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| 1 | Association of CagA and VacA presence with ulcer and non-ulcer dyspepsia in a Turkish population显示文摘AIM: The mostly known genotypic virulence features, of H. pyloriare cytotoxin associated gene A (ragA) and Vacuolating cytotoxin gene A (VacA). We investigated the association of these major virulence factors with ulcer and non-ulcer dyspepsia in our region.METHODS: One hundred and forty two dyspeptic patients were studied (average age 44.8±15.9 years, range 15-87years, 64 males and 78 females). Antral and corpus biopsies were taken for detecting and genotyping of H. pylori. 107patients who were H. pylori positive by histological assessment were divided into three groups according to endoscopic findings: Duodenal ulcer (DU), gastric ulcer (GU)and non-ulcer dyspepsia (NUD). The polymerase chain reaction (PCR) was used to detect CagA and VacA genes of H.pylori using specific primers.RESULTS: H.pyloriwas isolated from 75.4 % (107/142) of the patients. Of the 107 patients, 66 (61.7 %) were cagApositive and 82 (76.6 %) were Vacl-positive. CagA gene was positively associated with DU and GU (P<0.01, P<0.02),but not with NUD (P>0.05). Although VacA positivity in ulcer patients was higher than that in NUD group, the difference was not statistically significant (P>0.05).CONCLUSION: There is a significantly positive association between CagA genes and DU and GU. The presence of VacA is not a predictive marker for DU, GU, and NUD in our patients. | Kantarceken Bulent Aladag Murat Atik Esin Koksal Fatih Harputluoglu MMMurat Harputluoglu Hakan Karincaoglu Melih Ares Mehmet Yildirim Bulent Hilmioglu Fatih | 2003 | World Journal of Gastroenterology2003，9，7： | 8 |
| 2 | Demograph ic, clinical, and pathological characteristics of Turkish triplenegative breast cancer patients: single center experience 显示文摘 | Aksoy S Dizdar O Harputluoglu H Altundag K | 2007 | Ann Oncol2007，18，： | 1 |
| 3 | Fascioliasis presenting as colon cancer liver metastasis on 18Ffluorodeoxyglucose positron emission tomography/computed tomography: A case report显示文摘BACKGROUND Fascioliasis is caused by watercress and similar freshwater plants or drinking water or beverages contaminated with metacercariae. Fascioliasis can radiologically mimic many primary or metastatic liver tumors. Herein, we aimed to present the treatment process of a patient with fascioliasis mimicking colon cancer liver metastasis. CASE SUMMARY A 35-year-old woman who underwent right hemicolectomy due to cecum cancer was referred to our clinic for management of colon cancer liver metastasis. Both computed tomography and 18F-fluorodeoxyglucose positron emission tomography revealed several tumoral lesions localized in the right lobe of the liver. After a 6-course FOLFOX (folinic acid, fluorouracil, oxaliplatin) and bevacizumab regimen, the hypermetabolic state on both liver and abdominal lymph nodes continued, and chemotherapy was extended to a 12-course regimen. The patient was referred to our institute when the liver lesions were detected to be larger on dynamic liver magnetic resonance imaging 6 weeks after completion of chemotherapy. Right hepatectomy was performed, and histopathological examination was compatible with fascioliasis. Fasciola hepatica IgG enzyme-linked immunosorbent assay was positive. The patient was administered two doses of triclabendazole (10 mg/kg/dose) 24 h apart. During the follow-up period, dilatation was detected in the common bile duct, and Fasciola parasites were extracted from the common bile duct by endoscopic retrograde cholangiopancreatography (ERCP). Triclabendazole was administered to the patient after ERCP. CONCLUSION Parasitic diseases, such as those caused by Fasciola hepatica, should be kept in mind in the differential diagnosis of primary or metastatic liver tumors, such as colorectal cancer liver metastasis, in patients living in endemic areas. | Sami Akbulut Egemen Ozdemir Emine Samdanci Selver Unsal Murat Harputluoglu Sezai Yilmaz | 2019 | World Journal of Hepatology2019，11，8： | 1 |
| 4 | Severe hepatitis with prolonged cholestasis and bile duct injury due the long-term use of omidazole显示文摘 | Harputluoglu MM Demirel U Karadag N | 2007 | Acta Gastroenterol Belg2007，70，3： | 1 |
| 5 | Erectile dysfunction in testicular cancer patients treated with chemotherapy 显示文摘 | Tasdemir C Firdolas F Harputluoglu H | 2012 | An- drologia2012，44，4： | 1 |
| 6 | Prophylactic human papilloma virus vaccines for cervical cancer may also prevent development of breast and oropharyngeal cancers in women显示文摘 | Harputluoglu H Dizdar O Altundag K | | 0，，02： | 1 |
| 7 | Demographic, clinical, and pathological characteristics of Turkish triple-negative breast cancer patients: single center experience显示文摘 | Sksoy S Dizdar O Harputluoglu H | 2007 | Ann Oneol2007，18，11： | 1 |
| 8 | Characteristics of breast cancer patients with central nervous system metastases: a single-center experience 显示文摘 | Harputluoglu H Dizdar O Aksoy S | 2008 | J Natl Med Assoc2008，100，5： | 1 |
| 9 | Two findings of portal hypertension:Evaluation of correlation between serum ascites albumin gradient and esophageal varices in non alcohofic cirrhosis 显示文摘 | Demirel U Karincaoglu M Harputluoglu M | 2003 | Turk J Gastroenterod2003，14，4： | 1 |
| 10 | Serum and gastric fluid levels of cytokines and nitrates in gastric diseases infected with Helicobacter pylori显示文摘 | Mehmet N Refik M Harputluoglu M | 2004 | New Microbiol2004，27，2： | 1 |
| 11 | The Relationship of Heart Rate Variability with Severity and Prognosis of Cirrhosis显示文摘 | Fehmi Ates Ergun Topal Feridun Kosar Melih Karincaoglu Bulent Yildirim Yuksel Aksoy Murat Aladag Murat M. M. Harputluoglu Ulvi Demirel Hakan Alan Fatih Hilmioglu | 2006 | Digestive Diseases and Sciences2006，，9： | 1 |
| 12 | Demographic, clinical, and pathological characteristics of Turkish triple-negative breast cancer patients: single center experience显示文摘 | Sksoy S Dizdar O Harputluoglu H | 2007 | AnnOncol2007，18，： | 1 |
| 13 | Two findings of portal hypertension: Evaluation of correlation between serum-ascites albumin gradient and esophageal varices in non-alcoholic cirrhosis显示文摘 | Karincaoglu M Harputluoglu M | 2003 | Turk J Gastroenterol2003，14，： | 1 |
| 14 | Long -term efficacy of combination therapy with PEG -IFN and entecavir on HBsAg loss and anti -HBs seroconversion in pa- tients with chronic active hepatitis 显示文摘 | ALADAG M ALADAG H HARPUTLUOGLU M | 2012 | Hepatology2012，561，： | 1 |
| 15 | Two findings of portal hypertension:evaluation of correlation between senull-ascites albumin gradient and esophageal varices in non-alcoholic cirrhosis显示文摘 | Demirel U Karincaoglu M Harputluoglu M | 2003 | Turk J Gastroenterol2003，14，4： | 1 |
| 16 | Nasopharyngeal aerobic bacterial flora and staphylococcus aureus nasal carriage显示文摘 | HARPUTLUOGLU U EGELI E SAHIN I | 2005 | Internat J Pediat Otorhinolaryngol2005，69，1： | 1 |
| 17 | Demographic,clinical,and pathological characteristics of Turkish triple-negative breast cancer patients:single center experience显示文摘 | Aksoy S Dizdar O Harputluoglu H | 2007 | Ann Oncol2007，18，11： | 1 |
| 18 | Does topical ropivacaine reduce the post-tonsillectomy morbidity in pediatric patients?显示文摘 | Oghan F Harputluoglu U Guclu E | 2008 | Int Journal Pediatr Otorhinolaryngol2008，72，3： | 1 |
| 19 | Two findings of portal hypertension : Evaluation of correlation between serum-ascites albumin gradient and esophageal varices in non-alcoholic cirrhosis 显示文摘 | Demirel U Karincaoglu M Harputluoglu M | 2003 | Turk J Gastroenterol2003，14，4： | 1 |
| 20 | Demographic,clinical,and pathological characteristics of Turkish triple-negative breast cancer patients:single center experience显示文摘 | Aksoy S Dizdar O Harputluoglu H | 2007 | Ann Oncol2007，18，11： | 1 |
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