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| 1 | Association of CagA and VacA presence with ulcer and non-ulcer dyspepsia in a Turkish population显示文摘AIM: The mostly known genotypic virulence features, of H. pyloriare cytotoxin associated gene A (ragA) and Vacuolating cytotoxin gene A (VacA). We investigated the association of these major virulence factors with ulcer and non-ulcer dyspepsia in our region.METHODS: One hundred and forty two dyspeptic patients were studied (average age 44.8±15.9 years, range 15-87years, 64 males and 78 females). Antral and corpus biopsies were taken for detecting and genotyping of H. pylori. 107patients who were H. pylori positive by histological assessment were divided into three groups according to endoscopic findings: Duodenal ulcer (DU), gastric ulcer (GU)and non-ulcer dyspepsia (NUD). The polymerase chain reaction (PCR) was used to detect CagA and VacA genes of H.pylori using specific primers.RESULTS: H.pyloriwas isolated from 75.4 % (107/142) of the patients. Of the 107 patients, 66 (61.7 %) were cagApositive and 82 (76.6 %) were Vacl-positive. CagA gene was positively associated with DU and GU (P<0.01, P<0.02),but not with NUD (P>0.05). Although VacA positivity in ulcer patients was higher than that in NUD group, the difference was not statistically significant (P>0.05).CONCLUSION: There is a significantly positive association between CagA genes and DU and GU. The presence of VacA is not a predictive marker for DU, GU, and NUD in our patients. | Kantarceken Bulent Aladag Murat Atik Esin Koksal Fatih Harputluoglu MMMurat Harputluoglu Hakan Karincaoglu Melih Ares Mehmet Yildirim Bulent Hilmioglu Fatih | 2003 | World Journal of Gastroenterology2003，9，7： | 8 |
| 2 | Monilethrix: improvement with acitretin 显示文摘 | Karincaoglu Y Coskun BK Seyhan ME | 2005 | Am J Clin Dermatol2005，6，6： | 1 |
| 3 | Monilethrix: improvement with acitretin显示文摘 | Karincaoglu Y Coskun BK Seyhan ME | 2005 | Am J Clin Dermatol2005，6，6： | 1 |
| 4 | Two findings of portal hypertension:Evaluation of correlation between serum ascites albumin gradient and esophageal varices in non alcohofic cirrhosis 显示文摘 | Demirel U Karincaoglu M Harputluoglu M | 2003 | Turk J Gastroenterod2003，14，4： | 1 |
| 5 | Brain natriuretic peptide and severity of disease in non-alcoholic cirrhotic patients显示文摘 | Yildiz R Yildirim B Karincaoglu M | 2005 | J Gastroenterol Hepatol2005，20，7： | 1 |
| 6 | The Relationship of Heart Rate Variability with Severity and Prognosis of Cirrhosis显示文摘 | Fehmi Ates Ergun Topal Feridun Kosar Melih Karincaoglu Bulent Yildirim Yuksel Aksoy Murat Aladag Murat M. M. Harputluoglu Ulvi Demirel Hakan Alan Fatih Hilmioglu | 2006 | Digestive Diseases and Sciences2006，，9： | 1 |
| 7 | Two findings of portal hypertension: Evaluation of correlation between serum-ascites albumin gradient and esophageal varices in non-alcoholic cirrhosis显示文摘 | Karincaoglu M Harputluoglu M | 2003 | Turk J Gastroenterol2003，14，： | 1 |
| 8 | Brain natriuretic peptide and severityof disease in non-alcoholic cirrhotic patients显示文摘 | Yildiz R Yildirim B Karincaoglu M | 2005 | Gastroenterol Hepatol2005，20，12： | 1 |
| 9 | Scalp Ulcer as First Sign of Cholangiocarcinoma显示文摘 | Gursoy Dogan Yelda Karincaoglu Melih Karincaoglu N. Engin Aydin | 2006 | American Journal of Clinical Dermatology2006，，6： | 1 |
| 10 | Two findings of portal hypertension:evaluation of correlation between senull-ascites albumin gradient and esophageal varices in non-alcoholic cirrhosis显示文摘 | Demirel U Karincaoglu M Harputluoglu M | 2003 | Turk J Gastroenterol2003，14，4： | 1 |
| 11 | 急性胰腺炎患者肺功能检测的临床意义显示文摘The aim of the present study was to investigate changes in pulmonary function tests (PFTs) in patients with acute pancreatitis (AP), to compare them with those changes in healthy controls, and to analyze the relationship between these parameters and computed tomography severity index (CTSI) and Ranson’s criteria scores as markers of disease severity. This study included 40 patients with AP without a diagnosis of any pulmonary disease and 40 sex-and age-matched healthy controls. All participants were evaluated with simple PFTs and single-breath carbon monoxide (CO) diffusion tests. Patients with AP were also evaluated according to their CTSI and Ranson’s criteria scores as markers of disease severity. The forced vital capacity (FVC), forced expiratory volume in the first second (FEV1), FEV1/FVC, and peak expiratory flow, which determine lung capacity, were similar in the two groups. The forced expiratory volume during the middle half of the FVC (FEF25-75%), CO diffusing capacity (DLCO), and ratio of DLCO to alveolar ventilation (DLCO/VA), which determines alveolar membrane permeability, revealed a statistically significant decline in pulmonary gas exchange in patients with AP (P < 0.05). Correlation analysis showed that there is a significant negative relationship between CTSI and Ranson’s criteria scores with FEF25-75%, DLCO, and DLCO/V A (P < 0.05). We suggest that AP may cause impaired alveolar gas exchange without manifest pulmonary diseases. The effect of AP on FEF 25-75%, DLCO, and DLCO/VA appears to be dependent not only on the disease, but also on its severity. FEF25-75%, DLCO, and DLCO/VA may give additional prognostic information in patients with AP in the initial evaluation. | Ates F. Hacievliyagil S. S. Karincaoglu M. 纪泛扑(译) 史敏(校) | 2006 | 世界核心医学期刊文摘(胃肠病学分册)2006，2，6： | 1 |
| 12 | Two findings of portal hypertension : Evaluation of correlation between serum-ascites albumin gradient and esophageal varices in non-alcoholic cirrhosis 显示文摘 | Demirel U Karincaoglu M Harputluoglu M | 2003 | Turk J Gastroenterol2003，14，4： | 1 |
| 13 | The clinical importance of Demodex folliculorum presenting with nonspecific facial signs and symptoms显示文摘 | Karincaoglu Y Bayram N Aycan O | 2004 | J Dermatol2004，31，8： | 1 |
| 14 | Brain natriuretic peptide and severity of disease in non-alcoholic cirrhotic patients 显示文摘 | Yildiz R Yildirim B Karincaoglu M | 2005 | J Gastroenterol Hepatol2005，20，7： | 1 |
| 15 | Acute pancreatitis;an obscure complication of organophosphate intoxication显示文摘 | Harputluoglu MM Kantarceken B Karincaoglu M | 2003 | Hum Exp Toxicol2003，22，6： | 1 |
| 16 | Increased mean platelet volume in Beh(c)et′s disease with thrombotic tendency显示文摘 | Acikgoz N Karincaoglu Y Ermis N | 2010 | Tohoku J Exp Med2010，221，2： | 1 |
| 17 | Gastric Tissue Oxidative Changes in Portal Hypertension and Cirrhosis显示文摘 | Yuksel Seckin Murat M. M. Harputluoglu Kadir Batcioglu Melih Karincaoglu Bulent Yildirim Ramazan I. Oner Burcin Uyumlu Nurettin Aydogdu Fatih Hilmioglu | 2007 | Digestive Diseases and Sciences2007，，5： | 1 |
| 18 | Evaluation of 60 pa- tients with Pilonidal Sinus Treated with Laser Epilation显示文摘 | Oram Y Kahraman F Karincaoglu Y | 2010 | Der- matol Surg2010，36，： | 1 |
| 19 | Brain natriuretic peptide and severity of disease in non-alcoholic cirrhotic patients显示文摘 | Yildiz R Yildirim B Karincaoglu M | 2005 | J Gastroenterol Hepatol2005，20，： | 1 |
| 20 | The levels of plasma and salivary antioxidants in the patient with recurrent aphthous stomatitis显示文摘 | Karincaoglu Y Batcioglu K Erdem T Esrefoglu M Genc M | 2005 | J Oral Pathol Med2005，34，1： | 1 |
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