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| 1 | Neutrophil-lymphocyte ratio is useful for the prognosis of patients with hepatocellular carcinoma显示文摘There is increasing evidence that neutrophil-lymphocyte ratio(NLR)may play a role in predicting recurrence in patients with hepatitis B virus-related hepatocellular carcinoma(HCC)after liver transplantation.In the original study by Yan et al,it was aimed to determine whether an elevated NLR is associated with tumor recurrence.Total tumor size(>9 cm)and macro-vascular invasion were found to be more significant than NLR according to the multivariate logistic regression analysis.Therefore,substantive significance should be emphasized rather than NLR because total tumor size and macro-vascular invasion are easier and more expressive than NLR in assessing HCC recurrence.NLR and platelet-lymphocyte ratio(PLR)are markers which are easy to obtain and can be used as inflammation indicators.Moreover,assessment of both NLR and PLR may add some value as a good predictor of risk for post-liver transplantation HCC recurrence.However,while the study was constructed on whole blood analysis,further details about the features and performance characteristics of the whole-blood analyzer,and preanalytical/analytical variables should also be mentioned. | Huseyin Kayadibi Erdim Sertoglu Metin Uyanik Serkan Tapan | 2014 | World Journal of Gastroenterology2014，20，28： | 7 |
| 2 | Is increased red cell distribution width an indicating marker of nonalcoholic steatohepatitis and fibrotic stage?显示文摘Red cell distribution width(RDW)may play an important role in predicting steatohepatitis and liver fibrosis.In the original study,it was aimed to determine whether RDW could be used for this purpose or not.There are studies indicating that higher RDW is correlated well with components of metabolic syndrome.Because nonalcoholic fatty liver disease is now recognized as the hepatic manifestation of metabolic syndrome,possible impact of the accompanying confounders on the study findings should have been detailed.There may be a patient selection bias due to use of improper cutoff values for alcohol consumption and inclusion of only subjects with normal aminotransferase levels and normal abdominal ultrasonography.Patients without hepatosteatosis on ultrasonography and with any restriction of aminotransferase levels should have been included in the control group,because isolated aminotransferase elevation is not decisive in the diagnosis of hepatosteatosis.Although iron,vitamin B12 and folic acid deficiencies were included in exclusion criteria,functional forms of these molecules like methylmalonic acid,homocysteine,ferritin levels and total iron binding capacity,which are more sensitive and specific parameters for vitamin B12 and folic acid deficiencies,were not mentioned.Consequently,RDW,an inexpensive,non-invasive,but powerful indicator overlooked on whole blood analysis,itself without other inflammatory markers may not accurately provide information about progression of nonalcoholic steatohepatitis and fibrosis. | Huseyin Kayadibi Erdim Sertoglu Metin Uyanik Serkan Tapan | 2014 | World Journal of Gastroenterology2014，20，35： | 3 |
| 3 | Diagnostic value of serum prolidase enzyme activity to predict the liver histological lesions in non-alcoholic fatty liver disease:A surrogate marker to distinguish steatohepatitis from simple steatosis显示文摘 | Kayadibi H Gultepe M Yasar B | 2009 | Dig Dis Sci2009，54，8： | 1 |
| 4 | Diagnostic value of serum prolidase enzyme activity to predict the liver histological lesions in non-alcoholic fatty liver disease:a surrogate marker to distinguish steatohepatitis from simple steatosis显示文摘 | KAYADIBI H GULTEPE M YASAR B | 2009 | Dig Dis Sci2009，54，8： | 1 |
| 5 | Diagnostic value of serum prolidase enzyme activity to predict the liver histological lesions in non-alcoholic fatty liver disease:a surrogate marker to distinguish steatohepatitis from simple steatosis显示文摘 | Kayadibi H Gültepe M Yasar B | | Digestive Diseases and Sciences0，，： | 1 |
| 6 | The impact of share wave elastography in differentiation of hepatic hemangioma from malignant liver tumors in pediatric population 显示文摘 | Ozmen E Adaletli I Kayadibi Y | 2014 | Eur J Radiol2014，83，9： | 1 |
| 7 | The relationship of serum uric acid with non-alcoholic fatty liver disease显示文摘 | Erdim Sertoglu Cemal Nuri Ercin Gurkan Celebi Hasan Gurel Huseyin Kayadibi Halil Genc Muammer Kara Teoman Dogru | 2014 | Clinical Biochemistry2014，，： | 1 |
| 8 | The role of suture fixation on mesh contraction after abdominal hemia repair显示文摘 | Sekmen U Gurleyik G Kayadibi H | 2009 | J Invest Surg2009，22，2： | 1 |
| 9 | Biochemical view on 'Homocysteine and metabolic syndrome: From clustering to additional utility in prediction of coronary heart disease'显示文摘 | Sertoglu E Kayadibi H Uyanik M | 2014 | J Cardiol2014，29，14： | 1 |
| 10 | Density functional theory studies on the corrosion inhibition of benzoin, benzil, benzoin-( 4- phenylthiosemicarbazone) and benzil-(4-phenylthiosemicarbazone) of mild steel in hydrochloric acid 显示文摘 | KAYADIBI F SAGDINC S G KARA Y S | 2015 | Prot Met Phys Chem Surf2015，51，1： | 1 |
| 11 | Evaluation of re- lationship between CA-125 levels and ascites in patients with liver cirrhosis 显示文摘 | KAYADIBI H SERTOGLU E UYANIK M | 2014 | J Coil Physicians Surg Pak2014，24，11： | 1 |
| 12 | Commentary on'Simple non-invasive biomarkers of advanced fibrosis in the evaluation of non-alcoholic fatty liver disease'显示文摘Dear Editor,We read with great interest the recently published article by Tapper et al.[1].In this study,the authors’intention was to describe the clinical predictors of advanced histology in a tertiary referral centre population,and to describe the rate of advanced histology in patients with‘normal’ultrasound findings in a cohort of liver-biopsy-proven,non-alcoholic fatty liver disease(NAFLD)or non-alcoholic steatohepatitis(NASH)patients.In conclusion,aspartate aminotransferaseto-platelet ratio(APRI)greater than 1.0 was found to be the most significant predictor of advanced fibrosis.Additionally,20%and 16.7%of patients without ultrasound-detected steatosis had advanced fibrosis and active NASH,respectively.In accordance with these findings,the authors suggested that patients with suspected NAFLD should routinely be evaluated for advanced liver disease,including non-invasive indices of fibrosis such as APRI,and that serious consideration should be given to liver biopsy.However,we would like to share our thoughts and contributions to the original study. | Huseyin Kayadibi Erdim Sertoglu Metin Uyanik | 2014 | Gastroenterology Report2014，2，4： | 0 |
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