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| 1 | AGNP精神科治疗药物监测共识指南:2011显示文摘治疗药物监测(Therapeutic drug monitoring,TDM),如通过定量测定血清或血浆药物浓度指导用药剂量优化,已经成为对患者进行精神药物治疗的很有价值的工具。在患者用药依从性难以判断、药物耐受性不佳、治疗剂量下无效以及可能存在药代动力学药物-药物相互作用等情况下,测定药物浓度是很有用的。在精神科,有可能明显获益于TDM的主要患者群体包括儿童、孕妇、老年患者、智力障碍患者、涉及司法的患者、已知或怀疑携带药代动力学相关基因变异的患者,以及合并躯体疾病影响药代动力学的患者。然而,只有将TDM充分整合到临床治疗过程中去,才能发挥其优化药物治疗的潜在优势。为了促进TDM的合理应用,神经精神药理学与药物精神病学协会(Arbeitsgemeinschaft für Neuropsychopharmakologie und Pharmakopsychiatrie,AGNP)的TDM专家组在2004年发表了精神药物治疗药物监测指南。之后,随着知识不断更新,又有许多可能需要进行TDM的新药上市。因此,本次更新将神经精神药物的种类扩展到了128种,并将其TDM必要性划分为从'强烈推荐'到'可能有用'的四个等级。经过大量细致且全面的文献检索与分门别类的汇总整理,将基于循证医学理念的'治疗参考浓度范围'和'剂量相关参考浓度范围'呈现给大家。本共识指南引入了'实验室警戒浓度'的新概念,即实验室需要马上告知治疗医生的药物浓度上限。本共识指南还给出了诸如药物作为细胞色素P450酶的底物和抑制剂的性质,代谢物与母药浓度比值的常见范围,以及与结果解释相关的内容,还提供了何时将TDM与遗传药理学检测相结合的建议。遵循本指南,有助于改善许多患者精神药物治疗的效果,特别是那些存在药代动力学异常的患者。TDM是一门交叉学科,有时针对看起来不一致的数据,需要多学科坦诚地讨论,只有这样,患者才能从这种合作中获益。 | Hiemke C Baumann P Bergemann N Conca A Dietmaier O Egberts K Fric M Gerlach M Greiner C Gründer G Haen E Havemann-Reinecke U Jaquenoud Sirot E Kirchherr H Laux G Lutz UC Messer T Müller MJ Pfuhlmann B Rambeck B Riederer P Schoppek B Stingl J Uhr M Ulrich S Waschgler R Zernig G 李文标(译) 果伟(译) 阮灿军(译) 贺静(译) 汤宜朗(审校) 王传跃(审校) | 2016 | 实用药物与临床2016，19，10： | 37 |
| 2 | From crystalluria to kidney stones,some physicochemical aspects of calcium nephrolithiasis显示文摘Nephrolithiasis seems to be the result of crystal formation,aggregation and retention in the kidney during crystalluria.These processes have to occur within the short urinary transit time through the kidney being in the order of few minutes.Recently much work was done on rather qualitative aspects of nephrolithiasis like genetics,metabolism and morphology.In this review we try to provide some quantitative information on urinary supersaturation with respect to stone minerals,especially Ca oxalate(CaO x),on the formation and aggregation of Ca Ox crystals and on crystal retention in the kidney.The paper is centered on idiopathic Ca nephrolithiasis being the most frequent stone disease with only partially known pathogenesis.New aspects of the role of urinary macromolecules in stone formation and of the mechanism of crystal aggregation are provided. | Johannes M Baumann Beat Affolter | 2014 | World Journal of Nephrology2014，3，4： | 4 |
| 3 | The CSIRO automatic tester for length and strength 显示文摘 | Tompson R L Andrews M W Baumann A B | 1988 | J Text Inst1988，，79： | 2 |
| 4 | Preddctive factors in radiotheraphy for non-mall cell lung cancer:presentstatus 显示文摘 | Choi N Baumann M Flentjie M | 2001 | Lung Cancer2001，3，1： | 2 |
| 5 | Antibiotic Resistance in Salmonella Isolates from Imported Chicken Carcasses in Bhutan and from Pig Carcasses in Vietnam显示文摘 | Ellerbroek L Narapati D Tai N Phu Poosaran N Pinthong R Sirimalaisuwan A Tshering P Fries R Zessin K-h Baumann M Schroeter A | 2010 | Journal of Food Protection2010，，2： | 2 |
| 6 | Inhi- bition of Denitrification Activity but not of mRNA Induction in Paracoccus denitrificans by Nitrite at a Suboptimal pH 显示文摘 | BAUMANN B VAN DER MEER J R SNOZZI M | 1997 | Antonie van Leeuwenhoek1997，72，： | 1 |
| 7 | DNA self-recognition in the structure of Potl bound to telomeric single-stranded DNA显示文摘 | Lei M Podell E R Baumann P | 2003 | Nature2003，426，6963： | 1 |
| 8 | Linear-quadratic analysis of tumour response to fractionated radiotherapy: a study on human squamous cell carcinoma xenografts显示文摘 | Petersen C Baumann M Dubben H H | 1998 | Int J Radiat Biol1998，73，2： | 1 |
| 9 | Towards genetic prediction of radiation responses: ESTRO's GENEPI project 显示文摘 | Baumann M Holscher T Begg AC | 2003 | Radiother Oncol2003，69，2： | 1 |
| 10 | Effect of ozone dosage and hydrodynamic conditions on the permeate flux in a hybrid ozonation-ceramic ultrafiltration system treating natural waters显示文摘 | Kim J Davies S H R Baumann M J | 2008 | J Membr Sci2008，311，12： | 1 |
| 11 | Resveratrol modulates DNA double strand break repair pathways in an ATM/ATR- p53 and Nbs1-dependent manner显示文摘 | Gatz SA Keimling M Baumann C | 2008 | Carcinogenesis2008，29，3： | 1 |
| 12 | Species specific re- sponses of calcifying algae to changing seawater carbonate chemis- try 显示文摘 | Langer G Geisen M Baumann K H | 2006 | Geochemistry Geophysics Geosystems2006，7，9： | 1 |
| 13 | Stereotactic body radiotherapy for medically inoperable patients with stage I non-small cell lung cancer-a first report of toxicity related to COPD/CVD in a non-randomized prospective phaseⅡstudy显示文摘 | BAUMANN P NYMAN J HOYER M | | 0，，03： | 1 |
| 14 | In situ spatially and temporally resolved measurements of salt concentration between charging porous electrodes for desalination by capacitive deionization 显示文摘 | Suss M E Biesheuvel P M Baumann T F | 2014 | Environmental Science & Technology2014，48，3： | 1 |
| 15 | Prehypertensive renin - angiotensin - aldosterone system blockade in spontaneously hypertensive rats ameliorates the loss of long - term vascular function 显示文摘 | Baumann M Megens R Bartholome R | 2007 | Hypertens Res2007，30，9： | 1 |
| 16 | Growth hormone receptor is a target for presenilin-dependent gam- ma-secretase cleavage 显示文摘 | Cowan J W Wang X D Guan R He K Jiang J Baumann G Black R A Wolfe M S Frank S J | 2005 | J Biol Chem2005，280，19： | 1 |
| 17 | Association of ambulatory arterial stiff- ness index and brachial pulse pressure is restricted to dippers显示文摘 | Baumann M Dan L Nurnberger J | 2008 | J Hyper- tens2008，26，2： | 1 |
| 18 | Dose and fractionation conccpts in the primary radiotherapy of non - small cell lung cancer显示文摘 | Baumann M Appold S Petersen C | 2001 | Lung Cancer2001，331，： | 1 |
| 19 | Insulin-stimulated GLUT4 translocation requires the CAP-dependent activation of TC10显示文摘 | Chiang SH Baumann CA Kanzaki M | 2001 | Nature2001，410，6831： | 1 |
| 20 | Measurements of PAN,PPN,and MPAN made during the 1994 and 1995 Nashville Intensive of Southern Oxidant Study:Implications for regional Ozone production from biogenic hydrocarbons显示文摘 | Roberts J M Williams J Baumann K | 1998 | J Geophys Res1998，109，22： | 1 |
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