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| 1 | Exploratory study on microRNA profiles from plasma-derived extracellular vesicles in Alzheimer’s disease and dementia with Lewy bodies显示文摘Background:Because of the increasing life expectancy in our society,aging-related neurodegenerative disorders are one of the main issues in global health.Most of these diseases are characterized by the deposition of misfolded proteins and a progressive cognitive decline.Among these diseases,Alzheimer’s disease(AD)and dementia with Lewy bodies(DLB)are the most common types of degenerative dementia.Although both show specific features,an important neuropathological and clinical overlap between them hampers their correct diagnosis.In this work,we identified molecular biomarkers aiming to improve the misdiagnosis between both diseases.Methods:Plasma extracellular vesicles(EVs)-from DLB,AD and healthy controls-were isolated using size-exclusion chromatography(SEC)and characterized by flow cytometry,Nanoparticle Tracking Analysis(NTA)and cryo-electron microscopy.Next Generation Sequencing(NGS)and related bibliographic search was performed and a selected group of EV-associated microRNAs(miRNAs)was analysed by qPCR.Results:Results uncovered two miRNAs(hsa-miR-451a and hsa-miR-21-5p)significantly down-regulated in AD samples respect to DLB patients,and a set of four miRNAs(hsa-miR-23a-3p,hsa-miR-126-3p,hsa-let-7i-5p,and hsamiR-151a-3p)significantly decreased in AD respect to controls.The two miRNAs showing decreased expression in AD in comparison to DLB provided area under the curve(AUC)values of 0.9 in ROC curve analysis,thus suggesting their possible use as biomarkers to discriminate between both diseases.Target gene analysis of these miRNAs using prediction online tools showed accumulation of phosphorylation enzymes,presence of proteasome-related proteins and genes involved in cell death among others.Conclusion:Our data suggest that plasma-EV associated miRNAs may reflect a differential profile for a given dementia-related disorder which,once validated in larger cohorts of patients,could help to improve the differential diagnosis of DLB versus AD. | Ana Gámez-Valero Jaume Campdelacreu Dolores Vilas Lourdes Ispierto Ramón Reñé RamiroÁlvarez MPilar Armengol Francesc E.Borràs Katrin Beyer | 2019 | Translational Neurodegeneration2019，8，1： | 4 |
| 2 | Latencies to First Typical Generalized Spike-Wave Discharge in Idiopathic Generalized Epilepsies During Video-EEG Monitoring显示文摘 | Bernhard Oehl Katrin G?tz-Trabert Armin Brandt Christiane Lehmann Andreas Schulze-Bonhage | 2010 | Journal of Clinical Neurophysiology2010，，1： | 2 |
| 3 | Phenological adaptation of ant- dispersed plants to seasonal variation in ant activity 显示文摘 | Reik O Katrin B G | 2002 | Ecology2002，83，： | 1 |
| 4 | Male zebrafish (Danio rerio) courtship behaviour resists the feminizing effects of 17α-ethinyloestradiol -morphological sexual characteristics do not 显示文摘 | Mia G L Katrine B H Per G H | 2008 | Aquatic Toxicology2008，87，4： | 1 |
| 5 | Homozygosity for the CARD15 frameshift mutation 1007fs is predictive of early onset of Crohn’s disease with ileal stenosis, entero-enteral fistulas, and frequent need for surgical intervention with high risk of re-stenosis显示文摘 | Julia Seiderer Fabian Schnitzler Stephan Brand Tanja Staudinger Simone Pfennig Karin Herrmann Katrin Hofbauer Julia Dambacher Cornelia Tillack Michael Sackmann Burkhard G?ke Peter Lohse Thomas Ochsenkühn | 2006 | Scandinavian Journal of Gastroenterology2006，，12： | 1 |
| 6 | Review the multiple functions of coenzyme Q显示文摘 | Hans N Katrin S Lars G | 2001 | Bioorg Chem2001，29，1： | 1 |
| 7 | Review the multiple functions of coenzyme Q显示文摘 | HANS N KATRIN S LARS G | 2001 | Bioorg Cherm2001，29，： | 1 |
| 8 | Macroecology meets global change research显示文摘 | Ingolf K Katrin B G Wolfgang C | 2008 | Globle Ecology and Biogeography2008，17，1： | 1 |
| 9 | Psychology of sustainable travel behav- ior 显示文摘 | Tina G Katrin D Tommy G | 2013 | Transportation Research Part A :Policy and Practice2013，48，： | 1 |
| 10 | Kidney transplantation from related and unrelated living donors in a single German centre显示文摘 | ADINA VOICULESCU KATRIN IVENS HETZEL G R | 2003 | Nephrol Dial Transplant2003，18，： | 1 |
| 11 | Diclofenac release from phos- pholipid drug systems and permeation through excised human stratum corneum 显示文摘 | Katrin K Christel C Miller G | 1995 | Int J Pharm1995，125，2： | 1 |
| 12 | Angiographic progression of coronary artery disease in patients with endstage renal disea se显示文摘 | Frank G Katrin I | 2001 | Nephrol Dial Transplant2001，16，9： | 1 |
| 13 | Photosynthetic effi-ciency as a function of thermal stratification and phyto-plankton size structure in an oligotrophic alpine lake显示文摘 | Christina K Sonja G Katrin T | 2007 | Hydrobiologia2007，578，1： | 1 |
| 14 | Phosphatases in serum in health and disease 显示文摘 | KATRINE B WHITAKER L G WHITBY | 1977 | Clin Chim Acta1977，80，： | 1 |
| 15 | Regulation of planktonic ciliate dynamics and functional composition during spring in Lake Constance 显示文摘 | Katrin T Ursula G | 2007 | Aquat Microb Ecol2007，49，： | 1 |
| 16 | On Levels of Detail in Terrain显示文摘 | Mark de Berg Katrin T G Dobrindt | 1998 | Graphical Models and Image Processing1998，60，1： | 1 |
| 17 | Calorimetric investigatiOn Of urease inhibitionby heavy metal ions 显示文摘 | Katrin O Hfittl R Wolf G | 1998 | Thermvchimica Acta1998，310，： | 1 |
| 18 | Glioma stem cells as a target for treatment显示文摘 | Katrin Lamszus Hauke S. Günther | 2010 | Targeted Oncology2010，，3： | 1 |
| 19 | Inventory of glaciers in Isla Riesco, Patagonia, Chile, based on aerial photography and satellite imagery 显示文摘 | i Casassa G Katrine S Andres R etal | 2002 | Annuals of Glaciology2002，34，： | 1 |
| 20 | Inventory of Glaciers in Isla Ricseo, Palagonia, Chile, based on Aerial Photography and Satellite Imagery显示文摘 | Gasassa A G Katrine S And res R | 2002 | Annuals of Glaciology2002，34，： | 1 |
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