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| 1 | Reduction of ischemia reperfusion injury after liver resection and hepatic inflow occlusion by α-lipoic acid in humans显示文摘AIM: To evaluate the protective effects of precondition- ing by α-lipoic acid (LA) in patients undergoing hepatic resection under inflow occlusion of the liver. METHODS: Twenty-four patients undergoing liver re- section for various reasons either received 600 mg LA or NaCl 15 min before transection performed under inflow occlusion of the liver. Blood samples and liver wedge bi- opsy samples were obtained after opening of the abdo- men immediately after inflow occlusion of the liver, and 30 min after the end of inflow occlusion of the liver. RESULTS: Serum levels of aspartate transferase and alanine transferase were reduced at all time points in patients who received LA in comparison to those who received NaCL. This was accompanied by reduced histo- morphological features of oncosis. We observed TUNEL- positive hepatocytes in the livers of the untreated patients, especially after 30 min of ischemia. LA attenu- ated this increase of TUNEL-positive hepatocytes. Under preconditioning with LA, ATP content was significantly enhanced after 30 min of ischemia and after 30 min of reperfusion. CONCLUSION: This is the first report on the poten- tial for LA reducing ischemia/reperfusion injury (IRI) of the liver in humans who were undergoing liver surgery. Beside its simple and rapid application, side effects did not occur. LA might therefore represent a new strategy against hepatic IRI in humans. | Fritz Dünschede Kirsten Erbes Achim Kircher Stefanie Westermann Joachim Seifert Arno Schad Kempski Oliver Alexandra K Kiemer Junginger Theodor | 2006 | World Journal of Gastroenterology2006，12，42： | 6 |
| 2 | Experimental and nu- merical simulation of a stainless steel coating subjected to ther- mal fatigue显示文摘 | REVEL P KIRCHER D BOGARD V | 2000 | Materials Scienee and Engineering: A2000，290，12： | 1 |
| 3 | Driver Experience and Cognitive Workload in Different Traffic Environments显示文摘 | Patten C J D Kircher A Ostlund J | | 0，，05： | 1 |
| 4 | Phenotype,function and chimaerism of monocyte-derived blood dendritic cells after allogeneic haematopoietic stem cell transplantation显示文摘 | Nachbaur D Kircher B Elisendle K | 2003 | British J Haematology2003，123，1： | 1 |
| 5 | Granzymes A and B serum levels in allo-SCT显示文摘 | Kircher B Schumacber P Nachbaur D | 2009 | Bone Marrow Transplant2009，43，10： | 1 |
| 6 | Neural correlates of metaphor processing 显示文摘 | Rapp A M Leube D T Erb M Grodd W Kircher T T | 2004 | Cognitive Brain Research2004，，3： | 1 |
| 7 | Pediatric pain manage- ment in the emergency department:the triage nurses' perspec- tive显示文摘 | Thomas D Kircher J Plint AC | 2015 | J Emerg Nuts2015，41，5： | 1 |
| 8 | Phenotype, function and chimaerism of monocyte derived blood dendritic cells after allogeneic haematopoietic stem cell transplantation显示文摘 | Nachbaur D Kircher B Eisendle K | 2003 | BrJ Haematol2003，123，1： | 1 |
| 9 | Coordinated regulation ofArabidopsis thaliana development by light and gibberellins显示文摘 | Feng S H Martinez C Gusmaroli G Wang Y Zhou J L Wang F Chen L Y Yu L Lglesias-Pedraz J M Kircher S Schifer E Fu X D Fan L M Deng X W | | 0，，： | 1 |
| 10 | Phenotype,function and chimaerism of monocyte-derived blood dendritic cells after allogeneic haematopoietic stem cell transplantation显示文摘 | NACHBAUR D KIRCHER B EISENDLE K | 2003 | Br J Haematol2003，123，1： | 1 |
| 11 | Frequency, sensitivity, and specificity of individual signs of diverticulitis on thin - section helical CT with colonic contrast material : experience with 312 cases显示文摘 | Kircher MF Rhea JT Kihiczak D | 2002 | AJR2002，178，6： | 1 |
| 12 | Experimental and numerical simulation of a stainless steel coating subjected to thermal fatigue显示文摘 | REVEL P KIRCHER D BOGARD V | 2000 | Materials Science and Engineering2000，290，12： | 1 |
| 13 | Haze in cellulose acetate显示文摘 | Eigner W D Billiani J kircher H W | 1963 | TAPPI1963，46，： | 1 |
| 14 | Plasmas as antennas: Theory, experiment and applications 显示文摘 | G G Borg J H Harris N M Martin D Thorncraft R Milliken D G Miljak B Kwan T Ng and J Kircher | 2000 | Physics of Plasmas2000，7，5： | 1 |
| 15 | Dendritic cells in allogeneic hematopoietic stem cell transplantation显示文摘 | Nachbaur D Kircher B | 2005 | Leuk Lymphoma2005，46，10： | 1 |
| 16 | Phenotype,function and chimaerism of monocyte-derived blood dendritic cells after allogeneic haematopoietic stem cell transplantation显示文摘 | Nachbaur D Kircher B Eisendle K | 2003 | Br J Haematol2003，123，1： | 1 |
| 17 | Experimental and Numerical Simulation of a Stainless Steel Coating Subjected to Thermal Fatigue显示文摘 | Revel P Kircher D Bogard V | 2000 | Materials Science and Engineering2000，290，： | 1 |
| 18 | Phenotype,function and chimaerism of monocyte-derived blood dendritic cells after allogeneic haematopoietic stem cell transplantation显示文摘 | Nachbaur D Kircher B Eisendle K | 2003 | Br J Haematol2003，123，1： | 1 |
| 19 | Analyse des d6gsadationsd'outillages de forge ehaud t l'aide de la simulation num6rique 显示文摘 | Kircher D Michaud H Bogard V | 1999 | Mat6riauxet techniques1999，87，12： | 1 |
| 20 | Constitutive pho- tomorphogenesis 1 and multiple photoreceptors control deg- radation of phytochrome interacting factor 3, a transcription factor required for light signaling in Arabidopsis显示文摘 | BAUER D VICZIN A KIRCHER S | 2004 | The Plant Cell2004，16，6： | 1 |
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