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| 1 | 超重和正常体质量患者的心力衰竭新发率的荟萃分析显示文摘肥胖和新发心力衰竭之间的关系已经反复确立,关于超重与心力衰竭发展风险知之甚少。该系统回顾和荟萃分析旨在探讨超重、肥胖与新发心力衰竭发生率的关系。在该研究中,研究者从数据库创建开始到2017年6月,系统检索了MEDLINE,Medline InProcess and Other Non-Indexed Citations,EMBASE,Scopus和Cochrane对照试验中心登记册。 | Krittanawong C Tunhasiriwet A Wang Z Zhang H Prokop LJ Chirapongsathorn S Sun T Kitai T Tang WHW 刘青 叶鹏 | 2018 | 中华高血压杂志2018，26，4： | 4 |
| 2 | The relationship between tyrosine kinase inhibitor therapy and overall survival in patients with non-small cell lung cancer carrying EGFR mutations显示文摘For patients with epidermal growth factor receptor (EGFR) mutation-positive lung cancer, the relationship between the dose or duration of treatment with tyrosine kinase inhibitor (TKI) and overall survival remains unclear. Here, we analyzed clinical data of 39 patients who were diagnosed with EGFR mutation-positive non-small cell lung cancer and treated with TKI, but subsequently died. Several parameters were measured in this study: overall survival; first, second, and overall TKI therapy durations; first TKI intensity (actual dose/normal dose); and TKI rate (overall TKI therapy duration/overall survival). The response rate to TKI therapy was 50% , and the median survival was 553 days. After TKI therapy failed, 38.5% patients were re-challenged with TKI. We observed a moderate relationship [r = 0.534, 95% confidential interval (CI) = 0.263 to 0.727, P < 0.001] between overall TKI therapy duration and overall survival. However, we found no relationship between overall survival and first TKI intensity (r = 0.073, 95% CI = -0.380 to 0.247, P = 0.657) or TKI rate (r = 0.0345, 95% CI = -0.284 to 0.346, P = 0.835). Nonsmall cell lung cancer patients with mutation-positive tumors remained on TKI therapy for, on average, 33% of the overall survival time. These findings suggest that patients with EGFR mutation-positive tumors should not stick to using TKIs. | Hidekazu Suzuki Tomonori Hirashima Norio Okamoto Tadahiro Yamadori Motohiro Tamiya Naoko Morishita Takayuki Shiroyama Tomoyuki Otsuka Kanako Kitai Ichiro Kawase | 2013 | Chinese Journal of Cancer2013，32，3： | 3 |
| 3 | Signal transducer and activator of transcription 3 regulation by novel binding partners显示文摘Signal transducers and activators of transcription(STATs) mediate essential signals for various biological processes,including immune responses,hematopoiesis,and neurogenesis. STAT3,for example,is involved in the pathogenesis of various human diseases,including cancers,autoimmune and inflammatory disorders. STAT3 activation is therefore tightly regulated at multiple levels to prevent these pathological conditions. A number of proteins have been reported to associate with STAT3 and regulate its activity. These STAT3-interacting proteins function to modulate STAT3-mediated signaling at various steps and mediate the crosstalk of STAT3 with other cellular signaling pathways. This article reviews the roles of novel STAT3 binding partners such as DAXX,zipperinteracting protein kinase,Krüppel-associated box-associated protein 1,Y14,PDZ and LIM domain 2 and signal transducing adaptor protein-2,in the regulation of STAT3-mediated signaling. | Tadashi Matsuda Ryuta Muromoto Yuichi Sekine Sumihito Togi Yuichi Kitai Shigeyuki Kon Kenji Oritani | 2015 | World Journal of Biological Chemistry2015，6，4： | 2 |
| 4 | Contrast enhancement for ceramic insulator electroluminescent devices显示文摘 | Kitai AH | 1990 | J Electrochem Soc1990，137，9： | 1 |
| 5 | Propagation of moreton waves 显示文摘 | Zhang Y Kitai R Narukage N | 2011 | Publications of the Astronomical Society of Japan2011，63，3： | 1 |
| 6 | Increased platelet aggregability in response to shear stress in acute myocardial infarction and its inhibition by combined therapy with aspirin and cilostasol after coronary intervention 显示文摘 | Tanigawa T Nishikawa M Kitai T | 2000 | Am J Cardiol2000，85，3： | 1 |
| 7 | Cortical arousal induced by microinjection of orexins into the paraventricular nucleus of the rat显示文摘 | Sato-Suzuki I KitaI SCkiY | 2002 | Behavioural Brain Research2002，128，： | 1 |
| 8 | On the undetected error probability for shortened hamming codes 显示文摘 | Fujiwara T Kasami T Kitai A | 1985 | IEEE Transac- tions on Communications1985，33，6： | 1 |
| 9 | Comparison of systems for assessment of post-therapeutic response to sorafenib for hepatocellular carcinoma显示文摘 | Tadaaki Arizumi Kazuomi Ueshima Haruhiko Takeda Yukio Osaki Masahiro Takita Tatsuo Inoue Satoshi Kitai Norihisa Yada Satoru Hagiwara Yasunori Minami Toshiharu Sakurai Naoshi Nishida Masatoshi Kudo | 2014 | Journal of Gastroenterology2014，，12： | 1 |
| 10 | Differential Diagnosis of Hepatic Tumors: Value of Contrast-Enhanced Harmonic Sonography Using the Newly Developed Contrast Agent, Sonazoid显示文摘 | Hatanaka Kinuyo Kudo Masatoshi Minami Yasunori Ueda Taisuke Tatsumi Chie Kitai Satoshi Takahashi Shunsuke Inoue Tatsuo Hagiwara Satoru Chung Hobyung Ueshima Kazuomi Maekawa Kiyoshi | 2008 | Intervirology2008，，： | 1 |
| 11 | Noninvasive Evaluation of Hepatic Fibrosis Using Serum Fibrotic Markers, Transient Elastography (FibroScan) and Real-Time Tissue Elastography显示文摘 | Tatsumi Chie Kudo Masatoshi Ueshima Kazuomi Kitai Satoshi Takahashi Shunsuke Inoue Tatsuo Minami Yasunori Chung Hobyung Maekawa Kiyoshi Fujimoto Kenji Akiko Tonomura Takeshi Mitake | 2008 | Intervirology2008，，： | 1 |
| 12 | Detection by ELISA of antibodies to Japanese encephalitis virus nonstructural 1 protein induced in subclinically infected humans显示文摘 | Konishi E Kitai Y | | 0，，50： | 1 |
| 13 | Single burr hole surgery for the spheno-orbital fibrous dysplasia using intraoperative computed tomography显示文摘 | KITAI R SATO K IDO K | 2005 | Minim Invasive Neurosurg2005，48，： | 1 |
| 14 | Frontal Meningioma Incidentally Detected in the Routine Preoperative Assessment of Tongue Cancer: A Case Report and Literature Review显示文摘 | Kazuo Sano Ryuhei Kitai Hitoshi Yoshimura Seigo Ohba | 2013 | Journal of Oral and Maxillofacial Surgery2013，，12： | 1 |
| 15 | Epstein-Ban' virus-associat- ed primary central nervous system lymphoma in The Japanese popu- lation显示文摘 | Kitai R Matsuda K Adaehi E | 2010 | Neurol Med Chit (Tokyo)2010，50，2： | 1 |
| 16 | Differentiation of human liver-derived, insulin-producing cells toward the i3-cell phenotype显示文摘 | Zalzman M Anker- Kitai L Efrat S | 2005 | Diabetes2005，54，9： | 1 |
| 17 | Schwann cell transplantation improves reticulospinal axon growth and forelimb strength after severe cervical spinal cord contusion显示文摘 | Schaal SM Kitay BM Cho KS | 2007 | Cell Transplant2007，16，3： | 1 |
| 18 | Characterization of a novel human tumor necrosis factor-alpha mutant with increased cytotoxic activity 显示文摘 | Masegi T Kato A Kitai K | 1995 | Jpn J Cancer Res1995，86，1： | 1 |
| 19 | Membrane lipid saturation activates IRE 1α without inducing clustering显示文摘 | Yuto Kitai Hiroyuki Ariyama Nozomu Kono Daisuke Oikawa Takao Iwawaki Hiroyuki Arai | 2013 | Genes Cells2013，，9： | 1 |
| 20 | Trend of increase in the incidence of acute myocardial infarction in a Japanese population: Takashima AMI Registry, 1990-2001显示文摘 | RumanaN KitaY TurinTC | 2008 | Am J Epidemiol2008，167，13： | 1 |
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