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| 1 | Acute calculous cholecystitis: Review of current best practices显示文摘Acute calculous cholecystitis(ACC) is the most frequent complication of cholelithiasis and represents one-third of all surgical emergency hospital admissions, many aspects of the disease are still a matter of debate. Knowledge of the current evidence may allow the surgical team to develop practical bedside decision-making strategies, aiming at a less demanding procedure and lower frequency of complications. In this regard, recommendations on the diagnosis supported by specific criteria and severity scores are being implemented, to prioritize patients eligible for urgency surgery. Laparoscopic cholecystectomy is the best treatment for ACC and the procedure should ideally be performed within 72h. Early surgery is associated with better results in comparison to delayed surgery. In addition, when to suspect associated common bile duct stones and how to treat them when found are still debated. The antimicrobial agents are indicated for high-risk patients and especially in the presence of gallbladder necrosis. The use of broad-spectrum antibiotics and in some cases with antifungal agents is related to better prognosis. Moreover, an emerging strategy of not converting to open, a difficult laparoscopic cholecystectomy and performing a subtotal cholecystectomy is recommended by adept surgical teams. Some authors support the use of percutaneous cholecystostomy as an alternative emergency treatment for acute Cholecystitis for patients with severe comorbidities. | Carlos Augusto Gomes Cleber Soares Junior Salomone Di Saveiro Massimo Sartelli Michel Denis Kelly Camila Couto Gomes Felipe Couto Gomes Lívia Dornellas Correa Camila Brandao Alves Samuel de Fádel Guimaraes | 2017 | World Journal of Gastrointestinal Surgery2017，9，5： | 18 |
| 2 | The wonders of BMP9:From mesenchymal stem cell differentiation,angiogenesis,neurogenesis,tumorigenesis,and metabolism to regenerative medicine显示文摘Although bone morphogenetic proteins(BMPs)initially showed effective induction of ectopic bone growth in muscle,it has since been determined that these proteins,as members of the TGF-b superfamily,play a diverse and critical array of biological roles.These roles include regulating skeletal and bone formation,angiogenesis,and development and homeostasis of multiple organ systems.Disruptions of the members of the TGF-b/BMP superfamily result in severe skeletal and extra-skeletal irregularities,suggesting high therapeutic potential from understanding this family of BMP proteins.Although it was once one of the least characterized BMPs,BMP9 has revealed itself to have the highest osteogenic potential across numerous experiments both in vitro and in vivo,with recent studies suggesting that the exceptional potency of BMP9 may result from unique signaling pathways that differentiate it from other BMPs.The effectiveness of BMP9 in inducing bone formation was recently revealed in promising experiments that demonstrated efficacy in the repair of critical sized cranial defects as well as compatibility with bone-inducing bio-implants,revealing the great translational promise of BMP9.Furthermore,emerging evidence indicates that,besides its osteogenic activity,BMP9 exerts a broad range of biological functions,including stem cell differentiation,angiogenesis,neurogenesis,tumorigenesis,and metabolism.This review aims to summarize our current understanding of BMP9 across biology and the body. | Sami Mostafa Mikhail Pakvasa Elam Coalson Allen Zhu Alex Alverdy Hector Castillo Jiaming Fan Alex Li Yixiao Feng Di Wu Elliott Bishop Scott Du Mia Spezia Alissa Li Ofir Hagag Alison Deng Winny Liu Mingyang Li Sherwin S·Ho Aravind Athiviraham Michael J·Lee Jennifer Moriatis Wolf Guillermo A·Ameer Hue H·Luu Rex C·Haydon Jason Strelzow Kelly Hynes Tong-Chuan He Russell R·Reid | 2019 | Genes & Diseases2019，6，3： | 15 |
| 3 | 一个熟悉的陌生人:在脂肪质的织物的 SVF 房间的 CD34 表示和通常认为的功能显示文摘 Human adipose tissue obtained by liposuction is easily accessible and an abundant potential source of autologous cells for regenerative medicine applications. After digestion of the tissue and removal of differentiated adipocytes, the so-called stromal vascular fraction (SVF) of adipose, a mix of various cell types, is obtained. SVF contains mesenchymal fibroblastic cells, able to adhere to culture plastic and to generate large colonies in vitro , that closely resemble bone marrow-derived colony forming units-fibroblastic, and whose expanded progeny, adipose mesenchymal stem/stromal cells (ASC), show strong similarities with bone marrow mesenchymal stem cells. The sialomucin CD34, which is well known as a hematopoietic stem cell marker, is also expressed by ASC in native adipose tissue but its expression is gradually lost upon standard ASC expansion in vitro . Surprisingly little is known about the functional role of CD34 in the biology and tissue forming capacity of SVF cells and ASC. The present editorial provides a short introduction to the CD34 family of sialomucins and reviews the data from the literature concerning ex- pression and function of these proteins in SVF cells and their in vitro expanded progeny. | Arnaud Scherberich Nunzia Di Maggio Kelly M McNagny | 2013 | World Journal of Stem Cells2013，5，1： | 8 |
| 4 | Notch signaling:Its essential roles in bone and craniofacial development显示文摘Notch is a cellecell signaling pathway that is involved in a host of activities including development,oncogenesis,skeletal homeostasis,and much more.More specifically,recent research has demonstrated the importance of Notch signaling in osteogenic differentiation,bone healing,and in the development of the skeleton.The craniofacial skeleton is complex and understanding its development has remained an important focus in biology.In this review we briefly summarize what recent research has revealed about Notch signaling and the current understanding of how the skeleton,skull,and face develop.We then discuss the crucial role that Notch plays in both craniofacial development and the skeletal system,and what importance it may play in the future. | Mikhail Pakvasa Pranav Haravu Michael Boachie-Mensah Alonzo Jones Elam Coalson Junyi Liao Zongyue Zeng Di Wu Kevin Qin Xiaoxing Wu Huaxiu Luo Jing Zhang Meng Zhang Fang He Yukun Mao Yongtao Zhang Changchun Niu Meng Wu Xia Zhao Hao Wang Linjuan Huang Deyao Shi Qing Liu Na Ni Kai Fu Michael J.Lee Jennifer Moriatis Wolf Aravind Athiviraham Sherwin S.Ho Tong-Chuan He Kelly Hynes Jason Strelzow Mostafa El Dafrawy Russell R.Reid | 2021 | Genes & Diseases2021，8，1： | 4 |
| 5 | Development of anterior cingulate functional connectivity from late childhood to early adulthood 显示文摘 | Kelly AM Di Martino A Uddin LQ | 2009 | Cereb Cortex2009，19，： | 1 |
| 6 | Bone morphogenetic protein-2 causes commitmem and differentiation in C3H10T1/2 and 3T3 cells显示文摘 | Wang EA Israel DI Kelly S | 1993 | Growth Factors1993，9，： | 1 |
| 7 | Growing together and growing apart: regional and sex differences in the li{espan devel- opmental trajectories o{ functional homotopy 显示文摘 | Zuo X N Kelly C Di Martino A | 2010 | J Neurosci2010，30，15： | 1 |
| 8 | Laparoscopic Nissen fundoplication: clinical outcomes at 10 years 显示文摘 | Kelly JJ Watson DI Chin KF | 2007 | J Am Coll Surg2007，205，4： | 1 |
| 9 | Qoetiapine for the continuation treatment of bipolar depression: naturalistic prospective case series from the Stanley Bipolar Treatment Network 显示文摘 | Suppes T Kelly DI Keck PE JR | 2007 | Int Clin Psychopharmacol2007，22，6： | 1 |
| 10 | The oscillating brain : complex and reliable显示文摘 | Zuo XN Di Martino A Kelly C | 2010 | Neurolmage2010，49，14： | 1 |
| 11 | Growing together and growing apart:regional and sex differences in the lifespan developmental trajectories of functional homotopy显示文摘 | Zuo XN Kelly C Di Martino A | 2010 | J Neurosci2010，30，15： | 1 |
| 12 | Laparoscopie Nissen fun- doplieation: clinical outcomes at 10 years显示文摘 | Kelly JJ Watson DI Chin KF | 2007 | J Am Coll Surg2007，205，4： | 1 |
| 13 | Structural and functional neuroprotection in glaucoma: role of galantamine-mediated activation of muscarinic acetylcholine receptors显示文摘 | Almasieh M Zhou Y Kelly ME Casanova C Di Polo A | 2010 | CeU Death Dis2010，，： | 1 |
| 14 | Growing together and growing apart: regional and sex differences in the lifespan devel- opmental trajectories of functional homotopy 显示文摘 | Zuo X-N Kelly C Di Martino A | 2010 | The Journal of Neuroscience2010，30，15： | 1 |
| 15 | Growing together and growing apart:regional and sex differences in the lifespan developmental trajectories of functional homotopy显示文摘 | Zuo XN Kelly C Di Martino A | 2010 | J Neurosci2010，30，15： | 1 |
| 16 | Resuscitation with Lipid versus Epinephrine in a Rat Model of Bupivacaine Overdose显示文摘 | Guy L. Weinberg Guido Di Gregorio Richard Ripper Kemba Kelly Malek Massad Lucas Edelman David Schwartz Nirali Shah Sophie Zheng Douglas L. Feinstein | 2008 | Anesthesiology2008，，： | 1 |
| 17 | Targeting the Fas/Fas ligand pathway in cancer显示文摘 | O'Brien DI Nally K Kelly RG | 2005 | Expert Opin Ther Targets2005，9，5： | 1 |
| 18 | An analysis of thc natural history of cavernous angiomas显示文摘 | Curling OD Kelly DI Elster AD | 1991 | J Neurosurg1991，75，5： | 1 |
| 19 | The oscillating brain: complex and reliable显示文摘 | Zuo X N Di Martino A Kelly C | 2010 | Neuroimage2010，49，2： | 1 |
| 20 | The oscillating brain : complex and reliable显示文摘 | Zuo XN Di Martino A Kelly C | 2010 | Neuroimage2010，49，： | 1 |
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