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| 1 | Tumor immune escape mediated by indoleamine 2,3-dioxygenase显示文摘 | Maria Zamanakou Anastasios E. Germenis Vaios Karanikas | 2007 | Immunology Letters2007，，2： | 2 |
| 2 | Novel anti-androgen receptor signaling agents:Understanding the mechanisms of resistance显示文摘Prostate cancer remains an intractable threat to the lives of men worldwide.Although deaths from prostate cancer(PCa)in the United States have declined in recent years,in other parts of the world Pca mortality is increasing.The introduction of 2nd generation antiandrogen receptor agents into the therapeutic armamentarium for metastatic castrationresistant prostate cancer(mCRPC)has resulted in modestly increased survival advantages as demonstrated by initial clinical trials.However,analysis of the molecular pathways affected by these agents may lead to new insight into mechanisms of resistance that drive mCRPC,including proliferation and survival signaling pathways that are derepressed by maximum repression of androgen signaling.Combination therapies that involve anti-AR signaling agents together with agents that target these pathways establish a paradigm for the development of more effective treatment of mCRPC.In this review,we briefly summarize the current clinical trial literature with regard to novel anti-AR signaling agents such as abiraterone acetate and enzalutamide.We discuss observational data that point to mechanisms of resistance that emerged from these studies.We further present and discuss recent experimental studies that address the mechanisms of resistance to these treatments.Finally,we discuss novel and rational therapeutic approaches,including combination therapy,for patients with mCRPC. | Styliani Karanika Theodoros Karantanos Jianhua Yin Likun Li Timothy C.Thompson | 2014 | Asian Journal of Urology2014，1，1： | 2 |
| 3 | Staphylococcal scalded skin syn- drome in an adult, immunocompetent patient 显示文摘 | Koufakis T Gabranis I Karanikas K | 2015 | Braz J Infect Dis2015，19，2： | 1 |
| 4 | Foxp3 expression in human cancer cells显示文摘 | Karanikas V Speletas M Zamanakou M | 2008 | J Transl Med2008，22，6： | 1 |
| 5 | A monoclonal cytolytic T-lymphocyte response observed in a melanoma patient vaccinated with a tumor-specific antigenic peptide encoded by gene MAGE-3显示文摘 | Coulie P G Karanikas V Colau D | 2001 | Proc Natl Acad Sci USA2001，98，10： | 1 |
| 6 | Current surgical status of thyroid diseases显示文摘 | Touzopoulos P Karanikas M Zarogoulidis P | 2011 | J Muhidiscip Healthc2011，4，： | 1 |
| 7 | Development of muscle strength in knee,hip and ankle joints after ACL reconstruction显示文摘 | karanikas k Aramqatzis A Bruggemann GP | 2004 | Sportverletz Sportschaden2004，18，3： | 1 |
| 8 | Indoleamine 2,3 - dioxygenase (IDO) expression in lung cancer 显示文摘 | Karanikas V Zamanakou M Kerenidi T | 2007 | Cancer Biol Ther2007，6，10： | 1 |
| 9 | Cytolytic T-cell responses of cancer patients vaccinated with a MAGE antigen显示文摘 | Coulie P G Karanikas V Lurquin C | 2002 | Immunol Rev2002，188，1： | 1 |
| 10 | Induction of HLA-A2- restricted CTLs to the mucin 1 human breast cancer antigen 显示文摘 | Apostolopoulos V Karanikas V Haurum J S | 1997 | J Immunol1997，159，11： | 1 |
| 11 | [11C] Methionine and [18F] Fluorodeoxyglucose PET in the follow-up of glioblastoma multiforme显示文摘 | Christian P?tzi Alexander Becherer Christine Marosi Georgios Karanikas Monika Szabo Robert Dudczak Kurt Kletter Susanne Asenbaum | 2007 | Journal of Neuro - Oncology2007，，3： | 1 |
| 12 | Immune response after laparoscopic colectomy for cancer:a review显示文摘Background and aim:Colorectal cancer(CRC)is the third leading cause of cancer mortality worldwide and laparoscopic colectomy has been established as equivalent to the open approach in terms of oncological results and patients’safety.Survival benefits have been reported in favor of laparoscopic colectomy(LC)in stage III CRC patients.Different immune responses after surgery,in terms of innate and cellular immunity,may potentially explain some of the reported differences.This review summarizes the literature on differences in immune response after the laparoscopic and the open approach for CRC.Materials and Methods:A literature search of electronic databases was conducted and all studies published on‘colorectal cancer’,‘laparoscopic and open colectomy’‘immune response’and‘surgical stress laparoscopy versus open’were collected.Among these,the ones referring to CRC and those that had any clinical relevance offering information on perioperative parameters were used.Results:Despite the heterogeneity of studies,they support the view that innate immune response is activated to a greater degree in open colectomy(OC),which may be related to the more extensive trauma and surgical stress.On the other hand,cellular immunity is better preserved after LC.These differences are more pronounced in the immediate postoperative period.Conclusions:LC has been related to decreased up-regulation of innate immunity and better-preserved cellular immunity.The latter may be related to better anti-tumor activity and may be beneficial in terms of oncological survival in a subgroup of LC patients. | Styliani Karanika Theodoros Karantanos George E.Theodoropoulos | 2013 | Gastroenterology Report2013，1，2： | 1 |
| 13 | Dendritic cell vaccination with MAGE peptide is a novel therapeutic approach for gastro-intestinal carcinomas显示文摘 | Coulie P G Karanikas V Colau D | 2001 | Clin Cancer Res2001，7，8： | 1 |
| 14 | Isotopic renal function studies in severe hypothyroidism and after thyroid hormone replaeement therapy 显示文摘 | KARANIKAS G SCHLITZ M SZABO M | 2004 | American Journal of Nephrology2004，24，1： | 1 |
| 15 | Antibody and T cell respons- es of patients with adenocarcinoma immunized with mannan- MUCI fusion protein显示文摘 | Karanikas V Hwang LA Pearson J | 1997 | J Clin Invest1997，100，11： | 1 |
| 16 | Foxp3 expression in human cancer cells显示文摘 | Karanikas V Speletas M Zamanakou M | 2008 | Transl Med2008，6，1： | 1 |
| 17 | No immunological benefit of Selenium in consecutive patients with autoimmune thyroiditis显示文摘 | Karanikas G Schuetz M Kontur S | 2008 | Thyroid2008，18，1： | 1 |
| 18 | Indoleamine 2,3-dioxygenase (IDO) expression in lung cancer显示文摘 | Karanikas V Zamanakou M Kerenidi T ct al | 2007 | Cancer Biol Ther2007，6，8： | 1 |
| 19 | A monoclonal cytolytic T-lymphocyte response observed in a melanoma patient vaccinated with a tumor-specific antigenic peptide encoded by gene MAGE-3 显示文摘 | Karanikas V Colau D | 2001 | Proc Natl Acad Sci USA2001，98，10： | 1 |
| 20 | Current surgical status of thyroid diseases显示文摘 | Touzopoulos P Karanikas M Zarogoulidis P | 2011 | J Multidiscip Healthc2011，4，： | 1 |
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