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| 1 | H pylori seropositivity and cytokine gene polymorphisms显示文摘AIM: To investigate whether the pro- and anti-inflammatory cytokine gene polymorphisms, IL1B-511C/T, IL1B-31C/T, IL6-634C/G, TNF-1031T/C, TNF-857C/T, and IL10-1082A/G, interact with smoking and drinking habits to influence infection with H pylori.METHODS: The subjects were 410 Japanese transit company employees. C-reactive protein and conventional cardiovascular risk factors were evaluated. Serum anti-H pylori antibodies were measured. The genotypes of IL1B-511C/T, IL1B-31C/T, IL6-634C/G, TNF-1031T/C, TNF-857C/T, and IL10-1082A/G polymorphisms were determined by allelic discrimination using fluorogenic probes and a 5′nuclease assay.RESULTS: In gender- and age-adjusted logistic analyses, the subjects with TNF-857T/T had a significantly lower odds ratio (OR) for H pylori seropositivity (reference -857C/C; OR = 0.15, 95% CI: 0.03-0.59, P = 0.007). After stratification according to smoking and drinking status, among never-smokers, the subjects with IL1B-511C/T had a significantly lower OR (reference -511C/C; OR = 0.30, 95% CI: 0.10-0.90, P = 0.032). Among drinkers in the 1-5 times/wk category, the subjects with IL1B-511T/T had a significantly lower OR (reference C/C; OR = 0.38, 95% CI: 0.16-0.95, P = 0.039), and the subjects with IL1B-31C/T and T/T had a significantly higher OR (reference C/C; C/T: OR = 2.59, 95% CI, P = 0.042: 1.04-6.47; C/C: OR = 3.17, 95% CI: 1.23-8.14, P = 0.017). Among current smokers, the subjects withIL6-634C/G had a significantly higher OR (reference C/C; OR = 2.28, 95% CI: 1.13-4.58, P = 0.021). However, the interactions terms between the aforementioned genotypes and lifestyles were not statistically significant.CONCLUSION: Contrary to previous findings, the results herein suggest that the TNF-857T/T genotype may be protective against chronic infection with H pylori. Drinking and smoking habits may influence the effect of cytokine gene polymorphisms. Further studies are required to clarify the effects of the pro- and anti-inflammatory cytokine polymorphisms and gene-environmental interactions on H pylori infection. | Yasuaki Saijo Eiji Yoshioka Tomonori Fukui Mariko Kawaharada Fumihiro Sata Hirokazu Sato Reiko Kishi | 2007 | World Journal of Gastroenterology2007，13，33： | 5 |
| 2 | Pancreaticobiliary maljunction: retrospective and nationwide survey in Japan显示文摘 | Seiki Tashiro T. Imaizumi H. Ohkawa A. Okada T. Katoh Y. Kawaharada H. Shimada H. Takamatsu H. Miyake T. Todani | 2003 | Journal of Hepato - Biliary - Pancreatic Surgery2003，，5： | 4 |
| 3 | Thoracoabdominal or descending aortic aneurysm repair after preoperative demonstration of the Adamkiewicz artery by magnetic resonance angiography显示文摘 | Kawaharada N Morishita K Fukada J | 2002 | Eur J Cardiothorac Surg2002，21，6： | 1 |
| 4 | A safe strategy for surgical repair ofcoarctation of the aorta in an adult 显示文摘 | Yamada A Morishlta K Kawaharada N | 2003 | J Thorac Cardiovasc Surg2003，126，2： | 1 |
| 5 | Inducible nitric oxide synthase suppresses the development of allograft arteriosclerosis显示文摘 | Shears LL Kawaharada N Tzeng E | 1997 | J Clin Invest1997，100，： | 1 |
| 6 | High local production of nitric oxide as a possible mechanism by which rapamycin prevents transplant arteriosclerosis显示文摘 | Pham SM Shears LL Kawaharada N | 1998 | Transplant Proc1998，30，4： | 1 |
| 7 | Spinal cord ischemia after elective endovascular stent-graft repair of the thoracic aorta显示文摘 | Kawaharada N Morishita K Kurimoto Y | 2007 | Eur J Cardiothorac Surg2007，31，6： | 1 |
| 8 | Magnetic resonance angiographie localization of the artery of Adamkiewicz for spinal cord blood supply 显示文摘 | Kawaharada N Morishita K Hyodoh H | 2004 | Ann Thorac Surg2004，78，3： | 1 |
| 9 | Midterm results of surgical treatment of thoracic aortic disease in dialysis patients显示文摘 | Morishita K Kawaharada N Fukada J | 2005 | Ann Thorac Surg2005，80，1： | 1 |
| 10 | Thoracoabdominal or descending aortic aneurysm repair after preoperative demonstration of the Adamkiewicz artery by magnetic resonance angiography显示文摘 | Kawaharada N Morishita K Fukada J | 2002 | Eur J Cardiothorac Surg2002，21，6： | 1 |
| 11 | Simultaneous cardiac operations with pulmonary resection for lung carcinoma显示文摘 | Kiyofumi Morishita Nobuyoshi Kawaharada Toshiaki Watanabe Ryuji Koshima Yasuaki Fujisawa Atsushi Watanabe Katsuyuki Kusajima Tokuo Koshino Jyouji Fukada Tomio Abe | 2001 | The Japanese Journal of Thoracic and Cardiovascular Surgery2001，，12： | 1 |
| 12 | Rat embryonic stem cells create new era in development of genetically manipulated rat models显示文摘Embryonic stem(ES) cells are isolated from theinner cell mass of a blastocyst, and are used for the generation of gene-modified animals. In mice, the transplantation of gene-modified ES cells into recipient blastocysts leads to the creation of gene-targeted mice such as knock-in and knock-out mice; these gene-targeted mice contribute greatly to scientific development. Although the rat is considered a useful laboratory animal alongside the mouse, fewer genemodified rats have been produced due to the lack of robust establishment methods for rat ES cells. A new method for establishing rat ES cells using signaling inhibitors was reported in 2008. By considering the characteristics of rat ES cells, recent research has made progress in improving conditions for the stable culture of rat ES cells in order to generate gene-modified rats efficiently. In this review, we summarize several advanced methods to maintain rat ES cells and generate gene-targeted rats. | Kazushi Kawaharada Masaki Kawamata Takahiro Ochiya | 2015 | World Journal of Stem Cells2015，7，7： | 1 |
| 13 | Mechanical test method on the estimation of the lubricant performance by hyaluronic acid 显示文摘 | Toshitsu Yokobori Takashi Kawaharada Shigeru Sasaki | 1995 | Biomed Mater Eng1995，5，2： | 1 |
| 14 | Descending Thoracic Aortic Rupture : Role of Endovascular Stent-grafting显示文摘 | Morishita K Kurimoto Y Kawaharada N | 2004 | Ann Thorac Surg2004，78，5： | 1 |
| 15 | Usefulness of preoperative detection of artery of Adamkiewicz with dynamic contrast-enhanced MR angiography显示文摘 | Hyodoh H Kawaharada N Akiba H | 2005 | Radiology2005，236，10： | 1 |
| 16 | Less-invasive management of left subclavian artery in stem-grafting for distal aortic arch disease显示文摘 | Kurimoto Y Kawaharada N Ito T | 2009 | Interact Cardiovasc Thorac Surg2009，8，5： | 1 |
| 17 | Thermoelectric properties of CoSb3显示文摘 | Yoshiyuki Kawaharada Ken Kurosaki Masayoshi Uno | 2001 | Journal of Alloys and Compounds2001，，315： | 1 |
| 18 | Relations of occupational stress to occupational class in Japanese civil servants--analysis by two occupational stress models 显示文摘 | Kawaharada M Saijo Y Yoshioka E Sato T Sato H Kishi R | 2007 | Ind Health2007，45，2： | 1 |
| 19 | Treatment of delayed neurological deficits after surgical repair of thoracic aortic aneurysm 显示文摘 | Yanase Y Kawaharada N Maeda T | 2012 | Ann Thorac Cardiovasc Surg2012，18，： | 1 |
| 20 | Structural Aheration of Hybrid Supramolecular Capsule Induced by Guest Encapsulation显示文摘 | Yamanaka M Kawaharada M Nito Y | 2011 | J Am Chem Soc2011，133，16： | 1 |
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