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| 1 | 饲料混合及混合均匀度显示文摘合理的饲料配方能否真正在实际中发挥效用需要恰当的加工技术得以实现。混合是饲料生产过程中重要的工艺环节之一,但在实际生产中,混合往往没有得到大家足够的重视。混合的理想状态是要使最终饲料产品达到完全均一,使每一份样品的营养素含量均应相同。当然,在实际牛产中, | 武书庚 Keith C Behnke | 2010 | 中国畜牧杂志2010，46，12： | 13 |
| 2 | Dynamic chromatin states in human ES cells reveal potential regulatory sequences and genes involved in pluripotency显示文摘Pluripotency,一个细胞的能力区分并且产生所有胚胎的系,定义象胚胎的茎(ES ) 那样的哺乳动物的细胞类型的一个小数字细胞。当它通常被保持了时,那 pluripotency 是 transcriptional 的产品激活并且维持关键干细胞基因的表达式的规章的网络,积累的证据在建立并且保卫 ES 房间的 pluripotency 为 epigenetic 进程正在指向一个关键角色,象维持区分的房间类型的身份一样。以便更好在 pluripotency 理解 epigenetic 机制的角色,我们检验了在经历区别进一个 mesendodermal 系的人的 ES 房间(hESCs ) 染色体宽的染色质修正的动力学。我们发现在倡导者的染色质修正在区别期间仍然保持大部分不变,除了在在在 H3K27 的 acetylation 和 methylation 之间的一个动态开关标记在基因表示的激活和 silencing 之间的转变的倡导者的一个小数字,建议在在大多数差别上的房间命运承诺的一个层次表示了基因。我们也在 50 000 潜在的 enhancers 上印射,并且在染色质修正,特别 H3K4me1 和 H3K27ac 观察了大得多的动力学,它与他们的潜在的目标基因的表示相关。这些 enhancers 的进一步的分析揭示了 pluripotency 和可以在 hESCs 授与发展胜任的一个平衡状态的一口染色质签名陈述语气的潜在地关键的 transcriptional 管理者。我们的结果提供在定义 enhancers 和 pluripotency 支持染色质修正的角色的新证据。 | R David Hawkins Gary C Hon Chuhu Yang Jessica E Antosiewicz-Bourget Leonard K Lee Que-Minh Ngo Sarit Klugman Keith A Ching Lee E Edsall Zhen Ye Samantha Kuan Pengzhi Yu Hui Liu Xinmin Zhang Roland D Green Victor V Lobanenkov Ron Stewart James A Thomson Bing Ren | 2011 | Cell Research2011，21，10： | 6 |
| 3 | 饲料原料及加工技术对猪饲料质量的影响(下)显示文摘当今养猪生产中,生产者和营养师对日粮能量水平、氨基酸浓度和比例、最佳维生素和微量元素供给等方面都给予了极大的关注。选择价格合适、品质优良的饲料原料,采用适当的原料加工方式来配制饲料,对猪场获益非常重要,但良好饲料加工规范常被大家忽视。本文将讨论加工技术对饲料原料和配合饲料营养价值最大化的影响。 | Joe D.Hancock Keith C,Behnke 武书庚(译) 程宗佳(校) | 2007 | 中国畜牧杂志2007，43，12： | 5 |
| 4 | Novel role of phosphodiesterase inhibitors in the management of end-stage heart failure显示文摘In advanced heart failure(HF), chronic inotropic therapy with intravenous milrinone, a phosphodiesterase Ⅲ inhibitor, is used as a bridge to advanced management that includes transplantation, ventricular assist device implantation, or palliation. This is especially true when repeated attempts to wean off inotropic support result in symptomatic hypotension, worsened symptoms, and/or progressive organ dysfunction. Unfortunately, patients in this clinical predicament are considered hemodynamically labile and may escape the benefits of guidelinedirected HF therapy. In this scenario, chronic milrinone infusion may be beneficial as a bridge to introduction of evidence based HF therapy. However, this strategy is not well studied, and in general, chronic inotropic infusion is discouraged due to potential cardiotoxicity that accelerates disease progression and proarrhythmic effects that increase sudden death. Alternatively, chronic inotropic support with milrinone infusion is a unique opportunity in advanced HF. This review discusses evidence that long-term intravenous milrinone support may allow introduction of beta blocker(BB) therapy. When used together, milrinone does not attenuate the clinical benefits of BB therapy while BB mitigates cardiotoxic effects of milrinone. In addition, BB therapy decreases the risk of adverse arrhythmias associated with milrinone. We propose that advanced HF patients who are intolerant to BB therapy may benefit from a trial of intravenous milrinone as a bridge to BB initiation. The discussed clinical scenarios demonstrate that concomitant treatment with milrinone infusion and BB therapy does not adversely impact standard HF therapy and may improve left ventricular function and morbidity associated with advanced HF. | Abhishek Jaiswal Vinh Q Nguyen Thierry H Le Jemtel Keith C Ferdinand | 2016 | World Journal of Cardiology2016，8，7： | 4 |
| 5 | Endoscopic ultrasound-guided celiac plexus neurolysis using a reverse phase polymer显示文摘AIM:To assess the feasibility of endoscopic ultrasound(EUS)guided celiac plexus neurolysis(CPN) using a poloxamer. METHODS:In this prospective evaluation,six Yorkshire pigs underwent EUS-guided CPN.Three received an injection of 10 mL of 0.25%Lidocaine plus methylene blue(group 1) and three received an injection of 10 mL of 0.25%Lidocaine plus blue colored poloxamer(PS137-25)(group 2) .Necropsy was performed immediately after the animals were sacrificed.The abdominal and pelvic cavities were examined for the presence of methylene blue and the blue colored poloxamer.RESULTS:EUS-guided CPN was successfully performed in all 6 pigs without immediate complication.Methylene blue was identified throughout the peritoneal and retroperitoneal cavity in group 1.The blue colored poloxamer was found in the retroperitoneal cavity immediately adjacent to the aorta,in the exact location of the celiac plexus in group 2.CONCLUSION:EUS-guided CPN using a reverse phase polymer in a non-survival porcine model was technically feasible.The presence of a poloxamer gel at the site of the celiac plexus at necropsy indicates a precise delivery of the neurolytic agent. | Keith L Obstein Fernanda P Martins Gloria Fernández-Esparrach Christopher C Thompson | 2010 | World Journal of Gastroenterology2010，16，6： | 3 |
| 6 | Para-aortic lymph node involvement should not be a contraindication to resection of pancreatic ductal adenocarcinoma显示文摘BACKGROUND Para-aortic lymph nodes(PALN)are found in the aortocaval groove and they are staged as metastatic disease if involved by pancreatic ductal adenocarcinoma(PDAC).The data in the literature is conflicting with some studies having associated PALN involvement with poor prognosis,while others not sharing the same results.PALN resection is not included in the standard lymphadenectomy during pancreatic resections as per the International Study Group for Pancreatic Surgery and there is no consensus on the management of these cases.AIM To investigate the prognostic significance of PALN metastases on the oncological outcomes after resection for PDAC.METHODS This is a retrospective cohort study of data retrieved from a prospectively maintained database on consecutive patients undergoing pancreatectomies for PDAC where PALN was sampled between 2011 and 2020.Statistical comparison of the data between PALN+and PALN-subgroups,survival analysis with the Kaplan-Meier method and risk analysis with univariable and multivariable time to event Cox regression analysis were performed,specifically assessing oncological outcomes such as median overall survival(OS)and disease-free survival(DFS).RESULTS 81 cases had PALN sampling and 17(21%)were positive.Pathological N stage was significantly different between PALN+and PALN-patients(P=0.005),while no difference was observed in any of the other characteristics.Preoperative imaging diagnosed PALN positivity in one case.OS and DFS were comparable between PALN+and PALN-patients with lymph node positive disease(OS:13.2 mo vs 18.8 mo,P=0.161;DFS:13 mo vs 16.4 mo,P=0.179).No difference in OS or DFS was identified between PALN positive and negative patients when they received chemotherapy either in the neoadjuvant or in the adjuvant setting(OS:23.4 mo vs 20.6 mo,P=0.192;DFS:23.9 mo vs 20.5 mo,P=0.718).On the contrary,when patients did not receive chemotherapy,PALN disease had substantially shorter OS(5.5 mo vs 14.2 mo;P=0.015)and DFS(4.4 mo vs 9.8 mo;P<0.001).PALN involvement was not identified as an independent predictor for OS after multivariable analysis,while it was for DFS doubling the risk of recurrence.CONCLUSION PALN involvement does not affect OS when patients complete the indicated treatment pathway for PDAC,surgery and chemotherapy,and should not be considered as a contraindication to resection. | Rupaly Pande Shafiq Chughtai Manish Ahuja Rachel Brown David C Bartlett Bobby V Dasari Ravi Marudanayagam Darius Mirza Keith Roberts John Isaac Robert P Sutcliffe Nikolaos A Chatzizacharias | 2022 | World Journal of Gastrointestinal Surgery2022，14，5： | 2 |
| 7 | Relative importance of enterochromaffin cell hyperplasia, anxiety, and depression in postinfectious IBS显示文摘 | Simon P Dunlop David Jenkins Keith R Neal Robin C Spiller | 2003 | Gastroenterology2003，，6： | 2 |
| 8 | 基于一个大型随机试验预测稳定性心绞痛队列患者死亡、心肌梗死和卒中的危险评分显示文摘目的对需要抗心绞痛治疗并且左心室功能代偿症状稳定的心绞痛患者建立预测全因死亡、心肌梗死和导致致残性卒中的复合危险评分。设计大型多中心临床试验数据的多变量Cox回归分析。背景西欧、以色列、加拿大、澳大利亚和新西兰的心脏专科门诊患者。入选者7311例具有全部需要资料的患者被入选。主要结局的测量指标平均随访4.9年时间内所有原因的死亡、心肌梗死或者致残性卒中。结果1063例患者发生任何原因死亡或者持久性心肌梗死或者致残性卒中。这些复合终点的5年危险性在危险性最低的十分位患者为4%,而在危险性最高的十分位患者为35%。危险评分结合16项临床常规变量的降序排序是:年龄、左心室射血分数、吸烟、白细胞计数、糖尿病、随机血糖浓度、肌酐浓度、既往卒中病史、1周至少1次心绞痛发作、冠状动脉造影发现(如果能够获得)、降脂治疗、QT间期、收缩期血压≥150mmHg、抗心绞痛药物数量、陈旧性心肌梗死以及性别。把这个模型分别应用于任何原因所致的死亡、心肌梗死和卒中进行预测评估,所得的结果相似。危险评分似乎不能预测事件性质(39%的死亡、46%心肌梗死以及15%致残性卒中)或者冠状动脉造影或血管重建率(占29%的患者)。结论该危险评分对客观地决定稳定性心绞痛患者进一步治疗措施以减少重要预后事件发生是有帮助的。该危险评分同样可以用于将来的计划性试验。 | Tim C Clayton Stuart J Pocock Jacobus Lubsen Zoltán Vokó Bridget-Anne Kirwan Keith A A Fox Philip A Poole-Wilson | 2006 | 英国医学杂志中文版2006，9，1： | 2 |
| 9 | Employee performance cues in a hotel service environment: influence on perceived service quality, value, and word-of-mouth intentions显示文摘 | Michael D H Keith C J | 1996 | Journal of Business Research1996，35，6： | 1 |
| 10 | Cloning of a delta opioid receptor by functional expression显示文摘 | Evans C J Keith D E Morrison H | 1992 | Science1992，258，5090： | 1 |
| 11 | A new cascade multilevel H-bridge drive显示文摘 | kEITH C YAKOV F | | 0，，01： | 1 |
| 12 | Human Neuroblastonm( SH- SY5Y) Cell Culture and Differentiation in 3-D Collagen Hydrogels for Cell-Based Biosensing 显示文摘 | Desai A Kisaalita W S Keith C | 2006 | Biosensors and Bioelectronics2006，21，8： | 1 |
| 13 | Model-Set Adaptation Using a Fuzzy Kalman Filter显示文摘 | Ding Zhen Henry L Keith C | 2001 | Mathematical and Computer Modeling2001，34，： | 1 |
| 14 | Effects of simulated acidic rain on yields of field-grown crops显示文摘 | LNACE S E KEITH F L ELIZABETH A C | 1982 | New Phytol1982，91，： | 1 |
| 15 | The role of oxygen availability in em- bryonic development and stem cell function显示文摘 | Simon M C Keith B | 2008 | Nat Rev2008，9，： | 1 |
| 16 | PIK-Related Kinases: DNA repair, recombination, and cell cycle checkpoint显示文摘 | Keith C T Schreiber S L | 1995 | Science1995，270，1： | 1 |
| 17 | Factors controlling prolific gas production from low-permeability sandstone reservoirs= Implica- tions for resource assessment, prospect development, and risk analysis显示文摘 | Keith W S Robert M C John W R | 2004 | AAPG Bulletin2004，88，10： | 1 |
| 18 | The cloning of cattle interferon-A subtypes isolated from the gut epithelium of rotavirus infected calves显示文摘 | Paul J C Keith R P RobertA C | 1996 | Immunogenetics1996，44，： | 1 |
| 19 | Control of p70 S6 kinase by kinase activity of FRAP in vivo显示文摘 | Brown E J Beal P A Keith C T | 1995 | Nature1995，377，6548： | 1 |
| 20 | Modeling nonpoint source pollutants in vadose zone with GIS显示文摘 | DENNIS L C PETER J V KEITH L | 1997 | Environmental Science and Technology1997，31，8： | 1 |
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