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| 1 | Outcome of patients with acute, necrotizing pancreatitis requiring drainage-does drainage size matter?显示文摘AIM:To assess the outcome of patients with acute necrotizing pancreatitis treated by percutaneous drainage with special focus on the influence of drainage size and number. METHODS:We performed a retrospective analysis of 80 patients with acute pancreatitis requiring percutaneous drainage therapy for infected necroses. Endpoints were mortality and length of hospital stay. The influence of drainage characteristics such as the median drainage size, the largest drainage size per patient and the total drainage plane per patient on patient outcome was evaluated. RESULTS:Total hospital survival was 66%. Thirty-four patients out of all 80 patients (43%) survived acute necrotizing pancreatitis with percutaneous drainage therapy only. Eighteen patients out of all 80 patients needed additional percutaneous necrosectomy (23%). Ten out of these patients required surgical necrosectomy in addition, 6 patients received open necrosectomy without prior percutaneous necrosectomy. Elective surgery was performed in 3 patients receiving cholecystectomy and one patient receiving resection of the parathyroid gland. The number of drainages ranged from one to fourteen per patient. The drainage diameter ranged from 8 French catheters to 24 French catheters. The median drainage size as well as the largest drainage size used per patient and the total drainage area used per patient did not show statistically significant influence on mortality. CONCLUSION:Percutaneous drainage therapy is an effective tool for treatment of necrotizing pancreatitis.Large bore drainages did not prove to be more effective in controlling the septic focus. | T Bruennler J Langgartner S Lang CE Wrede F Klebl S Zierhut S Siebig F Mandraka F Rockmann B Salzberger S Feuerbach J Schoelmerich OW Hamer | 2008 | World Journal of Gastroenterology2008，14，5： | 23 |
| 2 | Significance of scintigraphy for the localisation of obscure gastrointestinal bleedings显示文摘AIM: To determine the role of scintigraphy in patients with gastrointestinal (GI) bleeding of unknown localisation. METHODS: We performed retrospective analyses on 92 patients receiving scintigraphies from 1993 to 2000 in the University of Regensburg hospital, which were done for localisation of GI bleeding as a diagnostic step after an unsuccessful endoscopy. In addition to the scintigraphies, further diagnostic steps such as endoscopy, angiography or operations were performed. In some of the scintigraphies with negative results, a provocation test for bleeding with heparinisation was carried out. RESULTS: 73% of all scintigraphies showed a positive result. In 4.5% of the positive results, the source was located in the stomach, in 37% the source was the small bowel, in 25% the source was the right colon, in 4.5% the source was the left colon, and in 20% no clear localisation was possible. Only 4% of all scintigraphies were false positive. A reliablepositive scintigraphy was independent of the age of the examined patient. A provocation test for bleeding with heparin resulted in an additional 46% of positive scintigraphies with a reliable localisation in primary negative scintigraphies. CONCLUSION: Our results show that scintigraphy and scintigraphy with heparin provocation tests are reliable procedures. They enable a reliable localisation in about half of the obscure GI-bleeding cases. Scintigraphy is superior to angiography in locating a bleeding. It is shown that even in the age of video capsule endoscopy and double-balloon enteroscopy, scintigraphy provides a reliable and directed localization of GI bleeding and offers carefully targeted guidance for other procedures. | Tanja Brünnler Frank Klebl Sascha Mundorff Christoph Eilles Michael Reng Hans von Korn Jürgen Schlmerich Julia Langgartner Stefan Grüne | 2008 | World Journal of Gastroenterology2008，14，32： | 3 |
| 3 | Protein kinase G from pathogenic mycobacteria promotes survival within macrophages显示文摘 | Walburger A Koul A Ferrari G Nguyen L PrescianottoBaschong C Huygen K Klebl B Thompson C Bacher G Pieters J | 2004 | Science2004，304，5678： | 1 |
| 4 | Ultrasound-guided per- cutaneous endoscopic gastrostomy in patients with negative diapha- noscopy 显示文摘 | Schlottmann K Klebl F Wiest R | 2007 | Endoscopy2007，39，8： | 1 |
| 5 | Role of protein kinase G in growth and glutamine metabolism of Mycobacterium bovis BCG显示文摘 | Nguyen L Walburger A Houben E Koul A Muller S Morbitzer M Klebl B Ferrari G Pieters J | 2005 | J Bacteriol2005，187，16： | 1 |
| 6 | Protein oxidation,tyrosine nitration,and inactivation of sarcoplasmic reticulum Ca^2+-ATPase in low-frequency stimulated rabbit muscle显示文摘 | Klebl BM Ayoub AT Pette D | 1998 | FEBS Lett1998，422，3： | 1 |
| 7 | Palliative therapy in cholangio-and gallbladder carcinoma显示文摘 | Klebl F Endlicher E Kullmann F | 2006 | Z Gastroenterol2006，44，7： | 1 |
| 8 | Protein kinase G from pathogenic mycobacteria promotes survival within macrophages显示文摘 | Walburger A Koul A Ferrari G Nguyen L Prescianotto-Baschong C Huygen K Klebl B Thompson C Bacher G Pieters J | 2004 | Science2004，304，5678： | 1 |
| 9 | Gleevec increases lev- els of the amyloid precursor protein intracellular domain and of the amyloid'beta degrading enzyme neprilysin显示文摘 | EISELE Y S BAUMANN M KLEBL B | 2007 | Molecular Biology of the Ce112007，18，9： | 1 |
| 10 | Risk factors for mortality in severe upper gastrointestinal bleeding显示文摘 | Klebl F Bregenzer N Schofer L | 2005 | Int J Colorectal Dis2005，20，1： | 1 |
| 11 | Fibrin glue in the endoscopic treatment of fistulae and anastomotic leakages of the gastrointestinal tract显示文摘 | Lippert E Klebl F Schweller F | | 0，，： | 1 |
| 12 | Functional expression of the Chlorella hcxose transporter in Schizosaccharomyces pombe显示文摘 | SAUER N CASPARI T KLEBL F | 1990 | PNAS1990，87，： | 1 |
| 13 | Histopathological parameters as predictors for the course of Crohn's disease显示文摘 | Bataille F Klebl F Rummele P | 2003 | Virchows Arch2003，443，4： | 1 |
| 14 | Serum soluble TNF receptor Ⅰ and Ⅱ levels correlate with disease activity in IBD patients 显示文摘 | Spoettl T Hausmann M Klebl F | 2007 | Inflam Bowel Dis2007，13，6： | 1 |
| 15 | Intraabdominal septic complications following bowel resection for Crohn’s disease: detrimental influence on long-term outcome显示文摘 | Igors Iesalnieks Alexandra Kilger Heidi Gla? Rene Müller-Wille Frank Klebl Claudia Ott Ulrike Strauch Pompiliu Piso Hans J. Schlitt Ayman Agha | 2008 | International Journal of Colorectal Disease2008，，12： | 1 |
| 16 | Protein kinase G from pathogenic mycobacteria promotes survival within maerophages 显示文摘 | Walburger A Koul A Ferrari G Nguyen L Prescianotto Baschong C Huygen K Klebl B Thompson C Bacher G Pieters J | 2004 | Science2004，304，5678： | 1 |
| 17 | Expression of macrophage-colony stimulating factor in normal and inflammatory bowel disease intestine显示文摘 | Klebl FH Olsen JE Jain S | 2001 | J Pathol2001，195，5： | 1 |
| 18 | Interplay between mycobacteria and host signalling pathways显示文摘 | Koul A Herget T Klebl B | 2004 | Nat Rev Microbiol2004，2，3： | 1 |
| 19 | Histopathological parameters as predictors for the course of Crohn's disease显示文摘 | Bataille F Klebl F Ruimmele P | 2003 | Virchows Arch2003，443，7： | 1 |
| 20 | Therapy insight:prophylaxis of stress-in-duced gastrointestinal bleeding in critically ill patients 显示文摘 | Klebl FH Scholmerich J | 2007 | Nat Clin Pract Gastmenterol Hepatol2007，4，10： | 1 |
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