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| 1 | 长QT综合征复极化离散与早期后除极致心律失常机制的跨壁光学标测研究显示文摘目的 尖端扭转性室性心动过速 (室速 )是长QT综合征 (LQTS)的致命性心律失常 ,相关机制的细胞学水平研究还不十分清楚。本文报道对复极化离散和触发机制在尖端扭转性室速发生中的作用的研究结果。方法 动脉灌注的犬左心室楔形心肌块 ,经电压敏感性荧光染色后 ,行跨壁包括百余位点跨膜动作电位的同步光学标测研究。d 索他洛尔、海银花 (ATX Ⅱ)分别用来模拟LQT2和LQT3。对照组、LQT2组、LQT3组各 6块。结果 正常对照组的平均动作电位时限 (APD)为 (2 91± 2 7)ms,跨壁复极化的离散(DOR)为 (2 4± 6 )ms;LQT2组APD为 (35 6± 2 0 )ms,DOR为 (35± 9)ms,与对照组相比差异有显著性 (P <0 0 5 ) ;LQT3组APD为 (6 0 9± 92 )ms,DOR为 (12 1± 85 )ms,与对照组相比差异有显著性 (P <0 0 5 )。在LQT3组 ,早期后除极现象可见于所有类型的心肌细胞 ,但以心内膜和中层心肌细胞多见。触发活动常常起源于中层心肌细胞部位。结论 在LQT条件下 ,跨壁动作电位不均一地延长是导致复极化离散的重要原因 ,为心律失常的发生提供了基质。 | 刘金秋 杨延宗 Kenneth R Laurita David S Rosenbaum | 2004 | 中华心律失常学杂志2004，8，4： | 5 |
| 2 | Efficacy of boceprevir, an NS3 protease inhibitor, in combination with peginterferon alfa-2b and ribavirin in treatment-naive patients with genotype 1 hepatitis C infection (SPRINT-1): an open-label, randomised, multicentre phase 2 trial显示文摘 | Paul Y Kwo Eric J Lawitz Jonathan McCone Eugene R Schiff John M Vierling David Pound Mitchell N Davis Joseph S Galati Stuart C Gordon Natarajan Ravendhran Lorenzo Rossaro Frank H Anderson Ira M Jacobson Raymond Rubin Kenneth Koury Lisa D Pedicone Clifford | 2010 | The Lancet2010，，9742： | 3 |
| 3 | Late relapses in patients successfully treated for thrombotic thrembocytopenic purpura显示文摘 | Kenneth H S Gail A R Rama C | 1995 | Ann Intern Med1995，122，8： | 1 |
| 4 | Reduced Amygdala Response to Fearful Expressions in Children and Adolescents With Callous-Unemotional Traits and Disruptive Behavior Disorders显示文摘 | Marsh Abigail A Finger Elizabeth C Mitchell Derek G V Reid Marguerite E Sims Courtney Kosson David S Towbin Kenneth E Leibenluft Ellen Pine Daniel S Blair R J R | 2008 | The American Journal of Psychiatry2008，，6： | 1 |
| 5 | The effect of extracellular ice and cryoprotective agenis on the water permeability parameters of human sperm plasma membrane during freezing 显示文摘 | RAMACHANDRA V D DAVID J S KENNETH P R | 2000 | Human Reproduction2000，15，5： | 1 |
| 6 | Autogenous healing of cement paste 显示文摘 | Kenneth R L Floyd O S | 1956 | ACIJournal1956，52，6： | 1 |
| 7 | Physiological responses of cabbage to incipient copper toxicity显示文摘 | Penelope A R Helen C H Kenneth L S | 1989 | J Amer Soc Hor Sci1989，114，1： | 1 |
| 8 | Subzero water permeability parameters of mouse spermatozoa in the presence of extraceUular ice and cryoprotective agents 显示文摘 | RAMACHANDRA V D DAVID J S KENNETH P R | 1999 | Biology of Reproduction1999，61，： | 1 |
| 9 | Multiple-Loop Feedback Topologies for the Design of Low Sensitivity Active Filters显示文摘 | KENNETH R L ROLF S MOHAMMED S G | 1979 | IEEE Trans on CAS1979，26，1： | 1 |
| 10 | 显示文摘 | | 1997 | J Chem Tech Biotechnol1997，68，3： | 1 |
| 11 | The utilization of risk assessments in tactical command decisions 显示文摘 | WARREN W J KENNETH R S G BRUCE B | 2002 | Sei Total Environ2002，288，： | 1 |
| 12 | Equilibrium swelling of hydrophilic polyacrylates in humidity environment 显示文摘 | Chen W L Kenneth R S | 1999 | Macromolecules1999，，32： | 1 |
| 13 | Achieving relationship marketing effectiveneas in business-to-busineas exchanges显示文摘 | ROBERT P W LISA'S K KENNETH R | 2008 | Journal of the Acadmy of Science Sunmmer2008，36，2： | 1 |
| 14 | GLUT1 glucose transporter expression in colorectal carcinoma :a marker for poor prognosis 显示文摘 | Richard s Haber Allison Rathan Kenneth R Weiser | 1998 | Cancer1998，83，： | 1 |
| 15 | Precision DC-to-AC power conversion by optimization of the output current waveform-the half bridge revisited显示文摘 | GERALD R S KENNETH M B | 1999 | IEEE Trans on Power Electronics1999，14，2： | 1 |
| 16 | A Field Study of Reflectivity and Z-R Relations Using Vertically Pointing Radars and Disdrometers显示文摘 | Tokay Ali Hartmann Peter Battaglia Alessandro Gage Kenneth S Clark Wallace L Williams Christopher R | 2009 | Journal of Atmospheric and Oceanic Technology2009，，6： | 1 |
| 17 | Multiple-Loop Feedback Topologies for the Design of Low Sensitivity Active Filters显示文摘 | KENNETH R L ROLF S MOHAMMED S G | 1979 | IEEE Trans on CAS1979，26，1： | 1 |
| 18 | Effects of feeding practical diets containing various protein levels on growth, survival, body composition, and processing traits of australian red claw crayfish (cherax quadricarinatus) and on pond water quality显示文摘 | Thompson Kenneth R Muzinic Laura A Engler Linda S | 2004 | Aquaculture Research2004，35，： | 1 |
| 19 | Microporous membrane formation via thermally-induced phase separation ( Ⅶ ) Effect of dilution, cooling rate, and nucleating agent addition on morphology 显示文摘 | McGuire Kenneth S Lloyd Douglas R | 1993 | J Membr Sci1993，79，1： | 1 |
| 20 | Mandatory steroid testing of high school athletes:A synthesis of state ini- tiatives and federal constitutional rights显示文摘 | KENNETH J S KEITH M C SHANTEL R K | 2012 | J Legal Aspects Sport2012，，21： | 1 |
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