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| 1 | Nanomaterial-based strategies in antimicrobial applications:Progress and perspectives显示文摘The dramatic increase of microbial resistances against conventional available antibiotics is a huge challenge to the effective treatment of infectious disease and thus becoming a daunting global threat of major concern,which necessitates the development of innovative therapeutics.Nanomaterial-based antimicrobial strategies have emerged as novel and promising tools to combat lethal bacteria and recalcitrant biofilm,featuring the abilities to evade existing drug resistance-related mechanisms.In this review,recent advances in“state-of-the-art”nanosystems which acting either as inherent therapeutics or nanocarriers for the precise delivery of antibiotics,are comprehensively summarized.Those nanosystems can effectively accumulate at the infectious sites,achieve multifunctional synergistic antibacterial efficacy,and provide controlled release of antibiotics in response to endogenous or exogenous stimulus(e.g.,low pH,enzymes,or illumination).Especially,the nanoplatform that integrated with photothermal/photodynamic therapy(PTT/PDT)can enhance the bacterial destruction and biofilm penetration or ablation.In addition,nanoparticle-based approaches with enzymatically promoting bacterial killing,anti-virulence,and other mechanisms were also involved.Overall,this review provides crucial insights into the recent progress and remaining limitations of various antimicrobial nanotherapeutic strategies,and enlightens the further developments in this field simultaneously,which eventually benefiting public health. | Yi Zhao Long Chen Yanan Wang Xinyu Song Keyang Li Xuefeng Yan Liangmin Yu Zhiyu He | 2021 | Nano Research2021，14，12： | 1 |
| 2 | A geometric model of a spherical gear with a double degree of freedom显示文摘 | YANG Shyuecheng CHEN Chaokuang LI Keyang | 2002 | Journal of Materials Procession Technol- ogy2002，123，2： | 1 |
| 3 | Type 2 diabetes in mice induces hepatic overexpression of sulfatase 2, a novel factor that suppresses uptake of remnant lipoproteins显示文摘 | Keyang Chen Ming‐Lin Liu Lana Schaffer Mingzhen Li Guenther Boden Xiangdong Wu Kevin Jon Williams | 2010 | Hepatology2010，，6： | 1 |
| 4 | SARS-CoV-2 Aerosol Transmission Through Vertical Sanitary Drains in High-Rise Buildings--Shenzhen,Guangdong Province,China,March 2022显示文摘Summary What is already known about this topic?Aerosol transmission of severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)via sanitary pipelines in high-rise buildings is possible,however,there is a lack of experimental evidence. | Keyang Lyu Siyang Feng Xia Li Qin Wang Xiaoning Zhao Shuyuan Yu Ping Zheng Jiajia Ji Guomin Chen Jing Liang Tao Lan Jinshu Feng Shuai Jiang Jianhua Lu Tianlong Xia Chaoqiong Peng Tiejian Feng Dongqun Xu | 2022 | China CDC weekly2022，4，23： | 1 |
| 5 | Roles of the fibroblast growth factor signal transduction system in tissue injury repair显示文摘Following injury,tissue autonomously initiates a complex repair process,resulting in either partial recovery or regeneration of tissue architecture and function in most organisms.Both the repair and regeneration processes are highly coordinated by a hierarchy of interplay among signal transduction pathways initiated by different growth factors,cytokines and other signaling molecules under normal conditions.However,under chronic traumatic or pathological conditions,the reparative or regenerative process of most tissues in different organs can lose control to different extents,leading to random,incomplete or even flawed cell and tissue reconstitution and thus often partial restoration of the original structure and function,accompanied by the development of fibrosis,scarring or even pathogenesis that could cause organ failure and death of the organism.Ample evidence suggests that the various combinatorial fibroblast growth factor(FGF)and receptor signal transduction systems play prominent roles in injury repair and the remodeling of adult tissues in addition to embryonic development and regulation of metabolic homeostasis.In this review,we attempt to provide a brief update on our current understanding of the roles,the underlying mechanisms and clinical application of FGFs in tissue injury repair. | Keyang Chen Zhiheng Rao Siyang Dong Yajing Chen Xulan Wang Yongde Luo Fanghua Gong Xiaokun Li | 2022 | Burns & Trauma2022，10，1： | 1 |
| 6 | Empirical Effective Interaction in 22MeV Proton Scattering显示文摘Inelastic differential cross sections of 22 MeV proton scattering for 5 excited states of 28Si have been measured from 10°to 115°.Empirical effective interactions were extracted within the frame of DWBA from the normal parity state data which transition densities were known from electron scattering.The fitting is good except for the forward angle of 4^(+)_(1) and 0^(+)_(2) states.The results are discussed. | AN Zhu CHEN Quan DING Dazhao SHI Zongren WAN Shuyang GAO Keyang | 1994 | Chinese Physics Letters1994，11，7： | 0 |
| 7 | Fabrication of a High-Performance and Reusable Planar Face Mask in Response to the COVID-19 Pandemic显示文摘The coronavirus disease 2019(COVID-19)pandemic has caused a surge in demand for face masks,with the massive consumption of masks leading to an increase in resource-related and environmental con-cerns.In this work,we fabricated meltblown polypropylene(mb-PP)-based high-performance planar face masks and investigated the effects of six commonly used disinfection methods and various mask-wearing periods on the reusability of these masks.The results show that,after three cycles of treatment using hot water at 70℃ for 30 min,which is one of the most scalable,user-friendly methods for viral disinfection,the particle filtration efficiency(PFE)of the mask remained almost unchanged.After mask wearing for 24 h and subsequent disinfection using the same treatment procedures,the PFE decreased to 91.3%;the average number of bacterial and fungal colonies was assessed to be 9.2 and 51.6 colony-forming units per gram(CFU∙g^(-1)),respectively;and coliform and pyogenic bacteria were not detected.Both the PFE and the microbial indicators are well above the standard for reusable masks after disinfection.Schlieren pho-tography was then used to assess the capabilities of used and disinfected masks during use;it showed that the masks exhibit a high performance in suppressing the spread of breathed air. | Shui Hu Hongchi Tian Shijia Zhang Dan Wang Guozhuo Gong Weihua Yue Keyang Liu Song Hong Rui Wang Qingqing Yuan Yonglai Lu Dong Wang Liqun Zhang Jianfeng Chen | 2022 | Engineering2022，8，2： | 0 |
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