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| 1 | 大麦黄矮病毒GPV外壳蛋白基因序列分析及其植物表达质粒的构建显示文摘大麦黄矮病毒GPV株系是我国特有的一个株系,与国外已报道的大麦黄矮病毒MAV,PAV,SGV,RPV和RMY在血清学上无反应.通过对GPV.外壳蛋白基因的序列分析,明确了病毒的外壳蛋白基因由603个核苷酸组成,编码201个氨基酸,分子量为22218ku.同MAV,PAV,RPV株系一样,在GPV外壳蛋白基因框架中(ORF)含有1个Vpg框架结构,分子量为17024ku.外壳蛋白基因序列同源性比较结果显示,GPV株系和RPV株系同源性较高,核苷酸和氨基酸的同源性分别为83.7%和77.5%.而与PAV和MAV株系同源性较低,核苷酸和氨基酸的同源性分别为56.9%,53.2%和44.1%,43.8%.按照GPV外壳蛋白基因序列,设计寡聚核苷酸引物,通过RT-PCR反应,得到GPV外壳蛋白基因全长cDNA,克隆到表达质粒,构建了高等植物表达载体pPPI1,pPPI2和pPPI5. | 成卓敏 何小源 吴茂森 周广和 Paul Keese P.M.Waterhouse | 1996 | 中国科学(C辑)1996，26，3： | 10 |
| 2 | EGF基因多态性与结直肠癌的关系显示文摘 | 吴国洋 Michael Keese Till Hasenberg Jrg W.Sturm | 2005 | 中华普通外科杂志2005，20，11： | 9 |
| 3 | Chronic mesenteric ischemia: Time to remember open revascularization显示文摘Chronic mesenteric ischemia is caused by stenosis or occlusion of one or more visceral arteries. It represents a therapeutic challenge and diagnosis and treatment require close interdisciplinary cooperation between gastroenterologist, vascular surgeon and radiologist. Although endovascular treatment modalities have been developed, the number of restenoses ultimately resulting in treatment failure is high. In patients fit for open surgery, the visceral arteries should be revascularized conventionally. These patients will then experience long term relief from the symptoms, a better quality of life and a better overall survival. | Michael Keese Thomas Schmitz-Rixen Thomas Schmandra | 2013 | World Journal of Gastroenterology2013，19，9： | 6 |
| 4 | 结直肠癌术后吻合口瘘与表皮生长因子、转化生长因子-β1、血管内皮生长因子基因多态性的关系显示文摘目的观察表皮生长因子(EGF)61*G/A、转化生长因子-β1(TGF-β1)-509*TIC、血管内皮生长因子(VEGF)936*T/C基因功能多态性对术后结肠吻合口瘘的影响。方法采用聚合酶链反应-限制性片段长度多态性(PCR—RFLP)方法检测伴有和不伴有术后结肠吻合口瘘结直肠癌患者的EGF 61*G/A,TGF-β1—509*T/C,VEGF 936*T/C基因型。结果伴有术后结肠吻合口瘘的结直肠癌患者TGF-β1-509*T/T基因型比例(0.0%)低于无术后吻合口瘘的患者(15.2%),两者差异有统计学意义(P〈0.05)。伴有术后结肠吻合口瘘的VEGF 936*C/C基因型和C等位基因比例(65.9%和80.6%)低于无术后吻合口瘘的患者(82.6%和90.5%),两者差异有统计学意义(基因型x^2=5.755,P〈0.05;等位基因x^2=5.275,P〈0.05)。伴有术后结肠吻合口瘘的结直肠癌患者EGF 61*G/G基因型比例(25.0%)低于无术后吻合口瘘的患者(55.5%),但两者差异无统计学意义(x^2=1.591,P〉0.05)。结论TGF-β1-509*T/T基因型,VEGF 936*C/C基因型或936*C等位基因有助于减少术后结肠吻合口瘘的发生。 | 吴国洋 王效民 Michael Keese Till Hasenberg Jǒrg W. Sturm | 2008 | 中华实验外科杂志2008，25，3： | 5 |
| 5 | 血管内皮生长因子936T/C基因多态性与结直肠癌及术后吻合口瘘的关系显示文摘目的通过研究血管内皮生长因子(VEGF)936T/C基因多态性了解该因子对结直肠癌生成及术后结肠吻合口瘘的影响。方法采用聚合酶链反应-限制性片段长度多态性(PCR-RFLP)方法检测结直肠癌及正常对照的VEGF936T/C基因型。结果结直肠癌患者VEGF936T/C基因型或等位基因与对照组相比无差异。伴有术后结肠吻合口瘘的结直肠癌患者其VEGF936C/C基因型及C等位基因比例低于无术后结肠吻合口瘘的患者,两者差异有统计学意义(P<0·05)。结论VEGF936C/C基因型或936C等位基因与结直肠癌的发生无关,但提示术后结肠吻合口瘘的发生率降低。 | 吴国洋 王效民 Michael Keese Till Hasenberg Jrg W. Sturm | 2006 | 中华外科杂志2006，44，21： | 4 |
| 6 | Gastric adenocarcinoma in patients 40 years of age or younger显示文摘 | Charles P. Theuer Christian de Virgilio Greg Keese Samuel French Tracey Arnell Jorge Tolmos Stanley Klein William Powers Tony Oh Bruce E. Stabile | 1996 | The American Journal of Surgery1996，，5： | 2 |
| 7 | Novel Therapies Focused on the High-Density Lipoprotein Particle显示文摘 | Julian C. van Capelleveen H. Bryan Brewer John J.P. Kastelein G. Kees Hovingh | 2014 | Circulation Research2014，，1： | 2 |
| 8 | Combined Thermo-Chemotherapy for Recurrent Bladder Cancer After Bacillus Calmette-Guerin显示文摘 | Ofer Nativ J. Alfred Witjes Kees Hendricksen Michael Cohen Daniel Kedar Ami Sidi Renzo Colombo Ilan Leibovitch | 2009 | The Journal of Urology2009，，4： | 2 |
| 9 | Selecting copulas for risk management显示文摘 | Erik Kole Kees Koedijk Marno Verbeek | 2007 | Journal of Banking and Finance2007，，8： | 2 |
| 10 | Biogeophysical effects of land use on climate: Model simulations of radiative forcing and large-scale temperature change显示文摘 | Richard A. Betts Peter D. Falloon Kees Klein Goldewijk Navin Ramankutty | 2006 | Agricultural and Forest Meteorology2006，，2： | 2 |
| 11 | TGF-β1-509 T/T基因型与结直肠癌患者术后结肠吻合口瘘的关系显示文摘目的通过研究转化生长因子-β1(TGF-β1)基因功能的多态性,了解TGF-β1因子对结直肠癌术后结肠吻合口瘘的影响。方法采用PCR-RFLP方法检测结直肠癌组内157例伴有或不伴有术后结肠吻合口瘘患者及对照组117例的TGF-β1-509 T/C基因型。结果伴有术后结肠吻合口瘘的患者TGF-β1-509 T/T。基因型比例(0)低于无吻合口瘘的患者(13.2%),两者差异有统计学意义(P=0.012)。结直肠癌组TGF-β1-509基因型或等位基因与对照组差异无统计学意义(基因型χ^2=0.981,P〉0.05;等位基因χ^2=0.000,P〉0.05)。结论具TGF-β1-509 T/T基因型者术后结肠吻合口瘘的发生率较低。而TGF-β1-509 T/C基因多态性与结直肠癌的发生及发展无关。 | 吴国洋 王效民 Michael Keese Till Hasenberg Jorg W. Sturm | 2007 | 中华普通外科杂志2007，22，5： | 2 |
| 12 | SJES14110700137731显示文摘 | Daniel J Rader G Kees Hovingh | 2014 | The Lancet . 2014 (9943)2014，，9943： | 2 |
| 13 | Nucleotide sequence of coat protein gene for GPV isolate of barley yellow dwarf virus and construction of expression plasmid for plant显示文摘GPV is a Chinese serotype isolate of barley yellow dwarf virus (BYDV) that has no reactionwith antiserum of MAV, PAV, SGV, RPV and RMV. The sequence of the coat protein (CP) of GPV isolate of BYDV was identified and its amino acid sequence was deduced. The coding region for the putative GPV CP is 603 bases nucleotides and encodes a Mr 22218 (22 ku) protein. The same as MAV, PAV and RPV, GPV contained a second ORF within the coat protein coding region. This protein of 17024 Mr (17 ku) is thought to correspond to the Virion protein genome linked (Vpg). Sequence comparisons of the CP coding region between the GPV isolate of BYDV and other isolates of BYDV have been done. The nucleotide and ammo acid sequence homology of GPV has a greater identity to the sequence of RPV than those of PAV and MAV. The GPV CP sequence shared 83.7% of nucleotide similarity and 77.5% of deduced amino add similarity, whereas that of the PAV and MAV shared 56.9%. 53.2% and 44.1%. 43.8% respectively. According to BYDV-GPV CP | 成卓敏 何小源 吴茂森 周广和 Paul Keese P.M.Waterhouse | 1996 | Science China(Life Sciences)1996，39，5： | 2 |
| 14 | A randomized trial of endoscopic balloon dilation and endoscopic sphincterotomy for removal of bile duct stones in patients with a prior Billroth II gastrectomy显示文摘 | Jacques J.G.H.M Bergman Anne-Marie van Berkel Marco J Bruno Paul Fockens Erik A.J Rauws Jan G.P Tijssen Guido N.J Tytgat Kees Huibregtse | 2001 | Gastrointestinal Endoscopy2001，，1： | 2 |
| 15 | Abdominal cocoon in children: A case report and review of literature显示文摘BACKGROUND Abdominal cocoon or“encapsulating peritoneal sclerosis”(EPS)is an uncommon and rare cause of intestinal obstruction.Only a few cases have been reported in paediatric patients.Typically,EPS is described as the primary form in young adolescent girls from tropical and subtropical countries because of viral peritonitis due to retrograde menstruation or a history of peritoneal dialysis.Most patients are asymptomatic or present with abdominal pain,which is likely to occur secondary to subacute bowel obstruction.Findings at imaging,such as ultrasound,computed tomography,and magnetic resonance imaging,are often nonspecific.When diagnosed,EPS is characterized by total or partial encasement of the bowel within a thick fibrocollagenous membrane that envelopes the small intestine in the form of a cocoon because of chronic intraabdominal fibroinflammatory processes.The membrane forms a fibrous tissue sheet that covers,fixes,and finely constricts the gut,compromising its motility.CASE SUMMARY We present a case of EPS in a 12-year-old boy 8 wk after primary surgery for resection of symptomatic jejunal angiodysplasia.There was no history of peritoneal dialysis or drug intake.CONCLUSION In this report,we sought to highlight the diagnostic,surgical,and histopathological characteristics and review the current literature on EPS in paediatric patients. | Daniel Keese Andrea Schmedding Kerstin Saalabian Georgy Lakshin Henning Fiegel Udo Rolle | 2021 | World Journal of Gastroenterology2021，27，37： | 2 |
| 16 | A Morphological Biosensor for Mammalian Cells显示文摘 | Giaever I Keese CR | 1993 | Nature1993，366，： | 1 |
| 17 | Doxorubicin and mitoxantrone drug eluting beads for the treatment of experimental peritoneal carcinomatosis in colorectal cancer 显示文摘 | Keese M Gasimova L Schwenke K | 2009 | lnt J Cancer2009，124，11： | 1 |
| 18 | Suicide显示文摘 | Keith Hawton Kees van Heeringen | 2009 | The Lancet2009，，9672： | 1 |
| 19 | The function of biodiversity in the ecology of vector borne zoonotic diseases显示文摘 | Ostfeld RS Keesing F | 2000 | Canadian Journal of Zoology2000，78，： | 1 |
| 20 | Understanding the costs of care for cystic fibrosis: an analysis by age and health state显示文摘 | Kees van Gool Richard Norman Martin B. Delatycki Jane Hall John Massie | 2012 | Value in Health2012，，： | 1 |
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