laparoscopic ovarian transposition before pelvic irradiation 显示文摘 | Huang KG Lee CL Tsai CS | 2007 | Gynecol Oncol2007，105，1： | 1 |
| 6 | Use of vacuum-assisted wound closure to manage limb wounds in patients suffering from acute necr- otizing fasciitis显示文摘 | Huang WS Hsieh SC Hsieh CS | 2006 | Asian J Surg2006，29，3： | 1 |
| 7 | New 5eco-prezizaane-type sesquiterpenes, jiadifenin with neurotrophic activity and1,2-dehydro-neomajucin from Illicium jiadifengpi 显示文摘 | Yokoyama R Huang JM Yang CS | 2002 | J NatProd2002，65，： | 1 |
| 8 | Hydrogen inhalation ameliorates ventilator-induced lung injury 显示文摘 | Huang CS Kawamura T Lee S | 2010 | Crit Care2010，14，： | 1 |
| 9 | Merrilactone A, a novel neurotrophic sesquiterpene dilactone from lllicium merrillianum 显示文摘 | Huang JM Yokoyama R Yang CS | 2000 | Tetrahedron Lett2000，41，32： | 1 |
| 10 | The partners' inseeure attaehment, depression, and psyehololgieal well-being predictors of diurnal eortisol patterns for breast cancer survivors and their spouses显示文摘 | Jow GM Kuo WH Huang CS Lai YM Liu YF Chang KJ | 2004 | Hsiao FH Stress2004，37，2： | 1 |
| 11 | Lymphocytes in the development of lung inflammation : a role for regulatory CD4 + T cells in indirect pulmonary lung injury 显示文摘 | Venet F Chung CS Huang X | 2009 | J Immunol2009，183，5： | 1 |
| 12 | Hydrogen inhalation re- duced epithelial apoptosis in ventilator-induced lung injury via a mechanism involving nuclear factor-kappa B activatlon显示文摘 | Huang CS Kawamura T Peng X | 2011 | Bio- ehem Biophys Res Commun2011，408，2： | 1 |
| 13 | Intensive blood pressure reduction in acute cerebral haemorrhage trial (INTERACT): a randomised pilot trial显示文摘 | Anderson CS Huang Y Wang JG | 2008 | Lancet Neurol2008，7，5： | 1 |
| 14 | Surgical improvement of brain edema related to hypertensive intracerebral hemorrahage 显示文摘 | Huang CF Tsai ZP Li CS | 2002 | Zhonghua Yi Xue Za Zhi( TAIBEI )2002，65，6： | 1 |
| 15 | Laparoscopic repair of vesicovaginal fistula显示文摘 | Ou CS Huang UC Tsuang M | | 0，，01： | 1 |
| 16 | Liver abscess forma- tion after transarterial chemoembolization for malignanthepat- ic tumor 显示文摘 | Huang SF Ko CW Chang CS | 2003 | Hepatogastroenterology2003，50，52： | 1 |
| 17 | Antioxidant, antinoeiceptive, and anti-inflammatory activities of Xan- thii Fructus extract 显示文摘 | Huang MH Wang BS Chiu CS | 2011 | J Ethnopharmacol2011，135，2： | 1 |
| 18 | Interdental distraction osteogenesis and rapid orthodontic tooth movement: A novel approach to approximate a wide alveolar cleft or bony defect显示文摘 | Liou EJ Chen PK Huang CS | 2000 | J Plast Reconstr2000，105，4： | 1 |
| 19 | Breast cancer risk associated with genotype polymorphism of the catechol estrogen metabolizing genes : a multigenic study on cancer susceptibility 显示文摘 | Cheng TC Chen ST Huang CS | 2005 | Int J Cancer2005，113，3： | 1 |
| 20 | Therapeutic effects of baicalin on lipopolysaccharide-induced acute lung injury in rats 显示文摘 | Huang KL Chen CS Hsu CW | 2008 | Am J Chin Med2008，36，2： | 1 |
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