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| 1 | Diagnosis and Treatment of Keloids and Hypertrophic Scars—Japan Scar Workshop Consensus Document 2018显示文摘There has been a long-standing need for guidelines on the diagnosis and treatment of keloids and hypertrophic scars that are based on an understanding of the pathomechanisms that underlie these skin fibrotic diseases.This is particularly true for clinicians who deal with Asian and African patients because these ethnicities are highly prone to these diseases.By contrast,Caucasians are less likely to develop keloids and hypertrophic scars,and if they do,the scars tend not to be severe.This ethnic disparity also means that countries vary in terms of their differential diagnostic algorithms.The lack of clear treatment guidelines also means that primary care physicians are currently applying a hotchpotch of treatments,with uneven outcomes.To overcome these issues,the Japan Scar Workshop(JSW)has created a tool that allows clinicians to objectively diagnose and distinguish between keloids,hypertrophic scars,and mature scars.This tool is called the JSW Scar Scale(JSS)and it involves scoring the risk factors of the individual patients and the affected areas.The tool is simple and easy to use.As a result,even physicians who are not accustomed to keloids and hypertrophic scars can easily diagnose them and judge their severity.The JSW has also established a committee that,in cooperation with outside experts in various fields,has prepared a Consensus Document on keloid and hypertrophic scar treatment guidelines.These guidelines are simple and will allow even inexperienced clinicians to choose the most appropriate treatment strategy.The Consensus Document is provided in this article.It describes(1)the diagnostic algorithm for pathological scars and how to differentiate them from clinically similar benign and malignant tumors,(2)the general treatment algorithms for keloids and hypertrophic scars at different medical facilities,(3)the rationale behind each treatment for keloids and hypertrophic scars,and(4)the body site-specific treatment protocols for these scars.We believe that this Consensus Document will be helpful for physicians from all over the world who treat keloids and hypertrophic scars. | Rei Ogawa Sadanori Akita Satoshi Akaishi Noriko Aramaki-Hattori Teruyuki Dohi Toshihiko Hayashi Kazuo Kishi Taro Kono Hajime Matsumura Gan Muneuchi Naoki Murao Munetomo Nagao Keisuke Okabe Fumiaki Shimizu Mamiko Tosa Yasuyoshi Tosa Satoko Yamawaki Shinichi Ansai Norihisa Inazu Toshiko Kamo Reiko Kazki Shigehiko Kuribayashi | 2019 | Burns & Trauma2019，7，1： | 31 |
| 2 | Suppression of experimental osteoarthritis by adenovirus-mediated double gene transfer显示文摘背景骨关节炎(OA ) 是一长期并且不治之症,缺乏的有效处理。基因治疗把一条激进的不同途径提供给关节炎的处理。尽管 OA 的病原学仍然保持不清楚,现在有可观的证据建议 thatinterleukin-1 (IL-1 ) 和肿瘤坏死因素 -- α(TNF- α) 是在 OA 的致病的主要调停人。这研究的目标是决定本地表示 ofinterleukin-1 受体对手(IL-1Ra ) 和可溶的肿瘤坏死因素的功效 -- α受体类型(sTNF-RI ) 我骨关节炎由在兔子的直接调停 adenoviral 的 intra 关节的基因交货当模特儿。包含 IL-1Ra 或 sTNF-RI 基因的方法 Adenoviral 向量被构造。中间的并行的系带的切除加中间的 meniscectomy 在 12 只新西兰白兔子的两后部的膝导致的 OAwas。在外科以后的五天,果汁饮料的约 1 x 10 个 ~8plaque 形式单位(pfu ) 没有病毒通过膝盖骨的腱被注入膝的联合空间。12 只操作兔子的一个总数被划分成四个组。三个试验性的兔子组收到了 1 X 10 ~ 编码任何一个 IL-1Ra (3 只兔子) 的侵入人体气管粘膜的病菌的 8 pfu, sTNF-RI (3rabbits ) 和在联合(3 只兔子) 的 sTNF-RI,进两个膝关节分别地。3 只兔子的 Aninflamed 控制组收到了进两个的 Ad-GFP 的 8 pfu 连接的约 1 x 10 ~ 。在侵入人体气管粘膜的病菌的注射以后的三天,每只兔子的两膝是通过膝盖骨的腱与盐溶液的 1 ml 变老的洗室。在白天 7 点,兔子被牺牲,并且膝是为 transgene 表示的效果变老,把并且分析的洗室。在恢复洗室年龄液体的 IL-1Ra andsTNF-RI 表示的层次用一个 cytokine ELISA 工具包被测量。Cartilagefrom 中间的大腿骨的髁和 synovium 的损害区域被修理,嵌入, sectioned 并且与 hematoxylin 和曙红和 toluidine 蓝色(软骨)( 软骨和 synovium ) 染色了。Thesamples 被评估的轻显微镜学和份量上检验。IL-1Ra 的结果 Intra-articulardelivery 导致了软骨降级的重要抑制,但是 affectsynovial 变化。相反,独自收到 sTNF-RI 的兔子膝关节没在软骨降级显示出更可检测的引出。然而, IL-1Ra 和 sTNF-RI 的两倍基因转移在滑膜炎导致了软骨降级和可见减小的更高的抑制。Thesedata 增加并且证实 IL-1Ra 有好 chondroprotective 性质,而是 TNF- α封锁在联合破坏上有小效果。在联合的两个对手的提高的治疗学的效果建议多重煽动性的 cytokines 的抑制的结论可能在对待 OA 独自是比任何一个 cytokine 的封锁更有效的。 | WANG Hai-jun YU Chang-long Kishi Hiroyuki Motoki Kazumi MAO Ze-bin Muraguchi Atsushi | 2006 | Chinese Medical Journal2006，，16： | 19 |
| 3 | Impact of endoscopic screening on mortality reduction from gastric cancer显示文摘AIM:To investigate mortality reduction from gastric cancer based on the results of endoscopic screening.METHODS:The study population consisted of participants of gastric cancer screening by endoscopy,regular radiography,and photofluorography at Niigata city in 2005.The observed numbers of cumulative deaths from gastric cancers and other cancers were accumulated by linkage with the Niigata Prefectural Cancer Registry.The standardized mortality ratio(SMR)of gastric cancer and other cancer deaths in each screening group was calculated by applying the mortality rate of the reference population.RESULTS:Based on the results calculated from the mortality rate of the population of Niigata city,the SMRs of gastric cancer death were 0.43(95%CI:0.30-0.57)for the endoscopic screening group,0.68(95%CI:0.55-0.79)for the regular radiographic screening group,and 0.85(95%CI:0.71-0.94)for the photofluorography screening group.The mortality reduction from gastric cancer was higher in the endoscopic screening group than in the regular radiographic screening group despite the nearly equal mortality rates of all cancers except gastric cancer.CONCLUSION:The 57%mortality reduction from gastric cancer might indicate the effectiveness of endoscopic screening for gastric cancer.Further studies and prudent interpretation of results are needed. | Chisato Hamashima Kazuei Ogoshi Rintarou Narisawa Tomoki Kishi Toshiyuki Kato Kazutaka Fujita Masatoshi Sano Satoshi Tsukioka | 2015 | World Journal of Gastroenterology2015，21，8： | 16 |
| 4 | Three benefits of microcatheters for retrograde transvenous obliteration of gastric varices显示文摘AIM:To evaluate the usefulness of the microcatheter techniques in balloon-occluded retrograde transvenous obliteration (BRTO) of gastric varices.METHODS:Fifty-six patients with gastric varices underwent BRTOs using microcatheters.A balloon catheter was inserted into gastrorenal or gastrocaval shunts.A microcatheter was navigated close to the varices,and sclerosant was injected into the varices through the microcatheter during balloon occlusion.The next morning,thrombosis of the varices was evaluated by contrast enhanced computed tomography (CE-CT).In patients with incomplete thrombosis of the varices,a second BRTO was performed the following day.Patients were followed up with CE-CT and endoscopy.RESULTS:In all 56 patients,sclerosant was selectively injected through the microcatheter close to the varices.In 9 patients,microcoil embolization of collateral veinswas performed using a microcatheter.In 12 patients with incomplete thrombosis of the varices,additional injection of sclerosant was performed through the microcatheter that remained inserted overnight.Complete thrombosis of the varices was achieved in 51 of 56 patients,and the remaining 5 patients showed incomplete thrombosis of the varices.No recurrence of the varices was found in the successful 51 patients after a median follow up time of 10.5 mo.We experienced one case of liver necrosis,and the other complications were transient.CONCLUSION:The microcatheter techniques are very effective methods for achieving a higher success rate of BRTO procedures. | Tetsuo Sonomura Wataru Ono Morio Sato Shinya Sahara Kouhei Nakata Hiroki Sanda Nobuyuki Kawai Hiroki Minamiguchi Motoki Nakai Kazushi Kishi | 2012 | World Journal of Gastroenterology2012，18，12： | 5 |
| 5 | H pylori seropositivity and cytokine gene polymorphisms显示文摘AIM: To investigate whether the pro- and anti-inflammatory cytokine gene polymorphisms, IL1B-511C/T, IL1B-31C/T, IL6-634C/G, TNF-1031T/C, TNF-857C/T, and IL10-1082A/G, interact with smoking and drinking habits to influence infection with H pylori.METHODS: The subjects were 410 Japanese transit company employees. C-reactive protein and conventional cardiovascular risk factors were evaluated. Serum anti-H pylori antibodies were measured. The genotypes of IL1B-511C/T, IL1B-31C/T, IL6-634C/G, TNF-1031T/C, TNF-857C/T, and IL10-1082A/G polymorphisms were determined by allelic discrimination using fluorogenic probes and a 5′nuclease assay.RESULTS: In gender- and age-adjusted logistic analyses, the subjects with TNF-857T/T had a significantly lower odds ratio (OR) for H pylori seropositivity (reference -857C/C; OR = 0.15, 95% CI: 0.03-0.59, P = 0.007). After stratification according to smoking and drinking status, among never-smokers, the subjects with IL1B-511C/T had a significantly lower OR (reference -511C/C; OR = 0.30, 95% CI: 0.10-0.90, P = 0.032). Among drinkers in the 1-5 times/wk category, the subjects with IL1B-511T/T had a significantly lower OR (reference C/C; OR = 0.38, 95% CI: 0.16-0.95, P = 0.039), and the subjects with IL1B-31C/T and T/T had a significantly higher OR (reference C/C; C/T: OR = 2.59, 95% CI, P = 0.042: 1.04-6.47; C/C: OR = 3.17, 95% CI: 1.23-8.14, P = 0.017). Among current smokers, the subjects withIL6-634C/G had a significantly higher OR (reference C/C; OR = 2.28, 95% CI: 1.13-4.58, P = 0.021). However, the interactions terms between the aforementioned genotypes and lifestyles were not statistically significant.CONCLUSION: Contrary to previous findings, the results herein suggest that the TNF-857T/T genotype may be protective against chronic infection with H pylori. Drinking and smoking habits may influence the effect of cytokine gene polymorphisms. Further studies are required to clarify the effects of the pro- and anti-inflammatory cytokine polymorphisms and gene-environmental interactions on H pylori infection. | Yasuaki Saijo Eiji Yoshioka Tomonori Fukui Mariko Kawaharada Fumihiro Sata Hirokazu Sato Reiko Kishi | 2007 | World Journal of Gastroenterology2007，13，33： | 5 |
| 6 | Proton pump inhibitor induced collagen expression in colonocytes is associated with collagenous colitis显示文摘AIM To elucidate the role of proton pump inhibitors(PPIs) in collagenous disease, direct effect of PPI on colonocytes was examined.METHODS Collagenous colitis is a common cause of non-bloody, watery diarrhea. Recently, there has been increasing focus on the use of proton PPIs as a risk factor for developing collagenous colitis. Mouse CT26 colonic cells were treated with PPI and/or PPI-induced alkaline media. Expression of fibrosis-associated genes was examined by RT-PCR. In human materials, collagen expression was examined by immunohistochemistry.RESULTS CT26 cells expressed a Na+-H+ exchanger gene(solute carrier family 9, member A2). Treatment with PPI and/or PPI-induced alkaline media caused growth inhibition and oxidative stress in CT26 cells. The treatment increased expression of fibrosis inducing factors, transforming growth factor β and fibroblast growth factor 2. The treatment also decreased expression of a negative regulator of collagen production, replication factor C1, resulting in increased expression of collagen types Ⅲ and Ⅳ in association with lipid peroxide. In biopsy specimens from patients with collagenous colitis, type Ⅲ and Ⅳ collagen were increased. Increase of type Ⅲ collagen was more pronounced in PPI-associated collagenous colitis than in non-PPI-associated disease. CONCLUSION From these findings, the reaction of colonocytes to PPI might participate in pathogenesis of collagenous colitis. | Shiori Mori Yui Kadochi Yi Luo Rina Fujiwara-Tani Yukiko Nishiguchi Shingo Kishi Kiyomu Fujii Hitoshi Ohmori Hiroki Kuniyasu | 2017 | World Journal of Gastroenterology2017，23，9： | 5 |
| 7 | Role of hepatectomy for recurrent or initially unresectable hepatocellular carcinoma显示文摘As a result of donor shortage and high postoperative morbidity and mortality after liver transplantation,hepatectomy is the most widely applicable and reliable option for curative treatment of hepatocellular carcinoma(HCC).Because intrahepatic tumor recurrence is frequent after loco-regional therapy,repeated treatments are advocated provided background liver function is maintained.Among treatments including local ablation and transarterial chemoembolization,hepatectomy provides the best long-term outcomes,but studies comparing hepatectomy with other nonsurgical treatments require careful review for selection bias.In patients with initially unresectable HCC,transarterial chemo-or radio-embolization,and/or systemic chemotherapy can down-stage the tumor and conversion to resectable HCC is achieved in approximately 20%of patients.However,complete response is rare,and salvage hepatectomy is essential to help prolong patients’survival.To counter the short recurrence-free survival,excellent overall survival is obtained by combining and repeating different treatments.It is important to recognize hepatectomy as a complement,rather than a contraindication,to other nonsurgical treatments in a mul-tidisciplinary approach for patients with HCC,including recurrent or unresectable tumors. | Yoji Kishi Kazuaki Shimada Satoshi Nara Minoru Esaki Tomoo Kosuge | 2014 | World Journal of Hepatology2014，6，12： | 5 |
| 8 | Three Hundred and One Consecutive Extended Right Hepatectomies: Evaluation of Outcome Based on Systematic Liver Volumetry显示文摘 | Yoji Kishi Eddie K. Abdalla Yun Shin Chun Daria Zorzi David C. Madoff Michael J. Wallace Steven A. Curley Jean-Nicolas Vauthey | 2009 | Annals of Surgery2009，，4： | 4 |
| 9 | Extended Preoperative Chemotherapy Does Not Improve Pathologic Response and Increases Postoperative Liver Insufficiency After Hepatic Resection for Colorectal Liver Metastases显示文摘 | Yoji Kishi MD Daria Zorzi MD Carlo M. Contreras MD Dipen M. Maru MD Scott Kopetz MD Dario Ribero MD Manuela Motta MD Nicoletta Ravarino MD Mauro Risio MD Steven A. Curley MD Eddie K. Abdalla MD Lorenzo Capussotti MD Jean-Nicolas Vauthey MD | 2010 | Annals of Surgical Oncology2010，，11： | 3 |
| 10 | Novel Radio on Fiber Access Eliminating External Electric Power Supply at Base Station显示文摘A novel Radio On Fiber(ROF) access is proposed and demonstrated which enables the pico-cell Base Station (BS) for high-speed wireless communications to eliminate external electric power supply facilities. We demonstrated 2.4-GHz band radio signal transmission through the BS without external electric power supply. The electrical power used for BS circuit is feeded by optical power over optical fiber from central station. | Tetsuya Miki Katsuyasu Kawano Nobuo Nakajima Naoto Kishi Masaru Miyamoto Tetsu Aoki | 2003 | 光学学报2003，23，S1： | 3 |
| 11 | 步行6min负荷超声心动图预测结缔组织病患者远期显性肺高血压显示文摘肺高血压是结缔组织病(connective tissue disease,CTD)的主要死因。运动负荷试验已用于筛查早期肺高血压[1],但由于缺乏相关证据,最新的指南已停止其作为发现肺高血压的方法。近期研究发现平均肺动脉压(mean pulmonary arterial pressure,mPAP)升高导致心输出量异常可用于评估肺高血压进展及肺功能分级[2]。该研究将步行6min后的超声心动图参数作为非侵入性负荷试验。 | Kusunose K Yamada H Hotchi J Bando M Nishio S Hirata Y Ise T Yamaguchi K Yagi S Soeki T Wakatsuki T Kishi J Sata M 曲浥晨 | 2015 | 中华高血压杂志2015，23，10： | 3 |
| 12 | Left hepatic trisectionectomy for advanced perihilar cholangiocarcinoma显示文摘 | M. Esaki K. Shimada S. Nara Y. Kishi Y. Sakamoto T. Kosuge T. Sano | 2013 | Br J Surg2013，，6： | 2 |
| 13 | Patterns of diabetic macular edema with optical coherence tomography显示文摘 | Tomohiro Otani Shoji Kishi Yasuhiro Maruyama | 1999 | American Journal of Ophthalmology1999，，6： | 2 |
| 14 | Emergency balloon-occluded retrograde transvenous obliteration of ruptured gastric varices显示文摘AIM: To evaluate the effectiveness and safety of emergency balloon-occluded retrograde transvenous obliteration(BRTO) for ruptured gastric varices.METHODS: Emergency BRTO was performed in 17 patients with gastric varices and gastrorenal or gastrocaval shunts within 24 h of hematemesis and/or tarry stool.The gastric varices were confirmed by endoscopy,and the gastrorenal or gastrocaval shunts were identified by contrast-enhanced computed tomography(CE-CT).A 6-Fr balloon catheter(Cobra type) was inserted into the gastrorenal shunt via the right internal jugular vein,or into the gastrocaval shunt via the right femoral vein,depending on the varices drainage route.The sclerosant,5% ethanolamine oleate iopamidol,was injected into the gastric varices through the catheter during balloon occlusion.In patients with incom plete thrombosis of the varices after the first BRTO,a second BRTO was performed the following day.Patients were followed up by endoscopy and CE-CT at 1 d,1 wk,and 1,3 and 6 mo after the procedure,and every 6 mo thereafter.RESULTS: Complete thrombosis of the gastric varices was not achieved with the first BRTO in 7/17 patients because of large gastric varices.These patients underwent a second BRTO on the next day,and additional sclerosant was injected through the catheter.Complete thrombosis which led to disappearance of the varices was achieved in 16/17 patients,while the remaining patient had incomplete thrombosis of the varices.None of the patients experienced rebleeding or recurrence of the gastric varices after a median follow-up of 1130 d(range 8-2739 d).No major complications occurred after the procedure.However,esophageal varices worsened in 5/17 patients after a mean follow-up of 8.6 mo.CONCLUSION: Emergency BRTO is an effective and safe treatment for ruptured gastric varices. | Tetsuo Sonomura Wataru Ono Morio Sato Shinya Sahara Kouhei Nakata Hiroki Sanda Nobuyuki Kawai Hiroki Minamiguchi Motoki Nakai Kazushi Kishi | 2013 | World Journal of Gastroenterology2013，19，31： | 2 |
| 15 | Coupling of an Individual-Based Model of Anchovy with Lower Trophic Level and Hydrodynamic Models显示文摘Anchovy (Engraulis japonicus), a small pelagic fish and food of other economic fishes, is a key species in the Yellow Sea ecosystem. Understanding the mechanisms of its recruitment and biomass variation is important for the prediction and management of fishery resources. Coupled with a hydrodynamic model (POM) and a lower trophic level ecosystem model (NEMURO), an individual-based model of anchovy is developed to study the influence of physical environment on anchovy's biomass variation. Seasonal variations of circulation, water temperature and mix-layer depth from POM are used as external forcing for NEMURO and the anchovy model. Biomasses of large zooplankton and predatory zooplankton which anchovy feeds on are output from NEMURO and are controlled by the consumption of anchovy on them. Survival fitness theory related to temperature and food is used to determine the swimming action of anchovy in the model. The simulation results agree well with observations and elucidate the influence of temperature in over-wintering migration and food in feeding migration. | WANG Yuheng WEI Hao Michio J. Kishi | 2013 | Journal of Ocean University of China2013，12，1： | 2 |
| 16 | Diffuse panbronchiolitis in rheumatoid arthritis显示文摘 | Homma S Kawabata M Kishi K t al | 1998 | Eur Respir J1998，2，2： | 2 |
| 17 | Base-metal electrode-multilayer ceramic capacitors:Past, present and future perspectives显示文摘 | Kishi H Mizuno Y Chazono H | 2003 | Japan J Appl Phys2003，42，1： | 2 |
| 18 | New approaches in laparoscopic surgery for colorectal diseases: The totally laparoscopic and single-incision approaches显示文摘More than 20 years have passed since the first report of laparoscopic colectomy in 1991. Thereafter, laparoscopic surgery for the management of colorectal diseases has been widely accepted as a prevailing option because of improved cosmetic outcomes, less postoperative pain, and shorter hospital stay in comparison with open surgery. To further the principle of minimally invasive surgery, two new approaches have been developed in this rapidly evolving field. The first is the totally laparoscopic approach. Currently most of standard techniques inevitably involve an abdominalincision for retrieval of the specimen and preparation for anastomosis, which might compromise the benefits of laparoscopic surgery. The totally laparoscopic approach dispenses with this incision by combining completely intraperitoneal anastomosis with retrieval of the specimen via a natural orifice, such as the anus or the vagina. Our new and reliable technique for intraperitoneal anastomosis is also described in detail in this article. The second is the single-incision approach. While three to six ports are needed in standard laparoscopic surgery, the single-incision approach uses the umbilicus as the sole access to the abdominal cavity. All of the laparoscopic procedures are performed entirely through the umbilicus, in which the surgical scar eventually becomes hidden, achieving virtually scarless surgery. This article reviews the current status of these two approaches and discusses the future of minimally invasive surgery for colorectal diseases. | Hiroki Akamatsu Masahiro Tanemura Kentaro Kishi Mitsuyoshi Tei Toru Masuzawa Masaki Wakasugi | 2015 | World Journal of Surgical Procedures2015，5，1： | 2 |
| 19 | Plasma levodopa peak delay and impaired gastric emptying in Parkinson’s disease显示文摘 | Hirokazu Doi Ryuji Sakakibara Mitsutoshi Sato Tohru Masaka Masahiko Kishi Akihiko Tateno Fuyuki Tateno Yohei Tsuyusaki Osamu Takahashi | 2012 | Journal of the Neurological Sciences . 2012 (1-2)2012，，1： | 2 |
| 20 | A chimeric antigen receptor for TRAIL-receptor 1 induces apoptosis in various types of tumor cells显示文摘 | Eiji Kobayashi Hiroyuki Kishi Tatsuhiko Ozawa Hiroshi Hamana Hidetoshi Nakagawa Aishun Jin Zhezhu Lin Atsushi Muraguchi | 2014 | Biochemical and Biophysical Research Communications2014，，： | 2 |
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