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| 1 | 阑尾炎:阑尾增粗超过6mm时新的CT诊断标准显示文摘 | Friederike Klein München 徐安辉 | 2008 | 放射学实践2008，23，2： | 6 |
| 2 | DNA methylation, heterochromatin and epigenetic carcinogens显示文摘 | Klein CB Costa M | 1997 | Mutat Res1997，386，2： | 4 |
| 3 | Bovine immunoglobulin protein isolates for the nutritional management of enteropathy显示文摘The gastrointestinal tract is responsible for a multitude of digestive and immune functions which depend upon the balanced interaction of the intestinal microbiota, diet, gut barrier function, and mucosal immune response. Disruptions in one or more of these factors can lead to intestinal disorders or enteropathies which are characterized by intestinal inflammation, increased gut permeability, and reduced capacity to absorb nutrients. Enteropathy is frequently associated with human immunodeficiency virus(HIV) infection, inflammatory bowel disease, autoimmune enteropathy, radiation enteritis, and irritable bowel syndrome(IBS), where pathologic changes in the intestinal tract lead to abdominal discomfort, bloating, abnormal bowel function(e.g., diarrhea, urgency, constipation and malabsorption). Unfortunately, effective therapies for the management ofenteropathy and restoring intestinal health are still not available. An accumulating body of preclinical studies has demonstrated that oral administration of plasmaor serum-derived protein concentrates containing high levels of immunoglobulins can improve weight, normalize gut barrier function, and reduce the severity of enteropathy in animal models. Recent studies in humans, using serum-derived bovine immunoglobulin/protein isolate, demonstrate that such protein preparations are safe and improve symptoms, nutritional status, and various biomarkers associated with enteropathy. Benefits have been shown in patients with HIV infection or diarrhea-predominant IBS. This review summarizes preclinical and clinical studies with plasma/serum protein concentrates and describes the effects on host nutrition, intestinal function, and markers of intestinal inflammation. It supports the concept that immunoglobulin-containing protein preparations may offer a new strategy for restoring functional homeostasis in the intestinal tract of patients with enteropathy. | Bryon W Petschow Anthony T Blikslager Eric M Weaver Joy M Campbell Javier Polo Audrey L Shaw Bruce P Burnett Gerald L Klein J Marc Rhoads | 2014 | World Journal of Gastroenterology2014，20，33： | 2 |
| 4 | 中国甘肃省中铺地区下白垩统河口群的兽脚类与蜥脚类足迹组合(英文)显示文摘近年来,中国西北部兰州-民和盆地的中铺地区河口群发现了一批恐龙骨骼化石和足迹化石。中铺地区的蜥脚类与兽脚类足迹组合相对丰富,但大多数标本保存较差。大夏足迹点发现了保存较好的类似亚洲足迹的跷脚龙类足迹(Asianopodus-like grallatorid tracks),足迹有着中趾弱前凸(weak mesaxony)。李家沟一号点的足迹组合包括了较大的兽脚类足迹和大型的、非三趾型四足类足迹,后者可能是蜥脚类足迹。李家沟二号点的足迹为多层的蜥脚类足迹,这表明了这类恐龙的活跃性,巨龙类的骨骸也可能来自同一层位。虽然中铺足迹组合不如同属河口群的盐锅峡足迹组合那么具有多样化与得以充分暴露,但依然体现了该地区以及中国早白垩世地层的典型足迹组合。 | 邢立达 李大庆 Lockley M G 张建平 尤海鲁 Klein H Marty D Persons IV W S 彭措 | 2014 | 古生物学报2014，53，3： | 2 |
| 5 | Effect of donor–recipient HLA matching at HLA A, B, C, and DRB1 on outcomes after umbilical-cord blood transplantation for leukaemia and myelodysplastic syndrome: a retrospective analysis显示文摘 | Mary Eapen John P Klein Guillermo F Sanz Stephen Spellman Annalisa Ruggeri Claudio Anasetti Maria Brown Richard E Champlin Joan Garcia-Lopez Gareth Hattersely Gesine Koegler Mary J Laughlin Gerard Michel Samir K Nabhan Franklin O Smith Mary M Horowitz Eli | 2011 | Lancet Oncology2011，，13： | 2 |
| 6 | Strategies to tackle the challenges of external beam radiotherapy for liver tumors显示文摘Primary and metastatic liver cancer is an increasingly common and difficult to control disease entity.Radiation offers a non-invasive treatment alternative for these patients who often have few options and a poor prognosis.However,the anatomy and aggressiveness of liver cancer poses significant challenges such as accurate localization at simulation and treatment,management of motion and appropriate selection of dose regimen.This article aims to review the options available and provide information for the practical implementation and/or improvement of liver cancer radiation programs within the context of stereotactic body radiotherapy and image-guided radiotherapy guidelines.Specific patient inclusion and exclusion criteria are presented given the significant toxicity found in certain sub-populations treated with radiation.Indeed,certain sub-populations,such as those with tumor thrombosis or those with larger lesions treated with transarterial chemoembolization,have been shown to have significant improvements in outcome with the addition of radiation and merit special consideration.Implementing a liver radiation programrequires three primary challenges to be addressed:(1) immobilization and motion management;(2) localization;and(3) dose regimen and constraint selection.Strategies to deal with motion include simple internal target volume(ITV) expansions,non-gated ITV reduction strategies,breath hold methods,and surrogate marker methods to enable gating or tracking.Localization of the tumor and organs-at-risk are addressed using contrast infusion techniques to take advantage of different normal liver and cancer vascular anatomy,imaging modalities,and margin management.Finally,a dose response has been demonstrated and dose regimens appear to be converging.A more uniform approach to treatment in terms of technique,dose selection and patient selection will allow us to study liver radiation in larger and,hopefully,multicenter randomized studies. | Michael I Lock Jonathan Klein Hans T Chung Joseph M Herman Edward Y Kim William Small Nina A Mayr Simon S Lo | 2017 | World Journal of Hepatology2017，9，14： | 2 |
| 7 | Growth differentiation factor 9 stirnulates proliferation but suppresses the follicle-stimulating hormone-induced differentiation of cultured granulose cells from small antral and preovulatory rat follicles显示文摘 | Vitt UA Hayushi M Klein C | 2002 | Bid Reprod2002，62，： | 1 |
| 8 | A note on negative thermal expansion coefficients显示文摘 | KLEIN M J MOUNTAIN R D | 1962 | J Phys ChemSolids1962，23，： | 1 |
| 9 | High-power multistage Rankine cycles显示文摘 | IBRAHIM O M KLEIN S A | 1995 | ASME Trans J Energy Res Tech1995，117，3： | 1 |
| 10 | EB virus-induced B lymphocyte cell lines producing specific antibody 显示文摘 | Steinitz M Klein G Koskimies S | 1977 | Nature1977，269，5627： | 1 |
| 11 | Proposed international clinical diabetic retinopathy and diabetic macular edema disease severity scales显示文摘 | Wilkinson CP Fen'is FL Klein RE Lee PP Agardh CD Davis M | 2003 | Ophthalmology2003，110，5： | 1 |
| 12 | Proteomics and diabetic retinopathy显示文摘 | Merchant M L Klein J B | 2009 | Clin Lab Med2009，29，1： | 1 |
| 13 | Burnout in mental health professionals in psychiatric hospitals显示文摘 | Messenzehl M Lukesch H Klein HE | 2007 | Psychiatr Prax2007，，： | 1 |
| 14 | Basilar artery atherosclerotic plaques in paramedian and lacunar pontine infarctions:a high-resolution MRI study显示文摘 | Klein IF Lavalle PC Mazighi M | 2010 | Stroke2010，41，7： | 1 |
| 15 | Mechanism of calcium current modulation underlying presynaptic facilitation and behavioral sensitization in Aplysia显示文摘 | Klein M Kandel ER | 1980 | Proc Natl Acad Sci USA1980，77，： | 1 |
| 16 | New Aspects of Score-shell Emulsion Polymerization Polybutylacrylate and Styrene Pair Systems显示文摘 | Min T I Klein A El-Aasser M S Vanderhoff J W | 1981 | Org Coat Appl Polym Sci Proc1981，46，： | 1 |
| 17 | Spectroscopic ellipsometry study of the diluted magnetic semiconductor system Zn(Mn,Fe, Co)Se 显示文摘 | Kim Y D Cooper S L Klein M V | 1994 | Phys Rev B1994，49，3： | 1 |
| 18 | Paracrine rather than autocrine regulation of myeloma-cell growth and differentiation by interleukin-6显示文摘 | Klein B Zhang X G Jourdan M | 1989 | Blood1989，73，2： | 1 |
| 19 | Proliferative cell activity in correlatio n to human chorionic gonadotrophin release of trophoblast tissue of tubal pregnancy显示文摘 | Kiss H Klein M Egarter C | 1998 | J Reprod Med1998，43，： | 1 |
| 20 | Positional cloning of a gene for nematode resistance in sugar beet显示文摘 | Cai D Kleine M Kifle S | 1997 | Science1997，275，： | 1 |
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