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| 1 | Mechanosignaling activation of TGFβmaintains intervertebral disc homeostasis显示文摘Intervertebral disc(IVD) degeneration is the leading cause of disability with no disease-modifying treatment.IVD degeneration is associated with instable mechanical loading in the spine, but little is known about how mechanical stress regulates nucleus notochordal(NC) cells to maintain IVD homeostasis. Here we report that mechanical stress can result in excessive integrin α_vβ_6-mediated activation of transforming growth factor beta(TGFβ), decreased NC cell vacuoles, and increased matrix proteoglycan production, and results in degenerative disc disease(DDD). Knockout of TGFβ type II receptor(TβRII) or integrin α_v in the NC cells inhibited functional activity of postnatal NC cells and also resulted in DDD under mechanical loading.Administration of RGD peptide, TGFβ, and α_vβ_6-neutralizing antibodies attenuated IVD degeneration. Thus,integrin-mediated activation of TGFβ plays a critical role in mechanical signaling transduction to regulate IVD cell function and homeostasis. Manipulation of this signaling pathway may be a potential therapeutic target to modify DDD. | Qin Bian Lei Ma Amit Jain Janet L Crane Khaled Kebaish Mei Wan Zhengdong Zhang X Edward Guo Paul D Sponseller Cheryle A Seguin Lee H Riley Yongjun Wang Xu Cao | 2017 | Bone Research2017，5，1： | 9 |
| 2 | Posterior only versus combined anterior and posterior approaches to lumbar scoliosis in adults: a radiographic analysis显示文摘 | Pateder DB Kebaish KM Cascio BM | 2007 | Spine2007，32，： | 1 |
| 3 | Use of vertebroplasty to prevent proximal junctional fractures in adult deformity surgery:a biomechanical cadaveric study显示文摘 | Kebaish KM Martin CT O′Brien JR | 2013 | Spine J2013，13，12： | 1 |
| 4 | Spinal epidural hematoma causing acute cauda equina syndrome显示文摘 | Kebaish K M Awad J N | 2004 | Neurosurg Focus2004，16，6： | 1 |
| 5 | Analysis of the risk factors for the development of post-operative spinal epidural haematoma显示文摘 | Awad K N Kebaish K M Donigan J | 2005 | J Bone Joint Surg Br2005，87，9： | 1 |
| 6 | Use of vertebroplasty to prevent proximal junctional fractures in adult deformity surgery:a biomechanical cadaveric study显示文摘 | Kebaish KM Martin CT O′Brien JR | 2013 | Spine J2013，13，12： | 1 |
| 7 | Scoliosis in adults aged forty years and older:prevalence and relationship to age,race,and gender显示文摘 | Kebaish KM Neubauer PR Voros GD | 2011 | Spine(Phila Pa 1976)2011，36，9： | 1 |
| 8 | Scoliosis in adultsaged forty years and older:prevalence and relationship to age,race,and gender显示文摘 | Kebaish KM Neubauer PR Voros GD | 2011 | Spine(Phila Pa 1976)2011，36，9： | 1 |
| 9 | Functional outcome after open supracondylar fractures of the humerus显示文摘 | Mckee MD Kim J Kebaish K | | 0，，05： | 1 |
| 10 | Functional outcome after open supracondylar fractures of the humerus显示文摘 | McKee MD Kim J Kebaish K | 2000 | J Bone Joint Surg( Br)2000，5，： | 1 |
| 11 | Functional outcome after open supracondylar fracture of the humerus:The effect of the surgical approach 显示文摘 | Mckee MD Kim J Kebaish K | 2000 | J Bone Joint Surg ( Br )2000，82，5： | 1 |
| 12 | Effect of Epsilon Aminocaproic Acid on Red-Cell Transfusion Requirements in Major Spinal Surgery显示文摘 | Sean M. Berenholtz Julius Cuong Pham Elizabeth Garrett-Mayer Christine W. Atchison John P. Kostuik David B. Cohen Shantanu Nundy Todd Dorman Paul M. Ness Michael J. Klag Peter J. Pronovost Khaled M. Kebaish | 2009 | Spine2009，，19： | 1 |
| 13 | Spinal epidural hematoma causing acutecauda equina syndrome 显示文摘 | Kebaish KM Awad JN | 2004 | Neurosurg Focus2004，16，6： | 1 |
| 14 | Spinal epidural hematoma causing acute cau-da equina syndrome显示文摘 | Kebaish KM Awad JN | 2004 | Neurosurg Focus2004，6，： | 1 |
| 15 | Analysis of the risk factors for the development of post - operative spinal epidural haematoma 显示文摘 | Awad JN Kebaish KM Donigan J | 2005 | J Bone Joint Surg Br2005，87，9： | 1 |
| 16 | Spinal epidural hematoma causing a- cute cauda equina syndrome显示文摘 | Kebaish KM Awad JN | 2004 | Neurosurg Focus2004，16，6： | 1 |
| 17 | Analysis of the risk factorsfor the development of post operative spinal epidural haematoma显示文摘 | Awad KN Kebaish KM Donigan J | 2005 | J Bone Joint Surg Br2005，9，： | 1 |
| 18 | Analysis of the risk factors for the development of post-operative spirted epidural haematoma显示文摘 | Awad KN Kebaish KM Donigan J | 2005 | J Bone Joint Surg Br2005，87，9： | 1 |
| 19 | Analysis of the risk factors for the development of post operative spinal epidural haematoma显示文摘 | Awad J N Kebaish K M Donigan J Cohen D B Kostuik J P | 2005 | J Bone Joint Surg Br2005，87，： | 1 |
| 20 | Spinal epidural hematoma causing acute cauda equina syndrome显示文摘 | Kebaish KM Awad JN | 2004 | Neurosurg Focus2004，16，6： | 1 |
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