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| 1 | A case of invasive hemolymphangioma of the pancreas显示文摘Hemolymphangioma of the pancreas is a very rare benign tumor. There were only five reports of this disease until March 2008. Herein, we report a case of hemolymphangioma of the pancreas with gastrointestinal bleeding due to duodenal invasion. A 53-year-old man had been admitted a referral hospital because of severe anemia due to gastrointestinal bleeding in December 2005. He was then transferred to our institute with a diagnosis of a tumor of the head of the pancreas with duodenal invasion in January 2006. No abnormalities were revealed except for anemia in laboratory data including CEA and CA19-9. Gastrointestinal endoscopy revealed bleeding at the duodenum. Computed tomography also demonstrated a heterogenous mass at the pancreatic head and suspected invasion to the duodenal wall. Ultrasonography showed a huge mass at the pancreatic head with a mixture of high and low echoic areas. Pylorous-preserving pancreatoduodenectomy was performed. The pancreatic tumor was soft and had invaded to the duodenum. The pathological diagnosis was a hemolymphangioma of the pancreas invaded to the duodenum. His postoperative course was uneventful and he was discharged on the 26th d after surgery. Hemolymphangioma of the pancreas is a very rare benign tumor. In a literature review until March 2008, we found five case reports. Major symptoms are abdominal pain and distension due to the enlarged tumor. However, we experienced a case of hemolymphangioma of the pancreas with gastrointestinal bleeding due to invasion to the duodenum. This disease is a very rare entity, but should be considered when patients have gastrointestinal bleeding. | Yoshikazu Toyoki Kenichi Hakamada Shunji Narumi Masaki Nara Daisuke Kudoh Keinosuke Ishido Mutsuo Sasaki | 2008 | World Journal of Gastroenterology2008，14，18： | 26 |
| 2 | An easier method for performing a pancreaticojejunostomy for the soft pancreas using a fast-absorbable suture显示文摘AIM: To clarify the usefulness of a new method for performing a pancreaticojejunostomy by using a fast-absorbable suture material irradiated polyglactin 910, and a temporary stent tube for a narrow pancreatic duct with a soft pancreatic texture.METHODS: Among 63 consecutive patients with soft pancreas undergoing a pancreaticoduodenectomy from 2003 to 2006, 35 patients were treated with a new reconstructive method. Briefly, after the pancreatic transaction, a stent tube was inserted into the lumen of the pancreatic duct and ligated with it by a fast-absorbable suture. Another tip of the stent tube was introduced into the intestinal lumen at the jejunal limb, where a purse-string suture was made by another fast-absorbable suture to roughly fix the tube. The pancreaticojejunostomy was completed by ligating two fast-absorbable sutures to approximate the ductal end and the jejunal mucosa, and by adding a rough anastomosis between the pancreatic parenchyma and the seromuscular layer of the jejunum. The initial surgical results with this method were retrospectively compared with those of the 28 patients treated with conventional duct-to-mucosa anastomosis.RESULTS: The incidences of postoperative morbidity including pancreatic fistula were comparable between the two groups (new; 3%-17% vs conventional; 7%-14% according to the definitions). There was no mortality and re-admission. Late complications were also rarely seen.CONCLUSION: A pancreaticojejunostomy using an irradiated polyglactin 910 suture material and a temporary stent is easy to perform and is feasible even in cases with a narrow pancreatic duct and a normal soft pancreas. | Kenichi Hakamada Shunji Narumi Yoshikazu Toyoki Masaki Nara Kenosuke Ishido Takuya Miura Norihito Kubo Mutsuo Sasaki | 2008 | World Journal of Gastroenterology2008，14，7： | 9 |
| 3 | 胰腺微小浸润型导管内乳头状黏液性癌:104例胰腺导管内乳头状黏液性肿瘤临床病理分析显示文摘 | Nara S Shimada K Kosuge T 黄文斌(摘译) | 2008 | 临床与实验病理学杂志2008，24，4： | 8 |
| 4 | Phase Behavior and Crystal Structure of Perovskite-Type Rare Earth Complex Oxides显示文摘Several compounds of rare earth complex oxides containing manganese and titanium were synthesized in Ar, and their crystal structures were analyzed by powder X-ray diffraction data and Rietveld method. Structures of A 0.67 Ln 0.33 Mn 0.33 Ti 0.67 O3 (A=Ca or Sr and Ln=rare earth) were found to have orthorhombic symmetry with the space group Pnma, and their interatomic distances and bond angles were obtained. This space group was also derived from electron microscopic study. Electrical conductivity of Ca 0.67 Ln 0.33 Mn 0.33 Ti 0.67 O3 for several rare earth elements showed a semiconducting property with the activation energy of 0.4 eV. Some of these compounds of the strontium system show the antiferromagnetic properties below 10 K. | Migaku Kobayashi Ryoko Katsuraya Tsubasa Nara Yusuke Tomita Hiromi Nakano Naoki Kamegashira | 2006 | Journal of Rare Earths2006，24，6： | 7 |
| 5 | Intraoperative ultrasound as an educational guide for laparoscopic biliary surgery显示文摘AIM: To analyze the efficacy of routine intraoperative ultrasound (IOUS) as a guide for understanding biliary tract anatomy, to avoid bile duct injury (BDI) after laparoscopic cholecystectomy (LC), as well as any burden during the learning period. METHODS: A retrospective analysis was performed using 644 consecutive patients who underwent LC from 1991 to 2006. An educational program with the use of IOUS as an operative guide has been used in 276 cases since 1998. RESULTS: IOUS was highly feasible even in patients with high-grade cholecystitis. No BDI was observed after the introduction of the educational program, despite 72% of operations being performed by inexperienced surgeons. Incidences of other morbidity, mortality, and late complications were comparable before and after the introduction of routine IOUS. However, the operation time was significantly extended after the educational program began (P < 0.001), and the grade of laparoscopic cholecystitis (P = 0.002), use of IOUS (P = 0.01), and the experience of the surgeons (P = 0.05) were significant factors for extending the length of operation. CONCLUSION: IOUS during LC was found to be a highly feasible modality, which provided accurate, real- time information about the biliary structures. Theeducational program using IOUS is expected to minimize the incidence of BDI following LC, especially when performed by less-skilled surgeons. | Kenichi Hakamada Shunji Narumi Yoshikazu Toyoki Masaki Nara Motonari Oohashi Takuya Miura Hiroyuki Jin Syuichi Yoshihara Michihiro Sugai Mutsuo Sasaki | 2008 | World Journal of Gastroenterology2008，14，15： | 6 |
| 6 | Risk of complications and urinary incontinence following cytoreductive prostatectomy: a multi-institutional study显示文摘当时,新兴的证据建议了 cytoreductive 前列腺切除术(CRP ) 允许优异 oncologic 控制与照顾雄激素剥夺标准的电流相比治疗独自一个。然而,在变形前列腺癌症(mPCa ) 的 cytoreduction 的安全和利益没被证明。因此,我们评估了在最新与 mPCa 诊断的人跟随 CRP 的复杂并发症的发生。在四个第三级的外科的中心从 2006 ~ 2014 经历了 CRP 的 68 个病人的一个总数与为临床上局部性的前列腺癌症(PCa ) 经历了激进的前列腺切除术的 598 个人相比。尿不能自制被定义为任何垫的使用。CRP 有更长起作用的时间(200 min 对 140 min, P < 0.0001 ) 并且更高估计的血损失(250 ml 对 125 ml, P < 0.0001 ) 与控制组相比。然而,外套(8.82% 对 5.85%) 和主要复杂并发症率(4.41% 对 2.17%) 在二个组之间是可比较的。重要地,尿不能自制率在在外科以后 1 年在 CRP 组是显著地更高的(57.4% 对 90.8% , P < 0.0001 ) 。Univariate 逻辑分析证明估计的血损失在 unadjusted 模型两个都是 perioperative 复杂并发症的唯一的独立预言者(或:1.18;95% CI:1.02-1.37;P = 0.025 ) 并且外科调整类型的模型(或:1.17;95% CI:1.01-1.36;P = 0.034 ) 。在结论, CRP 比激进的前列腺切除术更挑战性、与尿不能自制的尤其是更高的发生联系。不过, CRP 是为选择谁的 PCa 病人的一个技术上可行、安全的手术与节点积极或多骨的转移在场当由富有经验的外科医生表现了时。未来的、多机构的临床的试用当前是在进行之中的验证这个概念。 | Dae Keun Kim Jaspreet Singh Parihar Young Suk Kwon Sinae Kim Brian Shinder Nara Lee Nicholas Farber Thomas Ahlering Douglas Skarecky Bertram Yuh Nora Ruel Wun-lae Kim Koon Ho Rha Isaac Yi Kim | 2018 | Asian Journal of Andrology2018，20，1： | 5 |
| 7 | Role of hepatectomy for recurrent or initially unresectable hepatocellular carcinoma显示文摘As a result of donor shortage and high postoperative morbidity and mortality after liver transplantation,hepatectomy is the most widely applicable and reliable option for curative treatment of hepatocellular carcinoma(HCC).Because intrahepatic tumor recurrence is frequent after loco-regional therapy,repeated treatments are advocated provided background liver function is maintained.Among treatments including local ablation and transarterial chemoembolization,hepatectomy provides the best long-term outcomes,but studies comparing hepatectomy with other nonsurgical treatments require careful review for selection bias.In patients with initially unresectable HCC,transarterial chemo-or radio-embolization,and/or systemic chemotherapy can down-stage the tumor and conversion to resectable HCC is achieved in approximately 20%of patients.However,complete response is rare,and salvage hepatectomy is essential to help prolong patients’survival.To counter the short recurrence-free survival,excellent overall survival is obtained by combining and repeating different treatments.It is important to recognize hepatectomy as a complement,rather than a contraindication,to other nonsurgical treatments in a mul-tidisciplinary approach for patients with HCC,including recurrent or unresectable tumors. | Yoji Kishi Kazuaki Shimada Satoshi Nara Minoru Esaki Tomoo Kosuge | 2014 | World Journal of Hepatology2014，6，12： | 5 |
| 8 | 汉长安城桂宫三号建筑遗址发掘简报显示文摘This building site lies in the northwest of the Guigong Palace, about 160m east of Tiesuo village, Liucunbao township, Weiyang district, Xi'an city, Shaanxi province. It consists of two large-sized house-foundations arranged from north to south, seven small house-foundations between them, and six ruined walls. The unearthed terra-cotta and pottery objects include bricks, tiles, tile-ends, supports, spindle whorls, jars and lamps. In addition, there are irons, stone tools and copper coins. The houses seem to have not been suitable to human living and activities and must have been a complex of storage rooms built in the Guigong Palace in the mid and late Western Han period, the discovery of which provides important material for studying the structure and layout of the Guigong Palace. | Sino-Japanese Joint Archaeological Team from IA,CASS,and Nara National Cultural Properties Institute,Japan, | 2001 | 考古2001，，1： | 5 |
| 9 | Hemosuccus pancreaticus: Problems and pitfalls in diagnosis and treatment显示文摘Hemosuccus pancreaticus is a rare cause of intermittent upper gastrointestinal bleeding. We report two cases of hemosuccus pancreaticus with multiple episodes of upper gastrointestinal bleeding. The causes of hemorrhage were rupture of pseudoaneurysm of the splenic artery and bleeding from the wall of pancreatic pseudocyst. Interventional radiology is the first modality for early diagnosis and possible treatment of hemosuccus pancreaticus. When angiography shows no abnormal findings or interventional radiological therapy can not be successful, surgery should be considered without delay. Our patients herein underwent surgery without recurrence or sequelae. Intraoperative ultrasonography and pancreatoscopy were helpful modalities for confirming the source of hemorrhage and determining the cutting line of the pancreas. When we encounter intermittent upper gastrointestinal bleeding with an obscure source, hemosuccus pancreaticus should be included in differential diagnoses especially in patients with chronic pancreatitis, which would lead to a prompt and proper treatment. | Yoshikazu Toyoki Kenichi Hakamada Shunji Narumi Masaki Nara Keinosuke Ishido Mutsuo Sasaki | 2008 | World Journal of Gastroenterology2008，14，17： | 5 |
| 10 | Efficacy of a Hepatectomy and a Tumor Thrombectomy for Hepatocellular Carcinoma with Tumor Thrombus Extending to the Main Portal Vein显示文摘 | Daisuke Ban Kazuaki Shimada Yusuke Yamamoto Satoshi Nara Minoru Esaki Yoshihiro Sakamoto Tomoo Kosuge | 2009 | Journal of Gastrointestinal Surgery2009，，11： | 4 |
| 11 | Des-gamma-carboxy prothrombin as an important prognostic indicator in patients with small hepatocellular carcinoma显示文摘AIM:To clarify the effect of a high des-gamma-carboxy prothrombin (DCP) level on the invasiveness and prognosis of small hepatocellular carcinoma. METHODS: Among 142 consecutive patients with known DCP levels, who underwent hepatectomy because of hepatocellular carcinoma, 85 patients met the criteria for small hepatocellular carcinoma, i.e. one ≤ 5 cm sized single tumor or no more than three ≤ 3 cm sized tumors. RESULTS: The overall survival rate of the 142 patients was 92.1% for 1 year, 69.6% for 3 years, and 56.9% for 5 years. Multivariate analysis showed that microscopic vascular invasion (P = 0.03) and serum DCP ≥ 400 mAU/mL (P = 0.02) were independent prognostic factors. In the group of patients who met the criteria for small hepatocellular carcinoma, DCP ≥ 400 mAU/mL was found to be an independent prognostic factor for recurrence-free (P = 0.02) and overall survival (P = 0.0005). In patients who did not meet the criteria, the presence of vascular invasion was an independent factor for recurrence-free (P = 0.02) and overall survivals (P = 0.01). In 75% of patients with small hepatocellular carcinoma and high DCP levels, recurrence occurred extrahepatically. CONCLUSION: For small hepatocellular carcinoma, a high preoperative DCP level appears indicative fortumor recurrence. Because many patients with a high preoperative DCP level develop extrahepatic recurrence, it is necessary to screen the whole body. | Kenichi Hakamada Norihisa Kimura Takuya Miura Hajime Morohashi Keinosuke Ishido Masaki Nara Yoshikazu Toyoki Shunji Narumi Mutsuo Sasaki | 2008 | World Journal of Gastroenterology2008，14，9： | 4 |
| 12 | Priming with G-CSF effectively enhances low-dose Ara-C-induced in vivo apoptosis in myeloid leukemia cells显示文摘 | Amuguleng Bai Hiroshi Kojima Mitsuo Hori Nobuo Nara Takuya Komeno Yuichi Hasegawa Haruhiko Ninomiya Tsukasa Abe Toshiro Nagasawa | 1999 | Experimental Hematology1999，，2： | 3 |
| 13 | Left hepatic trisectionectomy for advanced perihilar cholangiocarcinoma显示文摘 | M. Esaki K. Shimada S. Nara Y. Kishi Y. Sakamoto T. Kosuge T. Sano | 2013 | Br J Surg2013，，6： | 2 |
| 14 | Implementation of genetic algotithm for distribution systems loss minimum reconfiguration显示文摘 | Nara K Shiose A Kitagawa M | 1992 | IEEE Trans on Power Systems1992，7，3： | 2 |
| 15 | Examining effective use of data sources and modeling algorithms for improving biomass estimation in a moist tropical forest of the Brazilian Amazon显示文摘Previous research has explored the potential to integrate lidar and optical data in aboveground biomass(AGB)estimation,but how different data sources,vegetation types,and modeling algorithms influence AGB estimation is poorly understood.This research conducts a comparative analysis of different data sources and modeling approaches in improving AGB estimation.RapidEye-based spectral responses and textures,lidar-derived metrics,and their combination were used to develop AGB estimation models.The results indicated that(1)overall,RapidEye data are not suitable for AGB estimation,but when AGB falls within 50–150 Mg/ha,support vector regression based on stratification of vegetation types provided good AGB estimation;(2)Lidar data provided stable and better estimations than RapidEye data;and stratification of vegetation types cannot improve estimation;(3)The combination of lidar and RapidEye data cannot provide better performance than lidar data alone;(4)AGB ranges affect the selection of the best AGB models,and a combination of different estimation results from the best model for each AGB range can improve AGB estimation;(5)This research implies that an optimal procedure for AGB estimation for a specific study exists,depending on the careful selection of data sources,modeling algorithms,forest types,and AGB ranges. | Yunyun Feng Dengsheng Lu Qi Chena Michael Keller Emilio Moran Maiza Nara dos-Santos Edson Luis Bolfe Mateus Batistella | 2017 | International Journal of Digital Earth2017，10，10： | 2 |
| 16 | Mechanisms of regulation of gene expression by fatty acids显示文摘 | Manabu T. Nakamura Yewon Cheon Yue Li Takayuki Y. Nara | 2004 | Lipids2004，，11： | 2 |
| 17 | 高脂饮食诱导的巨噬细胞抑制因子-1通过激活肿瘤间质细胞产生促肿瘤细胞因子促进前列腺癌的进展显示文摘背景与目的 最近研究表明高脂饮食(high-fat diet,HFD)和/或HFD诱导的肥胖可影响前列腺癌(prostate cancer,PCa)的进展,但HFD在PCa微环境中的作用尚不清楚。本研究旨在阐明HFD环境下PCa进展的分子机制,描述以巨噬细胞抑制因子-1(macrophage inhibitory cytokine-1,MIC-1)活性为主的肿瘤间质微环境的特征。方法 我们利用HFD或正常饮食的PC-3M-luc-C6 PCa小鼠模型,研究了HFD对PCa间质微环境和MIC-1信号活性的影响。我们分离了原发PCa患者来源的前列腺周围脂肪细胞,并研究了其对前列腺间质成纤维细胞活性及其分泌细胞因子的影响。进一步研究了MIC-1信号的表达模式及其对人PCa间质活性和肿瘤进展的影响。结果 在PC-3M-luc-C6 PCa小鼠模型中,HFD通过上调前列腺间质成纤维的MIC-1信号通路活性,增加了白介素(interleukin,IL)-8和IL-6的分泌,促进了PCa细胞的生长和侵袭。另外,前列腺周围脂肪细胞通过增加脂肪分解和游离脂肪酸的释放,直接促进了PC-3细胞产生MIC-1和前列腺间质成纤维细胞分泌IL-8。前列腺癌患者血清MIC-1水平增高与人PCa间质活性、高血清IL-8、IL-6水平、脂肪酶高活性、PCa患者疾病进展及高体重指数具有显著相关性。胶质细胞源性神经营养因子受体α(glial-derived neurotrophic factor receptor α-like,GFL)是MIC-1的特异性受体,在PCa细胞和癌周间质成纤维细胞中都出现高表达,雄激素去势治疗和化疗都降低了其表达水平。结论 HFD通过增加游离脂肪酸水平,在代谢水平上调了MIC-1信号活性,从而激活了PCa间质微环境,这可能是HFD和/或脂肪诱导的PCa进展的关键机制。 | Mingguo Huang Shintaro Narita Atsushi Koizumi Taketoshi Nara Kazuyuki Numakura Shigeru Satoh Hiroshi Nanjo Tomonori Habuchi | 2022 | 癌症2022，41，2： | 2 |
| 18 | Humanized monoclonal anti-interleukin-6 receptor antibody for treatment of intractable adult-onset Still's disease显示文摘 | Iwamoto M Nara H Himta D | 2002 | Arthritis Rheum2002，46，： | 1 |
| 19 | Tandem Synthesis of Photoactive Benzodifuran Moieties in the Formation of Microporous Organic Networks显示文摘 | Narae Kang Ji Hoon Park Kyoung Chul Ko Jiseul Chun Eunchul Kim Hee‐Won Shin Sang Moon Lee Hae Jin Kim Tae Kyu Ahn Jin Yong Lee Seung Uk Son | 2013 | Angew. Chem. Int. Ed2013，，24： | 1 |
| 20 | Paroxysmal Kinesigenic choreoathetosis associated with prenatal brain damage 显示文摘 | Hamano S Tanaka Y Nara T | 1995 | Acta Paediatr Jpn1995，37，： | 1 |
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