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| 1 | Activation of hypoxia-inducible factor 1 attenuates periapical inflammation and bone loss显示文摘Hypoxia(low oxygen level) is an important feature during infections and affects the host defence mechanisms. The host has evolved specific responses to address hypoxia, which are strongly dependent on the activation of hypoxia-inducible factor 1(HIF-1).Hypoxia interferes degradation of HIF-1 alpha subunit(HIF-1α), leading to stabilisation of HIF-1α, heterodimerization with HIF-1 beta subunit(HIF-1β) and subsequent activation of HIF-1 pathway. Apical periodontitis(periapical lesion) is a consequence of endodontic infection and ultimately results in destruction of tooth-supporting tissue, including alveolar bone. Thus far, the role of HIF-1 in periapical lesions has not been systematically examined. In the present study, we determined the role of HIF-1 in a wellcharacterised mouse periapical lesion model using two HIF-1α-activating strategies, dimethyloxalylglycine(DMOG) and adenovirusinduced constitutively active HIF-1α(CA-HIF1 A). Both DMOG and CA-HIF1 A attenuated periapical inflammation and tissue destruction. The attenuation in vivo was associated with downregulation of nuclear factor-κappa B(NF-κB) and osteoclastic gene expressions. These two agents also suppressed NF-κB activation and subsequent production of proinflammatory cytokines by macrophages. Furthermore, activation of HIF-1α by DMOG specifically suppressed lipopolysaccharide-stimulated macrophage differentiation into M1 cells, increasing the ratio of M2 macrophages against M1 cells. Taken together, our data indicated that activation of HIF-1 plays a protective role in the development of apical periodontitis via downregulation of NF-κB, proinflammatory cytokines, M1 macrophages and osteoclastogenesis. | Kimito Hirai Hisako Furusho Kiichi Hirota Hajime Sasaki | 2018 | International Journal of Oral Science2018，10，2： | 16 |
| 2 | Antipollution design criteria for line and station insultor显示文摘 | Kimito I Kito K Takatori T | | 0，，01： | 1 |
| 3 | A chemo-thermo-meehanically coupled numerical simulation of the subsurface ground deformations due to methane hydrate dissociation显示文摘 | Kimito S Oka F Fushita T | 2007 | Computers and Geotechnies2007，34，： | 1 |
| 4 | A chemo-thermo- mechanically coupled numerical simulation of the subsurface ground deformations due to methane hydrate dissociation显示文摘 | KIMITO S OKA F FUSHITA T | 2007 | Computers and Geotechnies2007，34，4： | 1 |
| 5 | A new process variable and dynamics selection method based on a genetic algorithm-based wavelength selection method显示文摘 | Hiromasa Kaneko Kimito Funatsu | 2012 | AIChE2012，58，6： | 1 |
| 6 | Development of a new soft sensor method using independent component analysis and partial least squares显示文摘 | Hiromasa Kaneko Masamoto Arakawa Kimito Funatsu | | 0，，01： | 1 |
| 7 | Diagnostic imaging in the preoperative management of lung cancer显示文摘 | Kazuhiro Imai Yoshihiro Minamiya Hajime Saito Satoru Motoyama Yusuke Sato Aki Ito Kei Yoshino Satoshi Kudo Shinogu Takashima Yasushi Kawaharada Nobuyasu Kurihara Kimito Orino Jun-ichi Ogawa | 2014 | Surgery Today2014，，7： | 1 |
| 8 | Added value of the presence of blue nodes or hot nodes in sentinel lymph node biopsy of breast cancer显示文摘 | Hiroyuki T Kimito S Masafumi K | 2006 | Breast Cancer2006，13，2： | 1 |
| 9 | Role of Carbon Dioxide in the Dehydrogenation of Ethane over Gallium-Loaded Catalysts显示文摘 | Kiyoharu Nakagawa Chiaki Kajita Kimito Okumura Na-oki Ikenaga Mikka Nishitani-Gamo Toshihiro Ando Tetsuhiko Kobayashi Toshimitsu Suzuki | 2001 | Journal of Catalysis2001，，1： | 1 |
| 10 | Antipollution design criteria for line and station insultor显示文摘 | Kimito K Takatori T | 1972 | IEEE Transactions on Power Apparatus and Systems1972，91，1： | 1 |
| 11 | Generation of CD4^+ CD25^+ regulatory T cell from autoreactive T cells simultaneously with their negative selection in the thymus and from nonautoreactive T cells by endogenous TCR expression 显示文摘 | Kimito Kawahata Yoshikata Misaki Michiko Yamauchi | 2002 | J Immunol2002，168，9： | 1 |
| 12 | 显示文摘 | Kimito M Yakawa A | 1990 | Meta1990，44，12： | 1 |
| 13 | Multi-way PLS Modeling of Structure-Activity Data by Incorporating Electrostatic and Lipoplilic Potentials on Molecular Surface 显示文摘 | Kiyoshi Hasegawa Shigeo Matsuokab Masamoto Arakawab Kimito Funatsu | 2003 | Computational Biology and chemistry2003，27，3： | 1 |
| 14 | Generation of CIM + CD25 + regulatory T cell from autoreactive T cells simultaneously with their negative selection in the thymus and from nonautoreactive T ceils by endogenous TCR expression 显示文摘 | Kimito Kawahata Yoshikata Misaki Michiko Yamauchi | 2002 | J Immunol2002，168，9： | 1 |
| 15 | Cell cycle regulation therapy combined with cytokine blockade enhances antiarthritic effects without increasing immune suppression显示文摘 | Hosoya Tadashi Iwai Hideyuki Yamaguchi Yu Kawahata Kimito Miyasaka Nobuyuki Kohsaka Hitoshi | 2016 | Annals of the Rheumatic Diseases2016，，1： | 1 |
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