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| 1 | Review on Zinc Oxide Nanoparticles: Antibacterial Activity and Toxicity Mechanism显示文摘Antibacterial activity of zinc oxide nanoparticles(Zn O-NPs) has received significant interest worldwide particularly by the implementation of nanotechnology to synthesize particles in the nanometer region. Many microorganisms exist in the range from hundreds of nanometers to tens of micrometers. Zn O-NPs exhibit attractive antibacterial properties due to increased specific surface area as the reduced particle size leading to enhanced particle surface reactivity. Zn O is a bio-safe material that possesses photo-oxidizing and photocatalysis impacts on chemical and biological species. This review covered Zn O-NPs antibacterial activity including testing methods, impact of UV illumination, Zn O particle properties(size, concentration, morphology, and defects), particle surface modification, and minimum inhibitory concentration. Particular emphasize was given to bactericidal and bacteriostatic mechanisms with focus on generation of reactive oxygen species(ROS) including hydrogen peroxide(H2O2), OH-(hydroxyl radicals), and O2-2(peroxide). ROS has been a major factor for several mechanisms including cell wall damage due to Zn O-localized interaction, enhanced membrane permeability, internalization of NPs due to loss of proton motive force and uptake of toxic dissolved zinc ions.These have led to mitochondria weakness, intracellular outflow, and release in gene expression of oxidative stress which caused eventual cell growth inhibition and cell death. In some cases, enhanced antibacterial activity can be attributed to surface defects on Zn O abrasive surface texture. One functional application of the Zn O antibacterial bioactivity was discussed in food packaging industry where Zn O-NPs are used as an antibacterial agent toward foodborne diseases. Proper incorporation of Zn O-NPs into packaging materials can cause interaction with foodborne pathogens, thereby releasing NPs onto food surface where they come in contact with bad bacteria and cause the bacterial death and/or inhibition. | Amna Sirelkhatim Shahrom Mahmud Azman Seeni Noor Haida Mohamad Kaus Ling Chuo Ann Siti Khadijah Mohd Bakhori Habsah Hasan Dasmawati Mohamad | 2015 | Nano-Micro Letters2015，7，3： | 76 |
| 2 | NLRP6 Inflammasome Regulates Colonic Microbial Ecology and Risk for Colitis显示文摘 | Eran Elinav Till Strowig Andrew L. Kau Jorge Henao-Mejia Christoph A. Thaiss Carmen J. Booth David R. Peaper John Bertin Stephanie C. Eisenbarth Jeffrey I. Gordon Richard A. Flavell | 2011 | Cell2011，，5： | 3 |
| 3 | The morality of software piracy: A cross-cultural analysis显示文摘 | W. R. Swinyard H. Rinne A. Keng Kau | 1990 | Journal of Business Ethics1990，，8： | 2 |
| 4 | 改进输配电系统接线以改善电能质量的评估显示文摘 | Teh Ah Kau 潘国美 | 2003 | 供用电2003，20，1： | 2 |
| 5 | Three-dimensional cone beam computerized tomography in orthodontics显示文摘 | Kau CH Richmond S Palomo JM | 2005 | J Orthod2005，32，： | 1 |
| 6 | Exatramed- ullary palsmacytoma: Tumor occurrence and therapeutic concepts 显示文摘 | Alexiou C Kau R J Dietzfelbinger H | 1999 | Cancer1999，85，11： | 1 |
| 7 | Prognostic value of pathologic complete response after primary chemotherapy in relation to hormone receptor status and other factors 显示文摘 | Guarneri V Broglio K Kau SW | 2006 | J Clin Oncol2006，24，7： | 1 |
| 8 | Factors influencing the application accuracy of neuronavigation systems显示文摘 | Steinmeier R Rachinger J Kaus M | 2000 | Stereotact Funct Neurosurg2000，75，4： | 1 |
| 9 | German Environmental Sur- vey 1998 (GerES III): environmental pollutants in the urine of the German population显示文摘 | Becker K Schulz C Kaus S | 2003 | Int J Hyg Environ Health2003，206，1： | 1 |
| 10 | Aortic development and anomalies显示文摘 | Kau T Sinzig M Gasser J | 2007 | Semin Intervent Radiol2007，24，2： | 1 |
| 11 | Three-dimensional cone beam computerize tomography in orthodontics显示文摘 | Kau CH Richmond S Palomo JM | 2005 | J Orthod2005，32，4： | 1 |
| 12 | Prictions, heterogeneity and optimality in mortgage modeling显示文摘 | Kau J B Jr Slawson V C | 2002 | Journal of Real Estate Finance and Economics2002，24，3： | 1 |
| 13 | A new LMl-based approach to relaxed quadratic stabilization of T-S fuzzy control systems显示文摘 | FANG C H LIU Y S KAU S W | 2006 | IEEE Transactions on Fuzzy Systems2006，14，3： | 1 |
| 14 | Vibrio parab- aemolyticus infectious for both humans and edible mollusk abalone 显示文摘 | Kuo - Kau Lee Ping - Chung Liu Chi - Yang Huang | 2003 | Microbes and Infection2003，5，6： | 1 |
| 15 | Human nutrition, the gut microbiome and the immune system显示文摘 | KAU A L AHEM P P GRIFFIN N W | 2011 | Nature2011，474，7351： | 1 |
| 16 | Volatile composition and antioxidant capacity of Arabica coffee显示文摘 | Mun Wai Cheong Kau Hin Tong Jeremy Jian Ming Ong | 2013 | Food Research International2013，51，： | 1 |
| 17 | Autism spectrum disorder in fragile X syndrome:communication,social interaction,and specific behaviors显示文摘 | Kaufmann WE Cortell R Kau AS | 2004 | American Journal of Medical Genetics2004，129，3： | 1 |
| 18 | Digital models vs plaster models using alginate and alginate substitute materials显示文摘 | Torassian G Kau CH English JD | 2010 | Angle Orthod2010，80，4： | 1 |
| 19 | Photopro- tection by silk cocoons显示文摘 | KAU'R J RAJKHOWA R TSUZUKI T | 2013 | Biomacromolecules2013，14，10： | 1 |
| 20 | The 3-Dimensional construction of the average 11-year-old child face: A clinical evaluation and application显示文摘 | Kau CH Zhurov A Richmond S | 2006 | J Oral Maxillofac Surg2006，64，7： | 1 |
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