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| 1 | Anti-chikungunya activity of luteolin and apigenin rich fraction from Cynodon dactylon显示文摘Objective:To obtain Iuteolin and apigenin rich fraction from the ethanolic extract of Cynodon dactylon(L.)(C.dactylon) Pers and evaluate the fraction's cytotoxicity and anti-Chikungunya potential using Vero cells.Methods:The ethanolic extract of C.dactylon was subjected to silica gel column chromatography to obtain anti-chikungunya virus(CHIKV) fraction.Reverse phase-HPLC and GC-MS studies were carried out to identily the major phytochemicals in the fraction using phylochemical standards.Cytotoxicity and the potential of the fraction against CHIKV were evaluated in vitro using Vero cells.Reduction in viral replication was assessed by reverse transcriptase-polymerase chain reaction(RT-PCR) after treating the viral infected Vero cells with the fraction.Results:Reverse Phase-HPLC and GC-MS studies confirmed the presence of flavonoids,luteolin and apigenin as major phytochemicals in the anti-CHIKV ethanolic fraction of C.dactylon- The fraction was found to exhibit potent viral inhibitory activity(about 98%) at the concentration of 50 μg/mL as observed by reduction in cytopathic effect,and the cytotoxic concentration of the fraction was found to be 250 μg/mL.RT-PCR analyses indicated that the reduction in viral mRNA synthesis in fraction treated infected cells was much higher than the viral infected control cells.Conclusions:Luteolin and apigenin rich ethanolic fraction from C.dactylon can be utilized as a potential therapeutic agent against CHIKV infection as the fraction does not show cytotoxicity while inhibiting the virus. | Krishnan Saravana Murali Srinivasan Sivasubramanian Savariar Vincent Shanmugaraj Bala Murugan Bupesh Giridaran Sundaram Dinesh Palani Gunasekaran Kaveri Krishnasamy Ramalingam Sathishkumar | 2015 | Asian Pacific Journal of Tropical Medicine2015，8，5： | 5 |
| 2 | Th17 cells, pathogenic or not? TGF-β3 imposes the embargo显示文摘 | Meenu Sharma | 2013 | Cellular & Molecular Immunology2013，10，2： | 2 |
| 3 | mpaired regulatory T cell function in autoimmune Jiseases: are microRNAs the culprits?显示文摘 | Varun K Sharma Srini V Kaveri Jagadeesh Bayry | 2016 | Cellular & Molecular Immunology2016，13，2： | 2 |
| 4 | Self-reactive antibodies (natural autoantibodies) in healthy individuals显示文摘 | Lacroix-Desmazes S Kaveri SV Mouthon L | 1998 | J Immunol Methods1998，216，12： | 1 |
| 5 | Structure of the gene for human beta2-adreenergic receptor: Expression and promoter characterizaation 显示文摘 | Emorine L J Mamllo S Kaveri S V | 1987 | Proc Natl Acad Sci USA1987，84，20： | 1 |
| 6 | Immunomodulation of autoimmune and inflammatory, diseases with intravenous immune globulin 显示文摘 | Kazatchkine M D Kaveri S V | 2001 | N Engl J Med2001，345，10： | 1 |
| 7 | Intravenous immunoglobulins-understanding properties and mechanisms显示文摘 | Durandy A Kaveri SV Kuijpers TW | 2009 | Clinical and Experimental Immunology2009，158，1： | 1 |
| 8 | Human dendritic cells acquire a semimature phenotype and lymph node homing potential through interaction with CD4^+CD25^+ regulatory T cells 显示文摘 | Bayry J Triebel F Kaveri SV | 2007 | J Immunol2007，178，7： | 1 |
| 9 | Cutting Edge:Human CD4 + CD25 + T cells restrain the maturation and antigen-presenting function of dendritic cells显示文摘 | Misra N Bayry J Lacroix-Desmazes S Kazatchkine MD & Kaveri SV | 2004 | J Immunol2004，172，： | 1 |
| 10 | Anti-metastatic action of anacardic acid targets VEGF-induced signalling pathways in epithelial to mesenchymal transition 显示文摘 | Shilpa P Kaveri K Salimath B P | 2015 | Drug Discov Ther2015，9，1： | 1 |
| 11 | Sonic hedgehog-depend- ent induction of microRNA 31 and microRNA 150 regulates Myeo- bacterium boris, BCG-driven toll-like receptor 2 signaling 显示文摘 | Ghorpade DS HoHa S Kaveri SV | 2013 | Mol Cell Biol2013，33，3： | 1 |
| 12 | Immunomodulation ofautoimmune and inflammatory diseases with intravenousimmune globulin显示文摘 | Kazatchkine MD Kaveri SV | 2001 | N Engl J Med2001，345，10： | 1 |
| 13 | Immunomodulation of autoimmune and inflammatory diseases with intravenous immunoglobulin显示文摘 | A. Ephrem N. Misra G. Hassan S. Dasgupta S. Delignat J.-P. Duong Huyen S. Chamat F. Prost S. Lacroix-Desmazes S. V. Kavery M. D Kazatchkine | 2005 | Clinical and Experimental Medicine2005，，4： | 1 |
| 14 | Th17 cells:biology,pathogenesis of autoimmuneand inflammatory diseases,and therapeutic strategies显示文摘 | Maddur MS Miossec P Kaveri SV | | 0，，01： | 1 |
| 15 | Structural engineering of a phage lysin that targets Gram-negative pathogens显示文摘 | Petra Lukacik Travis J. Barnard Paul W. Keller Kaveri S. Chaturvedi Nadir Seddiki James W. Fairman Nicholas Noinaj Tara L. Kirby Jeffrey P. Henderson Alasdair C. Steven B. Joseph Hinnebusch Susan K. Buchanan | 2012 | Proceedings of the National Academy of Sciences2012，，25： | 1 |
| 16 | Mycobacterium tu-berculosis Promotes Regulatory T-Cell Expansion via Inductionof Programmed Death-1 Ligand 1(PD-L1,CD274)on Den-dritic Cells显示文摘 | Trinath J Maddur M S Kaveri S V | 2012 | J Infect Dis2012，205，4： | 1 |
| 17 | Online com- munication and adolescent relationships 显示文摘 | Subrahmanyam Kaveri Patricia Greenfield | 2008 | The future of Children2008，，1： | 1 |
| 18 | Immunomodulation of auto-immune and inflammatory diseases with intravenous immune globulin显示文摘 | Kazatchkine MD Kaveri SV | 2001 | N Engl J Med2001，345，10： | 1 |
| 19 | Thl7 cells: bio logy, pathogenesis of autoimmune and inflammatory disea- ses,and therapeutic strategies 显示文摘 | Maddur MS Miossec P Kaveri SV | 2012 | Am J Pathol2012，，： | 1 |
| 20 | Immunomodulation autoimmune and inflammatory diseases with intravenous immune globulin显示文摘 | Kazatchkine MD Kaveri SV | 2001 | N Engl J Med2001，345，10： | 1 |
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