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| 1 | Multiple esophageal variceal ruptures with massive ascites due to myelofibrosis-induced portal hypertension显示文摘A 75-year old man had been diagnosed at 42 years of age as having polycythemia vera and had been monitored at another hospital. Progression of anemia had been recognized at about age 70 years, and the patient was thus referred to our center in 2008 where secondary myelofibrosis was diagnosed based on bone marrow biopsy findings. Hematemesis due to rupture of esophageal varices occurred in January and February of 2011. The bleeding was stopped by endoscopic variceal ligation. Furthermore, in March of the same year, hematemesis recurred and the patient was transported to our center. He was in irreversible hemorrhagic shock and died. The autopsy showed severe bone marrow fibrosis with mainly argyrophilic fibers, an observation consistent with myelofibrosis. The liver weighed 1856 g the spleen 1572 g, indicating marked hepatosplenomegaly. The liver and spleen both showed extramedullary hemopoiesis. Myelofibrosis is often complicated by portal hypertension and is occasionally associated with gastrointestinal hemorrhage due to esophageal varices. A patient diagnosed as having myelofibrosis needs to be screened for esophageal/gastric varices. Myelofibrosis has a poor prognosis. Therefore, it is necessary to carefully decide the therapeutic strategy in consideration of the patient's concomitant conditions, treatment invasiveness and quality of life. | Koichi Tokai Hiroyuki Miyatani Yukio Yoshida Shigeki Yamada | 2012 | World Journal of Gastroenterology2012，18，28： | 5 |
| 2 | NON-STATIONARY STOKES FLOWS UNDER LEAK BOUNDARY CONDITIONS OF FRICTION TYPE显示文摘This paper is concerned with the initial value problem for non-stationary Stokes flows, under a certain non-linear boundary condition which can be called the leak boundary condition of friction type. Theoretically, our main purpose is to show the strong solvability (i.e.,the unique existence of the L2-strong solution) of this initial value problem by means of the non-linear semi-group theory originated with Y. Komura. The method of analysis can be applied to other boundary or interface conditions of friction type. It should be noted that the result yields a sound basis of simulation methods for evolution problems involving these conditions., | Hiroshi Fujita (The Research institute of Educational Development, Tokai University, Shibuya-ku, Tokyo 151-0063, Japan) | 2001 | Journal of Computational Mathematics2001，19，1： | 3 |
| 3 | High K^+-induced contraction requires depolarization- induced Ca^2+ release from internal stores in rat gut smooth muscle显示文摘 | Timo KIRSCHSTEIN Mirko REHBERG Rika BAJORAT Tursonjan TOKAY Katrin PORATH Rudiger KOHLING | 2009 | Acta Pharmacologica Sinica2009，30，8： | 3 |
| 4 | Methods of determining the mesh selectivity curves of trawlnet显示文摘 | Tokai T Kitahara T | 1989 | Nippon Suisan Gakkaishi1989，55，： | 2 |
| 5 | Relationship between cognitive im-pairment and retinal morphological and visual functional abnormalities in Alzheimer disease 显示文摘 | Isefi PK Altinas O Tokay T | 2006 | J Neuroophthalmo12006，26，： | 1 |
| 6 | A static analysis of the tension and configu- ration of submerged plane nets 显示文摘 | Wan R Hu F Tokai T | 2002 | Fisheries Science2002，68，4： | 1 |
| 7 | MRI can determine the ade- quate area for debridement in the case of Fournier' s gangrene 显示文摘 | Yoneda A Fujita F Tokai H | 2010 | Int Surg2010，95，1： | 1 |
| 8 | Congenital intrarenal teratoma arising from a horseshoe kidney显示文摘 | Mochizuki K Ohno Y Tokai Y | 2006 | J Pediatr Surg2006，41，7： | 1 |
| 9 | An explanation for the existence of supercooled water at the top of cold clouds显示文摘 | Rauber R M A Tokay | 1991 | J Atmos Sci1991，48，8： | 1 |
| 10 | Risk ownership in contract manufacturing显示文摘 | Uklfi S Beril Tokay L Yiicesan E | 2007 | Manufacturing &: Service Op- erations Management2007，9，3： | 1 |
| 11 | Fusarium Tri4 encodes a key multifunctional cytochrome P450 monooxygenase for four consecutive oxygenation steps in trichothecene biosynthesis显示文摘 | TOKAI T KOSHINO H TAKAHASHI-ANDO N | 2007 | Biochem Biophys Res Commun2007，353，： | 1 |
| 12 | Computer simulation of shape and tension on fishing net and rope system 显示文摘 | WAN R HU F X TOKAI T | 2002 | Fisheries Science2002，，： | 1 |
| 13 | Blocking defects inSAPO-34 membranes with cyclodextrin 显示文摘 | Zhang Y Avila A M Tokay B | 2010 | Membr Sci2010，358，： | 1 |
| 14 | Hypothalamic orexin prevents hepatic insulin resistance via daily bidirectional regulation of autonomic nervous system in mice显示文摘 | Tsuneki t-I Tokai E Nakamura Y | 2015 | Diabetes2015，64，2： | 1 |
| 15 | A wheat xylanase inhibitor gene,Xip-Ⅰ,but not Taxi-Ⅰ,is significantly induced by biotic and abiotic signals that trigger plant defense显示文摘 | IGAWA T TOKAI T KUDO T | 2005 | Bioscience Biotechnology and Biochemistry2005，69，： | 1 |
| 16 | A method for analyzing static response of submerged rope system based on a finite olement method 显示文摘 | Wan R Hu F X Tokai T | 2002 | Fish Sci2002，68，： | 1 |
| 17 | A Field Study of Reflectivity and Z-R Relations Using Vertically Pointing Radars and Disdrometers显示文摘 | Tokay Ali Hartmann Peter Battaglia Alessandro Gage Kenneth S Clark Wallace L Williams Christopher R | 2009 | Journal of Atmospheric and Oceanic Technology2009，，6： | 1 |
| 18 | Evidence from tropical raindrop spectra of the origin of rain from stratiform versus convective clouds显示文摘 | TOKAY A SHORT D A | 1996 | J Appl Meteor1996，35，3： | 1 |
| 19 | A static analysis of the tension and configuration of submerged plane nets 显示文摘 | Wan R Hu F X Tokai T | 2002 | Fish Sci2002，68，： | 1 |
| 20 | A method of determining selectivity curve of separator grid 显示文摘 | Tokai T Omoto S Sato R | 1996 | Fish Res1996，27，13： | 1 |
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