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| 1 | 1α,25-dihydroxyvitamin D_(3) prevents DNA damage and restores antioxidant enzymes in rat hepatocarcinogenesis induced by diethylnitrosamine and promoted by phenobarbital显示文摘AIM:To investigate the chemopreventive iffects of 1α,25-dihydroxyvitamin D3 in diethylnitrosamine induced,phenobarbital promoted rat hepatocarcinogenesis.METHODS:The rats were randomly divided into 6 different groups(A-F).Group A,C and E rats received a single intraperitoneal (i.p) injection of diethylnitrosamine (DEN) at a dose of 200 mg/kg body mass in 9 g/L NaCl solution at 4 wk of age ,while group B served as normal vehicle control received normal saline once.After a brief recovery of 2 WK, all the DEN treated rats were given phenobarbital (PB) at 0.5g/L daily in the basal diet till WK 20.Group C was started 4 wk prior to DEN injection and continued thereafter till wk 20 at a dose (os) twice a week.Group E received the treatment of 1α,25-(OH)2D3 at the same dose mentioned as above for 15 wk.The rats in group D and F received 1α,25-(OH)2D3 alone as in group C without DEN injection.RESULTS:The comet assay showed statistically higher mean values for length to width ratios (L:W) of DNA mass and tailed cells (p<0.01;p<0.01 respectively) in DEN treated rats as compared to their normal controls.Continuous supplementation of 1α,25-dihydroxyvitaminD3 showed a significant (p<0.01) decrease in L:W ratio of DNA mass tailed cells.Furthermore,1α,25-(OH)2D3 supplementations elevated the super oxide dismutase (SOD) activety,hepatic malondialdehyde(MDA) levle,reduced glutathione (GSH) and glutathione S-transferase (GST) activety (p<0.01,p<0.01,p<0.05 and p<0.05 respectively).As an endpoint marker histological changes were observed to establish the chemopreventive effects of 1α,25-dihydroxyvitaminD3.CONCLUSION:Supplementations of 1α,25-(OH)2D3 has a marked protection against hepatic nodelogenesis,antioxidant enzymes and DNA damages in DEN induced rat hepatocarcinogenesis promoted by phenobarbital. | Mahendrakumar Chandrasekharappa Banakar Suresh Kanna Paramasivan Mitali Basu Chattopadhyay Subrata Datta Prabir Chakraborty Malay Chatterjee Kalaiselvi Kannan Elayaraja Thygarajan | 2004 | World Journal of Gastroenterology2004，10，9： | 5 |
| 2 | Secondary metabolite credentials ofEvolvulus alsinoides by high performance thin layer chromatography(HPTLC)显示文摘Plants and plant-based products are the bases of many modern pharmaceuticals that are current in use today for various diseases.The aim of the study was to investigate the biochemical constituents and high performance thin layer chromatography(HPTLC) finger printing of the ethanolic extract of Evolvulus alsinoides.Phytochemical screening was done by standard procedures and HPTLC method was also established to analyze alkaloids,flavonoids and phenolic compounds from the ethanolic extract of Evolvulus alsinoides.Preliminary phytochemical screening showed that ethanol extracted more secondary metabolites than other solvents.HPTLC fingerprinting analysis showed the presence of various alkaloids,flavonoids and phenols(quercetin) in the ethanolic extract.It can be concluded that Evolvulus alsinoides may serve as a source of potent antioxidants that may be used in the prevention of various diseases such as cancer,diabetes and cardiovascular diseases due to the presence of phenolic compounds.HPTLC finger print of Evolvulus alsinoides may be useful in the differentiation of the species from adulterants and act as a biochemical marker for this medicinally important plant in the pharmaceutical industry and plant systematic studies. | Duraisamy Gomathi Manokaran Kalaiselvi Ganesan Ravikumar Dominic Sophia Velliyur Kanniappan Gopalakrishnan Chandrasekar Uma | 2012 | The Journal of Biomedical Research2012，26，4： | 2 |
| 3 | Nuc-lear pore complex oxalate binding protein p62 : expression in different kidney disorders 显示文摘 | Sivakamasundari P Kalaiselvi P Sakthivel R | 2004 | Clinica Chimica Acta2004，347，： | 1 |
| 4 | Automatic brain extraction methods for TI magnetic resonance images using region labeling and morphological operations显示文摘 | SOMASUNDARAM K KALAISELVI T | 2011 | Computers in Biology and Medicine2011，41，8： | 1 |
| 5 | Counteraction of oxalate induced nitrosative stress by supplementation of L-arginine, a potent antilithic agent 显示文摘 | Pragasam V Kalaiselvi P Sumitra K | 2005 | Clin Chim Acta2005，354，12： | 1 |
| 6 | A protease from the medicinal mushroom Pleurotus sajor-caju; production, purification and partial characterization显示文摘 | Ravikumar G Gomathi D Kalaiselvi M | 2012 | Asian Pacific Journal of Tropical Biomedicine2012，2，1： | 1 |
| 7 | Microwave-assisted synthesis of LiNiO2-a preliminary investigation显示文摘 | Kalyani P Kalaiselvi N Renganathan N G | 2003 | J Power Sources2003，123，1： | 1 |
| 8 | Effect of L-carnitine on the status of lipid peroxidation and antioxidants in aged rats显示文摘 | Kalaiselvi T Pannerselvam C | | 0，，： | 1 |
| 9 | Exploration of artificial neural network[ANN]to predict the electrochemical characteristics of lithium-ion cells显示文摘 | T Parthiban R Ravi N Kalaiselvi | | 0，，04： | 1 |
| 10 | Biodegradation of azo dyes in a sequential anaerobic-aerobic system显示文摘 | Rajaguru P Kalaiselvi K Palanivel M | 2000 | Applied Microbi-ology and Biotechnology2000，54，2： | 1 |
| 11 | Chemopreventive Effect and HPTLC Fingerprinting Analysis of Jasminum sambac (L.) Ait. Extract Against DLA-Induced Lymphoma in Experimental Animals显示文摘 | M. Kalaiselvi R. Narmadha P. Ragavendran B. Vidya D. Gomathi C. Arul Raj T. Starlinraj V. K. Gopalakrishnan C. Uma K. Kalaivani | 2013 | Applied Biochemistry and Biotechnology2013，，4： | 1 |
| 12 | On the effects of simultaneous substitution of Al3+ and B3+ in LiNiO2 cathodes显示文摘 | Kalyani P Kalaiselvi N Muniyandi N | 2003 | J Electrochem Soc2003，150，6： | 1 |
| 13 | Microwave-assisted synthesis of-a preliminary investigation 显示文摘 | Kalyani P Kalaiselvi N Renganathan N G | 2003 | J Power Sources2003，123，： | 1 |
| 14 | CuFe204/SnO2 nanoeomposites as anodes for Li- ion batteries显示文摘 | Selvan R K Kalaiselvi N Augustin C O | 2006 | J Power Sources2006，157，1： | 1 |
| 15 | A checkpomting algorithm for an SCI based distributed shared memory system 显示文摘 | Kalaiselvi S Rajaraman V | 1998 | Microprocessors and Microsystem1998，22，10： | 1 |
| 16 | Various aspects of Li Ni O2 chemistry:a review显示文摘 | KALYANI P KALAISELVI N | 2005 | Sci Technol Adv Mater2005，6，6： | 1 |
| 17 | Various aspects of LiNiO2 chemistry:A review显示文摘 | Kalyani P Kalaiselvi N | 2005 | Science and Technology of Advanced Materials2005，6，6： | 1 |
| 18 | Nitrogen containing bio- carbon as a potential anode for lithium batteries 显示文摘 | K R Saravanan N Kalaiselvi | 2014 | Car- bon2014，81，： | 1 |
| 19 | Isolation and cDNA cloning of an Em-like protein from mung bean(Vigna radiata) axes显示文摘 | Manickam A van Damme E J M Kalaiselvi K | 1996 | Physiol Plantarum1996，97，3： | 1 |
| 20 | Microwave- assisted synthesis of LiNiO2 - a preliminary investigation 显示文摘 | Kalyani P Kalaiselvi N Renganathan N G | 2003 | Journal of Power Sources2003，123，1： | 1 |
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